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Sang-Yod rice bran hydrolysates alleviate hypertension, endothelial dysfunction, vascular remodeling, and oxidative stress in nitric oxide deficient hypertensive rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第1期11卷 10-19页

作者： Gulladawan Jan-On Akarachai Tubsakul Weerapon Sangartit poungrat pakdeechote Veerapol Kukongviriyapan Ketmanee Senaphan Chakree Thongraung Upa Kukongviriyapan Department of Physiology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand School of Medicine Walailak UniversityNakhon Si ThammaratThailand Department of Pharmacology Faculty of MedicineKhon Kaen UniversityKhon KaenThailand Division of Physiology Faculty of Veterinary MedicineKhon Kaen UniversityKhon KaenThailand Department of Food Technology Faculty of Agro-IndustryPrince of Songkla UniversitySongklaThailand

Objective:To evaluate the potential therapeutic effect of Sang-Yod rice bran hydrolysates(SRH)and in combination with lisinopril against hypertension,endothelial dysfunction,vascular remodeling,and oxidative stress in rats with nitric oxide deficiency-induced ***:Hypertension was induced in male Sprague-Dawley rats by administration of a nitric oxide synthase inhibitor,Nω-nitro-L-arginine methyl ester(L-NAME)in drinking water for 6 *** rats were administered daily with SRH(500 mg/kg/day),lisinopril(1 mg/kg/day),or the combination of SRH and lisinopril by gastric lavage for the last 3 weeks of L-NAME *** status,vascular reactivity to vasoactive agents,and vascular remodeling were *** and aortic tissues were collected for measurements of oxidative stress markers,plasma angiotensin-converting enzyme(ACE)activity,plasma angiotensinⅡ,and protein ***:L-NAME induced remarkable hypertension and severe oxidative stress,and altered contents of smooth muscle cells,elastin,and collagen of the aortic *** or lisinopril alone reduced blood pressure,restored endothelial function,decreased plasma ACEs and angiotensinⅡlevels,alleviated oxidant markers and glutathione redox status,and restored the vascular *** effects were associated with increased expression of endothelial nitric oxide synthase and decreased expression of gp91phox and AT1R *** combination of SRH and lisinopril was more effective than ***:SRH alone or in combination with lisinopril exert an antihypertensive effect and improve endothelial function and vascular remodeling through reducing oxidative stress and suppressing elevated renin-angiotensin system.

关键词： Sang-Yod rice bran hydrolysates Hypertension Endothelial dysfunction Oxidative stress Vascular remodeling

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