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The 15th World Veterinary poultry Congress

作者： poul h.jφrgensen Ole R.Therkildsen Kurt jensen handberg National Veterinary Institute Technical University of DenmarkDepartment of PoultryFish and Fur AnimalsHangoevej 2DK-8200 Aarhus NDenmark National Environmental Research Institute Department of Wildlife Ecology and BiodiversityUniversity ofAarhusGrenaavej 12DK-8410 RoendeDenmark. National Environmental Research Institute Department of Wildlife Ecology and BiodiversityUniversity ofAarhusGrenaavej 12.DK-8410 RoendeDenmark.National Veterinary InstituteTechnical University of DenmarkDepartment of PoultryFish and Fur AnimalsHangoevej 2DK-8200 Aarhus NDenmark

＜正＞Due to increasing concern of transmission of Avian Paramyxoviruses（APMV）and Avian Influenza（AI） viruses from wild birds to domestic poultry samples collected from wild migratory waterfowl in Denmark are inve...

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Serological response to vaccination with an inactivated h5N9 vaccine in zoo-birds is highly species specific

Serological response to vaccination with an inactivated H5N9...

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The 15th World Veterinary poultry Congress

作者： Mads F Bertelsen joan Klausen Elisabeth holm Carsten Gr dahl poul h.j gensen Centre for Zoo and Wild Animal health Copenhagen ZooRoskildevej 382000FrederiksbergDenmark. bNational Veterinary Institute Technical University of DenmarkB owsvej 27DK-1790 Copenhagen VDenmark. bNational Veterinary Institute Technical University of DenmarkB owsvej 27DK-1790 Copenhagen VDenmark. Centre for Zoo and Wild Animal health Copenhagen ZooRoskildevej 382000FrederiksbergDenmark. cNational Veterinary Institute Technical University of DenmarkHangovej 2DK-8200 Aarhus NDenmark

＜正＞Introduction Avian Influenza（AI,Orthomyxoviridae）is a highly contagious disease of poultry,which may in- fect most if not all bird *** October 2005 and july 2006,highly pathogenic（hP）AIV of subtype

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Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells-possibilities and current limitations

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World journal of Stem Cells 2020年第10期12卷 1171-1183页

作者： Kristine Karla Freude Sarkis Saruhanian Alanna McCauley Colton Paterson Madeleine Odette Annika Oostenink poul hyttel Mark Gillies henriette haukedal Miriam Kolko Department of Veterinary and Animal Sciences Group of Stem Cell Models for Studies of Neurodegenerative DiseasesSection for Pathobiological SciencesFaculty of Health and Medical SciencesUniversity of CopenhagenFrederiksberg 1870Denmark Department of Drug Design and Pharmacology University of CopenhagenCopenhagen 2100Denmark Save Sight Institute South BlockSydney Eye HospitalSydney 2000Australia Department of Ophthalmology Copenhagen University HospitalRigshospitalet-GlostrupGlostrup 2600Denmark

BACKGROUND Retinal organoids serve as excellent human-specific disease models for conditions affecting otherwise inaccessible retinal tissue from *** permit the isolation of key cell types affected in various eye diseases including retinal ganglion cells(RGCs)and Müller *** To refine human-induced pluripotent stem cells(hiPSCs)differentiated into threedimensional(3D)retinal organoids to generate sufficient numbers of RGCs and Müller glia progenitors for downstream *** In this study we described,evaluated,and refined methods with which to generate Müller glia and RGC progenitors,isolated them via magnetic-activated cell sorting,and assessed their lineage stability after prolonged 2D *** progenitor populations were characterized via quantitative PCR and immunocytochemistry,and the ultrastructural composition of retinal organoid cells was *** Our study confirms the feasibility of generating marker-characterized Müller glia and RGC progenitors within retinal *** retinal organoids can be dissociated and the Müller glia and RGC progenitor-like cells isolated via magnetic-activated cell sorting and propagated as *** Enrichment of Müller glia and RGC progenitors from retinal organoids is a feasible method with which to study cell type-specific disease phenotypes and to potentially generate specific retinal populations for cell replacement therapies.

