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Epigenetic regulation−The guardian of cellular homeostasis and lineage commitment

BIOCELL 2021年第3期45卷 501-515页

作者： KAVITHA GOVARTHANAN PIYUSH K UmaR gupta BINITA ZIPPORAHE REKHA GAHTORI SOUMYA PANDIT ram PRASAD Department of Biotechnology Indian Institute of Technology MadrasChennai600036India Department of Life Sciences Sharda UniversityGreater NoidaUttar Pradesh201310India Department of Biotechnology Campus–BhimtalKumaun UniversityNainitalUttarakhand263136India Department of Botany Mahatma Gandhi Central UniversityMotihariBihar845401India

Stem cells constitute the source of cells that replenishes the worn out or damaged cells in our tissue and enable the tissue to carry out the destined ***-specific stem cells are compartmentalized in a niche,which keeps the stem cells under quiescent ***,understanding the molecular events driving the successful differentiation of stem cells into several lineages is essential for its better manipulation of human *** the developmental aspects of the cell,the cellular function is greatly dependent on the epigenomics signature that in turn governs the expression profile of the *** stable inheritance of the epigenome is crucial for the development,modulation,and maintenance of the cell and its complex tissue-specific *** evidence suggesting that stem cell chromatin comprises a specialized state in which self-renewing genes and its downstream lineage-specific genes are kept paralleled poised for ***,the epigenetic regulatory network and pathway dictate lineage commitment and *** mainly modifies the chromatin landscape to facilitate euchromatin and heterochromatin architecture,which in turn alters the accessibility of transcription factors to the gene *** methylation and histone marks are the two widely studied epigenetic modifications regulating the transcriptome profile of a specific *** in the epigenetic landscape lead to diseases or ***,we emphasize the prominence of the epigenetic network and its regulation in normal tissue functioning and in the diseased ***,we highlighted the emerging role of epigenetic modifiers in lineage differentiation and epigenetic markers as novel druggable targets for cancer therapy.

关键词： Epigenetics Chromatin Genome Methylation Inheritance Modulation

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Bianchi Type-Ⅱ Inflationary Models with Stiff matter and Decaying Cosmological Term

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Chinese Physics Letters 2014年第7期31卷 27-31页

作者： Shri ram, Priyanka Department of mathematical Sciences Indian Institute of Technology Banaras Hindu University Varanasi 221 005 India

We deal with Einstein＇s field equations with a time-decaying cosmological term of the forms （i） ∧=β（a/a）＋ α/a62 and （ii）∧ = α/a^2, where a is the average scale factor of the universe, α and β are constants for a spatially homogeneous and anisotropic LRS Bianchi type-Ⅱ spacetime. Exact solutions of the field equations for stiff matter are obtained by applying a special law of variation for the Hubble parameter. Anisotropic cosmological models are presented with a constant negative deceleration parameter which corresponds to the accelerated phase of the present universe. The cosmological constant A is obtained as a decreasing function of time that is approaching a small positive value at the present epoch, which is corroborated by the consequences from recent supernovae Ia observations. The physical and kinematical behaviors of the models are also discussed.

关键词： Anisotropy

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Effect of heavy metals and phenol on bacterial decolourisation and COD reduction of sucrose-aspartic acid maillard product

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Journal of Environmental Sciences 2013年第1期25卷 172-180页

作者： Sangeeta Yadav ram Chandra Department of Environmental Microbiology School for Environmental SciencesBabasaheb Bhimrao Ambedkar University (A Central University)

Melanodins are amino-carbonyl complex, predominantly present in sugarcane molasses based distillery wastewater as major source of colourant. The microbial decolourisafion of melanoidin is a challenge due to its binding property with other co-pollutants of distillery waste. Results revealed that the presence of Zn2＋（2.00-20.00 mg/L） in melanoidin solution （1200 mg/L） stimulated the bacterial growth and sucrose-aspartic acid maillard product （SAA） decolourisation as compared to control, while Fe3＋ and Mn2＋ at the same concentration inhibited the process. However, the presence of phenol （100 mg/L） along with Zn2＋, Fe3＋ and Mn2＋ suppressed the bacterial growth, SAA decolourisation and MnP activity. The shrinkage and reduced number of bacterial cell count at higher concentration of heavy metals in presence of phenol was also observed under scanning electron microscope.

