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Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir poornima shaji Ana Martinez Bulnes Anupam Dhasmana Swathi Holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.Hafeez Manish K.Tripathi Vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash C.Chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of Computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas Center of Excellence in Cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA Himalayan School of Biosciences and Cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough Center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist Health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a CAF-like phenotype,which may be due to regulation of Ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAC tumors,thus imply feasibility of developing a novel personalized medicine for PDAC patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

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Suppression of ferroresonance using passive memristor emulator

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Chinese Physics B 2021年第6期30卷 667-674页

作者： S poornima Electrical Engineering Department Anna UniversityChennai-600025India

Power system inherently consists of capacitance and inductance in its components. Equipment with saturable inductance and circuit capacitance provides circumstances of generating ferroresonance, resulting in overvoltage and overcurrent in the connected system. The effects of ferroresonance result in insulation failure and hence damage to the equipment is unavoidable. Though many devices are proposed for mitigating such circumstances, a promising technology of using memristors may provide better performance than others in the future. A memristor emulator using the N-channel JFET J310 is used in this work. Unlike other electronic components that replicate memristor properties, the chosen memristor emulator is a passive device since it does not need any external power supply. Simulation and experimental results verify the design of a memristor emulator and the characteristics of an ideal memristor. Experimental results prove that the memristor emulator can suppress the fundamental ferroresonance induced in a prototype single phase transformer. The results of the harmonic analysis also validate the memristor performance against the conventional technique.

关键词： ferroresonance memristor emulator passive components single-phase transformer

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Exosome treatment for stroke with diabetic comorbidity

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Neural Regeneration Research 2022年第2期17卷 315-317页

作者： poornima Venkat Michael Chopp Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA

Ischemic stroke is a cerebrovasculardisease with a high risk of mortality andlong-lasting neurological *** advances have resulted in adeclining trend in stroke incidence anddeaths in the United States. However,increas... 详细信息

关键词： mortality morbidity Exosome

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Big Data analytics for privacy through ND-homomorphic encryption

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Journal of Control and Decision 2023年第1期10卷 64-71页

作者： S.Saravanan N.poornima Department of CSE SRM Institute of Science and TechnologyChennaiIndia Department of Data Science and Business Systems School of ComputingSRM Institute of Science and TechnologyKattankulathurIndia

Rapidly rising the quantity of Big Data is an opportunity to flout the privacy of people. Whenhigh processing capacity and massive storage are required for Big Data, distributed networkshave been used. There are several people involved in these activities, the system may contributeto privacy infringements frameworks have been developed for the preservation of privacy atvarious levels (e.g. information age, information the executives and information preparing) asfor the existing pattern of huge information. We plan to frame this paper as a literature surveyof these classifications, including the Privacy Processes in Big Data and the presentation of theAssociate Challenges. Homomorphic encryption is particularised aimed at solitary single actionon the ciphered information. Homomorphic enciphering is restrained to an honest operation onthe encoded data. The reference to encryption project fulfils many accurate trading operationson coded numerical data;therefore, it protects the written in code-sensible information evenmore.

关键词： Security and confidentiality vast statistics data encryption nondeterministic fully homomorphic encryption

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Impact of source and drain contact thickness on the performance of organic thin film transistors

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Journal of Semiconductors 2014年第12期35卷 21-27页

作者： poornima Mittal Y.S.Negi R.K.Singh Department of Electronics & Communication Engineering Graphic Era UniversityDehradun–248002 India Department of Electronics & Communication Engineering Uttarakhand Technical UniversityDehradun–248002 India Department of Polymer and Process Engineering Indian Institute of Technology Roorkee–246776 India

This paper analyzes the impact of source（ts） and drain（td） contact thicknesses on top contact（TC） and bottom contact（BC） organic thin film transistors（OTFTs） with a gate in the bottom, using a benchmarked industry standard Atlas 2-D numerical device simulator. The parameters including drive current（Ids）, mobility（μ）, threshold voltage（Vt）and current on-off ratio（ION/IOFF） are analyzed from the device physics point of view on different electrode thicknesses, ranging from infinitesimal to 50 nm, for both top and bottom contact structures. Observations demonstrate that the performance of the BC structure is more affected by scaling of ts=din comparison to its counterpart. In the linear region, the mobility is almost constant at all the values of ts=dfor both structures. However,an increment of 18% and 83% in saturation region mobility is found for TC andBC structures, respectively with scaling down ts=dfrom 50–0 nm. Besides this, the current on-off ratio increases more sharply in the BC *** analysis simplifies a number of issues related to the design and fabrication of organic material based devices and circuits.

