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Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： poornima d.e.weerasinghe-mud.yanselage Sohi Kang Joong-Sun Kim Sung-Ho Kim Hongbing Wang Taekyun Shin Changjong Moon department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(eAe)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in eAe *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in eAe-affected mice in the early phase(11 days post-immunization,dPI)and chronic phase(28dPI).eAe-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(dG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and dG subregions in the early phase of eAe,but only reduced in the dG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(eRK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the eRK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1331-1335页

作者： poornima d.e.weerasinghe-mud.yanselage Jeongtae Kim Yuna Choi Changjong Moon Taekyun Shin Meejung Ahn department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea department of Veterinary Anatomy College of Veterinary Medicine and BK21 Plus Project TeamChonnam National UniversityGwangjuRepublic of Korea department of Anatomy Kosin University College of MedicineBusanRepublic of Korea department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea

Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system *** its precise roles in these processes and involvement in spinal cord injury pathophysiology remain *** blot assay revealed that Ninjurin-1 levels in rats with spinal cord injury exhibited an upregulation until day 4 post-injury and slightly decreased thereafter compared with sham *** analysis revealed that Ninjurin-1 immunoreactivity in rats with spinal cord injury sharply increased on days 1 and 4 post-injury and slightly decreased on days 7 and 21 post-injury compared with sham ***-1 immunostaining was weak in vascular endothelial cells, ependymal cells, and some glial cells in sham controls while it was relatively strong in macrophages, microglia, and reactive *** findings suggest that a variety of cells, including vascular endothelial cells, macrophages, and microglia, secrete Ninjurin-1 and they participate in the pathophysiology of compression-induced spinal cord *** experimental procedures were approved by the Care and Use of Laboratory Animals of Jeju National University(approval No.2018-0029) on July 6, 2018.

关键词： astrocytes clip compression injury macrophage microglia neuroinflammation Ninjurin-1 rat spinal cord

exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir poornima Shaji Ana Martinez Bulnes Anupam dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew e.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile drug delivery Solutions UTHSCMemphisTN 38104USA department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas diabetes and Obesity Institute UTRGVMcAllenTX 78504USA dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(eXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-eXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(eXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived eXs(NAF-eXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-eXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(eMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-eXs for PdAC tumors,thus imply feasibility of developing a novel personalized medicine for PdAC patients using autologous NAF-eXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) desmoplasia extracellular vesicles exosomes Tumor targeting Ormeloxifene Personalized medicine

Big data analytics for privacy through Nd-homomorphic encryption

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Journal of Control and decision 2023年第1期10卷 64-71页

作者： S.Saravanan N.poornima department of CSe SRM Institute of Science and TechnologyChennaiIndia department of data Science and Business Systems School of ComputingSRM Institute of Science and TechnologyKattankulathurIndia

Rapidly rising the quantity of Big data is an opportunity to flout the privacy of people. Whenhigh processing capacity and massive storage are required for Big data, distributed networkshave been used. There are several people involved in these activities, the system may contributeto privacy infringements frameworks have been developed for the preservation of privacy atvarious levels (e.g. information age, information the executives and information preparing) asfor the existing pattern of huge information. We plan to frame this paper as a literature surveyof these classifications, including the Privacy Processes in Big data and the presentation of theAssociate Challenges. Homomorphic encryption is particularised aimed at solitary single actionon the ciphered information. Homomorphic enciphering is restrained to an honest operation onthe encoded data. The reference to encryption project fulfils many accurate trading operationson coded numerical data;therefore, it protects the written in code-sensible information evenmore.

关键词： Security and confidentiality vast statistics data encryption nondeterministic fully homomorphic encryption

Impact of source and drain contact thickness on the performance of organic thin film transistors

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Journal of Semiconductors 2014年第12期35卷 21-27页

作者： poornima Mittal Y.S.Negi R.K.Singh department of electronics & Communication engineering Graphic Era UniversityDehradun–248002 India department of electronics & Communication engineering Uttarakhand Technical UniversityDehradun–248002 India department of Polymer and Process engineering Indian Institute of Technology Roorkee–246776 India

