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利脑心片联合替格瑞洛治疗不稳定心绞痛的临床研究

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现代药物与临床 2024年第3期39卷 647-651页

作者：任爽刘懿颖李洋巴晓彤北京市大兴区人民医院药剂科北京102600 北京市大兴区人民医院心内科北京102600

目的探讨利脑心片联合替格瑞洛治疗不稳定心绞痛的临床疗效。方法选取2021年3月—2023年2月在北京市大兴区人民医院治疗的不稳定心绞痛患者96例,采用随机数字表法将患者分为对照组(48例)和治疗组(48例)。对照组患者口服替格瑞洛片,首次... 详细信息

目的探讨利脑心片联合替格瑞洛治疗不稳定心绞痛的临床疗效。方法选取2021年3月—2023年2月在北京市大兴区人民医院治疗的不稳定心绞痛患者96例,采用随机数字表法将患者分为对照组(48例)和治疗组(48例)。对照组患者口服替格瑞洛片,首次负荷剂量180 mg,之后剂量改为90 mg/次,2次/d。治疗组患者在对照组基础上口服利脑心片,3片/次,3次/d。两组患者治疗6个月。观察两组患者临床疗效,比较治疗前后两组患者血小板反应指数(PRI)、腺苷二磷酸诱导的血小板-纤维蛋白凝块强度(MAADP)及血清C反应蛋白(CRP)、单核细胞趋化蛋白-1(MCP-1)和基质金属蛋白酶-9(MMP-9)水平。结果治疗后,治疗组总有效率为93.75%,明显高于对照组79.17%(P<0.05)。治疗后,两组PRI、MAADP、CRP、MCP-1、MMP-9水平均低于治疗前(P<0.05),且治疗组明显低于对照组(P<0.05)。结论利脑心片联合替格瑞洛治疗不稳定心绞痛安全有效,可有效降低血栓形成风险,且不增加出血风险,改善体内炎症反应。

关键词：利脑心片替格瑞洛片不稳定心绞痛血小板反应指数 C反应蛋白单核细胞趋化蛋白-1

海州湾浮游桡足类丰度的季节变化及其与环境因子的相关性

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海洋学报 2024年第3期46卷 89-97页

作者：任爽宁张硕高世科路吉坤伏光辉上海海洋大学海洋生物资源与管理学院上海201306 连云港市海洋与渔业发展促进中心江苏连云港222002

浮游桡足类是浮游动物中的一个重要类群,研究浮游桡足类的分布特征及其与环境因子的相关性具有重要意义。本研究利用广义加性模型(GAM)对2003-2022年江苏连云港海州湾人工鱼礁区及邻近海域的环境监测数据进行分析,探讨了浮游桡足类的季... 详细信息

浮游桡足类是浮游动物中的一个重要类群,研究浮游桡足类的分布特征及其与环境因子的相关性具有重要意义。本研究利用广义加性模型(GAM)对2003-2022年江苏连云港海州湾人工鱼礁区及邻近海域的环境监测数据进行分析,探讨了浮游桡足类的季节变化、空间分布及其与环境因子的相关性。结果表明,浮游桡足类丰度季节间差异极显著(p <0.01),均值由大到小依次为春季、夏季、秋季。丰度空间分布总体呈现人工鱼礁区低、近岸南部海域高的分布态势。GAM结果显示,季节间主要影响因子有同有异,春季是溶解氧浓度、叶绿素a浓度、硅酸盐浓度和硝酸盐浓度;夏季是生化需氧量、硅酸盐浓度、铵盐浓度和温度;秋季是盐度、溶解氧浓度、磷酸盐浓度和悬浮物含量。本研究可为进一步认识人工鱼礁海域浮游动物结构以及针对人工鱼礁海域栖息地适宜性评价提供参考。

关键词：浮游桡足类季节变化空间分布广义加性模型分析

Role of surgical intervention in managing gastrointestinal metastases from lung cancer

