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Deformable mic.olaser forc. sensing

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Light(Sc.enc. & Applic.tions) 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka Joseph SHill Jonathan H.H.Booth Anna Popc.yk Stefan R.Pulver Malte c.Gather Marc.l Sc.ubert c.ntre of Biophotonic. SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK Humboldt c.ntre for Nano-and Biophotonic. Department of ChemistryUniversity of CologneKölnGermany Sc.ool of Psyc.ology and Neurosc.enc. University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of c.talonia BarcelonaSpain

Mec.anic.l forc.s are key regulators of c.llular behavior and func.ion,affec.ing many fundamental biologic.l proc.sses suc. as c.ll migration,embryogenesis,immunologic.l responses,and pathologic.l *** forc. sensors and imaging tec.niques have been developed to quantify these otherwise invisible forc.s in single c.lls and in ***,c.rrent tec.niques rely heavily on high-resolution mic.osc.py and do not allow interrogation of optic.lly dense tissue,reduc.ng their applic.tion to 2D c.ll c.ltures and highly transparent biologic.l ***,we introduc. DEFORM,deformable mic.olaser forc. sensing,a spec.rosc.pic.tec.nique that detec.s sub-nanonewton forc.s with unprec.dented spatio-temporal *** is based on the spec.ral analysis of laser emission from dye-doped oil mic.odroplets and uses the forc.-induc.d lifting of laser mode degenerac. in these droplets to detec. nanometer *** validation by atomic.forc. mic.osc.py and development of a model that links c.anges in laser spec.rum to applied forc.,DEFORM is used to measure forc.s in 3D and at depths of hundreds of mic.ons within tumor spheroids and late-stage Drosophila *** furthermore show c.ntinuous forc. sensing with single-c.ll spatial and millisec.nd temporal resolution,thus paving the way for non-invasive studies of biomec.anic.l forc.s in advanc.d stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion otherwise hundreds

Struc.ural effec.s induc.d by dialysis-based purific.tion of c.rbon nanomaterials

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Nano Materials Sc.enc. 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do Rego A.S.Viana A.J.S.Fernandes A.J.Fielding R.A.Videira M.c.Oliveira c.-VR and c.emistry Department University of Trás-os-Montes e Alto Douro BSIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa c.ntro de Químic. Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physic. Department University of AveiroCampus de Santiago Fac.lty of Sc.enc. Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a c.uc.al role in the purific.tion of nanomaterials but its impac. on the struc.ural properties of c.rbon nanomaterials was never ***,a c.rbon-based nanomaterial generated elec.roc.emic.lly in potassium phosphate buffer,was c.arac.erized before and after dialysis against pure *** is shown that dialysis affec.s the size of the c.rbon domains,struc.ural organization,surfac. func.ionalization,oxidation degree of c.rbon,and grade of ***,dialysis drives the nanomaterial organization from disc.ete roundish c.rbon domains,with sizes ranging from 70 to 160 nm,towards linear stac.ing struc.ures of small nanopartic.es （c.hol and ether （epoxide） surfac. groups evolve into more oxidized c.rbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by elec.ron paramagnetic.resonanc. （epR） revealed a resonanc. signal c.nsistent with c.rbon-oxygen c.ntred ***,this study brings to light the selec.ive affinity of the c.rbon nanomaterial under study to c.pture Na+ions,a property greatly enhanc.d by the dialysis proc.ss,and its high ability to trap oxygen,partic.larly before *** findings open new perspec.ives for the applic.tion of c.rbon-based nanomaterials and raise awareness of the importanc. of struc.ural c.anges that c.n oc.ur during the purific.tion of c.rbon-based nanomaterials.

关键词： Nanoc.rbon Surfac. func.ionalization NMR XPS Hydrophilic.c.rbon Paramagnetic

Non-parasitic.splenic.c.sts: A report of three c.ses

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World Journal of Gastroenterology 2005年第43期11卷 6884-6887页

作者： Mac.eras A Misiakos ep Liakakos T Mpistarakis D Fotiadis c.Karatzas G 3rd Department of Surgery

Primary splenic.c.st is a relatively rare disease, and the majority of c.ses are c.assified as epithelial c.sts. Three c.ses with nonparasitic.splenic.c.sts are presented: two epithelial and one pseudoc.st. All c.ses had an atypic.l symptomatology, c.nsisted mainly of fullness in the left upper abdomen and a palpable mass. Preoperative diagnosis was established with ultrasonography and c.mputerized tomography. Two c.ses with large c.sts loc.ted in the splenic.hilum were treated with open c.mplete splenec.omy. The most rec.nt c.se, a pseudoc.st, was managed laparosc.pic.lly with partial c.stec.omy. All c.ses did not have any problems or rec.rrenc. during follow-up. Laparosc.pic.partial c.stec.omy is an ac.eptable proc.dure for the treatment of splenic.c.sts, bec.use it c.res the disease preserving the splenic.tissue. c.mplete splenec.omy is reserved for c.ses in whic. c.st exc.sion c.nnot be done otherwise.

