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Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl_4-induced hepatotoxicity in rats

Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 524-529页

作者： El Moataz Bellah El Naggar Marta Chalupova Gabriela pra anov a Tom a Par ak Emil vajdlenka Milan emlika Pavel Such Department of Pharmacognosy Faculty of Pharmacy Damanhur UniversityEgypt Department of Human Pharmacology and Toxicology Faculty of Pharmacy University of Veterinary and Pharmaceutical SciencesBrnoCzech Republic Department of Natural Drugs Faculty of Pharmacy University of Veterinary and Pharmaceutical SciencesBrnomCzech Republic

Objective: To investigate the effects of perorally administered juice on tetrachloromethane(CCl4)-induced hepatotoxicity model in rats. Methods: Male Wistar rats were tubeadministrated silymarin, Ecballium juice at 0.2 mL/kg and 0.7 mL/kg daily for 3 consequent days, ie. 3.28 μg and 11.48 μg of cucurbitacin B per kg of body weight respectively. On the third day, liver damage was induced by intraperitoneal application of CCl4. On the fourth day, abdominal cavity was macroscopically examined and liver samples were taken for histopathological and immunochemical evaluation. HPLC was used to determine the content of the active substance cucurbitacin B. Results: The experiment revealed that 0.7 ml/kg juice concentration expressed the highest pro-apoptotic activity, but with prevailing negative effects. Compared with the lower concentration, there was an observable vasodilatation with consequent interstitial hemorrhages and a larger scope of inflammatory damage, which suppressed the hepatoprotective effect. In the 0.2 mL/kg concentration, there was a smaller pro-apoptotic activity but other parameters had better results, and the liver parenchyma damage was reversible. Conclusions: No reactions confirming the potentially allergic effect on laboratory rats were observed; its hepatoprotective and anti-inflammatory effect was confirmed on a model of acute liver damage.

关键词： Ecballium elaterium Rats Tetrachloromethane Hepatotoxicity Apoptosis

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