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Computer Science

英语世界 2021年第5期40卷 127-128页

作者： Jon porter

What would happen to the world if we took all the computers out of it tomorrow? What would happen if the Internet, which is called the World Wide Web for a very good reason, stopped working?Do you have a computer?

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Selection of a cut-off for high-and low-methane producers using a spot-methane breath test:results from a large north American dataset of hydrogen,methane and carbon dioxide measurements in breath

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Gastroenterology Report 2017年第3期5卷 193-199,I0001,I0002页

作者： klaus Gottlieb Chenxiong Le Vince Wacher Joe Sliman Christine Cruz Tyler porter Stephen Carter Synthetic Biologics Inc. RockvilleMarylandUSA Commonwealth Laboratories LLC SalemMassachusettsUSA

Background:Levels of breath methane,together with breath hydrogen,are determined by means of repeated collections of both,following ingestion of a carbohydrate substrate,at 15–20 minutes intervals,until 10 samples have been *** frequent sampling is required to capture a rise of hydrogen emissions,which typically occur later in the test:in contrast,methane levels are typically elevated at *** methane emissions represent the principal objective of the test,a spot methane test(i.e.a single-time-point sample taken after an overnight fast without administration of substrate)may be ***:We analysed 10-sample lactulose breath test data from 11674 consecutive unique subjects who submitted samples to Commonwealth Laboratories(Salem,MA,USA)from sites in all of the states of the USA over a one-year *** North American Consensus(NAC)guidelines criteria for breath testing served as a reference ***:The overall prevalence of methane-positive subjects(by NAC criteria)was 20.4%,based on corrected methane results,and 18.9% based on raw *** our USA dataset,the optimal cut-off level to maximize sensitivity and specificity was4ppm CH4,94.5%[confidence interval(CI):93.5–95.4%]and 95.0%(CI:94.6–95.5%),*** use of a correction factor(CF)(5%CO_(2) as numerator)led to reclassifications CH4-high to CH_(4)-low in 0.7% and CH_(4)-low to CH_(4)-high in 2.1%.Conclusions:A cut-off value for methane at baseline of either≥4 ppm,as in our USA dataset,or≥5 ppm,as described in a single institution study,are both highly accurate in identifying subjects at baseline that would be diagnosed as‘methanepositive’in a 10-sample lactulose breath test for small intestinal bacterial overgrowth.

关键词： breath tests spot-methane breath test diagnostic test small intestinal bacterial overgrowth

Therapeutic gene editing strategies using CRISPR-Cas9 for theβ-hemoglobinopathies

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The Journal of Biomedical Research 2021年第2期35卷 115-134页

作者： James B.Papizan Shaina N.porter Akshay Sharma Shondra M.Pruett-Miller Department of Cellular and Molecular Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Advanced Genome Engineering St.Jude Children's Research HospitalMemphisTN 38105USA Department of Bone Marrow Transplantation and Cellular Therapy St.Jude Children's Research HospitalMemphisTN 38105USA

With advancements in gene editing technologies,our ability to make precise and efficient modifications to the genome is increasing at a remarkable rate,paving the way for scientists and clinicians to uniquely treat a multitude of previously irremediable ***-Cas9,short for clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9,is a gene editing platform with the ability to alter the nucleotide sequence of the genome in living *** technology is increasing the number and pace at which new gene editing treatments for genetic disorders are moving toward the ***β-hemoglobinopathies are a group of monogenic diseases,which despite their high prevalence and chronic debilitating nature,continue to have few therapeutic options *** this review,we will discuss our existing comprehension of the genetics and current state of treatment forβ-hemoglobinopathies,consider potential genome editing therapeutic strategies,and provide an overview of the current state of clinical trials using CRISPR-Cas9 gene editing.

