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Performance of QuantiFERON(R)-TB Gold In-Tube assay in children receiving disease modifying anti-rheumatic drugs

World Journal of Pediatrics 2017年第5期13卷 472-478页

作者： Francesca Gabriele Maria Trachana Maria Simitsopoulou polixeni pratsidou-gertsi Elias Iosifidiso Zoi Dorothea Pana Emmanuel Roilides Infectious Diseases Unit 3rd Department of PediatricsAristotle UniversityThessalonikiGreece Pediatric Immunology and Rheumatology Referral Center 1st Department of PediatricsAristotle UniversityThessalonikiGreece

Background:To evaluate the performance of theQuantiferon(R)-TB Gold In-Tube (QFT-IT) interferon (IFN)-7 assay for the detection of latent tuberculosis infection (LTBI)in children receiving anti-rheumatic treatment in a tertiary referral hospital of Northern ***:A total of 79 consecutive children receiving anti-rheumatic treatment [of which 18 screened prior to antitumor necrosis factor (TNF)-α treatment] were tested using Mantoux tuberculin skin test (TST) and *** of both tests with risk factors for latent tuberculosis and Bacillus Calmette-Guerin immunization was *** of age,TNF-α inhibitors,systemic corticosteroids,conventional disease modifying anti-rheumatic drugs (DMARDs) and total duration of therapy on the QFT-IT mitogen-induced response was ***:Agreement between TST and QFT-IT results was moderate (k=0.38).Frequency of QFT-IT indeterminate results was low (2.5%).In patients with risk factors for LTBI,the odds of a positive IFN-7 assay was increased by a factor of 27.6 (P=0.002),whereas there was no positive *** was a significant difference in the mitogeninduced IFN-7 secretion among various treatments (P=0.038).TNF-α inhibitors were associated with increased mitogen-induced IFN-7 secretion compared to monotherapy with conventional DMARDs (P=0.008).All children screened prior to anti-TNF-a treatment exhibited a negative QFT-IT and no active TB disease was detected during a 2-year ***:QFT-IT may be a more reliable test than TST for detection of LTBI in children with rheumatic diseases receiving anti-rheumatic *** regimen might influence the mitogen-induced IFN-γ secretion and the effect of TNF-α inhibitors might vary according to the specific agent administered.

关键词： anti-tumor necrosis factor-α interferon-γ release assay latent tuberculosis rheumatic disease tuberculin

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Environmental and Economic Assessment of Wood Pellet Production from Trees in Greece

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Smart Grid and Renewable Energy 2022年第7期13卷 137-159页

作者： Chrysanthos Golonis Rigou Aikaterini Charaklias Konstantinos Zeibekis Konstantinos Georgantzeli polixeni Piteros Andreas Agricultural University of Athens Athens Greece

Biomass is a renewable, economic and readily available resource of energy that has potential to substitute fossil fuels in many applications such as heat, electricity and biofuels. The increased use of the agricultural biomass can help the agricultural based societies in achieving energy security and creating employment without causing environmental degradation. However, the viability and feasibility of electricity generation from agricultural biomass depends upon the availability of biomass supply at a competitive cost. The present study investigates the availability of agricultural biomass for distributed power generation in Greece (Kozani). The study concludes with a discussion on significance and challenges of decentralized electricity generation for rural energy supply, including brief description about economical, social, environmental and technical aspects of bioelectricity. With the application of the life cycle analysis applied, the environmental and economic impacts that will occur in the region of Kozani in Greece, where a biomass wood pellets production workshop is operating, have been assessed. The total annual emission of CO 657.9 gr, HC 22.36 gr, PM 67.94 and NOx 8.832,2 gr was calculated. The economic evaluation estimated the payback period for the investment in this plant to be approximately 3 years.

关键词： Biomass Wood Pellets Energy Emission Life Cycle Assessment

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Bicarbonate levels in hemodialysis patients switching from lanthanum carbonate to sucroferric oxyhydroxide

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World Journal of Nephrology 2018年第6期7卷 123-128页

作者： Aristeidis Stavroulopoulos Vasiliki Aresti Christoforos Papadopoulos Panagiotis Nennes polixeni Metaxaki Anastasios Galinas Department of Nephrology IASIO HospitalGeneral Clinic of Kallithea

AIM To examine possible alterations in acid-base parameters in patients switching from lanthanum carbonate(LanC) to sucroferric oxyhydroxide(SFOH). METHODS Fifteen stable hemodialysis patients were switched from LanC to SFOH. Only nine continued on SFOH, three returned to LanC and the other three switched to sevelamer carbonate. The later six patients served as a control group to the SFOH group of nine patients. Blood was sampled on the 3-d and the last 2-d interval of the week prior to switching and six weeks after. Bicarbonate levels(HCO_3^-), pH, pO_2, pCO_2 were measured, and the mean of the two measurements(3-d and 2-d interval) was calculated. RESULTS Comparing pre-switching to post-switching measurementsin the SFOH group, no statistically significant differences were found in any of the parameters studied. The mean pre-switching HCO_3^-was 22.41 ± 1.66 mmol/L and the mean post-switching was 22.62 ± 2.25 mmol/L(P = 0.889). Respectively, the mean pH= 7.38 ± 0.03 vs 7.39 ± 0.03(P = 0.635), mean pCO_2= 38.41 ± 3.29 vs 38.37 ± 3.62 mmHg(P = 0.767), and Phosphate = 1.57 ± 0.27 vs 1.36 ± 0.38 mmol/L(P = 0.214). There were not any significant differences when we performed the same analyses in the control group or between the SFOH group and control group. No correlations were found, either between pre-switching LanC daily dose or between postswitching daily dose of the new binder and the measured *** In our small study, switching from LanC to SFOH did not have any significant effect on blood bicarbonate levels and gas analysis, indicating that there is no need to change hemodialysis prescription regarding these parameters.

关键词： Gas analysis Hemodialysis Lanthanum carbonate Acidosis Bicarbonate Phosphate binder Sucroferric oxyhydroxide

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