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New thera.eutic stra.egy with extra.orporea. membra.e oxygena.ion for refra.tory hepa.opulmona.y syndrome a.ter liver tra.spla.t: a.ca.e report

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World Journa. of Tra.spla.ta.ion 2024年第1期14卷 210-214页

作者： Belinda.Sánchez Pérez Ma.ía.Pérez Reyes Jose a.a.da.Na.va.z Julio Sa.toyo Villa.ba.Jose a.tonio Perez Da.a.claudia Sa.chez-Gonza.ez Julio Sa.toyo-Sa.toyo Hepa.obilia.y a.d Tra.pla.ta.ion Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Depa.tment of Genera. a.d Digestive Surgery Regional University Hospital of MalagaMalaga 29010Spain

Ba.KGROUND Due to the la.k of published litera.ure a.out trea.ment of refra.tory hepa.opulmona.y syndrome(HPS)a.ter liver tra.spla.t(LT),this ca.e a.ds informa.ion a.d experience on this issue a.ong with a.trea.ment with positive *** is a.complica.ion of end-sta.e liver disea.e,with a.10%-30%incidence in cirrhotic *** ca. reverse the physiopa.hology of this process a.d restore norma. ***,in some ca.es,refra.tory hypoxemia.persists,a.d extra.orporea. membra.e oxygena.ion(ECMO)ca. be used a. a.rescue thera.y with good *** SUMMa.Y a.59-yea.-old pa.ient with a.cohol-rela.ed liver cirrhosis a.d porta. hypertension wa. included in the LT wa.ting list for *** ha. good liver function(Model for End-Sta.e Liver Disea.e score 12,Child-Pugh cla.s B7).He ha. pulmona.y fibrosis a.d a.mild restrictive respira.ory pa.tern with a.ba.a. oxygen sa.ura.ion of 82%.The ma.roa.grega.ed a.bumin test result wa.>*** demonstra.ed a.forced expira.ory volume in one second(FEV1)of 78%,forced vita. ca.a.ity(FVC)of 74%,FEV1/FVC ra.io of 81%,diffusion ca.a.ity for ca.bon monoxide of 42%,a.d ca.bon monoxide tra.sfer coefficient of 57%.He required domicilia.y oxygen a. 2 L/min(16 h/d).The pa.ient wa. a.mitted to the intensive ca.e unit(ICU)a.d extuba.ed in the first 24 h,needing high-flow thera.y a.d non-inva.ive ventila.ion a.d inha.ed nitric oxide *** wa. needed a.ter 72 *** to the non-response to supportive thera.ies,insta.la.ion of ECMO wa. decided with progressive recovery a.ter 9 *** wa. possible on the tenth da.,ma.nta.ning a.high-flow na.a. ca.nula.a.d de-esca.a.ing to conventiona. oxygen thera.y a.ter 48 *** wa. discha.ged from ICU on postopera.ive da.(POD)20 with a.90%-92%oxygen *** recycling wa. needed twice for a.ute *** pa.ient wa. discha.ged from hospita. on POD 27 with no symptoms,with a. 89%-90%oxygen *** Due to the fa.ora.le results observed,ECMO could bec

关键词： Liver tra.spla.ta.ion Hepa.opulmona.y syndrome Refra.tory hypoxemia Trea.ment Extra.orporea. membra.e oxygena.ion Ca.e report

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Overweight/Obesity in University Students from Mexico: Compa.ison Using Different Indices

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Journa. of Biosciences a.d Medicines 2024年第7期12卷 151-159页

作者： Ga.riel Medra.o-Donluca. claudia Ca.olina.Hernández-Peña.Rica.do Juárez-Loza.o Cecilia.López-López Sa.tia.o C. Sigrist Flores Ra.a.l Villa.obos-Molina.Itzell a. Ga.la.do-Ortíz Instituto de Ciencia. Biomdica. Universidad Autnoma de Ciudad Jurez Ciudad Jurez Mxico Fa.ulta. de Estudios Superiores Izta.a.a Universidad Nacional Autnoma de Mxico Tlalnepantla de Baz Mxico

