检索结果-南通市图书馆

The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage

Neural Regeneration Research 2021年第10期16卷 2071-2077页

作者： Ning Sha Hua-Wei Wang Bin Sun Min Gong po Miao Xiao-Lu Jiang Xiao-Feng yang Mei Li Li-Xiao Xu Chen-Xi Feng yuan-yuan yang Jie Zhang Wen-Jing Zhu yuan-yuan Gao Xing Feng Xin Ding Soochow Key Laboratory of Prevention and Treatment of Child Brain injury Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatrics Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’anJiangsu ProvinceChina Pediatrics Research Institute Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatrics The First Affiliated Hospital of Soochow University(Dushuhu Branch)SuzhouJiangsu ProvinceChina Cambridge-SU Genomic Resource Center Soochow UniversitySuzhouJiangsu ProvinceChina Clinical Laboratory Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely *** previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm *** better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in *** found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with ***,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of *** addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal *** established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 ***3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same ***,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and *** together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal *** clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,*** experiments were approved by An

关键词： brain injury circadian rhythm hypoxic-ischemic brain damage miRNA neonate pineal gland sleep transcription factor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimal array layout of cylindrical baffles to reduce energy of rock avalanche

引用

Journal of Mountain Science 2022年第2期19卷 493-512页

作者： BI Yu-zhang WANG Dong-po FU Xian-lei LIN Yi-xiong SUN Xin-po JIANG Zhe-yuan B-Z geotechnical Company Nanjing 210096China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Civil Engineering Sichuan University of Science and EngineeringZigong 643000China Jiangsu Key Laboratory of Urban Underground Engineering&Environmental Safety Institute of Geotechnical EngineeringSoutheast UniversityNanjing 210096China

The array of baffles protection structure is a flow resistance structure with good drainage,blocking,and intercepting effects on the rock *** this research,the physical model test on rock avalanches was *** parameters(column spacing,row spacing,and a number of baffles)were used as indicators to determine the optimal layout of the array of baffles for energy efficiency consumption ***,the lattice Boltzmann numerical simulation method was used to build a numerical simulation model of rock avalanches-array of the baffles-hazard-bearing body to obtain the rock’s velocity attenuation and flow trajectory avalanches in the impact baffle protection ***,the results of the physical model test and the numerical simulation were mutually *** following conclusions were drawn through two methods of physical model test and numerical simulation.(1)The optimal layout parameters of array of baffles were determined as three rows of array of baffles(The number of baffles in each row is 7,8,9),column spacing Sc=3.5,and row spacing Sr=4.5.(2)Under the conditions of high baffle density(such as Sc=1.5,2.5),the rock avalanches would produce a certain degree of circumfluence,which would increase the fluid velocity by at least 24.5% over the average velocity,so the column spacing density should be increased appropriately to achieve the optimal effect of reducing the energy of rock avalanches.(3)In the event of a prototype grooved rock avalanches with a velocity close to 24.5 m/s and a flow depth of about 1.5 m,the three-row array of baffles protection with the parameters Sc^(*)=1.18 m and Sr^(*)=1.51 m could be arranged,playing the role of optimizing the array of baffles to guide the flow and block the energy *** experiments can be used to replace laboratory experiments to some *** Lattice Boltzmann method-Discrete element method(LBM-DEM)studies are required before applications to practical engineering.

关键词： Lattice Boltzmann Physical model Numerical simulation Energy consumption optimization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effective N-methyl-2-pyrrolidone wet cleaning for fabricating highperformance monolayer MoS2 transistors

引用

Nano Research 2019年第2期12卷 303-308页

作者： po-Chun Chen Chih-Pin Lin Chuan-Jie Hong Chih-Hao yang Yun-Yan Lin Ming-yang Li Lain-Jong Li Tung-yuan Yu Chun-Jung Su Kai-Shin Li yuan-Liang Zhong Tuo-Hung Hou Yann-Wen Lan Department of Physics "National Taiwan Normal University" Taipei 11677 Taiwan China Department of Electronics Engineering and Institute of Electronics "National Chiao Tung University' Hsinchu 30010 Taiwan China Department of Physics and Center for Nanotechnology Chung Yuan Christian University Chungli 32023 Taiwan China Research Center for Applied Sciences Academia Siriica: Taipei 11529 Taiwan China Physical Sci. and Eng. King Abdullah University of Sci.and Technology Thuwal 23955 Kingdom of Saudi Arabia "National Nano Device Laboratories:"National Applied Research Laboratories" Hsinchu 30078 Taiwan China

Two-dimensional semiconductors,such as MoS2 are known to be highly susceptible to diverse molecular adsorbates on the surface during fabrication,which could adversely affect device *** ensure high device yield,uniformity and performance,the semiconductor industry has long employed wet chemical cleaning strategies to remove undesirable surface contaminations,adsorbates,and native oxides from the surface of Si wafers.A similarly effective surface cleaning technique for two-dimensional materials has not yet been fully *** this study,we propose a wet chemical cleaning strategy for MoS2 by using *** cleaning process not only preserves the intrinsic properties of monolayer MoS2,but also significantly improves the performance of monolayer MoS2 *** device on current of 12 μA·μm-1 for a channel length of 400 nm,contact resistance of 15 kΩ·μm,field-effect mobility of 15.5 cm^2·V^-1·s^-1,and the average on-off current ratio of 10^8 were successfully demonstrated.

