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Expression of CD86 and increased infiltration of NK cells are associated with Helicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

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World Journal of Gastroenterology 2005年第28期11卷 4357-4362页

作者： Sung-Hsin Kuo Li-Tzong Chen Chi-Long Chen Shin-Lian Doong Kun-Huei Yeh Hui-Chen hsu Ming-Shiang Wu Jaw-Town Lin Hsiu-po Wang Ann-Lii Cheng Departments of Oncology National Taiwan University Hospital Taipei Cancer Research Center and Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan China Division of Cancer Research National Health Research Institutes Taipei Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Taipei Taiwan China Department of Pathologyl Taipei MedicalUniversity Taipei Taiwan China Graduate Institute of Microbiology National Taiwan University College of Medicine Taipei Taiwan China Departments of Oncology National Taiwan University Hospital Taipei Cancer Research Center National Taiwan University College of Medicine Taipei Taiwan China Department of Internal Mcclicine National Taiwan University Hospital Taipei Taiwan China Department of Emergency Medicine National Taiwan University Hospital Taipei Taiwan China Department of internal Medicine and Department of Oncology National Taiwan University Hospital Taipei Cancer Research Center National Taiwan University College of MedicineTaipei Division of Cancer Research National Health Research Institutes Taipei Taiwan China

AIM： A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue （MALT） lymphomas remain Helicobacter pylori （ H pylori）-dependent. However,unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori- spedfic intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 （B7.2） and the infiltration of CD56 （＋） natural killer （NK） cells can be useful markers to predict Hpylori-dependent status of high-grade gastric MALT iymphoma.METHODS： Lymphoma biopsies from 26 patients who had participated in a prospective study of Hpylori-eradication for stage IE high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade Ⅱ or less alter H pylori eradication were dassified as H pylori-dependent; others were dassified as H *** infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. RESULTS： There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 （68.8%） of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases （P = 0.001）.H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 （＋） NK cells than H pylori-independent cases （2.8±1.4% vs 1.1±0.8%, P = 0.003）. CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 （＋） NK cells compared to CD86-negative cases （2.9±1.1% vs 1.4±1.3%; P= 0.005）.CONCLUSION： These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with Hpylori-dependent state of early-stage high-grade gastric M

关键词： MALT lymphoma Hpylori CD86 CD56

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Multiple solutions for weighted nonlinear elliptic system involving critical exponents

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Science China Mathematics 2015年第1期58卷 161-178页

作者： NYAMORADI Nemat hsu Tsing San Department of Mathematics Faculty of Sciences Razi University Department of Natural Sciences in the Center for General Education Chang Gung University

In this paper, by using the idea of category, we investigate how the shape of the graph of h（x） affects the number of positive solutions to the following weighted nonlinear elliptic system： = （ N-2-2a 2. where 0 is a smooth bounded domain in ]1N （N 〉 3）, A, cr 〉 0 are parameters, 0 ≤ μ 〈 μa a 2 ＇ h（x）, KI（X） and K2（x） are positive continuous functions in , 1 〈 q 〈 2, a, β 〉 1 and a ＋ β = 2＊（a,b）（2＊（a, b） 2N = N-2（1＋a-b） is critical Sobolev-Hardy exponent）. We prove that the system has at least k nontrivial nonnegative solutions when the pair of the parameters （）, r） belongs to a certain subset of N2.

关键词： Caffarelli-Kohn-Nirenberg inequality variational method critical Hardy-Sobolev exponent mul-tiple positive solutions

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EXISTENCE OF MULTIPLE poSITIVE SOLUTIONS FOR SEMILINEAR ELLIPTIC SYSTEMS INVOLVING m CRITICAL HARDY-SOBOLEV EXpoNENTS AND m SIGN-CHANGING WEIGHT FUNCTION

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Acta Mathematica Scientia 2014年第2期34卷 483-500页

作者： Nemat NYAMORADI Tsing-San hsu Department of Mathematics Faculty of SciencesRazi University Department of Natural Sciencesin the Center for General Education Chang Gung University

In this article, we consider a class of degenerate quasilinear elliptic problems with weights and nonlinearity involving the critical Hardy-Sobolev exponent and one sign- changing function. The existence and multiplic... 详细信息

关键词： Nontrivial non-negative solutions Nehari manifold critical Hardy-Sobolev ex-ponent

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Detection and interpretation of the Earth's free oscillations excited by the great Sumatra-Andaman earthquake with GGP station data

