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高敏心肌肌钙蛋白T与高血压风险的关系

中华高血压杂志 2015年第11期23卷 1052-1052页

作者：李金凤叶鹏 McEvoy JW Chen Y Nambi V Ballantyne CM Sharrett AR Appel LJ post ws Blumenthal RS Matsushita K Selvin E

心脏结构异常经常先于高血压发生。该研究探讨慢性亚临床心肌损害的标记物——高敏心肌肌钙蛋白T（high-sensitivity cardiac troponin-T,hs-cTNT）能否鉴别具有高血压或左心室肥厚（left ventricular hypertrophy,LVH）患病风险的人群。

关键词：心肌肌钙蛋白肌损害 troponin hypertrophy 心室肥厚心脏结构异常患病风险亚临床正常血压正常高值血压

MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

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World Journal of Gastroenterology 2018年第27期24卷 2949-2973页

作者： Kenneth KW To Christy ws Tong Mingxia Wu William CS Cho School of Pharmacy Faculty of Medicine the Chinese University of Hong Kong Department of Clinical Oncology Queen Elizabeth Hospital

MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.

关键词： microRNA colorectal cancer multidrug resistance prognosis therapeutic target apoptosis metastasis recurrence risk stratification

Impact of silymarin enriched semen extender on bull sperm preservability

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Asian pacific Journal of Reproduction 2017年第2期6卷 81-84页

作者： El-Sheshtawy RI El-Nattat ws Animal Reproduction and AI Dept. Veterinary Research DivisionNational Research CentreDokkiEgypt

Objective:To explore the effect of silymarin on bull spermatozoa during cooling and cryopreservation. Methods: Pooled bull semen were diluted by Tris-Citrate-Fructose egg yolk diluents, purified silymarin powder (obtained from the milk thistle silybum marianum), purchased from Unipharma, Al Obour city, Egypt, was soaked in Tris-citric acid-fructose diluent for 48 h at 10℃ making a stock solution (70 mg/mL), from this stock solution we obtained concentrations of 0.18 mg/mL, 0.36 mg/mL, 0.54 mg/mL, 0.72 mg/mL, 0.90 mg/mL in addition to the control (0.0 mg/mL) reaching a final volume of 5 mL in each tube. Egg yolk was added to each tube to obtain silymarin enriched semen extender (SEE) with 20% egg yolk, cooled slowly up to 5℃ and equilibrated for 4 h. Semen was packed into 0.25 mL polyvinyl French straws (IMV, France). After equilibration periods, the straws were placed horizontally on a rack and frozen in a vapor 4 cm above liquid nitrogen for 10 min and were then dipped in liquid nitrogen. Extended semen was subjected to evaluation (motility, alive %, abnormality %, intact sperm membrane (HOST)% and conception rate) in both chilled and frozen ***: Table 1 revealed that Sperm motility of the concentrations 2, 3 and 4 after 8 d of chilling were significantly (Ppost thawing sperm motility as high as the control (47.50±2.81 and 45.00±2.58, respectively) while other concentration have lower effects on motility as compared to the control. Addition of silymarin improved post thawing alive% and was significantly higher (Ppost thawing abnormal sperm in concentration 3 and 4 (11.83±0.65 and 16.00±0.58, respectively). SEE improved significantly (Ppost thawing intact spermatozoa

关键词： Cattle Semen Preservation Silymarin

Effect ofDiospyros kakienriched extender on cattle bull sperm parameters and conception rate

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Asian pacific Journal of Reproduction 2017年第3期6卷 128-132页

作者： El-Sheshtawy RI El-Nattat ws Animal Reproduction and AI Department. Veterinary Research DivisionNational Research CentreDokkiEgypt

Objective:To explore the effect of Diospyros kaki on cattle spermatozoa during chilling and ***: Five milliliter of blended Persimmon (Diospyros kaki) flesh was added to 45 mL TCF to obtain 10% stock solution. Kaki enriched extender (KEE) was prepared by adding to TCF in concentrations 0.0/5.0 mL (control, 0%), 0.5/4.5 mL (1%), 1/4 mL (2%), 1.5/3.5 mL (3%), 2.0/3.0 mL (4%), 2.5/2.5 mL (5%), 3.0/2.0 mL (6%), 3.5/1.5 mL (7%), 4.0/1.0 mL (8%), 4.5/0.5 mL (9%) and 5.0/0.0 mL (10%) to obtain a final volume 5 mL in each tube. Whole egg yolk was added to each tube to obtain KEE with 20% egg yolk (KEEY), all tubes were centrifuged to get rid of debris. Semen was added to the supernatants in other tubes. Extended semen was subjected to evaluation (motility, alive sperm and intact sperm membrane (HOST) %) in both chilled and cryopreserved semen. Conception rate was carried ***:Sperm motility was significantly (Ppost thawing sperm motility % with the concentrations 1, 2, 3, 4, 5 and 6% as compared to the control (51.67±5.27, 55.00±3.16, 48.33±1.05, 45.00±3.96, 57.00±2.50, 55.00±5.00 and 43.33±5.11 respectively).While the other concentrations exhibit no effect. Addition of KEE maintained alive sperm%, abnormalities% and % of intact spermatozoa membranes (HOST %) as good as the control with all concentrations of kaki used in our study. The conception rate upon using frozen semen in insemination showed higher conception rate in concentrations of 2%, 4% and 6 % KEE in ***: It could be concluded that some concentrations ofDiospyros kaki improved bull semen quality post-chilling and post-freezing.