This paper analyzes the impact of source（ts） and drain（td） contact thicknesses on top contact（TC） and bottom contact（BC） organic thin film transistors（OTFTs） with a gate in the bottom, using a benchmarked industry standard Atlas 2-d numerical device simulator. The parameters including drive current（Ids）, mobility（μ）, threshold voltage（Vt）and current on-off ratio（ION/IOFF） are analyzed from the device physics point of view on different electrode thicknesses, ranging from infinitesimal to 50 nm, for both top and bottom contact structures. Observations demonstrate that the performance of the BC structure is more affected by scaling of ts=din comparison to its counterpart. In the linear region, the mobility is almost constant at all the values of ts=dfor both structures. However,an increment of 18% and 83% in saturation region mobility is found for TC andBC structures, respectively with scaling down ts=dfrom 50–0 nm. Besides this, the current on-off ratio increases more sharply in the BC *** analysis simplifies a number of issues related to the design and fabrication of organic material based devices and circuits.

关键词： contact thickness organic semiconductor organic thin film transistor bottom contact top contact structure

Inter-annual and seasonal variations in hydrological parameters and its implications on chlorophyll a distribution along the southwest coast of Bay of Bengal

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Acta Oceanologica Sinica 2015年第6期34卷 94-100页

作者： Shanthi R. poornima d. Raja K. Sarangi R.K. Saravanakumar A. Thangaradjou T. Centre of Advanced Study in Marine Biology Faculty of Marine Sciences Annamalai University Marine Geo and Planetary Sciences Group Space Application Centre (ISRO)

Seasonal and inter-annual variability of hydrological parameters and its impact on chlorophyll distribution was studied from January 2009 to december 2011 at four coastal stations along the southwest Bay of Bengal. Statistical analysis （principal component analysis （PCA）, two-way analysis of variance （ANOVA） and correlation analysis） showed the significant impact of hydrological parameters on chlorophyll distribution in the study area. The ranges of different parameters recorded were 23.8-33.8℃ （SST）, 4.00-36.00 （salinity）, 7.0-9.2 （pH）, 4.41-8.32 mg/L （dissolved oxygen）, 0.04-2.45 μmol/L （nitrite）, 0.33-16.10 μmol/L （nitrate）, 0.02-2.51 μmol/L （ammonia）, 0.04-3.32 μmol/L （inorganic phosphate）, 10.09-85.28 μmol/L （reactive silicate） and 0.04-13.8 μg/L （chlorophyll）. PCA analysis carried out for different seasons found variations in the relationship between physico-chemical parameters and chlorophyll in which nitrate and chlorophyll were positively loaded at PC1 （principal component 1） during spring inter-monsoon and at PC2 （principal component 2） during other seasons. Likewise correlation analysis also showed significant positive relationship between chlorophyll and nutrients especially with nitrate （~0.734）. distribution of hydrobiological parameters between stations and distances was significantly varying as evidenced from the ANOVA results. The study found that the spatial and temporal distribution of chlorophyll was highly dependent on the availability of nutrients especially, nitrate in the southwest Bay of Bengal coastal waters.

关键词： chlorophyll nutrients PCA nitrate correlation analysis Bay of Bengal

Particulate matter emissions and gaseous air toxic pollutants from commercial meat cooking operations

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Journal of environmental Sciences 2018年第3期30卷 162-170页

作者： Nicholas Gysel William A.Welch Chia-Li Chen poornima dixit david R.Cocker Ⅲ Georgios Karavalakis department of Chemical and environmental engineering University of CaliforniaRiverside Center for environmental Research and Technology University of CaliforniaRiverside

This study assessed the effectiveness of three novel control technologies for particulate matter（PM） and volatile organic compound（VOC） removal from commercial meat cooking operations. All experiments were conducted using standardized procedures at University of California, Riverside＇s commercial test cooking facility. PM mass emissions collected using South Coast Air Quality Management district（SCAQMd） Method 5.1, as well as a dilution tunnel-based PM method showed statistically significantly reductions for each control technology when compared to baseline testing（i.e., without a catalyst）. Overall, particle number emissions decreased with the use of control technologies, with the exception of control technology 2（CT2）, which is a grease removal technology based on boundary layer momentum transfer（BLMT） theory. Particle size distributions were unimodal with CT2 resulting in higher particle number populations at lower particle diameters. Organic carbon was the dominant PM component（ 99%） for all experiments. Formaldehyde and acetaldehyde were the most abundant carbonyl compounds and showed reductions with the application of the control technologies. Some reductions in mono-aromatic VOCs were also observed with CT2 and the electrostatic precipitator（eSP） CT3 compared to the baseline testing.