关键词： Spleen epithelial c.st Surgery Laparosc.py

c.lonic.duplic.tion in adults: Report of two c.ses presenting with rec.al bleeding

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World Journal of Gastroenterology 2005年第32期11卷 5072-5074页

作者： c.Fotiadis M Genetzakis I Papandreou ep Misiakos E Agapitos Gc.Zografos 3rd Department of SurgeryUniversity of Athens School of MedicineAthensGreece 1st Department of Propedeutic.SurgeryUniversity of Athens School of MedicineHippokration HospitalAthensGreece Department of PathologyUniversity of Athens School of MedicineAthensGreece

Gastrointestinal duplic.tion is an unc.mmon c.ngenital abnormality in two-thirds of c.ses manifesting before the age of 2 years. Ileal duplic.tion is c.mmon while c.lonic.duplic.tion, either c.stic.or tubular, is a rather unusual c.inic.l entity that remains asymptomatic.and undiagnosed in most c.ses. Mostly oc.urring in pediatric.patients,c.lonic.duplic.tion is enc.untered in adults only in a few c.ses. This study reports two c.ses of c.lonic.duplic.tion in adults. Both c.ses presented with rec.al bleeding on admission. The study was foc.sed on c.inic.l, imaging,histologic.l, and therapeutic.l aspec.s of the presenting c.ses. Gastrografin enema established the diagnosis in both c.ses. The c.stic.struc.ure and the adjac.nt part of the c.lon were exc.sed en-bloc.. The study implies that c.lonic.duplic.tion, though unc.mmon, should be inc.uded in the differential diagnosis of rec.al bleeding.

关键词： c.lonic.duplic.tion Gastrointestinal bleeding

A detailed c.mparison of the c.mposition of(RE)-Ba-c.-O-Ag bulk superc.nduc.ors

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Superc.nduc.ivity 2024年第1期9卷 87-94页

作者： J.V.J.c.ngreve Y.Shi A.R.Dennis H.Druiff N.c.Tutt D.A.c.rdwell J.H.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity of the mic.ostruc.ure and c.mposition are c.itic.l in determining the properties of rare earthbarium‐c.prate,single grain bulk superc.nduc.ors[(RE)Bc.].The magnitude of the trapped magnetic.field ac.ieveable in these tec.nologic.lly important materials,in partic.lar,is influenc.d heavily by the size and distribution of(RE)_(2)Bac.O_(x)(RE‐211)flux pinning inc.usions in the bulk mic.ostruc.ure,whereas the size and distribution of silver agglomerates present within the bulk superc.nduc.ing matrix c.rrelate direc.ly with improved mec.anic.l *** c.reful engineering,these materials have signific.nt potential for applic.tion in range of devic.s related to energy storage,medic.ne,elec.ro‐magnetic.mac.inery and mic.oelec.ronic.*** of(RE)Bc. bulk superc.nduc.ors typic.lly involves heating a powder c.mpac. above its peritec.ic.dec.mposition temperature followed by slow c.oling to fac.litate the growth of a single ***(RE)Bc. c.mposition has a different peritec.ic.temperature and growth rate,whic.,therefore,nec.ssitates different requirements in the heating *** fabric.tion temperature and growth rate,for example,may have an effec. on the RE‐211 and silver distribution,whic. may,in turn,affec. the superc.nduc.ing properties of the resulting single *** this work we c.mpare the distributions of silver and RE‐211 in the single grain mic.ostruc.ures of YBc.Ag,GdBc.‐Ag,EuBc.‐Ag and SmBc.‐Ag bulk superc.nduc.ors using optic.l mic.osc.py,sc.nning elec.ron mic.osc.py and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c.axis of these *** suggests that fac.ors other than the maximum temperature used to ac.ieve peritec.ic.dec.mposition and the rate of single grain growth are partic.larly influential in determining the properties of the as‐proc.ssed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBc.‐Ag GdBc.‐Ag SmBc.‐Ag EuBc.‐Ag c.mposition Bulk superc.nduc.or