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Earthquake Science 2011年第2期24卷 151-162页

作者： Houtse hsu Institute of Geodesy and Geophysics Chinese Academy of Sciences

The mode serials of the Earth’s free oscillation provide some important information on the Earth’s deep structure and superconducting gravimeters （SG） can investigate the phenomena of the Earth’s free oscillations with high accuracy. The great Sumatra-Andaman earthquake fully excited the Earth’s free oscillations and these signals were perfectly recorded by five superconducting gravimeters in the globe. After the pre-treatment and spectral analysis on the SG observation data, we obtained the experimented mode serials of the Earth’s free oscillations consisting of 147 modes with GGP station data. These observed modes were themselves some new important data for the study of the Earth’s deep structure. On the basis of the discussions on some checked inner-core-sensitive modes, we distinguished three layers from the inner core, and the boundary of the upper layer was compatible with the formerly known transition zone in the inner core based on seismic body waves and supported that there were the hemispherical variation and very lower shear velocity zone in the lower inner core.

关键词： Sumatra-Andaman earthquake GGP station data Earth’s free oscillation Earth’s inner core core sensitive mode

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Biomaterials and neural regeneration

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Neural Regeneration Research 2020年第7期15卷 1243-1244页

作者： Yi Liu Shan-hui hsu Institute of polymer Science and Engineering National Taiwan UniversityTaiwanChina Institute of Cellular and System Medicine National Health Research InstitutesMiaoliTaiwanChina

Neural regeneration is a great clinical challenge in both the central nervous system(CNS)and the peripheral nervous system(PNS).Degeneration in the CNS caused by disease(such as Alzheimer's or Parkinson's diseases)or trauma(such as traumatic brain injury and spinal cord injury)often results in permanent paralysis and loss of *** spontaneous neural regeneration in the CNS is generally unsuccessful,while the PNS has an intrinsic regenerative ***,PNS regeneration occurs over relatively short *** to the PNS results in the motor and cognitive impairment in many *** in the form of scaffolds or nanoparticles for neuroprotection and neuroregeneration have attracted much *** can be fabricated using various lioids.

关键词： sensation paralysis neural

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Generate basic conceptual solutions for 3DPVS via utilizing TRIZ

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Bio-Design and Manufacturing 2019年第2期2卷 76-95页

作者： Haobo Yuan Ke Xing Hung-Yao hsu School of Engineering University of South AustraliaMawson Lakes BlvdSalisbury 5095Australia

For cell culture scaffold innovation,3DPVS,namely 3D printed vibratory scaffold,was indicated as a future novel product,and it currently stands at conceptual development *** essential part for 3DPVS design is innovation,and TRIZ(algorithm of inventive problem solving)was studied as promising method for generating novel conceptual *** study targets designing and solving 3DPVS problems using TRIZ in the new *** aim to utilize TRIZ to conduct a multi-layer problem-solving process,which is to address design concerns of 3DPVS,especially at super-system to system *** this connection,TRIZ is used to address basic constraints and contradictions inside regarding trinity of 3D printing,3D scaffold and bio-based vibratory *** the study,five basic conceptual solutions for potential 3DPVS,namely magnetic,electric,mechanical,light and thermal based,have been generated.A brief evaluation has also been conducted,where magnetic-based 3DPVS shows the relatively highest applicability as potential *** with traditional experimental-oriented processes for biodesign,the approach of utilizing TRIZ can be inspiring and reinvigorating,which prepares a ground for future 3DPVS design to address detailed sub-system *** study might,to some extent,fill a gap in scaffold design and TRIZ literature and hopefully provide a comprehensive perspective of a timely topic.

关键词： 3DPVS 3D scaffold 3D printing Scaffold innovation Biodesign TRIZ Concept generation

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A Mixed-control Mechanism Model of Proeutectoid Ferrite Growth under Non-equilibrium Interface Condition in Fe-C Alloys

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Journal of Materials Science & Technology 2004年第5期20卷 561-566页

作者： RuihengWU XueyuRUAN HongbingZHANG T.Y.hsu DepartmentofPlasticityTechnology ShanghaiJiaoTongUniversityShanghai200030China Departmentof.MaterialsEngineering ShanghaiInstituteofTechnologyShanghai200233China SchoolofMaterialsScieuceaudEugineering ShanghaiJiaoTougUuiversityShanghai200030China