关键词： Charbroiled meat cooking Particulate emissions Particle number Carbonyl compounds VOCs

A rare synchrony of adenocarcinoma of the ampulla with an ileal gastrointestinal stromal tumor: A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2253-2265页

作者： Venkata Vinod Kumar Matli Gazi B Zibari Gregory Wellman poornima Ramadas Sudha Pandit James Morris department of Internal Medicine Christus Highland Medical CenterShreveportLA 71106United States division of Hepatobiliary Surgery Willis-Knighton Health SystemShreveportLA 711103United States department of Gastrointestinal and Liver Pathology Christus Highland Medical CenterShreveportLA 71105United States division of Hematology and Oncology Louisiana State University Health Sciences CenterShreveportLA 71103United States division of Gastroenterology and Hepatology Louisiana State University Health Sciences CenterShreveportLA 71103United States

BACKGROUNd This is a unique case of a patient who was found to have two extremely rare primary malignancies synchronously,i.e.,an ampullary adenocarcinoma arising from a high-grade dysplastic tubulovillous adenoma of the ampulla of Vater(TVAoA)with a high-grade ileal gastrointestinal stromal tumor(GIST).Based on a literature review and to the best of our knowledge,this is the first report of this *** ampullary tumors are extremely rare,with an incidence of four cases per million population,which is approximately 0.0004%.distal duodenal polyps are uncommon and have a preponderance of occurring around the ampulla of *** adenoma of the ampulla(AoA)may occur sporadically or with a familial inheritance pattern,as in hereditary genetic polyposis syndrome such as familial adenomatous polyposis syndrome(FAPS).We report a case of a 77-year-old male who was admitted for painless obstructive jaundice with a 40-pound weight loss over a two-month period and who was subsequently diagnosed with two extremely rare primary malignancies,i.e.,an adenocarcinoma of the ampulla arising from a high-grade TVAoA and a high-grade ileal GIST found *** SUMMARY A 77-year-old male was admitted for generalized weakness with an associated weight loss of 40 pounds in the previous two months and was noted to have painless obstructive *** physical examination was benign except for bilateral scleral and palmar *** results were significant for an obstructive pattern on liver *** lipase and carbohydrate antigen-19-9 levels were *** tomography(CT)of the abdomen and pelvis and magnetic resonance cholangiopancreatography were consistent with a polypoid mass at the level of the common bile duct(CBd)and the ampulla of Vater with CBd *** same lesions were visualized with endoscopic retrograde *** of endoscopic forceps biopsy showed *** of the surgical specimen of the

关键词： Tubulovillous adenoma of the ampulla of Vater Ampullary adenocarcinoma Gastrointestinal stromal tumor Ampullary polyp Small bowel mesenchymal tumor Case report

Axial variations in anatomical properties and basic density of eucalypt urograndis hybrid(eucalyptus grandis × e. urophylla)clones

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Journal of Forestry Research 2015年第3期26卷 739-744页

作者： S. K. Sharma S. R. Shukla S. Shashikala V. Sri poornima Wood Properties and engineered Wood division Institute of Wood Science and Technology P.O. MalleswaramBangalore 560 003 India

We studied two clones of eucalypt urograndis hybrid （eucalyptus grandis × e. urophylla）, GR283 and GR330, grown in Tumkur district of Kamataka （India）, and felled 5-6 years old three trees of each clone. We recorded axial variations in heartwood content, bark properties, wood density and anatomical characteristics of wood in- cluding fibre length, fibre diameter, fibre wall thickness, lumen diameter, vessel frequency, vessel diameter and vessel element length. Clone GR283 had about 10 % heartwood, significantly lower than for clone GR330 （37 %）. Basic wood density along the tree height varied significantly within and between the clones. We observed significant variations in fibre length, fibre diameter and wall thickness within and between the two clones. Vessel frequency and vessel element length did not vary but vessel diameter differed significantly between the clones. With a greater proportion of sapwood, clone GR283 can be uti- lized for paper and pulp applications. Clone GR330 had a higher proportion of heartwood and lower wood density and, hence, is more suitable for light-weight material applications.

关键词： eucalypt urograndis hybrid (eucalyptusgrandis × e. urophylla) Fibre characteristics - Vesselcharacteristics - Wood density Bark density