检索结果-南通市图书馆

Effects of the number of neoadjuvant therapy cycles on clinical outcomes, safety, and survival in patients with metastatic colorectal cancer undergoing metastasectomy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2022年第2期30卷 65-76页

作者： YUNG-SUNG YEH HSIANG-LIN TSAI YEN-CHENG CHEN WEI-CHIH SU po-JUNG CHEN TSUNG-KUN CHANG CHING-CHUN LI CHING-WEN HUANG JAW-yuan WANG Division of Trauma and Surgical Critical Care Department of SurgeryKaohsiungMedical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Emergency Medicine Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipeiTaiwanChina Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Center for Cancer Research Kaohsiung Medical UniversityKaohsiungTaiwanChina Pingtung Hospital Ministry of Health and WelfarePingtungTaiwanChina

The controversial outcomes in patients with metastatic colorectal cancer(mCRC)highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical *** optimal treatment cycles in patients with mCRC for metastasectomy remain undeﬁ*** retrospective study compared the efﬁcacy,safety,and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such ***-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April ***-eight patients received 6 cycles of chemotherapy/targeted therapy,whereas 36 patients received≥7 cycles(median,13;range,7–20).Clinical outcomes,including response,progression-free survival(PFS),overall survival(OS),and adverse events,were compared between these two *** the 64 patients,47(73.4%)were included in the response group,and 17(26.6%)were included in the nonresponse *** analysis revealed chemotherapy/targeted therapy cycle and pretreatment serum carcinoembryonic antigen(CEA)level as independent predictors of the response as well as overall survival and chemotherapy/targeted therapy cycle as an independent predictor of progression(all pponse rate,lower progression rate,and higher survival rate in≥7 cycles of chemotherapy/targeted therapy group(all p0.05).The median OS and PFS were 48 months(95%CI,40.855–55.145)and 28 months(95%CI,18.952–37.48)in the≥7-cycle group and 24 months(95%CI,22.038–25.962)and 13 months(95%CI,11.674–14.326)in the 6-cycle group,respectively(both p<0.001).The oncological outcomes in the≥7-cycle group were signiﬁcantly better than those in the 6-cycle group,without signiﬁcant increases in adverse ***,prospective randomized trials are mand

关键词： Metastatic colorectal cancer Neoadjuvant chemotherapy/targeted therapy Treatment cycles Metastasectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

“攀援”现象与明清小说观念建构

海南大学学报（人文社会科学版） 2013年第4期31卷 64-69页

作者：袁宪泼南开大学文学院天津300071

明清小说评点动辄攀援经史是文学批评史上的一种重要现象,是对传统推源溯流法的继承,具有时代情景性和复杂性。攀援对象大体可以分为四类:史书、经书、佛道、诗文。在取法攀援对象的基础上,形成了明清小说关于叙事、义旨、笔法以及文采... 详细信息

明清小说评点动辄攀援经史是文学批评史上的一种重要现象,是对传统推源溯流法的继承,具有时代情景性和复杂性。攀援对象大体可以分为四类:史书、经书、佛道、诗文。在取法攀援对象的基础上,形成了明清小说关于叙事、义旨、笔法以及文采的认识。同样,也形成了真与实、通俗与教诲、补史与稗官的小说观念。

关键词：攀援推源溯流文体惯例观念建构

Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)*** obtained using long-read and Hi-C sequencing

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1214-1224页

作者： Jiawei Wang Weizhen Liu Dongzi Zhu po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui yuan Qingzhong Liu Shandong Key Laboratory of Fruit Biotechnology Breeding Shandong Institute of PomologyTaianShandong 271000China School of Computer Science and Technology Wuhan University of TechnologyWuhanHubei 430070China State Key Laboratory of Crop Biology Shandong Agricultural UniversityTaianShandong 271018China Gooal Gene WuhanHubei 430070China

Sweet cherry(Prunus avium)is an economically significant fruit species in the genus ***,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read *** incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry *** final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 ***-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled *** annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally *** the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet *** auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening *** addition,772 resistance genes were identified and functionally predicted in the sweet cherry *** high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding.

关键词： sweet bases assembly

Triterpenoids from the roots of Rubus parvifolius

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2016年第5期14卷 377-381页

作者： ZHANG Xu ZHU Zhi-Xiang WANG Juan yang Wan-Qing SU Cong LI Jun ZHANG yuan ZHENG Jiao SHI She-po TU Peng-Fei Modern Research Center for Traditional Chinese Medicine Beijing University of Chinese Medicine School of Chinese Materia Medica Beijing University of Chinese Medicine

Two new oleanane-type triterpenoids, parvifolactone A(1) and rubuside P(2), together with 11 known triterpenoids, fupenzic acid(3), 18,19-seco,2α,3α-dihydroxyl-19-oxo-urs-11,13(18)-dien-28-oic acid(4), euscaphic acid(5), maslinic acid(6), 1β-hydroxyeuscaphic acid(7), 2α,3α,19α,23-tetrahydroxyolean-12-en-28-oic acid(8), 2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid(9), glucosyl pinfaensate(10), rubuside J(11), 2α,3α,19α,23-tetrahydroxyurs-12-en-24,28-dioic acid(12), and 2α,3β,19α- trihydroxyurs-12-en-23,28-dioic acid(13), were isolated from the roots of Rubus parvifolius.