关键词： sickle cell disease sickle cell anemia fetal hemoglobin hemoglobinopathy CRISPR gene editing genome engineering

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Weldable high-strength steels: Challenges and engineering applications

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机械制造文摘（焊接分册） 2015年第4期 26-28页

作者： David A.porter 谷森 Centre for Advanced Steels Research Materials Engineering University of Oulu 哈尔滨焊接研究所

68 IIW Annual Assembly&International; Conference of the International Institute of Welding,2-3 July 2015,Helsinki,Finland Portevin LectureHigh-strength steels are finding ever-wider applications as awareness of the potential benefits spread and the knowledge required by designers *** to the different processing routes,the YS levels of high-strength steels are commercially available as follows:

关键词： steels awareness Finland Welding commercially bene

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Prevalence of hyponatremia in acute medical admissions in tropical Asia Pacific Australia

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 40-43页

作者： Usman H.Malabu David porter Venkat N.Vangaveti Monsur kazi R.Lee kennedy Department of Medicine Townsville Hospital/James Cook UniversityQueenslandAustralia Department of Pathology Townsville Hospital/James Cook UniversityQueenslandAustralia Department of Medicine Deakin UniversityVictoriaAustralia

Objective:To determine prevalence of hyponatremia in acute medical admissions in Northern ***:We studied 469 consecutive acute medical admissions to a hospital in Australia's Far North Queensland during the colder months of June and July *** of hyponatremia and its relationship with gender,age,diagnosis and prognosis in acute medical admissions were ***:On admission,hyponatremia(plasma sodiumkalemia were present in 17.0%and 18.1*,***,275/469 patients(58.6*)presented with an electrolyte *** were significant correlations of hyponatremia with age but not with gender and in-hospital *** of hyponatremia was high across all diagnostic ***:The prevalence of hyponatremia appears to be high in the tropical North Australian population,being the highest prevalence reported amongst acute hospital *** previously reported correlations with age and mortality do appear to hold good for this population with a high prevalence of electrolyte *** prospective analysis on a larger population in the area is needed to confirm our findings.

关键词： Hyponatremia Prevalence Acute admissions Tropical Asia Pacific Australia

Crystallization kinetics of Poly(3-hydroxybutyrate) Granules in Different Environmental Conditions

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Journal of Biomaterials and Nanobiotechnology 2011年第3期2卷 301-310页

作者： Michael porter Jian Yu 不详

Poly(3-hydroxybutyrate) (PHB) is a natural biopolyester accumulated in microbial cells as tiny amorphous granules. The nano- micro-particles have a variety of potential applications and behave differently in different environments. In this work, the in situ crystallization of native PHB granules was investigated under different environmental conditions. The isothermal crystallization kinetics of the granules was shown to follow Avrami’s equation. The model parameter describing crystal growth is a function of temperature or pH and estimated from in situ crystallization measurements with attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Empirical equations describing crystal growth are derived for the parameter values. PHB granules heated at 80-140°C in acidic solution (pH 2) up to 4 hr showed an increase in crystallinity from about 5% to 35% and moderate particle aggregation. PHB granules suspended in alkaline solutions (pH 9-12) at room temperature up to 4 hr showed an increase in crystallinity up to 45% and very little particle aggregation. It was found that the amorphousness of PHB granules in vivo is stabilized by water, lipids and proteins. Upon removal of these impurities, partial crystallization is induced which may inhibit extensive particle aggregation.

关键词： Avrami model crystallization kinetics PHA PHB granules biopolyester particles

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Gastroenterology Report 2018年第3期6卷 242-242,I0003页

Gastroenterol Rep(Oxf).2017 doi:10.1093/gastro/*** authors wish to inform the reader that any references to‘confidential interval’throughout the paper have been corrected to‘confidence interval’.The paper has now ... 详细信息

关键词： methane dioxide corrected

China shipbuilding industry encountered cold snap from soaring steel price

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中国船检 2004年第4期 22-23页

作者： porter Cui Liande

Accumulation sequence of Chinese loess and climatic records of Greenland ice core during the last 130 ka

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Chinese Science Bulletin 1995年第15期40卷 1272-1276页

作者：安芷生孙东怀张小曳周卫建 S.C.porter J.Shaw 张代州 Xi'an Laboratory of Loess and Quaternary Geology. Chinese Academy of Sciences. Xi'an 710061 China Quaternary Research Centre. University of Washington. Seattle. USA Geomagnetism Laboratory. University of Liverpool UK Department of Geophysics. Peking University. Beijing 100871 China

The present winter climate of continental China is associated with cold air *** cold air forming Siberian high pressure comes from the Northern Barents *** kara Sea and Northern Atlantic Ocean (fig.1). in other words,... 详细信息

关键词： winter monsoon GRIP core and Chinese loess.

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