关键词： contact thickness organic semiconductor organic thin film transistor bottom contact top contact structure

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Burkitt's lymphoma of maxillary gingiva: A case report

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World Journal of Clinical Cases 2015年第12期3卷 1011-1016页

作者： Sangeeta Patankar poornima Venkatraman Gokul Sridharan Shubhada Kane Department of Oral Pathology and Microbiology YMT Dental College and Hospital Department of Pathology Tata Memorial Ho- spital

Burkitt's lymphoma(BL) is an aggressive form of nonHodgkin's B-cell lymphoma with three variants namely endemic, sporadic, and immunodeficiency-associated types. It is endemic in Africa and sporadic in other parts of the world. While the endemic form is widely reported to occur in early childhood and commonly involves the jaw bones, the sporadic form typically presents as an abdominal mass. This presentation reports a rare case of sporadic form of BL clinically manifesting as a generalized gingival enlargement in an immunocompetent adult male which demonstrated an aggressive behavior. The patient reported with a prominent anterior gingival swelling of 6 mo duration which slowly enlarged in size and associated with multiple lymph node involvement. Microscopic examination of the lesion using H, E and immunohistochemical diagnosis confirmed the diagnosis as BL. The patient succumbed to the disease before any therapy could be instituted. Since a wide array of causes can be attributed to gingival enlargements, it is necessary to consider malignancies as one of the important differential diagnosis so as to facilitate the need for appropriate diagnosis and prompt treatment.

关键词： Lymphoma Diagnosis Differential Non-Hodgkin’s Gingival overgrowth Prognosis Pathology Oral Immunohistochemistry

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Revolutionizing Biodegradable and Sustainable Materials:Exploring the Synergy of Polylactic Acid Blends with Sea Shells

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Journal of Renewable Materials 2024年第12期12卷 2115-2134页

作者： Prashanth K P Rudresh M Venkatesh N poornima Gubbi Shivarathri Shwetha Rajappa Department of Mechanical Engineering Acharya Institute of TechnologyBangalore560107India Department of Robotics and Artificial Intelligence Dayananda Sagar College of EngineeringBangalore560111India Department of Mechanical Engineering University of Visvesvaraya College of EngineeringBangalore560001India Department of Chemistry New Horizon College of EngineeringBangalore560103India Department of Sciences and Humanities Christ(Deemed to be University)Bangalore560074India

This study explores the mechanical properties of a novel composite material,blending polylactic acid(PLA)with sea shells,through a comprehensive tensile test *** tensile test results offer valuable insights into the material’s behavior under axial loading,shedding light on its strength,stiffness,and deformation *** results suggest that the incorporation of sea shells decrease the tensile strength of 14.55%and increase the modulus of 27.44%for 15 wt%SSP(sea shell powder)into PLA,emphasizing the reinforcing potential of the mineral-rich sea shell ***,a potential trade-off between decreased strength and reduced ductility is noted,highlighting the need for a delicate balance in material *** study underscores the importance of uniform sea shell particle distribution within the PLA matrix for consistent mechanical *** results offer a basis for additional PLA-sea shell blend optimization,directing future efforts to balance strength,flexibility,and other critical attributes for a range of applications,including biomedical devices and sustainable *** investigation opens the door to more sustainable and mechanically strong materials in the field of additive manufacturing by demonstrating the positive synergy between nature-inspired materials and cutting-edge testing techniques.