关键词： Triterpenoid Parvifolactone A Rubuside P Rubus parvifolius

Synergistically enhancing cycleability and rate performance of sodium titanate nanowire anode via hydrogenation and carbon coating for advanced sodium ion batteries

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第12期41卷 4075-4085页

作者： De-Liang Ba Wei-Hua Zhu yuan-yuan Li Jin-Ping Liu School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China School of Chemistry Chemical Engineering and Life ScienceState Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhan 430070China State Center for International Cooperation on Designer Low-Carbon and Environmental Materials and School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

Layered alkali-metal titanate materials are considered as attractive anodes for sodium ion batteries due to their favorable safety and low ***,their practical implementation faces major challenges of low electronic conductivity and inevitable volume variation during Na^(+)intercalation and de-intercalation,which are generally difficult to conquer by a single modification ***,a synergistic ally enhancing strategy to promote the electrochemical performance of Na_(2)Ti_(2)O_(5)nanowire array anode via simultaneous hydrogenation and carbon coating is *** leads to partially reduced titanium;together with conductive carbon layer,it endows Na_(2)Ti_(2)O_(5)with fast electron transport and structural *** resulting H-Na_(2)Ti_(2)O_(5)@C anode exhibits enhanced rate capability(8.0C,165 mAh·g^(-1))and stable cycle performance up to 1000 times in sodium-ion half-cells(the capacity of H-Na_(2)Ti_(2)O_(5)without carbon fades drastically after only 100 cycles).In addition,a newcoupling full cell is further designed with graphene hybridized high-voltage Na_(3)(VO_(0.5))_(2)(po4)_(2)F_(2)as cathode,capable of delivering a high specific energy density of 212.1 Wh·kg^(-1)(based on the mass of both anode and cathode)and good rate and cycling *** work may offer inspiration for synergistic optimization of electrode materials for advanced electrochemical energy storage devices.

关键词： Sodium ion batteries(SIBs) Na2Ti2O5 nanowire Hydrogenation Carbon coating Enhanced performance

Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第6期13卷 934-938页

作者： Hong Li Hou-Fa Cao Jun Wan yuan Li Mei-Ling Zhu po Zhao Inpatient Department of Medical Health Center Chinese PLA General Hospital Beijing 100853 China Department of Nanlou Digestion Chinese PLA General Hospital Beijing 100853 China PO Zhao Department of Pathology Chinese PLA General Hospital Beijing 100853 China Department of Pathology Chinese PLA General Hospital Beijing 100853 China

AIM： To observe the growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line Caco-2. METHODS： Recombinant plasmid pCI-neo-Kras2 with wild type Kras2 open reading frame was constructed. The Caco-2 cells were transfected with either pCI-neo or pCI-neo-Kras2 using Upofectamine 2000. The expression of wild type Kras2 was examined by Northern blot analysis. And the expression of wild type Kras2 protein was examined by Western blot analysis. The effects of wild-type Kras2 on cell proliferation were analyzed by monotetrazolium （MTT） assay, meanwhile analyses of cell cycle and spontaneous apoptosis rate were carried out by flow cytometry （FCM）. RESULTS： The plasmid of pCI-neo-Kras2 was successfully established. The growth rate of cells transfected with pCI-neo-Kras2 was significantly lower than the control cells transfected with the empty pCI- neo vector （P 〈 0.05）. Cell cycle analysis revealed arrest of the pCI-neo-Kras2 transfected cells in G0/G1 phases, decreased DNA synthesis and decreased fractions of cells in S phase. The proliferative index of cells transfected with pCI-neo-Kras2 was decreased compared with the control cells （49.78% vs 64.21%）, while the apoptotic rate of Caco-2 cells with stable Kras2 expression increased （0.30% vs 0.02%）. CONCLUSION： The wild-type Kras2 gene effectively inhibits the growth of the colonic adenocarcinoma cell line Caco-2.

关键词： Colonic adenocarcinoma Wild-b/pe Kras2 Cell cycle Apoptosis

Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第8期35卷 205-210页

作者： Zhe Li Ping-Zhao Liang Li Xu Fei-Yu yang Tian-Bing Ren Lin yuan Xia Yin Xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Photodynamic therapy(PDT)has emerged as a significant cancer therapy ***,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after ***,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some ***,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(Lpos)level,which evoke the non-apoptotic death manner of tumor ***,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor ***,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.

