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Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl_4-induced hepatotoxicity in rats

Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 524-529页

作者： El Moataz Bellah El Naggar Marta Chalupova Gabriela pra anov a Tom a Par ak Emil vajdlenka Milan emlika Pavel Such Department of Pharmacognosy Faculty of Pharmacy Damanhur UniversityEgypt Department of Human Pharmacology and Toxicology Faculty of Pharmacy University of Veterinary and Pharmaceutical SciencesBrnoCzech Republic Department of Natural Drugs Faculty of Pharmacy University of Veterinary and Pharmaceutical SciencesBrnomCzech Republic

Objective: To investigate the effects of perorally administered juice on tetrachloromethane(CCl4)-induced hepatotoxicity model in rats. Methods: Male Wistar rats were tubeadministrated silymarin, Ecballium juice at 0.2 mL/kg and 0.7 mL/kg daily for 3 consequent days, ie. 3.28 μg and 11.48 μg of cucurbitacin B per kg of body weight respectively. On the third day, liver damage was induced by intraperitoneal application of CCl4. On the fourth day, abdominal cavity was macroscopically examined and liver samples were taken for histopathological and immunochemical evaluation. HPLC was used to determine the content of the active substance cucurbitacin B. Results: The experiment revealed that 0.7 ml/kg juice concentration expressed the highest pro-apoptotic activity, but with prevailing negative effects. Compared with the lower concentration, there was an observable vasodilatation with consequent interstitial hemorrhages and a larger scope of inflammatory damage, which suppressed the hepatoprotective effect. In the 0.2 mL/kg concentration, there was a smaller pro-apoptotic activity but other parameters had better results, and the liver parenchyma damage was reversible. Conclusions: No reactions confirming the potentially allergic effect on laboratory rats were observed; its hepatoprotective and anti-inflammatory effect was confirmed on a model of acute liver damage.

关键词： Ecballium elaterium Rats Tetrachloromethane Hepatotoxicity Apoptosis

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Organizational Culture and Favorable Environment for the Development of Innovations

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Social Networking 2022年第2期11卷 15-32页

作者： Manuel Fernandes Neto Denise Del pra Netto Machado University of Southern Santa Catarina S&#227 o Paulo Brazil

The objective of the research dialogues with recent studies on the presence of a favorable environment for innovation while respecting and guided by theoretical perspectives that were built by classic authors in this field of research, such as Geert Hofstede and Edgar Schein. 258 questionnaires were answered and the data obtained were analyzed using structural equation modeling (SEM) after tabulation in statistical analysis software. The research model is quantitative-descriptive and is based on the methodology developed by MIRP and later adapted by other authors. As a result of this research, it was identified that employees perceive the culture of the analyzed organization with a high level of collectivism and high cultural congruence. It was found that employees have a perception that there is a small power distance. At the end of the research, it is possible to affirm that there is a relationship between the organizational culture and the favorable environment for the development of innovations in the analyzed company.

关键词： Organizational Culture Innovation Innovation Environment

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Ion-bunch energy acoustic tracing by modulation of the depth-dose curve

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High Power Laser Science and Engineering 2023年第3期 90-97页

作者： A.pra?elsperger F.Balling H.-P.Wieser K.Parodi J.Schreiber Fakult?t für Physik Ludwig-Maximilians-Universit?t München

Characterizing exact energy density distributions for laser-accelerated ion bunches in a medium is challenging due to very high beam intensities and the electro-magnetic pulse emitted in the laser±plasma interaction. Ion-bunch energy acoustic tracing allows for reconstructing the spatial energy density from the ionoacoustic wave generated upon impact in water. We have extended this approach to tracing ionoacoustic modulations of broad energy distributions by introducing thin foils in the water reservoir to shape the acoustic waves at distinct points along the depth-dose curve. Here, we present first simulation studies of this new detector and reconstruction approach, which provides an online read-out of the deposited energy with depth within the centimeter range behind the ion source of state-of-the-art laser-plasma-based accelerators.

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Ion-bunch energy acoustic tracing by modulation of the depth-dose curve

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高功率激光科学与工程:英文版 2023年第3期11卷 86-93页

作者： A.praßelsperger F.Balling H.-P.Wieser K.Parodi J.Schreiber Fakultät für Physik Ludwig-Maximilians-Universität MünchenGarchingGermany

Characterizing exact energy density distributions for laser-accelerated ion bunches in a medium is challenging due to very high beam intensities and the electro-magnetic pulse emitted in the laser-plasma ***-bunch energy acoustic tracing allows for reconstructing the spatial energy density from the ionoacoustic wave generated upon impact in *** have extended this approach to tracing ionoacoustic modulations of broad energy distributions by introducing thin foils in the water reservoir to shape the acoustic waves at distinct points along the depth-dose ***,we present first simulation studies of this new detector and reconstruction approach,which provides an online read-out of the deposited energy with depth within the centimeter range behind the ion source of state-of-the-art laser-plasma-based accelerators.