关键词： monolayer M0S2 devices standard wet cleaning field-effect transistors N-methyl-2-pyrrolidone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rational design of three-dimensional nitrogen and phosphorus co-doped graphene nanoribbons/CNTs composite for the oxygen reduction

引用

Chinese Chemical Letters 2016年第4期27卷 597-601页

作者： Jie Wang Ze-Xing Wu Li-Li Han yuan-yang Liu Jun-po Guo Huolin L.Xin De-Li Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Center for Functional Nanomaterials Brookhaven National Laboratory School of Materials Science and Engineering Tianjin University

In the present work, we report nitrogen and phosphorus co-doped 3-D structured carbon nanotube intercalated graphene nanoribbon composite. The graphene nanoribbons are prepared via partial exfoliation of multi-walled carbon nanotubes. In the graphene nanoribbons/CNTs composite, carbon nanotubes play a role of skeleton and support the exfoliated graphene nanoribbons to form the stereo structure. After high temperature heat-treatment with ammonium dihydrogen phosphate, the unique structure reserves both the properties of carbon nanotube and graphene, exhibiting excellent catalytic performance for the ORR with excellent onset and half-wave potential, which is similar to commercial Pt/C electrocatalysts.

关键词： Graphene nanoribbons Carbon nanotube Doping Electrocatalyst Oxygen reduction reaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of Microstructure and Residual Stress Between TIG and MAG Welding Using Low Transformation Temperature Welding Filler

引用

Acta Metallurgica Sinica(English Letters) 2018年第3期31卷 263-272页

作者： Zhong-yuan Feng Xin-Jie Di Shi-Pin Wu Dong-po Wang Xiao-Qian Liu School of Materials Science and Engineering Tianjin UniversityNo.135 Yaguan RoadJinnan DistrictTianjin 300350China Tianjin Key Laboratory of Advanced Joining Technology Tianjin 300350 China

A Cr-Ni type of low transformation temperature（LTT）welding filler was devised in the present *** LTT weld microstructures of the tungsten inert gas（TIG）and metal active gas（MAG）weldings were investigated by using electron-backscattered diffraction and orientation imaging *** results showed that the LTT weld microstructures prepared by TIG and MAG weldings were primarily martensite with 17.5% and 8.0% retained austenite,*** LTT weld metal using TIG welding had larger grain size than using *** addition,based on the Taylor factor calculation,the weld metal using MAG welding was more competent in repressing fatigue crack ***,the high angle and coincidence site lattice grain boundaries were dominant in the LTT weld metal using MAG ***,the hardness of the LTT weld metal using MAG welding was higher than that of using *** on heat input and phase transformation,finite element method was applied to analyzing the tensile residual stress（RS）reduction in welded joints prepared by both conventional and LTT welding fillers,*** corresponding outcome confirmed that the LTT weld metal using MAG welding was more beneficial to tensile RS reduction.

关键词： Martensitic transformation Taylor factor Grain boundaries Residual stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A High-Accuracy Finite Difference Scheme for Solving Reaction-Convection-Diffusion Problems with a Small Diffusivity

引用

Advances in Applied Mathematics and Mechanics 2014年第5期6卷 637-662页

作者： po-Wen Hsieh Suh-Yuh yang Cheng-Shu You Department of Applied Mathematics Chung Yuan Christian UniversityJhongli CityTaoyuan County 32023Taiwan Department of Mathematics National Central UniversityJhongli CityTaoyuan County 32001Taiwan

This paper is devoted to a new high-accuracy finite difference scheme for solving reaction-convection-diffusion problems with a small diffusivityε.With a novel treatment for the reaction term,we first derive a difference scheme of accuracy O(ε^(2)h+εh^(2)+h^(3))for the 1-D *** the alternating direction technique,we then extend the scheme to the 2-D case on a nine-point *** apply the high-accuracy finite difference scheme to solve the 2-D steady incompressible Navier-Stokes equations in the stream function-vorticity *** examples are given to illustrate the effectiveness of the proposed difference *** made with some high-order compact difference schemes show that the newly proposed scheme can achieve good accuracy with a better stability。

关键词： Reaction-convection-diffusion equation incompressible Navier-Stokes equations boundary layer interior layer finite difference scheme

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enrichment of anchoring sites by introducing supramolecular halogen bonds for the efficient perovskite nanocrystal LEDs

引用

Light(Science & Applications) 2023年第10期12卷 2122-2130页

作者： po Lu Ting Li Min Lu Cheng Ruan Siqi Sun Zhennan Wu yuan Zhong Fujun Zhang Yanbo Gao Yaowei Huang yang Wang Junhua Hu Fengping Yan Yu Zhang State Key Laboratory of Integrated Optoelectronics and College of Electronic Science and Engineering Jilin UniversityChangchunChina School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijingChina Changchun Cedar Electronics Technology Co. Ltd.ChangchunChina Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina Key Laboratory of Materials Physics of Ministry of Education Department of Physics and Engineering Zhengzhou UniversityZhengzhouChina