关键词： Cattle Semen Preservation Diospyros kaki

Effect of tris-extender supplemented with various concentrations of strawberry (Fragaria spp.) on bull semen preservability

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Asian pacific Journal of Reproduction 2018年第2期7卷 93-96页

作者： El-Sheshtawy RI El-Nattat ws Animal Reproduction and Artificial Insemination Department Veterinary DivisionNational Research CenterDokkiGiza

Objective:To evaluate effect of tris-extender supplemented with various concentrations of strawberry (Fragaria spp.) on bull semen ***: Pooled bull semen were extended with tris-citrate-fructose egg yolk diluent (control, 0% strawberry) and various concentrations of tris strawberry (TSB) (1%-6%) to achieve 60 million motile spermatozoa per milliliter. Extended semen were subjected to semen freezing protocol. Semen assessment including motility, alive%, abnormality%, intact sperm membrane (hypo-osmotic swelling test) and conception rate were carried out for both chilled and frozen semen. Results: Results showed that sperm motility after chilling was enhanced in groups treated with various concentrations of TSB from 1% to 5% and exhibited higher significance (Ppost-chilling. In frozen semen, 3%, 4%, 5% and 6% concentrations gave the best significance (P<0.0001) on sperm motility in comparison with the control. Concentration 1% revealed the highest significance (P<0.0001) on alive% as compared to the control. Hypo-osmotic swelling test was maintained as the control. Concentration 3% gave the lowest significance (P<0.0001) considering abnormality%. The conception rate upon using frozen semen in insemination showed higher conception rate in concentrations of 5% and 6% in ***: It is concluded that 1%-5% concentrations of TSB ameliorate bull semen characteristics after chilling, and 3%-6% concentrations of TSB improve bull semen characteristics after freezing. Higher conception rate exists in 5% and 6% concentration of TSB.

关键词： Cattle Semen Preservation Strawberry

Preservability of bull spermatozoa in Tris-egg yolk extender enriched with different concentrations of butylated hydroxytoluene

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Asian pacific Journal of Reproduction 2017年第2期6卷 77-80页

作者： El-Sheshtawy RI El-Nattat ws Gamal A.El-Sisy Animal Reproduction and AI Dept. Veterinary Research DivisionNational Research CentreDokkiEgypt

Objective:To explore the effect of BHT on cattle spermatozoa during cooling and ***: Pooled bull semen were diluted by Tris-Citrate-Fructose egg yolk (TCFY) diluent considered as control (0 BHT) and different concentrations of BHT (1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 mM were prepared in ethanol in prewarmed (37℃) test tubes. The ethanol was allowed to evaporate so that, a thin crystallized layer of BHT was deposited on the inner surface of the tubes. Then extended semen was added into the tubes and incubated at 37℃ for 5 min to allow uptake of BHT by spermatozoa. The tubes were cooled slowly (approximately for 2 h) up to 5℃ and equilibrated for 4 h. After equilibration, semen freezing process was carried out. Extended semen was subjected to evaluation (motility, alive sperm, intact sperm membrane (HOST) % and acrosome integrity) in both cooled and cryopreserved semen. Results:The result revealed that sperm motility of post-cooled spermatozoa improved (Ppost-thawed frozen semen in the concentrations of BHT (1, 2, 3 and 4 mM) if compared to the control. The sperm membrane integrity were significantly improved at all concentrations of BHT. Acrosome integrity was significantly higher at BHT concentration 1 mM (81.80±0.57) and (76.00±2.05), ***: It could be concluded that some concentrations of BHT improved bull semen quality post-cooling and post-freezing.

关键词： Cattle Semen Preservation BHT

Vagus nerve magnetic modulation for post-stroke dysphagia

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中华物理医学与康复杂志 2018年第4期40卷 317-317页

作者： Lin ws Chou CL Chang MH

BACKGROUND AND OBJECTIVE Stroke involving the brainstem causes a wide spectrum of neurologic deficits,including oral pharyngeal dysphagia(OD).As studies of vagus nerve stimulation in animals with stroke have shown improvement in motor function,this study investigated the effect of repetitive transcranial magnetic stimulation(rTMS)in restoring swallowing function after stroke in humans.