关键词： PLA sea shell additive manufacturing tensile flexural biodegradability

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Ninjurin-1: a biomarker for reflecting the process of neuroinflammation after spinal cord injury

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Neural Regeneration Research 2021年第7期16卷 1331-1335页

作者： poornima D.E.Weerasinghe-Mudiyanselage Jeongtae Kim Yuna Choi Changjong Moon Taekyun Shin Meejung Ahn Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and BK21 Plus Project TeamChonnam National UniversityGwangjuRepublic of Korea Department of Anatomy Kosin University College of MedicineBusanRepublic of Korea Department of Animal Science College of Life ScienceSangji UniversityWonjuRepublic of Korea

Previous studies have shown that Ninjurin-1 participates in cell trafficking and axonal growth following central and peripheral nervous system *** its precise roles in these processes and involvement in spinal cord injury pathophysiology remain *** blot assay revealed that Ninjurin-1 levels in rats with spinal cord injury exhibited an upregulation until day 4 post-injury and slightly decreased thereafter compared with sham *** analysis revealed that Ninjurin-1 immunoreactivity in rats with spinal cord injury sharply increased on days 1 and 4 post-injury and slightly decreased on days 7 and 21 post-injury compared with sham ***-1 immunostaining was weak in vascular endothelial cells, ependymal cells, and some glial cells in sham controls while it was relatively strong in macrophages, microglia, and reactive *** findings suggest that a variety of cells, including vascular endothelial cells, macrophages, and microglia, secrete Ninjurin-1 and they participate in the pathophysiology of compression-induced spinal cord *** experimental procedures were approved by the Care and Use of Laboratory Animals of Jeju National University(approval No.2018-0029) on July 6, 2018.

关键词： astrocytes clip compression injury macrophage microglia neuroinflammation Ninjurin-1 rat spinal cord

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Particulate matter emissions and gaseous air toxic pollutants from commercial meat cooking operations

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Journal of Environmental Sciences 2018年第3期30卷 162-170页

作者： Nicholas Gysel William A.Welch Chia-Li Chen poornima Dixit David R.Cocker Ⅲ Georgios Karavalakis Department of Chemical and Environmental Engineering University of CaliforniaRiverside Center for Environmental Research and Technology University of CaliforniaRiverside

This study assessed the effectiveness of three novel control technologies for particulate matter（PM） and volatile organic compound（VOC） removal from commercial meat cooking operations. All experiments were conducted using standardized procedures at University of California, Riverside＇s commercial test cooking facility. PM mass emissions collected using South Coast Air Quality Management District（SCAQMD） Method 5.1, as well as a dilution tunnel-based PM method showed statistically significantly reductions for each control technology when compared to baseline testing（i.e., without a catalyst）. Overall, particle number emissions decreased with the use of control technologies, with the exception of control technology 2（CT2）, which is a grease removal technology based on boundary layer momentum transfer（BLMT） theory. Particle size distributions were unimodal with CT2 resulting in higher particle number populations at lower particle diameters. Organic carbon was the dominant PM component（ 99%） for all experiments. Formaldehyde and acetaldehyde were the most abundant carbonyl compounds and showed reductions with the application of the control technologies. Some reductions in mono-aromatic VOCs were also observed with CT2 and the electrostatic precipitator（ESP） CT3 compared to the baseline testing.

关键词： Charbroiled meat cooking Particulate emissions Particle number Carbonyl compounds VOCs

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Understanding the spectrum of non-motor symptoms in multiple sclerosis:insights from animal models

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Neural Regeneration Research 2024年第1期19卷 84-91页

作者： poornima D.E.Weerasinghe-Mudiyanselage Joong-Sun Kim Taekyun Shin Changjong Moon Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR programChonnam National UniversityGwangjuRepublic of Korea Department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJejuRepublic of Korea

Multiple sclerosis is a chronic autoimmune disease of the central nervous system and is generally considered to be a non-traumatic,physically debilitating neurological *** addition to experiencing motor disability,patients with multiple sclerosis also experience a variety of nonmotor symptoms,including cognitive deficits,anxiety,depression,sensory impairments,and ***,the pathogenesis and treatment of such non-motor symptoms in multiple scle rosis are still under *** studies for multiple sclerosis benefit from the use of disease-appropriate animal models,including experimental autoimmune *** to understanding the pathophysiology and developing treatments for non-motor symptoms,it is critical to chara cterize the animal model in terms of its ability to replicate certain non-motor features of multiple *** such,no single animal model can mimic the entire spectrum of *** review focuses on the non-motor symptoms that have been investigated in animal models of multiple sclerosis as well as possible underlying ***,we highlighted gaps in the literature to explain the nonmotor aspects of multiple sclerosis in expe rimental animal models,which will serve as the basis for future studies.

关键词： anxiety cognitive deficit depression experimental autoimmune encephalomyelitis motor disability neurological disorder pain pathophysiology preclinical study sensory impairments

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