关键词： Water-soluble Three positive charge Photosensitizer Nonapoptotic Tumor therapy

Surveillance Imaging and GAAD/GALAD Scores for Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第11期12卷 907-916页

作者： Chung-Feng Huang Konstantin Kroeniger Chih-Wen Wang Tyng-yuan Jang Ming-Lun Yeh po-Cheng Liang Yu-Ju Wei po-Yao Hsu Ching-I Huang Ming-Yen Hsieh Yi-Hung Lin Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ashish Sharma Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung PhD Program in Translational Medicine College of MedicineKaohsiung Medical Universityand Academia SinicaKaohsiung Faculty of Internal Medicine School of Medicine and Hepatitis Research CenterCollege of MedicineKaohsiung Medical UniversityKaohsiung Clinical Algorithms&Biomarker Statistics Roche Diagnostics GmbHPenzbergGermany Department of Internal Medicine Kaohsiung Municipal Siaogang HospitalKaohsiung Medical UniversityKaohsiung Department of Internal Medicine Kaohsiung Municipal Ta-Tung HospitalKaohsiung Medical UniversityKaohsiung Clinical Development&Medical Affairs Roche Diagnostics International AGRotkreuzSwitzerland School of Medicine and Doctoral Program of Clinical and Experimental Medicine College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver DiseaseNational Sun Yat-sen UniversityKaohsiung

Background and Aims:Early detection of hepatocellular carcinoma(HCC)is crucial for improving survival in patients with chronic *** GALAD algorithm combines gen-der(biological sex),age,α-fetoprotein(AFP),Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and protein in-duced by vitamin K absence or antagonist-II(PIVKA-II)for HCC ***,the GAAD algorithm incorporates gender(biological sex),age,AFP,and *** study aimed to assess the clinical utility of AFP-L3 in the GALAD algorithm and its potential synergies with *** compared the clinical performance of GALAD with GAAD;AFP;AFP-L3;and PIVKA-II,with or without ultrasound,in Taiwan residents ***:A total of 439 serum samples were analyzed using a Cobas®e 601 analyzer(healthy con-trols,n=200;chronic liver disease controls,n=177;HCC cases,n=62).Performance was assessed through receiver operating characteristic curve analyses to calculate the area under the ***:The area under the curve for dif-ferentiating early-stage HCC from patients with chronic liver disease was optimal for PIVKA-II(84.9%),GAAD(79.8%),and GALAD(79.4%),with slightly improved performance for detecting all-stage *** performance was unaffected by disease stage or *** for early-stage HCC was highest for GAAD(57.6%)and GALAD(57.6%).Sen-sitivity for each strategy was further enhanced when com-bined with ultrasound,regardless of disease stage or etiology(Pporting the use of GAAD for HCC detection.A combination of GAAD,GALAD,or PIVKA-II with ultrasound may improve diagnostic efficiency compared with recommended strategies.

关键词： Algorithm Biomarkers Cirrhosis Diagnosis Detection GAAD GALAD Hepatocellular carcinoma Liver cancer Surveillance Ultrasound

细颗粒沉积物分布区地下水源热泵抽灌井施工工艺探讨

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

水文地质工程地质 2017年第1期44卷 36-40,56页

作者：刘洪战田源杨坡河南省地质调查院河南郑州450001 地下清洁能源勘查开发技术创新战略联盟河南郑州450001 河南省地质矿产勘查开发局第一地质环境调查院河南郑州450045

郑州市广泛分布着第四系松散堆积物,其特点是颗粒细,厚度大,含水介质主要为细颗粒的砂层。由于地下水富水性好,目前郑州市浅层地温能开发利用主要以地下水地源热泵工程为主。传统正循环泥浆钻探工艺施工的地温空调井,普遍存在洗井困难... 详细信息

郑州市广泛分布着第四系松散堆积物,其特点是颗粒细,厚度大,含水介质主要为细颗粒的砂层。由于地下水富水性好,目前郑州市浅层地温能开发利用主要以地下水地源热泵工程为主。传统正循环泥浆钻探工艺施工的地温空调井,普遍存在洗井困难、涌水量和回灌量偏小的问题,在很大程度上限制了地下水地源热泵工程的推广使用。针对这一问题,本次采用泵吸反循环工艺施工地温空调井。施工过程及试验数据对比分析表明,在细颗粒松散沉积物分布区,采用泵吸反循环钻探工艺施工地温空调井,对提高施工进度、增大出水量和回灌量等方面具有显著优势,可以为类似地区地温空调井的施工提供借鉴。

关键词：泵吸反循环钻探细颗粒松散堆积物回灌量地下水源热泵抽灌井