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Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B_(12) status

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World Journal of Gastroenterology 2008年第23期14卷 3662-3671页

作者： pooneh mokarram Fakhraddin Naghibalhossaini Mehdi Saberi Firoozi Seyed Vahid Hosseini Ahmad Izadpanah Heshmetalah Salahi Seyed Ali Malek-Hosseini Abdoulrasool Talei Mehra Mojallal Department of Biochemistry Shiraz University of Medical SciencesSchool of MedicineShiraz 71345Iran Department of Internal Medicine and Gastroenterohepatology Research Centre Shiraz University of Medical SciencesShiraz 71345Iran Department of Surgery(colorectal ward) and Gastroenterohepatology Research Centre Shiraz University of Medical SciencesShiraz 71345Iran Department of Surgery and Organ Transplantation Research Centre Namazee HospitalShiraz University of Medical SciencesShiraz 71345Iran Department of Surgery and Institute of Cancer Research Shiraz University of Medical SciencesShiraz 71345Iran Pathology Laboratory Dena HospitalShiraz 71345Iran

AIM:To evaluate joint effects of Methylentetra-hydrofolate reductase(MTHFR) C677T genotypes,and serum folate/vitamin B12 concentrations on promoter methylation of tumor-associated genes among Iranian colorectal cancer patients. METHODS:We examined the associations between MTHFR C677T genotype,and promoter methylation of P16,hMLH1,and hMSH2 tumor-related genes among151 sporadic colorectal cancer patients. The promoter methylation of tumor-related genes was determined by methylation-specific PCR. Eighty six patients from whom fresh tumor samples were obtained and 81 controls were also examined for serum folate and vitamin B12 concentrations by a commercial radioimmunoassay kit. RESULTS:We found 29.1% of cases had tumors with at least one methylated gene promoter. In case-case comparison,we did not find a significant association between methylation in tumors and any single genotype. However,in comparison to controls with the CC genotype,an increased risk of tumor methylation was associated with the CT genotype(OR = 2.5;95% CI,1.1-5.6) . In case-case comparisons,folate/vitamin B12 levels were positively associated with tumor methylation. Adjusted odds ratios for tumor methylation in cases with high(above median) versus low(below median) serum folate/vitamin B12 levels were 4.9(95% CI,1.4-17.7) ,and 3.9(95% CI,1.1-13.9) ,respectively. The frequency of methylated tumors was significantly higher in high methyl donor than low methyl donor group,especially in those with MTHFR CT(P = 0.01) ,and CT/TT(P = 0.002) genotypes,but not in those with the CC genotype(P = 1.0) . CONCLUSION:We conclude that high concentrations of serum folate/vitamin B12 levels are associated with the risk of promoter methylation in tumor-specific genes,and this relationship is modified by MTHFR C677T genotypes.

关键词： Metthylentetrahydrofolate reductase Folate Vitamin 1322 Methylation Colorectal cancer

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Clinical characteristics,gastrointestinal manifestations and outcomes of COVID-19 patients in Iran;does the location matters?

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World Journal of Clinical Cases 2021年第18期9卷 4654-4667页

作者： pooneh mokarram Maryam Mehdipour Dalivand Antonio Pizuorno Farnaz Aligolighasemabadi Mohammadamin Sadeghdoust Ebtesam Sadeghdoust Farshad Aduli Gholamreza Oskrochi Hassan Brim Hassan Ashktorab Autophagy Research Center Department of BiochemistryShiraz University of Medical SciencesShiraz 71348Iran Department of Medicine Howard UniversityWashingtonDC 20060United States Department of Medicine La Universidad del ZuliaFaculty of MedicineMaracaibo 4002Venezuela Department of Internal Medicine Mashhad Medical Sciences BranchIslamic Azad UniversityMashhad 13131Iran Department of Internal Medicine School of MedicineDezful University of Medical SciencesDezful 64616Iran Collage of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait

BACKGROUND Coronavirus disease 2019(COVID-19)started in Asia,and Iran was one of its first *** To study the gastrointestinal(GI)symptoms and comorbidities associated with this pandemic in four different regions of *** We analyzed data from severe acute respiratory syndrome coronavirus 2 positive patients evaluated at four hospitals of Iran(n=91),including South(Shiraz),Southeast(Dezful),Rasht(North),and Northwest(Mashhad)between April and September ***,comorbidities and clinical findings including GI symptoms were *** descriptive analysis and correlation analyses of symptoms,comorbidities,and mortality were *** The average age of COVID-19 patients was 51.1 years,and 56%were *** rate was 17%.Cough with 84.6%,shortness of breath with 71.4%,fever with 52.7%,and loss of appetite with 43.9%were the main *** cardiac disease was the most common comorbidity with an average of 28.5%followed by hypertension(28.5%)and diabetes(25.2%).The highest comorbidity in North(Rasht)was diabetes(30%)and in South(Dezful)hypertension(37%).Shiraz leads cardiac disease with 43.4%.The most reported GI symptoms included nausea,diarrhea,vomiting,and abdominal pain,with 42.8%,31.8%,26.8%,and 12%prevalence,*** addition,albumin,alkaline phosphatase,aspartate aminotransferase,and alanine aminotransferase were elevated in 26.3%.CONCLUSION Our results show hypertension and diabetes as the most common comorbidities,but their distribution was different in COVID-19 patients in the four studied regions of ***,diarrhea,and elevated liver enzymes were the most common GI *** was also a high mortality rate that was associated with high infection rates in Iran at the beginning of the pandemic.

关键词： COVID-19 Pandemic Gastrointestinal manifestation Iran

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