关键词： degradation manganese peroxidase melanoidin

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An Overview of High-Performance Aircraft Structural Al Alloy-AA7085

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Acta Metallurgica Sinica(English Letters) 2015年第7期28卷 909-921页

作者： T.ram Prabhu CEMILAC Defence R&D Organization

AA7085 Al alloy is a new-generation,high-strength,quench-insensitive alloy that features in airframe applications such as massive bulkhead and wing spars structures in Airbus A380 and Joint Strike Fighter *** alloy has a great potential in replacing currently used high-strength AA7 xxx alloys in many international and national military aircraft programs [Hawk,Su-30,Mi G series,light combat aircraft（Tejas）,Hindustan turbo/jet trainer,light combat helicopter,advanced light helicopter,and fifth-generation fighter aircrafts].An effort has been made to highlight the processing,heat treatment,properties and applications of the AA7085 Al alloy from the existing literature on the AA7085 *** potential applications of this alloy are presented and compared with the currently used AA7075 Al alloy.A typical process cycle involved in the manufacturing of wrought AA7085 alloy products is described in ***,the precipitation mechanisms involved in the different temper conditions are critically reviewed with the supporting *** mechanical properties with a particular emphasis on tensile,fatigue,and fracture toughness properties are discussed in detail based on the analysis of experimental *** effects of temper conditions on the stress corrosion cracking and exfoliation corrosion have also been reviewed critically.

关键词： Al alloys Heat treatment material processing Mechanical properties Corrosion

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Syntrophic co-culture of Bacillus subtilis and Klebsiella pneumonia for degradation of kraft lignin discharged from rayon grade pulp industry

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Journal of Environmental Sciences 2015年第7期27卷 229-238页

作者： Sangeeta Yadav ram Chandra Department of Environmental Microbiology School for Environmental Sciences Babasaheb Bhimrao Ambedkar University (A Central University)

In order to search the degradability of kraft lignin, the potential bacterial strains Bacillus subtilis（GU193980） and Klebsiella pneumoniae（GU193981） were isolated, screened and applied in axenic and co-culture conditions. Results revealed that mixed culture showed better decolorization efficiency（80%） and reduction of pollution parameters（COD 73% and BOD62%） than axenic culture. This indicated syntrophic growth of these two bacteria rather than any antagonistic effect. The HPLC analysis of degraded samples of kraft lignin has shown the reduction in peak area compared to control, suggesting that decrease in color intensity might be largely attributed to the degradation of lignin by isolated ***, the GC-MS analysis showed that most of the compounds detected in control were diminished after bacterial treatment. Further, the seed germination test using Phaseolus aureus has supported the detoxification of bacterial decolorized kraft lignin for environmental safety. All these observations have revealed that the developed bacterial co-culture was capable for the effective degradation and decolorization of lignin containing rayon grade pulp mill wastewater for environmental safety.

关键词： Degradation GC-MS Kraft lignin Seed germination test Syntropic

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Choice of precipitant and calcination temperature of precursor for synthesis of NiCo_2O_4 for control of CO–CH_4 emissions from CNG vehicles

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Journal of Environmental Sciences 2018年第3期30卷 62-71页

作者： Suverna Trivedi ram Prasad Department of Chemical Engineering &Technology Indian Institute of Technology (BHU)

Compressed natural gas（CNG）is most appropriate an alternative of conventional fuel for ***,emissions of carbon-monoxide and methane from such vehicles adversely affect human health and ***,to abate emissions from CNG vehicles,development of highly efficient and inexpensive catalysts is ***,the present work attempts to scan the effects of precipitants（Na2CO3,KOH and urea）for nickel cobaltite（Ni Co2O4）catalysts prepared by co-precipitation from nitrate solutions and calcined in a lean CO-air mixture at 400℃.The catalysts were used for oxidation of a mixture of CO and CH4（1：1）.The catalysts were characterized by X-ray diffractometer,Brunauer–Emmett–Teller surface-area,X-ray photoelectron spectroscopy;temperature programmedreductionandScanningelectronmicroscopycoupledwith Energy-Dispersive X-Ray *** Na2CO3was adjudged as the best precipitant for production of catalyst,which completely oxidized CO-CH4mixture at the lowest temperature（T（100）=350℃）.Whereas,for catalyst prepared using urea,T（100）=362℃.On the other hand the conversion of CO-CH4mixture over the catalyst synthesized by KOH limited to 97%even beyond 400℃.Further,the effect of higher calcination temperatures of 500 and600℃ was examined for the best *** total oxidation of the mixture was attained at higher temperatures of 375 and 410℃ over catalysts calcined at 500 and 600℃ ***,the best precipitant established was Na2CO3and the optimum calcination temperature of 400℃ was found to synthesize the Ni Co2O4catalyst for the best performance in CO-CH4oxidation.