关键词：迷走神经磁性调整动物

An evaluation of compliance and performance following the introduction of the Inter-Facility Transport Triage Guideline

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World Journal of Emergency Medicine 2011年第2期2卷 99-103页

作者： Venus ws Siu Y Pau PY Lok Larry LY Lee Simon YH Tang Jimmy TS Chan Hospital Authority Head Office Hong Kong China Emergency Department Alice Ho Miu Ling Nethersole Hospital Hong Kong China

BACKGROUND：In Hong Kong, the reorganization of healthcare frame work for better utilization of resources has led to an increase in the frequency of inter-facility transport in recent years. An Inter-Facility Transport Triage Guideline （IFTTG） was introduced and evaluated on its compliance and performance. This study aimed to evaluate the compliance to the IFTTG and performance of inter-facility transport after the IFTTG was implemented. METHODS： The patients who required emergency IFT with accompanying personnel in two consecutive periods （pre-implementation period： January 1,2006 to April 30, 2006; post-implementation period： May 1,2006 to August 31,2006） were included. The compliance to pre-transport triage and transport team configuration was evaluated by a review panel with eight performance indicators identified. The performance indicators were compared individually and as an overall score. RESULTS：Sixty-eight （26 in the pre-implementation period and 42 in the post-implementation period） IFTs were reviewed. There was demonstrable improvement on compliance to the IFTTG. The appropriateness of pre-transport triage increased from 34.6% to 54.8% whereas appropriateness of transport team configuration rose significantly from 73.1% to 92.9% （P〈0.05）. Staff performance on individual IFT performance indicator was satisfactory in both periods and the means of overall score on performance indicators were 7.12 and 7.29 respectively. The most improved performance indicator was the appropriateness of transport team configuration. CONCLUSIONS： The compliance and performance with the newly implemented IFTTG were satisfactory. However, staff comment and satisfaction with the use of the new guideline should be collected so as to achieve continuous quality improvement.

关键词： Transportation of patients Emergency medical services Pratice guideline Evaluation studies

Chemokine receptor 8 expression may be linked to disease severity and elevated interleukin 6 secretion in acute pancreatitis

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World Journal of Gastrointestinal Pathophysiology 2021年第6期12卷 115-133页

作者： Mwangala Nalisa Ekene Emmanuel Nweke Martin D Smith Jones Omoshoro-Jones John ws Devar Rebecca Metzger Tanya N Augustine Pascaline N Fru Department of Surgery School of Clinical MedicineFaculty of Health SciencesUniversity of the WitwatersrandJohannesburg 2193GautengSouth Africa Department of Surgery Chris Hani Baragwanath Academic HospitalJohannesburg 1864GautengSouth Africa Institut für Immunologie Ludwig-Maximilians-Universität MünchenMünchen 80539Germany School of Anatomical Sciences Faculty of Health ScienceUniversity of the WitwatersrandJohannesburg 2193GautengSouth Africa

BACKGROUND Acute pancreatitis(AP)is an inflammatory disease,which presents with epigastric pain and is clinically diagnosed by amylase and lipase three times the upper limit of *** 2012 Atlanta classification stratifies the severity of AP as one of three risk categories namely,mild AP(MAP),moderately severe AP(MSAP),and severe AP(SAP).Challenges in stratifying AP upon diagnosis suggest that a better understanding of the underlying complex pathophysiology may be *** To identify the role of the chemokine receptor 8(CCR8),expressed by T-helper type-2 Lymphocytes and peritoneal macrophages,and its possible association to Interleukin(IL)-6 and AP *** This study was a prospective case-control study.A total of 40 patients were recruited from the Chris Hani Baragwanath Academic Hospital and the Charlotte Maxeke Johannesburg Academic *** were performed on 29 patients(14 MAP,11 MSAP,and 4 SAP)and 6 healthy controls as part of a preliminary study.A total of 12 mL of blood samples were collected at Day(D)1,3,5,and 7 post epigastric *** multiplex immunoassay panels,real-time polymerase chain reaction(qRT-PCR)arrays,and multicolour flow cytometry analysis,immune response-related proteins,genes,and cells were profiled *** Prism^(TM) software and fold change(FC)analysis was used to determine differences between the groups.Ppost epigastric pain in both the MAP group and MSAP group with P=0.001 and P=0.013 respectively,in a multiplex *** a FC of 2 was applied to identify differentially expressed genes using RT2 Profiler,CCR8 was shown to increase steadily with disease severity from MAP(1.33),MSAP(38.28)to SAP(1172.45)median *** verification studies using RT-PCR showed fold change increases of CCR8 in MSAP and SAP ranging from 1000 to 1000000 times when represented as Log10,compared to healthy co

关键词： Acute Pancreatitis Severity Stratification,Interleukin-6 Chemokine Receptor 8 Lymphocytes Monocytes