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Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients

World Journal of Gastroenterology 2006年第39期12卷 6299-6304页

作者： Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis poulam m patel Section of Gastrointestinal Surgery University of Nottingham Queens' Medical Centre Nottingham United Kingdom Academic Department of Clinical Oncology University of Nottingham Institute of Infections Immunity and Inflammation City Hospital Nottingham United Kingdom Academic Department of Clinical Oncology (with LGD ZM DS and PMP) University of Nottingham Institute of Infections Immunity and Inflammation City Hospital Nottingham United Kingdom Department of Histopathology Nottingham City Hospital and University of Nottingham Nottingham United Kingdom

AIm: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. mETHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNm stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome.

关键词： Colorectal cancer Tissue microarray p27^Kip1 Prognostic factor

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