关键词： CNG vehicular emissions CO-CH4 oxidation NiG0204 Precipitants Calcinations

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Mysteries of R^ik=0： A novel paradigm in Einstein＇s theory of gravitation

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Frontiers of physics 2014年第1期9卷 98-112页

作者： ram Gopal Vishwakarma Unidad Academica de matemdticas Universidad Autdnoma de Zacatecas C.P. 98068 Zacatecas ZAC Mexico

Despite a century-long effort, a proper energy-stress tensor of the gravitational field, could not have been discovered. Furthermore, it has been discovered recently that the standard formulation of the energy-stress tensor of matter, suffers from various inconsistencies and paradoxes, concluding that the tensor is not consistent with the geometric formulation of gravitation [Astrophys. Space Sci., 2009, 321： 151; Astrophys. Space Sei., 2012, 340： 373]. This perhaps hints that a consistent theory of gravitation should not have any bearing on the energy-stress tensor. It is shown here that the so-called ＂vacuum＂ field equations Rik = 0 do not represent an empty spacetime, and the energy, momenta and angular momenta of the gravitational and the matter fields are revealed through the geometry, without including any formulation thereof in the field equations. Though, this novel discovery appears baffling and orthogonal to the usual understanding, is consistent with the observations at all scales, without requiring the Moreover, the resulting theory circumvents the besides explaining some unexplained puzzles. hypothetical dark matter, dark energy or inflation long-standing problems of the standard cosmology

关键词： general relativity and gravitation - fundamental problems and general formalism cos-mological observations

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Mysteries of the geometrization of gravitation

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Research in Astronomy and Astrophysics 2013年第12期13卷 1409-1422页

作者： ram Gopal Vishwakarma Unidad Acad'emica de matem'aticas Universidad Aut'onoma de Zacatecas

As we now know, there are at least two major difficulties with general rel- ativity （GR）. The first one is related to its incompatibility with quantum mechanics, in the absence of a consistent, widely accepted theory that combines the two theo- ries. The second problem is related to the requirement of the dark sectors-inflaton, dark matter and dark energy by the energy-stress tensor, which are needed to explain a variety of astronomical and cosmological observations. Research has indicated that the dark sectors themselves do not have any non-gravitational or laboratory evidence. Moreover, the dark energy poses, in addition, a serious confrontation between funda- mental physics and cosmology. Guided by theoretical and observational evidences, we are led to an idea that the source of gravitation and its manifestation in GR should be modified. The result is in striking agreement with not only the theory, but also the ob- servations, without requiring the dark sectors of the standard approach. Additionally, it provides natural explanations to some unexplained puzzles.

关键词： general relativity and gravitation -- fundamental problems and generalformalism -- cosmology: observations

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Probabilistic seismic hazard analysis in Nepal

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Earthquake Engineering and Engineering Vibration 2013年第4期12卷 577-586页

作者： Thapa Dilli ram Wang Guoxin State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology

The seismic ground motion hazard for Nepal has been estimated using a probabilistic approach. A catalogue of earthquakes has been compiled for Nepal and the surrounding region （latitude 26% N and 31.7% N and longitude 79° E and 90° E） from 1255 to 2011. The distribution of catalogued earthquakes, together with available geological and tectonic information were used to delineate twenty-three seismic source seismic source information and probabilistic earthquake hazard prediction relationship, peak ground accelerations （PGAs） have zones in Nepal and the surrounding region. By using the parameters in conjunction with a selected ground motion been calculated at bedrock level with 63%, 10%, and 2% probability of exceedance in 50 years. The estimated PGA values are in the range of 0.07-0.16 g, 0.21 0.62 g, and 0.38-1.1 g for 63%, 10%, and 2% probability of exceedance in 50 years, respectively. The resulting ground motion maps show different characteristics of PGA distribution, i.e., high hazard in the far-western and eastern sections, and low hazard in southern Nepal. The quantified PGA values at bedrock level provide information for microzonation studies in different parts of the country.

关键词： seismic hazard assessment peak ground acceleration earthquake Nepal Himalaya

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Linear Plus Linear Fractional Capacitated Transportation Problem with Restricted Flow

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American Journal of Operations Research 2013年第6期3卷 581-588页

作者： Kavita gupta Shri ram Arora Department of mathematics Hans Raj College University of Delhi Delhi India Department of mathematics Ramjas College University of Delhi Delhi India

In this paper, a transportation problem with an objective function as the sum of a linear and fractional function is considered. The linear function represents the total transportation cost incurred when the goods are shipped from various sources to the destinations and the fractional function gives the ratio of sales tax to the total public expenditure. Our objective is to determine the transportation schedule which minimizes the sum of total transportation cost and ratio of total sales tax paid to the total public expenditure. Sometimes, situations arise where either reserve stocks have to be kept at the supply points, for emergencies or there may be extra demand in the markets. In such situations, the total flow needs to be controlled or enhanced. In this paper, a special class of transportation problems is studied where in the total transportation flow is restricted to a known specified level. A related transportation problem is formulated and it is shown that to each basic feasible solution which is called corner feasible solution to related transportation problem, there is a corresponding feasible solution to this restricted flow problem. The optimal solution to restricted flow problem may be obtained from the optimal solution to related transportation problem. An algorithm is presented to solve a capacitated linear plus linear fractional transportation problem with restricted flow. The algorithm is supported by a real life example of a manufacturing company.

关键词： Transportation Problem Linear Plus Linear Fractional Restricted Flow Corner Feasible Solution

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