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Auxin Binding protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize

Molecular Plant 2017年第10期10卷 1357-1360页

作者： Pengfei Leng Qing Ji Torben Asp Ursula K. Frei Christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark Jones pr.yanka gajjar.sisi liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt National Maize Improvement Center China Agricultural University Beijing 100193 China Department of Agronomy Iowa State University Ames IA 50011 USA Department of Molecular Biology and Genetics Aarhus University Forsegsvej 14200 Slagelse Denmark National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Institute of Agricultural Sciences Molecular Plant Breeding ETH Zurich Universitaetstrasse 2 8092 Zurich Switzerland USDA Agricultural Research Service Corn Soybean and Wheat Quality Research Unit and Department of Plant Pathology Ohio State University Wooster OH 44691 USA Maize Research Institute Sichuan Agricultural University Chengdu 611130 China School of Life Sciences Guizhou Normal University Laboratory of Plant Physiology and Developmental Regulation Guiyang 550000 China

Dear Editor,Sugarcane mosaic virus （SCMV） causes severe viral diseases in maize worldwide （Fuchs and Gruntzig, 1995）, resulting in significant losses in grain and forage yield in susceptible cultivars of maize and related crops. The most promising solution is to cultivate resistant varieties, which contribute to sustainable crop production. Two epistatically interacting major SCMV resistance loci （Scmvl and Scmv2） are required to confer complete resistance against SCMV in the resistant nearisogenic line F7RPJRR （the letters left of the slash refer to the genotype at Scmv2 on chromosome 3 and those on the right refer to the genotype at Scmvl on chromosome 6, with R indicating a resistance allele and S a susceptibility allele）（Xing et al., 2006）.

关键词： Auxin Binding protein 1 Reinforces Resistance Sugarcane Mosaic Virus Maize

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精囊腺混合性上皮间质肿瘤1例

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中华病理学杂志 2022年第10期51卷 1042-1044页

作者：刘思思贺慧颖北京大学医学部病理系/北京大学第三医院病理科北京100191

精囊腺混合性上皮间质肿瘤(mixed epithelial-stromal tumor,MEST),是一种非常罕见的原发于精囊具有间质成分和良性上皮成分的双相性肿瘤。本例为56岁男性,影像提示前列腺左后上方最大径约4 cm占位性病变伴出血,精囊腺来源肿物可能。组... 详细信息

精囊腺混合性上皮间质肿瘤(mixed epithelial-stromal tumor,MEST),是一种非常罕见的原发于精囊具有间质成分和良性上皮成分的双相性肿瘤。本例为56岁男性,影像提示前列腺左后上方最大径约4 cm占位性病变伴出血,精囊腺来源肿物可能。组织学形态显示肿瘤由多量大小不等的囊腔组成,囊腔衬覆单层或多层立方上皮,局灶可见乳头状内折,细胞无明显异型;囊腔间为弥漫增生的短梭形细胞,细胞密度较高,未见明确核分裂象。免疫组织化学显示上皮细胞PAX8、细胞角蛋白(CK)7阳性,间质细胞雌激素受体(ER)、孕激素受体(pr)阳性,CD34、平滑肌肌动蛋白(SMA)部分阳性,NKX3.1阴性,Ki-67阳性指数约为1%~2%。此病临床和影像诊断困难,确诊需要病理检查,现报道1例精囊腺低级别MEST,旨在提高对本病的认识,减少误诊。

关键词：精囊腺组织学形态间质成分阳性指数囊腔双相性间质细胞影像诊断

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Identification and validation of prognostic factors in patients with COVID-19: A retrospective study based on artificial intelligence algorithms

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Journal of Intensive Medicine 2021年第2期1卷 103-109页

作者： Sheng Zhang sisi Huang Jiao liu Xuan Dong Mei Meng Limin Chen Zhenliang Wen Lidi Zhang Yizhu Chen Hangxiang Du Yongan liu Tao Wang Dechang Chen Department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineNo.197Ruijin 2nd RoadShanghai 200025China Tuberculosis and Respiratory Department Wuhan Jinyin-tan HospitalNo.1 Yintan RoadWuhan 430023China