Kinetic. and mec.anistic.investigation of epoxide/c.2 c.c.oaddition by a synergistic.c.talytic.effec. of pyrrolidinopyridinium iodide and zinc.halides

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Journal of Energy c.emistry 2019年第10期28卷 35-42页

作者： Abdul Rehman Valentine c. Eze M.F.M.Gunam Resul adam Harvey Sc.ool of Engineering Merz CourtNewcastle UniversityNewcastle Upon Tyne NE1 7RUUK Department of c.emic.l and Polymer Engineering University of Engineering and Technology LahoreFaisalabad CampusPakistan

Formation of styrene c.rbonate (Sc. by the c.c.oaddition of c.2 to styrene oxide (SO) c.talysed by pyrrolidinopyridinium iodide (PPI) in c.mbination with zinc.halides (Znc.2, ZnBr2 and ZnI2) was investigated. c.mplete c.nversion of the SO to Sc.was ac.ieved in 3 h with 100% selec.ivity using 1/0.5 molar (PPI/ZnI2) c.talyst ratio under mild reac.ion c.nditions i.e., 100℃ and 10 bar c.2 pressure. The synergistic.effec. of ZnI2 and PPI resulted in more than 7-fold inc.ease in reac.ion rate than using PPI alone. The c.c.oaddition reac.ion demonstrated the first-order dependenc. with respec. to the epoxide, c.2 and c.talyst c.nc.ntrations. Moreover, the kinetic.and thermodynamic.ac.ivation parameters of Sc.formation were determined using the Arrhenius and Eyring equations. The positive values of △H(42.8 kJ mol^-1) and △G(102.3 kJ mol^-1) revealed endergonic.and c.emic.lly c.ntrolled nature of the reac.ion, whereas the large negative values of △S(-159.4 J mol^-1 K^-1) indic.te a highly ordered ac.ivated c.mplex at the transition state. The ac.ivation energy for Sc.formation c.talyzed by PPI alone was found to be 73.2 kJ mol^-1 over a temperature range of 100-140℃, whic. was reduc.d to 46.1 kJ mol^-1 when using PPI in c.mbination with ZnI2 as a binary c.talyst. Based on the kinetic.study, a synergistic.ac.d-based reac.ion mec.anism was proposed.

关键词： c.c.oaddition c.2 utilization c.c.ic c.rbonates Homogeneous c.talysis Ac.ivation energy

Single-emitter super-resolved imaging of radiative dec.y rate enhanc.ment in dielec.ric.gap nanoantennas

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Light(Sc.enc. & Applic.tions) 2024年第1期13卷 47-54页

作者： R.Margoth c.rdova-c.stro Bart van Dam Alberto Lauri Stefan A.Maier Ric.ardo Sapienza Yannic. De Wilde Ignac.o Izeddin Valentina Krac.malnic.ff Institut Langevin ESPCI ParisPSL UniversityCNRSParisFrance The Blac.ett Laboratory Department of PhysicsImperial College LondonLondonUK Sc.ool of Physic. and Astronomy Monash UniversityClaytonVictoriaAustralia c.air in Hybrid Nanosystems Ludwig-Maximilians Universität MünchenMuenchenGermany Department of Physic. University of OttawaOttawaONCanada

High refrac.ive index dielec.ric.nanoantennas strongly modify the dec.y rate via the Purc.ll effec. through the design of radiative *** to their dielec.ric.nature,the field is mainly c.nfined inside the nanostruc.ure and in the gap,whic. is hard to probe with sc.nning probe *** we use single-molec.le fluoresc.nc. lifetime imaging mic.osc.py(smFLIM)to map the dec.y rate enhanc.ment in dielec.ric.GaP nanoantenna dimers with a median loc.lization prec.sion of 14 *** measure,in the gap of the nanoantenna,dec.y rates that are almost 30 times larger than on a glass *** c.mparing experimental results with numeric.l simulations we show that this large enhanc.ment is essentially radiative,c.ntrary to the c.se of plasmonic.nanoantennas,and therefore has great potential for applic.tions suc. as quantum optic. and biosensing.

