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对绝经前妇女受体阳性、淋巴结阴性的乳腺癌行戈舍瑞林联合依西美坦加/不加替勃龙的辅助治疗的II期研究:ADAGIO研究(德国)

世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 61-62页

作者： pollow k Schaffrath M klb H. 柳蕴 Abteilung für Experimentelle Endokrinologie Universitt frauenklinik Johannes- Gutenberg- Universitt Langenbeckstraβe1 55101 MainzGermany

Purpose: Goserelin suppresses ovarian function, but does not inhibit oestrogen production in peripheral tissues. Therefore addition of the aromatase inactivator exemestane may optimally decrease oestrogen levels. The combination of goserelin and exemestane may therefore be useful in the adjuvant treatment of primary breast cancer. The climacteric symptoms expected with this regimen may be relieved by tibolone. Material and Methods: The 24- week, open, randomised, multicentre ADAGIO (Adjuvant Aromasin combined with Goserelin) pilot study was conducted in 48 premenopausal women (aged 35- 55 years)- with histologically confirmed oestrogen and/or progesterone receptor- positive, node negative primary breast cancer (pT1, M0 [grade 1- 2]) of low or intermediate risk. Patients were randomised to one of four groups: goserelin 3.6 mg depot implanted s.c. every 28 days; goserelin plus oral exemestane 25 mg/day; goserelin plus oral tibolone 2.5 mg/day; or goserelin plus exemestane and tibolone. Results: There was a rapid fall in serum oestradiol, oestrone and oestrone sulphate to postmenopausal levels in all four treatment groups; there were no significant differences between the groups. LH and FSH were also suppressed. Climacteric symptoms increased in intensity in all groups, although patients receiving tibolone had significantly fewer hot flushes (p < 0.01), sleep disorders (p < 0.05), loss of libido (p < 0.01) and vaginal dryness (p < 0.05). The combination of goserelin and exemestane did not reduce bone mineral density (BMD) more than goserelin alone. There was a trend towards a protective effect of tibolone on BMD. There were no significant differences in adverse events between the four groups and no serious adverse events were observed. Conclusions: Combination treatment with goserelin and exemestane is as safe and well tolerated as standard treat ment with goserelin alone. The addition of tibolone reduces the severity of some climacteric symptoms and may also reduce bo

关键词：依西美坦 ADAGIO II 淋巴结阴性戈舍瑞林替勃龙更年期症状芳香化酶阴道干涩黄体生成激素

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抗苗勒激素对ICSI治疗中卵巢反应的预测价值

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同济大学学报（医学版） 2011年第1期32卷 40-45页

作者：韩巍巍 Schaffrath M Holze V pollow k Seufert R 童晓文同济大学附属同济医院妇保中心上海200065 德国美因茨大学医院妇产科生殖中心德国美因茨55101

目的探讨接受卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)治疗患者血清及卵泡液中AMH水平对卵巢反应性的预测价值。方法 53例接受ICSI治疗的患者分别使用促性腺激素释放激素激动剂(GnRH-a,40例)长方案和促性腺激素释放... 详细信息

目的探讨接受卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)治疗患者血清及卵泡液中AMH水平对卵巢反应性的预测价值。方法 53例接受ICSI治疗的患者分别使用促性腺激素释放激素激动剂(GnRH-a,40例)长方案和促性腺激素释放激素拮抗剂(GnRH拮抗剂,13例)联合方案促排卵。接受GnRH-a长方案治疗患者降调节后促性腺激素使用第2天检测血清AMH水平。53例患者卵泡穿刺(oocyte pick-up,OPU)当天检测血清及卵泡液中AMH水平。应用SPSS10.0软件分析血清及卵泡液中AMH水平与卵巢反应的相关性。结果 GnRH-a长方案组和GnRH-拮抗剂联合方案组,OPU当天血清及卵泡液中AMH水平差异无统计学意义。GnRH-a长方案促性腺激素治疗第2天血清AMH水平,两组OPU当天血清及卵泡液中AMH水平与获卵数、成熟卵数成正相关,与患者年龄、促性腺激素使用剂量呈负相关,与受精率没有明显相关性。结论控制性超排卵治疗周期血清及卵泡液中AMH水平能预测ICSI治疗后的卵巢反应性。

关键词：抗苗勒激素卵巢反应性卵胞浆内单精子注射

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卵巢癌:DR-70TM免疫测定纤维蛋白降解产物联合CA-125测定的临床有效性

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 40-41页

作者： Schaffrath M. Harter P. Wulgaris S. k.pollow 马超 klinikum der Johannes-Gutenberg- Universitt Mainz Abt. für Exp. Endokrinologie Langenbeckstr. 1 55101 Mainz GermanyDr.

Background and question: Malignant cells characteristically possess high levels of proteases (e.g. plasminogen activator, cathepsin etc.), which should induce fibrinolysis. The DR- 70(tm) immunoassay quantifies the amount of fibrin degradation products (FDP) in the body. This test system has successfully been used for the detection of a number of cancers including lung, stomach, breast, rectum, liver, colon and uterus cancer. In this paper we tested the diagnostic validity of DR- 70(tm) relative to CA- 125 as a tumor marker for the detection of ovarian carcinoma. Methods: We have simultaneously investigated the serum activities of DR- 70(tm)and CA- 125 from 61 preoperative patients with histologically confirmed ovarian carcinoma. One hundred healthy blood donors served as control group. We measured the FDP utilizing the DR- 70(tm) ELISA as per test instructions of its manufacturer AMDL (Tustin, CA, USA). Results: Low levels of FDP measured by DR- 70(tm) have been detected in the serum of 100 apparently healthy persons (mean ± S.D., 0.41 ± 0.19 μ g/ml). Among the 61 ovarian carcinoma patients, DR- 70(tm) mean value (± S.D.) was 7.0 ± 10.5 μ g/ml in a range of 0.6 to 58.5 μ g/ml. The cut- off level for DR- 70(tm) was set at > 1.2 μ g/ml. The specificity was 100% , whereas the sensitivity was at 83.6% . Relative to CA- 125 a cut- off level of > 65 U/ml was applied. The comparable sensitivity of DR- 70(tm) was higher by 13.1 % . Conclusions: Malignant cells with high levels of proteases are significant contributors to fibrinolysis. The DR- 70(tm) immunoassay has been designed to measure the level of FDP in the serum. DR- 70(tm) represents a tumor marker with which ovarian carcinoma can be diagnosed at levels of sensitivity and specificity which compare favorably to those measured with CA- 125.

关键词： DR-70TM 纤维蛋白降解产物 CA-125 免疫测定法卵巢癌患者临床有效性纤溶酶原激活物肿瘤标志物检测 ELISA检测联合

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保障多晶硅的高效生产

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流程工业 2014年第12期 42-43页

作者： Barbara Schubler Silke pollow

像巴西一样，卡塔尔也在举办世界杯足球赛的体育场中为球迷们准备了光伏太阳能空调设备。生产光伏太阳能制冷设备所需的多晶硅是一个高清洁度的化工产品生产过程。为了保证多晶硅生产设备工作的可靠性和高效率，使用了新一代高可靠性的... 详细信息

像巴西一样，卡塔尔也在举办世界杯足球赛的体育场中为球迷们准备了光伏太阳能空调设备。生产光伏太阳能制冷设备所需的多晶硅是一个高清洁度的化工产品生产过程。为了保证多晶硅生产设备工作的可靠性和高效率，使用了新一代高可靠性的换热器。

关键词：生产过程多晶硅光伏太阳能保障世界杯足球赛高可靠性空调设备化工产品

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