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Molecular exposition of broad‑spectrum antibacterial efficacy by p‑coumaric acid from an edible mushroom Termitomyces heimii:in vitro and in silico approach

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 750-764页

作者： Krishanu Singha Amrita Banerjee Arijit Jana poushali bandyopadhyay Smarajit Maiti Bikas Ranjan Pati Pradeep Kumar Das Mohapatra Department of Microbiology Vidyasagar UniversityMidnaporeWest Bengal 721102India Department of Biotechnology Oriental Institute of Science and TechnologyMidnaporeWest Bengal 721102India Department of Chemical Engineering IIT RoorkeeUttarakhand 247667India Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India

P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer *** with these,the present work has been conducted to study the antibacterial activity of p-coumaric *** could be used to control broad-spectrum microbiome-based inflammation or in cancer *** analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal *** predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 *** common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran ***,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell ***,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.

关键词： p-Coumaric acid Bactericidal Docking ACE value PgsA Lysis

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MXene-Based Elastomer Mimetic StretchableSensors: Design, Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： poushali Das Parham Khoshbakht Marvi Sayan Ganguly Xiaowu(Shirley)Tang Bo Wang Seshasai Srinivasan Amin Reza Rajabzadeh Andreas Rosenkranz School of Biomedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision Research(CEVR) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth School of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in human-machine *** of the motivating factors behind the progress of flexible sensors is the steady arrival of new conductive ***,a new family of 2D nanomaterials,have been draw-ing attention since the last decade due to their high electronic conduc-tivity,processability,mechanical robustness and chemical *** this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor ***,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,but also their future perspective and market throughout the *** our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

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