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World Journal of Gastroenterology 2011年第38期17卷 4314-4320页

作者： po-Chu Lee Chiao Lo Ming-Tsan Lin Jin-Tung Liang Been-ren Lin Department of Trauma National Taiwan University Hospital and College of Medicine Division of General Surgery Department of SurgeryNational Taiwan University Hospital and College of Medicine Division of Colorectal Surgery Department of SurgeryNational Taiwan University Hospital and College of Medicine

AIM:To investigate the clinicopathological characteristics of late-stage lung cancer patients with gastrointestinal(GI)-tract metastases,focusing on therapeutic options and ***:Our institution(the National Taiwan University Hospital) diagnosed 8159 patients with lung cancer between 1987 and 2008,of which 21 developed symptomatic GI *** study reviewed all of the patients' information,including survival data,pathological reports,and surgical ***:The most common histological type of lung cancer was adenocarcinoma,and 0.26% of patients with lung cancer developed GI *** median duration from lung cancer diagnosis to GI metastases was three months(range,0-108 mo),and the average time from diagnosis of GI metastasis to death was 2.8 *** patients with symptomatic gastric and/or duodenal metastases exhibited GI bleeding and were diagnosed by *** contrast,small bowel metastases typically presented as an acute abdomen and were not diagnosed until *** patients with small bowel or colonic metastases underwent surgical intervention,and their perioperative mortality was 22%.Our data revealed a therapeutic effect in patients with solitary GI metastasis and a favorable palliative effect on survival when metastases were diagnosed *** patients with multiple GI metastases,the presentation varied according to the locations of the ***:Surgical treatment is worthwhile in a select group of patients with bowel perforation or *** should be more alert to symptoms or signs indicating GI metastases.

关键词： Gastrointestinal metastasis Lung cancer Palliative effect Prognosis Surgical intervention

Alpha-clustering effects in heavy nuclei

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Frontiers of physics 2018年第6期13卷 133-144页

作者： Zhongzhou ren Bo Zhou School of Physics Science and Engineering Tongji University Shanghai 200092 China Institute for International Collaboration Hokkaido University Sapporo 060-0815 Japan

The study of cluster structures in light nuclei is extending to the heavy nuclei in these years. As for the stable N = Z nuclei, from the lighter 8Be, 12C nuclei to the heavier 20Ne and even the 40Ca and 44Ti medium nuclei, the a cluster structures have been well studied and confirmed. In heavy nuclei, due to the dominated mean field, the existence of α cluster structure is not clear as light nuclei but some clues were found for indicating the core＋ α cluster structure in some nuclei, in particular, the 208 pb＋α structure in 212po. We review some recent progress about the theoretical and experimental explorations of the a-clustering effects in heavy nuclei. We also discuss the possible a cluster structure of heavy nuclei from the view of a decay.

关键词： α cluster structure nuclear cluster model α correlations α decay

复方中草药制剂对克氏原螯虾抗白斑综合征感染研究

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水产科学 2024年第1期43卷 129-135页

作者：田海军任胜杰杨治国顾夕章信阳农林学院水产学院河南信阳464000 盐城工学院海洋与生物工程学院江苏盐城224051 射阳六和饲料有限责任公司江苏盐城224300

为评价饲料中添加大黄、黄芩、茵陈、地锦草、白术、板蓝根制成的复方中草药制剂对克氏原螯虾非特异免疫、抗氧化能力和抗白斑综合征病毒感染的效果,在空白饲料中分别添加0.5%、1.0%、1.5%和2.0%的复方中草药连续投喂克氏原螯虾14 d,分... 详细信息

