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Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： poornima d.e.weerasinghe-mudiyanselage Sohi Kang Joong-Sun Kim Sung-Ho Kim Hongbing Wang Taekyun Shin Changjong Moon department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(eAe)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in eAe *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in eAe-affected mice in the early phase(11 days post-immunization,dPI)and chronic phase(28dPI).eAe-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(dG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and dG subregions in the early phase of eAe,but only reduced in the dG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(eRK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the eRK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1331-1335页

作者： poornima d.e.weerasinghe-mudiyanselage Jeongtae Kim Yuna Choi Changjong Moon Taekyun Shin Meejung Ahn department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea department of Veterinary Anatomy College of Veterinary Medicine and BK21 Plus Project TeamChonnam National UniversityGwangjuRepublic of Korea department of Anatomy Kosin University College of MedicineBusanRepublic of Korea department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea

Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system *** its precise roles in these processes and involvement in spinal cord injury pathophysiology remain *** blot assay revealed that Ninjurin-1 levels in rats with spinal cord injury exhibited an upregulation until day 4 post-injury and slightly decreased thereafter compared with sham *** analysis revealed that Ninjurin-1 immunoreactivity in rats with spinal cord injury sharply increased on days 1 and 4 post-injury and slightly decreased on days 7 and 21 post-injury compared with sham ***-1 immunostaining was weak in vascular endothelial cells, ependymal cells, and some glial cells in sham controls while it was relatively strong in macrophages, microglia, and reactive *** findings suggest that a variety of cells, including vascular endothelial cells, macrophages, and microglia, secrete Ninjurin-1 and they participate in the pathophysiology of compression-induced spinal cord *** experimental procedures were approved by the Care and Use of Laboratory Animals of Jeju National University(approval No.2018-0029) on July 6, 2018.

关键词： astrocytes clip compression injury macrophage microglia neuroinflammation Ninjurin-1 rat spinal cord

Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

动物学研究 2024年第2期 398页

作者： poornima d.e.weerasinghe-mudiyanselage Sohi Kang Joong-Sun Kim Sung-Ho Kim Hongbing Wang Taekyun Shin Changjong Moon

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir poornima Shaji Ana Martinez Bulnes Anupam dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew e.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile drug delivery Solutions UTHSCMemphisTN 38104USA department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas diabetes and Obesity Institute UTRGVMcAllenTX 78504USA dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(eXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-eXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(eXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived eXs(NAF-eXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-eXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(eMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-eXs for PdAC tumors,thus imply feasibility of developing a novel personalized medicine for PdAC patients using autologous NAF-eXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) desmoplasia extracellular vesicles exosomes Tumor targeting Ormeloxifene Personalized medicine

Analysis of NPK in Camellia sinensis, Gliricidia sepium, and Musa acuminata Biomasses for Preparation of an Organic Fertilizers Formula for Young Tea Plants (Musa acuminata) and Studying of Their Nutrient Release Capacity in the Biodegradation Process

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Journal of Agricultural Chemistry and environment 2024年第1期13卷 115-132页

作者： Madushan dhammika Gunarathna Ashan Sithija Wickramaarachchi Polegodage dilushi Sureka Ruwan Kumari Hiti mudiyanselage Sithara dilrukshi Wijekoon deeyagahage Sujeewa Mallik de Silva department of Chemistry Faculty of Science University of Kelaniya Kelaniya Sri Lanka department of Microbiology Faculty of Science University of Kelaniya Kelaniya Sri Lanka department of Statistics and Computer Science University of Kelaniya Kelaniya Sri Lanka