Considering the multi-functionalization of ligands,it is crucial for ligand molecular design to reveal the landscape of anchoring ***,a typical triphenylphosphine(TPP)ligand was employed to explore its effect on the surface of CsPbI_(3)perovskite nanocrystals(PNCs).Except for the conventionally considered P-Pb coordination,an P-I supramolecular halogen bonding was also found on the NC *** coexistence of the above two types of bonding significantly increased the formation energy of iodine vacancy defects and improved the photoluminescence quantum yield of PNCs up to 93%.Meanwhile,the direct interaction of P and I enhanced the stability of the Pb-I octahedra and dramatically inhibited the migration of I ***,the introduction of additional benzene rings(2-(Diphenylphosphino)-biphenyl(DPB))increased the delocalized properties of the PNC surface and significantly improved the charge transport of the *** a result,the DPB passivated CsPbI_(3)NCs based top-emitting LEDs exhibite a peak external quantum efficiency(EQE)of 22.8%,a maximum luminance of 15,204 cd m^(−2),and an extremely low-efficiency roll-off of 2.6%at the current density of 500 mA cm^(−2).

关键词： halo bonding quantum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Measurement of the Optical Constants of Thin Metal Films by THz Differential Time Domain Spectroscopy

引用

Chinese Physics Letters 2011年第9期28卷 249-252页

作者： MA Feng-Ying SU Jian-po GONG Qiao-Xia yang Jing DU Yan-Li GUO Mao-Tian yuan Bin School of Physical Science and Engineering Zhengzhou UniversityZhengzhou 450001

Three kinds of nanometer-scale metal films(Cr,Ni and Ti)with different thicknesses are *** complex refractive indices of the three metal films are quantitatively measured by using THz differential time-domain spectroscopy(THz-DTDS).The orders of the complex refractive indices of the thin metal films are equal to those of the reported *** results validated that THz-DTDS can be used to study the features of the ultra-thin metal films.

关键词： refractive indices orders

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Precise Object Detection Using Iterative Superpixels Grouping Method

引用

Journal of Electronic Science and Technology 2017年第2期15卷 153-160页

作者： Cheng-Chang Lien Yu-Wei Lin Huan-po Hsu Kun-Ming Yu Ming-yuan Lei Department of Computer Science and infonnation Engineering Chung Hua University Hsinchu 300 Architecture and Building Research lnstitute New Taipci Citv 100

The region completeness of object detection is very crucial to video surveillance, such as the pedestrian and vehicle identifications. However, many conventional object detection approaches cannot guarantee the object region completeness because the object detection can be influenced by the illumination variations and clustering backgrounds. In order to overcome this problem, we propose the iterative superpixels grouping （ISPG） method to extract the precise object boundary and generate the object region with high completeness after the object detection. First, by extending the superpixel segmentation method, the proposed ISPG method can improve the inaccurate segmentation problem and guarantee the region completeness on the object regions. Second, the multi- resolution superpixel-based region completeness enhancement method is proposed to extract the object region with high precision and completeness. The simulation results show that the proposed method outperforms the conventional object detection methods in terms of object completeness evaluation.

关键词： Index Terms-lterative superpixels grouping method (ISPG) object completeness object detection superpixel video surveillance.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EZ-Manipulator:Designing a mobile,fast,and ambiguity-free 3D manipulation interface using smartphones

引用

Computational Visual Media 2018年第2期4卷 139-147页

作者： po-Huan Wseng Shih-Hsuan Hung Pei-Ying Chiang Chih-yuan Yao Hung-Kuo Chu "National Tsing Hua University" Hsinchu 30013TaiwanChina. "National Taiwan University of Science and Technology" Taipei 10607TaiwanChina. "National Taipei University of Technology" Taipei 10607TaiwanChina.

Interacting with digital contents in 3 D is an essential task in various applications such as modeling packages, gaming, virtual reality, etc. Traditional interfaces using keyboard and mouse or trackball usually require a non-trivial amount of working space as well as a learning process. We present the design of EZ-Manipulator, a new 3 D manipulation interface using smartphones that supports mobile, fast, and ambiguity-free interaction with 3 D objects. Our system leverages the built-in multi-touch input and gyroscope sensor of smartphones to achieve 9 degrees-of-freedom axis-constrained manipulation and free-form *** EZ-Manipulator to manipulate objects in 3 D is easy. The user merely has to perform intuitive singleor two-finger gestures and rotate the hand-held device to perform manipulations at fine-grained and coarse levels respectively. We further investigate the ambiguity in manipulation introduced by indirect manipulations using a multi-touch interface, and propose a dynamic virtual camera adjustment to effectively resolve the ambiguity. A preliminary study shows that our system has significant lower task completion time compared to conventional use of a keyboard–mouse interface, and provides a positive user experience to both novices and experts.

关键词： 3D manipulation interface interaction technique multi-touch gyroscope sensorl mobile device input device

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：