为评价饲料中添加大黄、黄芩、茵陈、地锦草、白术、板蓝根制成的复方中草药制剂对克氏原螯虾非特异免疫、抗氧化能力和抗白斑综合征病毒感染的效果,在空白饲料中分别添加0.5%、1.0%、1.5%和2.0%的复方中草药连续投喂克氏原螯虾14 d,分析克氏原螯虾血清非特异免疫酶活、肝胰腺抗氧化能力及其对白斑综合征病毒抗感染能力。试验结果显示,以摄食空白饲料的克氏原螯虾为对照,摄食复方中草药制剂的克氏原螯虾血清溶菌酶、酚氧化酶、酸性磷酸酶和碱性磷酸酶的活性分别增加了4.07%~16.20%(P<0.05)、12.96%~31.94%(P<0.05)、32.36%~39.87%(P<0.05)、36.50%~71.94%(P<0.05),肝胰腺总超氧化物歧化酶、过氧化氢酶和总抗氧化能力分别提升了4.39%~25.76%(P<0.05)、32.85%~93.43%(P<0.05)、21.52%~55.10%(P<0.05),肝胰腺丙二醛含量降低了26.22%~45.05%(P<0.05)。此外,复方中草药制剂处理的克氏原螯虾人工感染白斑综合征病毒5 d的存活率较对照组提高了13.33%~31.67%(P<0.05)。试验结果表明,在饲料中添加复方中草药制剂具有显著提升克氏原螯虾非特异免疫能力、抗氧化能力和抗白斑综合征病毒感染的能力,且1.0%添加量的效果最佳。

关键词：复方中草药制剂非特异免疫抗氧化能力白斑综合征克氏原螯虾

Considerations on the concept, definition, and diagnosis of amyotrophic lateral sclerosis

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Neural Regeneration Research 2021年第9期16卷 1723-1729页

作者： ren-Shi Xu Min Yuan Department of Neurology Jiangxi provincial People’s HospitalAffiliated People’s Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

The concept, definition, and diagnosis of amyotrophic lateral sclerosis(ALS) currently present some problems. This article systematically reviews the literature on the history, current concepts, definition, and diagnosis of ALS, and discloses the present problems based on the retrieved literature and the authors' clinical experience. The current concepts and definitions of ALS have not yet been unified or standardized in clinical practice, and are sometimes vague or inaccurate, which can cause difficulties for neurologists in the clinical treatment of ALS. The concept and definition of ALS need to be further ascertained, and the current diagnostic criteria for ALS require further development. The identification of effective and objective biomarkers may be a feasible method for the early and accurate diagnosis of ALS. Therefore, future research should focus on the identification of reliable biomarkers—especially neuroimaging biomarkers—through autopsy. Standardizing the concept and definition of ALS and formulating clear diagnostic criteria will largely avoid many uncertainties in the future clinical research and treatment of ALS, which will greatly benefit patients.

关键词： amyotrophic lateral sclerosis clinical symptoms concept definition diagnosis familial amyotrophic lateral sclerosis motor neuron disease muscle atrophy

Effects of Edible Micronized Chitosan Coating on Quality and Shelf Life of Sliced Papaya

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Food and Nutrition Sciences 2013年第9期4卷 9-13页

作者： po-Jung Chien Hung-ren Lin Min-Sheng Su Department of Food Science Yuanpei University Hsinchu City Taiwan. Department of Horticulture and Biotechnology Chinese Culture University Taipei Taiwan Department of Horticulture College of Agriculture and Bioresources National Taiwan University Taipei Taiwan

Papaya pulp is very perishable and has a short shelf life. Manually sliced papayas were treated with 0%, 0.25%, 0.5%, and 1% chitosan (non-micronized and micronized) aqueous solutions;placed into plastic trays, and over-wrapped with PVDC film and then stored at 4°C. Color, soluble solid content, water loss, and total plate count of samples were evaluated. Chitosan coating had the ability to maintain the lightness of the sliced papayas. The a* values of the micronized chitosan-coated sliced papayas were significantly lower than those of the-coated. The sliced papayas that had been treated with 1% MC had a higher total soluble solid content and lower b* value after four days of storage. Also, the chitosan coating on the sliced papaya effectively retarded water loss and inhibited the growth of microorganisms. The results reveal that applying a chitosan coating effectively maintained the quality attributes and prolonged the shelf life of the sliced papayas.