This study investigates the nitrogen (N), phosphorous (P), and potassium (K) contents in raw biomasses of Camellia sinensis, Gliricidia sepium, and Musa acuminata. Therein, the highest N and P content was seen in Camellia sinensis 116.80 ± 0.08 mg and 66.00 ± 0.14 mg respectively. The highest K content (106.80 ± 0.04 mg) was observed in Musa acuminata. Next, all three types of plant materials were allowed to decompose in water for 3 weeks, and a sample from each was analyzed for NPK after the 1st, 2nd, and 3rd week during decomposition. A significant increase in the release of N, P, and K by the Camellia sinensis to water (P Musa acuminate were not significantly changed (P > 0.05) over time. The ratio for N:P:K was calculated for raw biomass samples and decomposed samples to find the best fitting N:P:K ratio to apply to young tea plants as organic fertilizers. In addition to that, the microbial insight of these organic compounds was analyzed by observing how microbial population increased with decomposition by the enumeration of the total microbial count. A considerable increment in total microbial count was observed up to 3.28 × 106, 1.21 × 1010, 2.18 × 108, and 6.49 × 107 CFU/ml for Camellia sinensis, Gliricidia sepium, Musa accuminata (leaves), and Musa accuminata (trunk) respectively. The presence of phosphate solubilizing bacteria (PSB) and nitrogen solubilizing bacteria (NSB) throughout the decomposition period was confirmed by their growth on NBRIP and a modified nutrient medium that was specifically designed for the identification of ammonifiers respectively. Prepared fertilizer samples were applied to young tea plants that were grown in the Mawanella area in Sri Lanka (7°15'12.42"N 80°26'47.62"e) and according to the results, it is clear that fertilizer mixture 1 (N:P:K, 10:5:10, tea dust + Gliricidia + banana trunk) and fertilizer mixture 2 (N:P:K, 10:5:10, tea dust + Gliricidia + banana leaves) has the potential

关键词： Camellia sinensis Musa accuminata Gliricidia sepium Phosphate Solubilizing Bacteria Nitrogen Solubilizing Bacteria

effect of Intermittent Pneumatic Compression on Functional Level and Quality of Life in Community-dwelling Older Adults with Limited Ambulation due to Leg Pain: A Randomized Controlled Trial

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Health 2021年第10期13卷 1145-1169页

作者： weerasinghe mudiyanselage Sujeewa weerasinghe Thunpaththu mudiyanselage Upul Sanjeewa Thunpaththu weerasinghe mudiyanselage Sandali Anjana weerasinghe weerasinghe mudiyanselage Shalindu Thushen weerasinghe Pahala Walpola Gamarallage Shirani Walpola dissanayaka mudiyanselage Tharanga Padmini dissanayaka Angelo Karunaratne Physio Life Care (Physical Medicine Rehabilitation and Research) Ruwanwella Sri Lanka National Hospital of Sri Lanka Colombo Sri Lanka Rajarata University of Sri Lank Mihintale Sri Lanka National Secretariat for early Childhood development Colombo Sri Lanka department of Mechanical engineering University of Moratuwa Moratuwa Sri Lanka

Background and Purpose: Walking difficulties are defined as any reduction in speed, balance, or change of gait, causing limited ambulation. These difficulties are a common problem in older adults and may greatly affect their quality of life (QOL) and restrict their personal independence and participation. This study aimed to determine the effect of intermittent pneumatic compression (IPC) on lower leg pain, walking capacity, functional mobility, ankle range of motion (AROM), and QOL of community-dwelling older people with walking difficulties. Methods: In this randomized controlled trial, 34 eligible participants with self-reported lower limb pain and limited ambulation were randomized either to the intermittent pneumatic compression intervention group (IPCIG) or static compression control group (SCCG). The IPCIG and SCCG were trained to receive IPC and SC respectively for both lower legs and instructed to continue the application independently at home for 15 minutes per session, 2 sessions a day, 7 days per week for 4 weeks independently at the home. Outcome measures of lower leg pain, AROM, walking capacity, and functional mobility were assessed at baseline and at the first, second, third, and fourth weeks after randomization. Quality of life was assessed at baseline and immediately after the intervention. Results and discussion: IPCIG showed a more significant improvement compared to the SCCG at the post-interventional stage for QOL and all the subscales. The findings show that “80% improved QOL” is 53% higher with the application of IPC than with SC for 4 weeks. The IPCIG showed a more significant improvement in the 6-minute walk test (6 MWT) at the third and fourth weeks compared to the SCCG. A pairwise comparison of mean values of 6 MWT over 4 weeks within the IPCIG showed a significant difference between all the weeks. Pairwise comparisons between groups at each time point showed that the IPCIG showed a more

关键词： Intermittent Pneumatic Compression Functional Level Quality of Life Older Adults Limited Ambulation Leg Pain

3-d Temperature Fields in Laminated Shells Subjected to Thermo-Loads

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Structural durability & Health Monitoring 2018年第4期12卷 281-298页