关键词： human induced pluripotent stem cells Retinal organoids Retinal ganglion cells Müller glia Progenitors Cell-type enrichment

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Investigation of Plasmodium falciparum Resistance Biomarkers among Primary School Children in Western Kenya

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American journal of Molecular Biology 2022年第2期12卷 43-53页

作者： Otilmoi poul Stephen Tonny Teya Nyandwaro Robinson Mugasiali Irekwa Rebecca Wanjiku Waihenya Matthew Mutinda Munyao Peter Kipkemboi Rotich Caroline Wangui Njoroge Anne Wanjiru Mwangi joanne jepkemei Yego Nicole Sian Tanchu Dawala Koromtili Oumar Grace Ngendo Kanyita Primrose Muthoni Ndungu Samson Muuo Nzou Department of Molecular Biology and Biotechnology Pan-African University Institute of Basic Sciences Technology and Innovation Nairobi Kenya Innovation Technology Transfer Department Kenya Medical Research Institute (ITTD-KEMRI) Nairobi Kenya Zoology Department School of Biological Sciences College of Pure and Applied Sciences Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya Production Department KEMRI Nairobi Kenya Centre for Microbiology Research Kenya Medical Research Institute Nairobi Kenya Nagasaki University Institute of Tropical Medicine Kenya Medical Research Institute (NUITM-KEMRI) Nairobi Kenya Department of Biochemistry Microbiology and Biotechnology Kenyatta University Nairobi Kenya Department of Pharmacology and Pharmacognosy University of Nairobi Nairobi Kenya

Background: A marked decrease in malaria-related deaths worldwide has been attributed to the administration of effective antimalarials against Plasmodium falciparum. however, the continuous spread of P. falciparum resistance to anti-malarial drugs is raising a serious problem in controlling Malaria to the vulnerable children’s immune system. In recent studies, Plasmodium falciparum Kelch 13 propeller gene (Pfk13) has been reported to develop resistance to artemisinin in South Asia. In this study, we checked Plasmodium falciparum chloroquine resistance transporter gene (Pfcrt) involved in chloroquine (CQ) resistance. Method: In this study, archived 280 samples were collected from Alupe primary school children in Busia, Western Kenya from May, 2016 to November, 2016. Genomic DNA was extracted using the MightyPrep reagent. The samples were investigated for P. falciparum positivity out of which 67 of them tested positive giving a prevalence rate of 24%. The sixty-seven were subjected to PCR amplification for the molecular marker resistance to Pfcrt. After PCR amplification, the amplicons were purified and sequenced using Sanger Sequencing. The sequence data were analyzed using BioEdit software to identify point mutations. Results: 14 samples sequences were analyzed on Bioedit software giving the following amino acid changes F76C, Y66h, L70A, Y58C, T59V, V65I, P67L, T81L, Y60S, Y66S, P67T and I71F). New mutations have been reported at position 76 leading to an amino acid change, one of Pfcrt gold standard biomarkers. however, amino acid changes Y66h, L70A, Y58C, T59V, V65I, P67L, T81L, Y60S, Y66S, P67T and I71F are newly reported giving an increase in Pfcrt prevalence of concern from zero to 5.0%. A phylogenetic evolutionary relationship was constructed as shown below. Generally, the results showed a continuous resistance of *** to Pfcrt which calls for robust continuous monitoring and surveillance. Conclusion: Due to the increase of the resistant Pfcrt gene pre

关键词： P. falciparum Chloroquine Drug Resistance Malaria P. falciparum Chloroquine Resistance Transporter Gene Mutations

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钢铁研究 1978年第Z1期 75-77页

作者： M.h.Mueller W.P.Chernock poul A.Beck 柳璞如

对于Barrett以前用过的图harris引入了反极图这个术语来说明具有纤维织构的样品中相对于纤维轴的不同取向上材料的体积分数P(α,β)。纤维轴相对于晶体点阵的方向是由两个独立的角变量α和β所规定的。在这样一个图里,P给出了各个不同... 详细信息

对于Barrett以前用过的图harris引入了反极图这个术语来说明具有纤维织构的样品中相对于纤维轴的不同取向上材料的体积分数P(α,β)。纤维轴相对于晶体点阵的方向是由两个独立的角变量α和β所规定的。在这样一个图里,P给出了各个不同晶体学方向纤维轴密度的分布。P(α,β)可以在二维图里用极射赤面投影中等强线(P=常数)给出。反极图把