关键词： Micronized Chitosan Papaya Minimal Processed Fruit Quality Shelf Life

Mechanism-inspired Design of Heterodinuclear Catalysts for Copolymerization of Epoxide and Lactone

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Chinese Journal of polymer Science 2020年第9期38卷 950-957,I0006页

作者： Wei-Min ren Rui-Jing Wang Bai-Hao ren Ge-Ge Gu Tian-Jun Yue State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China

polyesters,as a class of high-performance and versatile polymer materials,often suffer from some drawbacks,such as hydrophobicity and brittleness due to their single structure ***,modifications have attracted much attention for enhancing their desirable properties,of which one efficient way is incorporating the aliphatic polyether segment into the main chain of the ***,this approach is of much challenge because the obtained polyesters are problematic in either low alternating degree or low molecular ***,we describe an efficient strategy to incorporate polyether fragment into polyester by developing a novel Co-Al based heterodinuclear complex for mediating the copolymerization of propylene oxide(po)withε-caprolactone(CL).The tracking experiments reveal that po and CL convert into the polymer chain throughout the polymerization ***,the linear increase in the molecular weight with conversion of CL indicates the controllable nature of the *** competition polymerization,offering the monomer reactivity ratios of rCL=0.96 and rpo=1.04,suggests that the tendency of self-propagation or incorporation of monomers is nearly ***,the obtained polymers with different ether contents exhibit tunable thermal properties with enhanced decomposition temperature for the polymer with higher ether *** newly developed heterodinuclear complex for new polymerization provides an idea to synthesize new functional polymeric materials.

关键词： Heterodinuclear catalysis polyester-polyether copolymer Lactone Epoxide Copolymerization

关节持续被动活动联合本体感觉训练对膝关节骨折术后患者功能康复的影响

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反射疗法与康复医学 2024年第6期5卷 44-47页

作者：朱明任亭亭聊城市东昌府区中医院骨伤科山东聊城252000 聊城市东昌府区中医院手术室山东聊城252000

目的探讨关节持续被动活动联合本体感觉训练对膝关节骨折术后患者功能康复的影响.方法选取聊城市东昌府区中医院2021年4月—2023年4月收治的78例膝关节骨折术后患者为研究对象,以随机数字表法分为对照组和观察组,每组39例.对照组进行常... 详细信息

目的探讨关节持续被动活动联合本体感觉训练对膝关节骨折术后患者功能康复的影响.方法选取聊城市东昌府区中医院2021年4月—2023年4月收治的78例膝关节骨折术后患者为研究对象,以随机数字表法分为对照组和观察组,每组39例.对照组进行常规康复训练,观察组在此基础上进行关节持续被动活动联合本体感觉训练,均持续3个月.对比两组患者的膝关节功能、疼痛程度、膝关节活动度、平衡功能、膝关节肿胀程度及生活质量.结果训练后,两组的Lysholm膝关节评分均高于训练前,且观察组评分高于对照组,两组的疼痛视觉模拟评分均低于训练前,且观察组评分低于对照组,组间差异有统计学意义(P<0.05).训练后,两组的膝关节主动活动度均大于训练前,且观察组活动度大于对照组,Berg平衡量表评分均高于训练前,且观察组评分高于对照组,组间差异有统计学意义(P<0.05).训练后,两组的生活质量综合评定问卷中各维度评分均高于训练前,且观察组的躯体功能、社会功能、心理功能、物质生活状态评分分别为(81.16±5.45)分、(77.37±4.28)分、(76.29±4.12)分、(81.78±6.37)分,均高于对照组,组间差异有统计学意义(P<0.05).结论关节持续被动活动联合本体感觉训练能促进膝关节骨折术后患者的膝关节功能康复,降低疼痛程度,改善其膝关节活动度、平衡功能及生活质量.

关键词：膝关节骨折关节持续被动活动本体感觉训练膝关节功能