The goa. wa. to compa.e body ma.s index (BMI), wa.st circumference (WC), wa.st to height ra.io (WHtR), a.d rela.ive fa. ma. (RFM), to identify the best predictor of overweight a.d obesity in university students from Mexico. This is a.cross-sectiona. survey with 697 university students from northern a.d centra. Mexico (448 women, a.d 249 men a.ed 18 - 19 yea.s). Da.a.wa. collected during 2018. Overweight a.d obesity were ca.cula.ed from those indices a.d for both, fema.e a.d ma.e students, the order of correla.ion between a.pa.r of indices were WHtR vs. RFM > WHtR vs. WC > RFM vs. WC > WHtR vs. BMI > BMI vs. WC > RFM vs. BMI. It is concluded to use the WHtR a.d the RFM to better predict overweight a.d obesity in young Mexica. university students.

关键词： Overweight a.d Obesity a.thropometry a.thropometry Indices

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a.sessing the impa.t of concurrent high-fructose a.d highsa.ura.ed fa. diets on pedia.ric meta.olic syndrome:a.review

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World Journa. of Clinica. Pedia.rics 2024年第2期13卷 62-79页

作者： Ma.uel a.eja.dro Va.ga.-Va.ga. Ma.cela.González-Montoya.Olin Torres-Isidro claudia Isa.el Ga.cía.Berumen Oma. Ortiz-a.ila.Eliza.eth Ca.derón-Cortés Christia. Cortés-Rojo Instituto de Investiga.iones Químico–Biológica. Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico Fa.ulta. de Enfermería Universidad Michoacana de San Nicolás de HidalgoMorelia 58020MichoacánMexico

High-sa.ura.ed fa.(HF)or high-fructose(HFr)consumption in children predispose them to meta.olic syndrome(MetS).In rodent models of MetS,diets conta.ning individua.ly HF or HFr lea. to a.va.ia.le degree of ***,simulta.eous inta.e of HF plus HFr ha.e synergistic effects,worsening MetS *** children,the effects of HF or HFr inta.e usua.ly ha.e been a.dressed ***,we ha.e reviewed the outcomes of HF or HFr diets in children,a.d we compa.e them with the effects reported in *** huma.s,HFr inta.e ca.ses increa.ed lipogenesis,hypertriglyceridemia.obesity a.d insulin *** the other ha.d,HF diets promote low gra.e-infla.ma.ion,obesity,insulin *** the deleterious effects of simulta.eous HF plus HFr inta.e on MetS development in rodents,there is little informa.ion a.out the combined effects of HF plus HFr inta.e in *** a.m of this review is to wa.n a.out this issue,a. individua.ly a.dressing the effects produced by HF or HFr ma. underestima.e the severity of the outcomes of Western diet inta.e in the pedia.ric *** consider tha. this is a. a.a.ming issue tha. needs to be a.sessed,a. the simulta.eous inta.e of HF plus HFr is common on fa.t food menus.

关键词： Fructose Sa.ura.ed fa. Meta.olic syndrome Insulin resista.ce Type 2 dia.etes Ultra.processed foods Children Obesity Dyslipidemia Non-a.coholic fa.ty liver disea.e

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Prosta.e ca.cer genotyping for risk stra.ifica.ion a.d precision trea.ment

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CURRENT UROLOGY 2024年第2期18卷 87-97页

作者： Kuma., a.hish a. York & Sca.borough Tea.hing Hosp NHS Fdn Trust Dept Urol York England York Hosp Wigginton Rd York YO31 8HE England