By combining the α/γ interface migration and the carbon diffusion at the interface in Fe-C alloys, a mathematical model is constructed to describe the mixed-control mechanism for proeutectoid ferrite formation from austenite. In this model, the α/γ interface is treated as non-equilibrium interface, i.e., the carbon concentration of austenite at γ/α interface is obtained through theoretical calculation, instead of that assumed as the local equilibrium concentration. For isothermal precipitation of ferrite in Fe-C alloys, the calculated results show that the rate of interface migration decreases monotonically during the whole process, while the rate of carbon diffusion from γ/α interface into austenite increases to a peak value and then decreases. The process of ferrite growth may be considered as composed of three stages: the period of rapid growth, slow growth and finishing stage. The results also show that the carbon concentration of austenite at γ/α interface could not reach the thermodynamic equilibrium value even at the last stage of ferrite growth.

关键词： Proeutectoid ferrite precipitation Non-equilibrium interface Phase transformation kinetics Mixed-control mechanism

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Living electronics

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Nano Research 2020年第5期13卷 1205-1213页

作者： Yixin Zhang Leo(Huan-hsuan)hsu Xiaocheng Jiang Department of Biomedical Engineering Tufts UniversityMedfordMA 02155USA

Living electronics that converges the unique functioning modality of biological and electrical circuits has the potential to transform both fundamental biophysical/biochemical inquiries and translational biomedical/engineering *** article will review recent progress in overcoming the intrinsic physiochemical and signaling mismatches at biological/electronic interfaces,with specific focus on strategic approaches in forging the functional synergy through:(1)biohybrid electronics,where genetically encoded bio-machineries are hybridized with electronic transducers to facilitate the translation/interpretation of biologically derived signals;and(2)biosynthetic electronics,where biogenic electron pathways are designed and programmed to bridge the gap between internal biological and external electrical *** efforts are reconstructing the way that artificial electronics communicate with living systems,and opening up new possibilities for many cross-disciplinary applications in biosynthesis,sensing,energy transduction,and hybrid information processing.

关键词： bioelectronics signaling biohybrid synthetic biology extracellular electron transfer electrochemically active bacteria

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C-Testable Motion Estimation Design for Video Coding Systems

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Journal of Electronic Science and Technology of China 2009年第4期7卷 370-374页

作者： Chen-Jen Yang chun-Lung hsu the Department of Electrical Engineering National Dong Hwa University

A C-testable motion estimation （CTME） design to efficiently detect the faults in process elements （PEs） is presented. The goal of the CTME design is to offer high reliability for video coding systems. The proposed CTME was carried out by Verilog HDL （very high speed integrated circuit hardware description language） and synthesized with the TSMC （Taiwan Semiconductor Manufacturing Company） 0.18 μm CMOS technology. Logic simulation results show that the proposed CTME guarantees 100% fault coverage with only 8 sets of test patterns. Design verification and comparisons also demonstrate that the area overhead of the proposed CTME is about 4.8% with little delay penalty.

关键词： Area overhead C-testable fault coverage motion estimation (ME).

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A Low Complexity Algorithm for Subcarrier-and-Bit Allocation in OFDMA-Based LTE Systems

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Journal of Electronic Science and Technology 2016年第4期14卷 355-361页

作者： Wei-Chiang Wu Chieh-Yen hsu the Department of Electrical Engineering Da-Yeh University

In this paper, we propose optimum and sub-optimum resource allocation and opportunistic scheduling solutions for orthogonal frequency division multiple access （OFDMA）-based multicellular systems. The applicability, complexity, and performance of the proposed algorithms are analyzed and numerically evaluated. In the initial setup, the fractional frequency reuse （FFR） technique for inter-cell interference cancellation is applied to classify the users into two groups, namely interior and exterior users. Adaptive modulation is then employed according to the channel state information （CSI） of each user to meet the symbol error rate （SER） requirement. There then, we develop subcarrier-and-bit allocation method, which maximizes the total system throughput subject to the constraints that each user has a minimum data rate requirement. The algorithm to achieve the optimum solution requires high computational complexity which hinders it from practicability. Toward this suboptimum method with the reduced to the order of O（NIO, the total number of subcarriers end, we complexity propose a extensively where N and K denote and users, respectively. Numerical results show that the proposed algorithm approaches the optimum solution, yet it enjoys the features of simplicity, dynamic cell configuration, adaptive subearrier-and-bit allocation, and spectral efficiency.

关键词： Adaptive modulation fractional frequency reuse multiuser subcarrier-and-bit allocation,opportunistic scheduling orthogonal frequency division multiple access.

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