关键词：纤维织构图表书籍结构反极图取向分布纤维轴

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Deployment of Pre-Industrial Autonomous Microbe Sensor in Saudi Arabia’s Injection Seawater System

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journal of Sensor Technology 2018年第1期8卷 1-17页

作者： Mohammed A.Al-Moniee Xiangyang Zhu Rikke Markfoged Aabdullah h.Al-Wadei poul L.Pedersen Anders K.Tuxen Fuad I.Al-Nuwaiser Lone Tang Tinna Stagh.j Roesen Thomas Lundgaard Saudi Arabian Oil Company(Saudi Aramco) DhahranSaudi Arabia Danish Technological Institute(DTI) AarhusDenmark

Microbial growth in water injection systems can lead to many problems, including biofouling, water quality deterioration, injectivity loss, microbial corrosion, and reservoir formation damage. Monitoring of microbial activities is required in any mitigation strategy, enabling operators to apply and adjust countermeasures properly and in due time. In this study, the pre-industrial autonomous microbe sensor (AMS) was constructed with technical improvements from the prototype for increased sensitivity, durability, robustness, and maintainability. The pre-industrial AMS was lab validated, field proven, and deployed at critical locations of seawater injection network for automated detection of microorganisms under the Saudi Arabia’s harsh environment. An excellent correlation between AMS measurement data (fluorescence count) and actual count of microbial cell number under microscope was established (coefficient of determination, R2 > 0.99) for converting AMS fluorescence count to cell numbers (cell mL-1) in the injection seawater. The pre-industrial AMS only required monthly maintenance with solutions refill, and was able to cope with hot summer months even without protection in an air-conditioned shelter. The study team recommended wider deployment of the online AMS for real-time monitoring of bacteria numbers in the various strategic locations in Saudi Aramco’s complex seawater injection network, as an integral component of pipeline corrosion and leak mitigation program.

关键词： Automated Monitoring Autonomous Microbe Sensor Microbial Sensor DNA Staining Injection Seawater

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18F-FDGPET／CT鉴别颈部恶性坏死淋巴结与良性囊性病变

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中华核医学与分子影像杂志 2017年第10期37卷 671-671页

作者：顾佳唐军苏州大学医学部放射医学与防护学院 215123 苏州大学附属第二医院核医学科 215004

目的颈部有囊性病变而没有明显恶性征象患者的诊断困难，因为细针穿刺抽吸活组织检查往往不能准确诊断，需要手术切除活组织检查才能确诊。对颈部囊性肿块与各种良性病变进行鉴别前。须先排除恶性肿瘤。该研究探讨18F-FDGPET／CT显像在... 详细信息

目的颈部有囊性病变而没有明显恶性征象患者的诊断困难，因为细针穿刺抽吸活组织检查往往不能准确诊断，需要手术切除活组织检查才能确诊。对颈部囊性肿块与各种良性病变进行鉴别前。须先排除恶性肿瘤。该研究探讨18F-FDGPET／CT显像在颈部恶性病变中的诊断效能。方法回顾性分析因孤立性颈部囊性病变而进行18F-FDGPET／CT显像的耳鼻喉科及头颈外科患者．将显像结果与病理组织学结果进行比较分析，且对患者进行随访。结果研究纳入58例患者，其中20例（34％）在随访期间被诊断为恶性病变。PET／CT显像34例结果阳性（19例真阳性、15例假阳性），24例阴性（23例真阴性、1例假阴性）。其灵敏度、特异性、准确性、阳性预测值、阴性预测值（括号中数值为95％CI）分别为：95％（76％～99％）、61％（45％～74％）、72％（60％-82％）、56％（39％～71％）和96％（80％～99％）。20例确诊恶性病变的患者中有14例为原发肿瘤。与肿瘤体积大小、肿瘤内部是否有间隔等因素相比，PET显像所示糖代谢水平增加是唯一与颈部囊性恶性病变独立相关的因素，其比值比为1．27（1．07—1．50），P=O．006。结论尽管因有较多的假阳性结果而需进一步鉴别诊断，18F-FDGPET／CT显像仍能可靠地排除颈部囊性恶性肿瘤（阴性预测值为96％）。糖代谢增加是鉴别颈部囊性恶性和良性病变的最佳影像学参数。

关键词：颈部囊肿鳃裂囊肿坏死淋巴结颈部转移 FDG PET/CT 颈部囊性病变PET/CT 显像

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