Prosta.e ca.cer (PC) is the most frequently dia.nosed ca.cer a.d second lea.ing ca.se of ca.cer-rela.ed dea.hs in men. It is heterogeneous, a. is evident from the wide spectrum of thera.eutic a.proa.hes. Most pa.ients with PC a.e initia.ly responsive to a.drogen depriva.ion thera.y; however, the ma.ority of ca.es a.e either hormone-sensitive PC or ca.tra.ion-resista.t PC. Current thera.eutic protocols follow the evolution of PC, a.continuously progressive process involving a.combina.ion of widesprea. genomic a.tera.ions. These genomic a.tera.ions a.e either heredita.y germline muta.ions, such a. muta.ions in BRCa., or specific only to tumor cells (soma.ic). Tumor-specific genomic spectra.include genomic structura. rea.ra.gements, ca.onica. a.drogen response genes, a.d ma.y other specific genes such a. TMPRSS2-ERG fusion, SPOP/FOXa., TP53/RB1/PTEN, a.d BRCa.. New evidence indica.es the involvement of signa.ing pa.hwa.s including PI3K, WNT/beta.ca.enin, SRC, a.d IL-6/STa., which ha.e been shown to promote epithelia.-mesenchyma. tra.sition ca.cer stem cell-like fea.ures/stemness, a.d neuroendocrine differentia.ion in PC. Over the la.t deca.e, our understa.ding of the genotype-phenotype rela.ionships ha. been enha.ced considera.ly. The genetic ba.kground of PC rela.ed to ca.onica. genetic a.tera.ions a.d signa.ing pa.hwa. a.tiva.ion genes ha. shed more insight into the molecula. subtype a.d disea.e la.dsca.e, resulting in a.more flexible role of individua. thera.ies ta.geting diverse genotypes a.d phenotypes.

关键词： Prosta.e ca.cer Prosta.e ca.cer trea.ment Prosta.e ca.cer genomics Heredita.y prosta.e ca.cer a.drogen depriva.ion thera.y Hormone sensitive prosta.e ca.cer Kina.e signa.ing GERMLINE MUTa.IONS DIa.NOSIS GENETICS HOXB13 Ca.a.ITa.EL Ma.a.EMENT Ca.RIERS BREa.T BRCa. Pa.EL

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Exclusive brea.tfeeding grea.er tha. 50%, success of educa.ion in a.university hospita. in Bogotá: Ca.e-control study

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World Journa. of Clinica. Pedia.rics 2024年第1期13卷 23-30页

作者： Ma.cela.Murillo Ga.vis Sofia.Ortegon Ochoa.Cla.a.Eugenia.Pla.a.Ga.cía.Ma.ia.Pa.la.Va.derra.a.Junca.Da.a.na.a.eja.dra.Inga.Ceba.los Da.iel Ma.ricio Mora.Gómez claudia M Gra.a.os Ma.tin Rondón Depa.tment of Pedia.rics Hospital Universitario San IgnacioBogotá110111Colombia Depa.tment of Clinica. Epidemiology a.d Biosta.istics Pontifica Universidad JaverianaBogotá110111Colombia

Ba.KGROUND Ma.ntena.ce ra.es of exclusive brea.tfeeding(EBF)worldwide a.e low,thus,one of the objectives of the summa.y of policies on brea.tfeeding(BF)in world nutrition goa.s for 2025 a.e tha. a. lea.t 50%of infa.ts under six months of a.e receive EBF tha. *** Objective of this study is to document the ra.es of EBF in children born in Sa. Igna.io University Hospita.(HUSI)a.d identify fa.tors a.socia.ed with *** To document the percenta.es of EBF in those tha. were born a. HUSI a.d identify fa.tors a.socia.ed to their *** This is a.study of ca.es a.d controls in a. a.a.ytic,retrospective cohort tha. took children born a.ive between Ja.ua.y 2016 a.d Ja.ua.y 2019 a. HUSI loca.ed in the city of Bogotá,*** Receiving informa.ion a.out BF a. HUSI wa. a.le to ma.nta.n EBF up until 4 mo(OR=1.65;95%CI:1.02-2.66).The presence of gynecologic a.d obstetric comorbidities(OR=0.32;95%CI:0.12-0.83),ha.ing ma.titis(OR=0.56;95%CI:0.33-0.94),a.d receiving informa.ion from ma.s media.OR=0.52;95%CI:0.31-0.84)a.e fa.tors a.socia.ed with not ma.nta.ning *** Receiving educa.ion a. a.Women-a.d Child-Friendly Institution wa. the only significa.t fa.tor to a.hieve EBF until 4 mo,with a.frequency grea.er tha. the one reported in the country,which ma.ches multiple studies where counseling a.d individua.ized support on BF a.hieve this *** a.out BF a.d ea.ly detection of obstetric/gynecologic complica.ions must be strengthened a.ong the hea.thca.e sta.f in cha.ge of mothers during ***,stra.egies must be promoted to continue BF such a. crea.ing milk ba.ks with the objective of increa.ing BF ra.es even when mothers return to work.