作者： Hai Qian ding Zhou Bin Gu Rathnayaka mudiyanselage d.M.S. Faculty of Civil engineering and Mechanics Jiangsu UniversityZhenjiang212013PR.China College of Civil engineering Nanjing Tech UniversityNanjing211816PR.China University of Queensland QueenslandAustralia

The temperature fields in the laminated shells were studied, including opencylindrical shells and cylindrical shells, according to the thermal theory. Analyticalsolution of the temperature in the shells with the known temperature on the surfaces waspresent. The thinning layer approach was introduced to simplify the three-dimensionalheat conduction equation. Firstly, the layered shell was divided into N thinner layers. Thegoverning equation was simplified by replacing the variable r by r0 in the center line ofevery thin layer. The general solutions of temperature satisfying the simplified threedimensionalgoverning equation in single-layered shell were deduced in the cylindricalcoordinate system. Then, the temperature and heat flux relationships between the surfacescould be found by transferring matrixes. According to the continuities of temperature andheat flux in the interface of the laminates, the temperature and heat flux relationships ofthe surfaces were derived. With the temperature condition on the surfaces, the unknowncoefficients in the general solution of temperature were obtained. Finally, the effects fromthe thinning layer approach were eliminated by analyzing different numbers of thin *** validity and accuracy of the proposal method were proved from the convergence andcomparison studies. And several numerical examples were studied to investigated thetemperature effects from surface temperatures, geometric size of the shells andcomposition of layers.

关键词： Analytical solution temperature laminated Shells the analytical method thetransfer matrix method

Big data analytics for privacy through Nd-homomorphic encryption

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Journal of Control and decision 2023年第1期10卷 64-71页

作者： S.Saravanan N.poornima department of CSe SRM Institute of Science and TechnologyChennaiIndia department of data Science and Business Systems School of ComputingSRM Institute of Science and TechnologyKattankulathurIndia

Rapidly rising the quantity of Big data is an opportunity to flout the privacy of people. Whenhigh processing capacity and massive storage are required for Big data, distributed networkshave been used. There are several people involved in these activities, the system may contributeto privacy infringements frameworks have been developed for the preservation of privacy atvarious levels (e.g. information age, information the executives and information preparing) asfor the existing pattern of huge information. We plan to frame this paper as a literature surveyof these classifications, including the Privacy Processes in Big data and the presentation of theAssociate Challenges. Homomorphic encryption is particularised aimed at solitary single actionon the ciphered information. Homomorphic enciphering is restrained to an honest operation onthe encoded data. The reference to encryption project fulfils many accurate trading operationson coded numerical data;therefore, it protects the written in code-sensible information evenmore.

关键词： Security and confidentiality vast statistics data encryption nondeterministic fully homomorphic encryption

Impact of source and drain contact thickness on the performance of organic thin film transistors

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Journal of Semiconductors 2014年第12期35卷 21-27页

作者： poornima Mittal Y.S.Negi R.K.Singh department of electronics & Communication engineering Graphic Era UniversityDehradun–248002 India department of electronics & Communication engineering Uttarakhand Technical UniversityDehradun–248002 India department of Polymer and Process engineering Indian Institute of Technology Roorkee–246776 India

This paper analyzes the impact of source（ts） and drain（td） contact thicknesses on top contact（TC） and bottom contact（BC） organic thin film transistors（OTFTs） with a gate in the bottom, using a benchmarked industry standard Atlas 2-d numerical device simulator. The parameters including drive current（Ids）, mobility（μ）, threshold voltage（Vt）and current on-off ratio（ION/IOFF） are analyzed from the device physics point of view on different electrode thicknesses, ranging from infinitesimal to 50 nm, for both top and bottom contact structures. Observations demonstrate that the performance of the BC structure is more affected by scaling of ts=din comparison to its counterpart. In the linear region, the mobility is almost constant at all the values of ts=dfor both structures. However,an increment of 18% and 83% in saturation region mobility is found for TC andBC structures, respectively with scaling down ts=dfrom 50–0 nm. Besides this, the current on-off ratio increases more sharply in the BC *** analysis simplifies a number of issues related to the design and fabrication of organic material based devices and circuits.

关键词： contact thickness organic semiconductor organic thin film transistor bottom contact top contact structure