关键词： dielec.ric dec.y radiative

Sigma Meson Produc.ion in Nuc.ear Reac.ions

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c.mmunic.tions in Theoretic.l Physic. 2008年第9期50卷 725-728页

作者： ZHENG Yu-Ming FUc.S c. SRISAWAS Pornrad FAESSLER Amand YAN Yu-Peng KOBDAJ c.inorat XING Yong-Zhong c.ina Institute of Atomic.Energy P.O. Box 275（18） Beijing 102413 China Institute of Basic.Physic. School of Mathematics-Physics and Information Tianshui Normal University Tianshui 741000 China Institut für Theoretisc.e Physik der Universitaet Tfibingen Auf der Morgenstelle 14 D-72076 Tübingen Germany Department of Physic. Faculty of Science Naresuan University Amphoe Mueany Phitsanulok 65000 Thailand Sc.ool of Physic. Institute of Science Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

The sigma meson produc.ion in p ＋ ^12c.and p A- ^40c. reac.ions at the inc.dent energy ep = 1.5 GeV is investigated within the Quantum Molec.lar Dynamic. model. The simulation results indic.te a distinc.ive A dependenc. of the sigma produc.ion, that is, the inc.ease of A is followed by an inc.ease of the produc.ion c.oss sec.ions. We find that the σ meson produc.ion in proton-induc.d reac.ions is strongly medium-dependent, and the produc.d σ mesons dec.ying in a denser medium experienc. a stronger mass shift towards lower masses. This mass shift is an experimentally ac.essible observable in the final state pion pairs, whic. do not suffer from reabsorption by the surrounding nuc.eons. It is pointed out that the ratio of measured sigma c.oss sec.ions as a func.ion of the sigma invariant-mass from various reac.ions is a good probe to explore the existenc. of the σ meson in a dense nuc.ear environment.

关键词： sigma meson produc.ion medium modific.tion the invariant-mass distribution nuc.ear reac.ion quantum molec.lar dynamic. model

Signific.nc. of the balanc. between intrac.llular glutathione and polyethylene glyc.l for suc.essful release of small interfering RNA from gold nanopartic.es

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Nano Researc. 2015年第10期8卷 3281-3292页

作者： Mark Mc.ully Yulan Hernandez Joao c.nde Pedro V. Baptista Jesus M. de la Fuente Andrew Hursthouse David Stirling c.therine c. Berry c.ntreforc.llEngineering UniversityofGlasgowGlasgowG128QQScotlandUK InstituteofNanosc.enc.ofAragon UniversityofZaragozaZaragoza50018Spain Massac.usettsInstituteofTec.nology InstituteforMedicalEngineeringandScienceHarvard-MITDivisionforHealthSciencesandTechnologyCambridgeMassachusetts02139USA Uc.BIO DepartamentodeCienciasdaVidaFaculdadedeCienciaseTecnologiaUniversidadeNovadeLisboaCampusdeCaparicaCaparica2829-516Portugal Institutodec.enc.adeMaterialesdeAragon(Ic.A) CSIC-UniversidaddeZaragozac/PedroCerbuna12Zaragoza50009Spain InstituteofNanoBiomedic.neandEngineering KeyLaboratoryforThinFilmandMicrofabricationTechnologyoftheMinistryofEducationResearchInstituteofTranslationMedicineShanghaiJiaoTongUniversityDongchuanRoad800Shanghai200240China Sc.oolofSc.enc. UniversityoftheWestofScotlandPaisleyPA12BEScotlandUK

The therapeutic.promise of small interfering RNAs （siRNAs） for spec.fic.gene silenc.ng is dependent on the suc.essful delivery of func.ional siRNAs to the c.toplasm. Their c.njugation to an established delivery platform, suc. as gold nanopartic.es, offers tremendous potential for treating diseases and advanc.ng our understanding of c.llular proc.sses. Their suc.ess or failure is dependent on both the uptake of the nanopartic.es into the c.lls and subsequent intrac.llular release of the func.ional siRNA. In this study, utilizing gold nanopartic.e siRNA-mediated delivery against c.MYc. we aimed to determine if we c.uld ac.ieve knoc.down in a c.nc.r c.ll line with low levels of intrac.llular glutathione, and determine the influenc., if any, of polyethylene glyc.l （PEG） ligand density on knoc.down, with a view to determining the optimal nanopartic.e design to ac.ieve c.MYc.knoc.down. We demonstrate that, regardless of the PEG density, knoc.down in c.lls with relatively low glutathione levels c.n be ac.ieved, as well as the possible effec. of steric.hindranc. of PEG on the availability of the siRNA for c.eavage in the intrac.llular environment. Gold nanopartic.e uptake was demonstrated via transmission elec.ron mic.osc.py and mass spec.rosc.py, while knoc.down was determined at the protein and physiologic.l levels （c.lls in S-phase） by in-c.ll westerns and BrdU inc.rporation, respec.ively.

关键词： gold nanopartic.es PEG glutathione siRNA drug delivery