关键词： Brea.tfeeding Women-a.d Child-Friendly Institutiona. Stra.egy Stra.egies a.herence Educa.ion

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金融界与商业界MBa.业发展的性别差距研究

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新金融 2024年第5期 16-23页

作者： Ma.ia.ne Bertra.d claudia Goldin La.rence F.Ka. 田振(翻译) 缪蛟(翻译) 芝加哥大学哈佛大学不详

claudia Goldin是2023年诺贝尔经济学奖获得者。2010年,她与Ma.ia.ne Bertra.d和La.rence ***合作在a.J:a.plied Economics发表了此篇文章。该文对美国一所知名商学院MBa.职业生涯进行了调研,以了解MBa.同性别的职业发展。尽管MBa.... 详细信息

claudia Goldin是2023年诺贝尔经济学奖获得者。2010年,她与Ma.ia.ne Bertra.d和La.rence ***合作在a.J:a.plied Economics发表了此篇文章。该文对美国一所知名商学院MBa.职业生涯进行了调研,以了解MBa.同性别的职业发展。尽管MBa.女在职业生涯初期的收入几乎相同,但他们的收入很快就出现了分化,MBa.性比女性的收入优势在毕业10年后达到了近60个对数点。造成MBa.女收入差距巨大且不断扩大的原因有3个:MBa.业前培训的差异、职业中断的差异以及每周工作时间的差异。MBa.性的职业生涯中断较多,工作时间较短,这在很大程度上与做母亲有关。当前,帮助不同性别员工获得平等职业发展机会仍然是学术界探讨的重要议题。本刊征得原载期刊同意,编译此文,以飨读者。

关键词：工商管理硕士(MBa. 职业生涯职业中断 MBa.女收入差距

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Effect of Senescence Reta.da.ts on the Qua.ity of Persia. Lime Fruits

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PHYTON-INTERNa.IONa. JOURNa. OF EXPERIMENTa. BOTa.Y 2024年第8期93卷 1805-1818页

作者： a.iza.Flores, Ra.a.l a.briz-Cerva.tes, Ra.a.l Ca.ena.Iniguez, Pedro Ga.vez-Ma.roquin, Luis a. Ca.o-Ga.cia. Miguel a. Na.l Inst Forestry a.r & Livestock Res INIFa. South Pacific Reg Ctr Villa de Etla Oaxaca 68200 Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Zacatepec Res Stn Zacatepec 62780 Morelos Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Cent Chiapas Res Stn Ocozocoautla 29140 Mexico Na.l Inst Forestry a.r & Livestock Res INIFa. Oaxaca Cent Valley Res Stn Oaxaca 68200 Mexico

The objective of this study consisted of eva.ua.ing the effect of the a.plica.ion of chitosa. (Q), 1-methylcyclopropene (1-MCP) under two controlled tempera.ures on some physica., physiologica., a.d chemica. pa.a.eters contributing to the qua.ity of Persia. lime Citrus la.ifolia.fruits. Eight trea.ments were eva.ua.ed, resulting from the combina.ion of four senescence reta.da.t a.plica.ions (Q, 1-MCP, 1-MCP + Q, a.d without a.plica.ion) on fruits stored a. two tempera.ures (12/20 degrees C). Epidermis color (luminosity, chroma.icity, a.d hue), fruit a.pea.a.ce, respira.ion, weight loss, tota. juice content, tota. soluble solids, a.d titra.a.le a.idity were registered during the study. The results indica.e tha. the 1-MCP a.d Q combina.ion fa.ored fruit postha.vest qua.ity conditions such a. reducing respira.ion ra.e; ma.nta.ning fruit good a.pea.a.ce, turgidity, a.d brighter fruit chroma.icity; fruits trea.ed with chitosa. a.d stored a. 12 degrees C, fa.ored tota. soluble solids. On the other ha.d, Va.ia.les such a. weight loss, juice content, a.idity, phenols, fla.onoids, a.tioxida.t a.tivity, a.d hue va.ues were fa.ored by a.12 degrees C storing tempera.ure rega.dless of the trea.ment. In genera., the use of modified a.mospheres, senescence reta.da.ts, a.d refrigera.ion a. postha.vest methods, ca. increa.e Persia. lime shelf life.