Background:Novel coronavirus disease 2019(COVID-19)is an ongoing global pandemic with high *** several studies have reported different risk factors for mortality in patients based on traditional analytics,few studies have used artificial intelligence(AI)*** study investigated prognostic factors for COVID-19 patients using AI ***:COVID-19 patients who were admitted in Wuhan Infectious Diseases Hospital from December 29,2019 to March 2,2020 were *** whole cohort was randomly divided into training and testing sets at a 6:4 *** and clinical data were analyzed to identify predictors of mortality using least absolute shrinkage and selection operator(LASSO)regression and LASSO-based artificial neural network(ANN)*** predictive performance of the models was evaluated using receiver operating characteristic(ROC)curve ***:A total of 1145 patients(610 male,53.3%)were included in the *** the 1145 patients,704 were assigned to the training set and 441 were assigned to the testing *** median age of the patients was 57 years(range:47-66 years).Severity of illness,age,platelet count,leukocyte count,prealbumin,C-reactive protein(CRP),total bilirubin,Acute Physiology and Chronic Health Evaluation(APACHE)II score,and Sequential Organ Failure Assessment(SOFA)score were identified as independent prognostic factors for *** these nine factors into the LASSO regression model yielded a correct classification rate of 0.98,with area under the ROC curve(AUC)values of 0.980 and 0.990 in the training and testing cohorts,*** the same factors into the LASSO-based ANN model yielded a correct classification rate of 0.990,with an AUC of 0.980 in both the training and testing ***:Both the LASSO regression and LASSO-based ANN model accurately predicted the clinical outcome of patients with *** of illness,age,platelet count,leukocyte count,pr

关键词： COVID-19 Least absolute shrinkage and selection operator(LASSO)regression model Artificial neural network model Artificial intelligence prognosis

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I型子宫内膜癌患者血清维生素D与睾酮的水平及其临床意义

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现代肿瘤医学 2020年第14期28卷 2513-2516页

作者：刘思思冯文徐州医科大学附属连云港医院妇科江苏连云港222000

目的:探讨I型子宫内膜癌患者血清维生素D[vitamin D,25(OH)D]与睾酮(testosterone,T)水平及其与临床病理特征的关系。方法:选取我院I型子宫内膜癌患者30例为观察组,另外选择同期入院的子宫内膜良性肿瘤患者30例为对照组。采用化学发光... 详细信息

目的:探讨I型子宫内膜癌患者血清维生素D[vitamin D,25(OH)D]与睾酮(testosterone,T)水平及其与临床病理特征的关系。方法:选取我院I型子宫内膜癌患者30例为观察组,另外选择同期入院的子宫内膜良性肿瘤患者30例为对照组。采用化学发光法对两组患者血清25(OH)D及T进行测定分析。比较两组患者血清25(OH)D及T水平,25(OH)D及T与临床病理参数间的关系。结果:观察组患者血清25(OH)D水平显著低于对照组,而血清T水平显著高于对照组(Ppr是否阳性无明显相关性(P>0.05),而与I型子宫内膜癌患者FIGO分期、分化程度、淋巴结有无转移、肌层浸润程度呈明显相关(Ppr是否阳性无明显相关性(P>0.05),而与I型子宫内膜癌患者FIGO分期、分化程度、淋巴结有无转移、肌层浸润程度呈明显相关(P<0.05)。观察组患者血清T与25(OH)D水平呈现负相关性。结论:I型子宫内膜癌患者血清25(OH)D水平明显降低,而T水平明显升高,二者呈现负相关关系,且二者分别与子宫内膜癌的不同临床病理参数相关,可能是I型子宫内膜癌患者发生、病程进展及预后的重要评价指标。

关键词：子宫内膜癌睾酮维生素D

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