关键词： ion-bunch energy acoustic tracing ion detector ionoacoustics laser-ion acceleration

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Deadwood affects the soil organic matter fractions and enzyme activity of soils in altitude gradient of temperate forests

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Forest Ecosystems 2023年第3期10卷 316-327页

作者： Ewa Błońska Wojciech prazuch Jarosław Lasota Department of Ecology and Silviculture Faculty of ForestryUniversity of Agriculture in Krakow29 Listopada 46 Str.31-425KrakowPoland

The main objective of our study has been to determine the role of deadwood in the shaping of the amount of soil organic matter fractions in mountain forest *** this purpose,a climosequence approach comprising north(N)and south(S)exposure along the altitudinal gradient(600,800,1000 and 1200 m a.s.l.)was set *** comparing the properties of decomposing deadwood and those of the soils located directly beneath the decaying wood we drew conclusions about the role of deadwood in the shaping of soil organic matter fractions and soil carbon storage in different climate *** basic properties,enzymatic activity and fractions of soil organic matter(SOM)were determined in deadwood and affected directly by the components released from decaying *** decomposed deadwood impacts soil organic matter stabilization more strongly than the less decayed deadwood and the light fraction of SOM is more sensitive to deadwood effects than the heavy fraction regardless of the location in the altitude *** in SOM mineral-associated fraction C content is more pronounced in soils under the influence of deadwood located in lower locations of warmer *** released from decaying wood stimulate the enzymatic activity of soils that are within the range of deadwood influence.

关键词： Enzyme activity Forest soils Heavy fraction Light fraction Soil organic matter

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Comparison between the Energy Required for Production of PV Module and the Output Energy Througout the Product Life Time

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Journal of Energy and Power Engineering 2015年第6期9卷 592-597页

作者： Lea Beatriz Dai pra Joao Batista Dias Amanda Goncalves Kieling Laboratorio de Energias Renovaveis UNISINOS (Universidade do Vale do Rio dos Sinos) Sao Leopoldo 93.022-000 Brazil

Electrical energy consumption is growing and is necessary to improve the technologies related to energy production. We have carried out a pilot study about environmental impacts during the manufacturing process of PV （photovoltaic） modules and compared between the energy requirement for the production of PV cells and modules and generation throughout the life time of the finished good that is PV module. It was taken into account the generation of environmental aspects and impacts in the manufacture of monocrystalline silicon PV modules （consisting of three components： silicon cell, fiat tempered glass and aluminum frame）, and an analysis of a grid-connected PV system using an energetic alternative in residences was considered. Results show that, this kind of renewable energy is really clean and can be considered as a way to change the energy technology.

关键词： Manufacturing of PV modules generation of environmental impacts grid-connected PV system.

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Strategies to Promote Regional Innovation

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Chinese Business Review 2016年第10期15卷 466-478页

作者： Andriele De pra Carvalho Paula Regina Zarelli Marco Antonio Harms Dias UTFPR Francisco Beltrao Brasil UNIVALI Itajai Brasil

A favorable environment for the exchange of information and innovation is able to provide the economic and social progress. Thus, this article aims to propose a study methodology to develop strategies for promoting technological innovation, to answer the research question： What actions to leverage the innovative potential of a region？ Data were collected through qualitative and quantitative approaches. The study was characterized as exploratory, descriptive, and inventory. The study sample was composed of the industrial spectrum of Francisco Beltrao region. Innovation indexes were identified companies operating in areas of greatest economic importance. Representatives of the companies were interviewed for the researcher could analyze their knowledge of the laws that encourage innovation and actions imposed by the interested parties and the municipal government. Interested parties were also interviewed to verify the effectiveness of actions. The main results indicated a low overall rate of innovation of companies in the Francisco Beltrao region. Another point was the very low number of companies they knew about laws and incentives. The higher content of knowledge of these laws and actions of stakeholders were among the companies participating in the single business hub of the city looking for technological innovation. The main conclusions brought proposed strategies to promote technological innovation.

关键词： regional development innovation management sustainable development innovation sustainable management

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巴西Arauaí河流域长期水量平衡分析(英文)

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Journal of Geographical Sciences 2010年第6期20卷 938-946页

作者： LEITE Mariangela Garcia praa FUJACO Maria Augusta Gonalves Federal University of Ouro Preto Geology DepartmentCampos Morro do Cruzeiro

Semi-arid and arid areas exhibit great temporal variability in water *** some of these regions,a one-or two-day rainfall is followed by intervening dry periods of variable *** recent decades,many rivers of the semi-arid portion of the Jequitinhonha Basin have been undergoing a progressive discharge reduction,mainly of their base flow,the Arauaí River is one of *** order to understand this transformation,a long-term analysis of the annual water balance of the Arauaí River Basin was performed,the results of which are presented *** images,hydrometeorological and river discharge data were analyzed;mean and variance tests were conducted to determine temporal *** pluviometric data analysis shows no corresponding precipitation reduction and temperature undergoes only a slight increase in the same *** the other hand,evaporation is extremely high,higher than precipitation during most of the year,leaving almost no water for infiltration(aquifer recharge) and ***,the Arauaí headwaters of its tributaries are now occupied by a monoculture,Eucaliptus sp.,used for paper *** of the decreased fluvial discharges,its lowlands,usually used for agriculture and pasture,are abandoned and partially eroded.

关键词： river discharge evaporation Jequitinhonha Basin

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pra在社区发展和环境恢复中的实践与探索 1

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2005年

作者：云南省pra网社区发展与土地利用小组编

本书分三部分收录了“云南参与性研究行动网络(YNpra)”土地利用与社区发展小组成员近期的一些作品。从不同角度对社区，尤其是对农村社区的参与性发展进行研究总结的工作结晶。

ISBN: (纸本)7541622648

关键词：农村不发达地区经济发展研究云南省

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加拿大硅灰石选矿

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国外建材科技 1991年第2期12卷 69-72页

作者： And.,pra 孙红

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