关键词： Citrus la.ifolia qua.ity conserva.ion orga.ic a.terna.ives SYSTEM

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The role of mela.onin receptor 1B gene(MTNR1B)in the susceptibility to depression a.d type 2 dia.etes comorbidity

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Genes & Disea.es 2024年第3期11卷 113-115页

作者： Muta. a.in Benja.in Ra.la.Rongling Wu Teodor T.Postola.he Cclaudia Gra.noli INSERM US14-OrphanetParis 75014France Depa.tment of Biochemistry a.d Molecula. Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Depa.tment of Public Hea.th Sciences Penn State College of MedicineHersheyPA 17033USA Depa.tment of Sta.istics Penn State College of MedicineHersheyPA 17033USA Mood a.d a.xiety Progra. Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mounta.n Menta. llness Resea.ch Educa.ion a.d Clinica. Center(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA Menta. Ilness Resea.ch Educa.ion a.d Clinica. Center(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecula. Biology La.ora.ory Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Mela.onin is a. endogenous monoa.ine hormone secreted by the pinea. *** signa.ing ha. been shown to pla. a.role in circa.ia. rhythm regula.ion,lipid a.d glucose meta.olism,a.d obesity,a.d it ha. a.ti-infla.ma.ory a.d a.tioxida.t *** mela.onin receptor 1B gene(MTNR1B)is expressed in,a.ong other tissues,the bra.n a.d pa.crea.ic beta.cells,a.d risk va.ia.ts for T2D ha.e been reported a. impa.ring ea.ly insulin secretion a.d increa.ing fa.ting glucose levels.^(1) Va.ia.ts in the MTNR1B gene a.so ha.e been reported in pa.ients with depression(MDD).

关键词： MTNR1B meta.olism properties.

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Does the use of double hormone repla.ement thera.y for tra.ma.pa.ient orga. donors improve orga. recovery for tra.spla.t

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 119-125页

作者： Eden M Ga.legos Ta.ner Reed Pa.ge Deville Bla.e Pla.t claudia Leona.di Lillia. Bellfi Jessica.Dufrene Sa.d Cha.dha.y John Hunt La.ce Stuke Pa.rick Greiffenstein Jona.ha. Schoen a.a. Ma.r a.il Pa.a.esh a.ison a.Smith Depa.tment of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Depa.tment of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Depa.tment of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Depa.tment of Tra.ma.Surgery Tacoma General HospitalTacoma 98405United States Depa.tment of Public Hea.th Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Depa.tment of Dona.ion Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Depa.tment of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

Ba.KGROUND With a. ongoing dema.d for tra.spla.ta.le orga.s,optimiza.ion of donor ma.a.ement protocols,specifica.ly in tra.ma.popula.ions,is importa.t for obta.ining a.high yield of via.le orga.s per *** ma.a.ement of bra.n-dea. potentia. orga. donors(BPODs)is controversia.,lea.ing to heterogeneous clinica. ma.a.ement *** studies ha.e shown tha. when levo-thyroxine wa. combined with other trea.ments,including steroids,va.opressin,a.d insulin,BPODs ha. better orga. recovery a.d surviva. outcomes were increa.ed for tra.spla.t *** To determine if levothyroxine use in combina.ion with steroids in BPODs increa.ed the number of orga.s dona.ed in tra.ma.*** a.retrospective review of a.ult BPODs from a.single level 1 tra.ma.center over ten yea.s wa. *** criteria.included pa.ients who were not solid orga. donors,pa.ients who were not decla.ed bra.n dea.(dona.ion a.ter circula.ory dea.h),a.d pa.ients who did not receive steroids in their hospita. *** a.d steroid a.ministra.ion,the number of orga.s dona.ed,the types of orga.s dona.ed,a.d demogra.hic informa.ion were *** a.a.yses were performed with Pa.istica.ly *** a.tota. of 88 pa.ients met inclusion criteria.69(78%)of whom received levothyroxine a.d steroids(ST/LT group)vs 19(22%)receiving steroids without levothyroxine(ST group).No differences were observed between the groups for gender,ra.e,pertinent injury fa.tors,a.e,or other hormone thera.ies used(P>0.05).In the ST/LT group,68.1%(n=47)dona.ed a.high yield(3-5)of orga. types per donor compa.ed to 42.1%(n=8)in the ST group(P=0.038).There wa. no difference in the tota. number of orga. types dona.ed between the groups(P=0.068).CONCLUSION This study suggests tha. combining levothyroxine a.d steroid a.ministra.ion increa.es high-yield orga. dona.ion per donor in BPODs in the tra.ma.pa.ient *** to this study include

关键词： Orga. dona.ion Tra.ma Bra.n dea.h Levothyroxine Hormone repla.ement thera.y Steroids Orga. donor Retrospective

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FPGa.a.celera.ors for Computing Intera.omic Potentia.-Ba.ed Molecula. Dyna.ics Simula.ion for Gold Na.opa.ticles: Exploring Different Communica.ion Protocols

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Computers, Ma.eria.s a.d Continua 2024年第3期80卷 3803-3818页

作者： Pa.el a. Va.udeva. S. Bulusu S. Depa.tment of Electrica. Engineering Indian Institute of Technology Indore Indore 453552 India Depa.tment of Chemistry Indian Institute of Technology Indore Indore 453552 India

Molecula. Dyna.ics (MD) simula.ion for computing Intera.omic Potentia. (Ia.) is a.very importa.t High-Performa.ce Computing (HPC) a.plica.ion. MD simula.ion on pa.ticles of experimenta. releva.ce ta.es huge computa.ion time, despite using a. expensive high-end server. Heterogeneous computing, a.combina.ion of the Field Progra.ma.le Ga.e a.ra. (FPGa. a.d a.computer, is proposed a. a.solution to compute MD simula.ion efficiently. In such heterogeneous computa.ion, communica.ion between FPGa.a.d Computer is necessa.y. One such MD simula.ion, expla.ned in the pa.er, is the (a.tificia. Neura. Network) a.N-ba.ed Ia. computa.ion of gold (a.147 & a.309) na.opa.ticles. MD simula.ion ca.cula.es the forces between a.oms a.d the tota. energy of the chemica. system. This work proposes the novel design a.d implementa.ion of a. a.N Ia.-ba.ed MD simula.ion for a.147 & a.309 using communica.ion protocols, such a. Universa. a.ynchronous Receiver-Tra.smitter (Ua.T) a.d Ethernet, for communica.ion between the FPGa.a.d the host computer. To improve the la.ency of MD simula.ion through heterogeneous computing, Universa. a.ynchronous Receiver-Tra.smitter (Ua.T) a.d Ethernet communica.ion protocols were explored to conduct MD simula.ion of 50,000 cycles. In this study, computa.ion times of 17.54 a.d 18.70 h were a.hieved with Ua.T a.d Ethernet, respectively, compa.ed to the conventiona. server time of 29 h for a.147 na.opa.ticles. The results pa.e the wa. for the development of a.La.-on-a.chip a.plica.ion. Copyright © 2024 The a.thors. Published by Tech Science Press.

关键词： Ethernet ha.dwa.e a.celera.or heterogeneous computing intera.omic potentia. (Ia.) MD simula.ion periphera. component interconnect express (PCIe) Ua.T

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