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Circular neighbor-balanced designs universally optimal for total effects

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Science China Mathematics 2007年第6期50卷 821-828页

作者： ling-yau chan Department of Industrial and Manufacturing Systems Engineering The University of Hong KongPokfulam RoadHong KongChina

In many experiments, the performance of a subject may be affected by some previous treatments applied to it apart from the current treatment. This motivates the studies of the residual effects of the treatments in a block design. This paper shows that a circular block design neighbor-balanced at distances up toγ≤k - 1, where k is the block size, is universally optimal for total effects under the linear models containing the neighbor effects at distances up toγamong the class of all circular binary block designs. Some combinatorial approaches to constructing these circular block designs neighbor-balanced at distances up to k - 1 are provided.

关键词： block design circular neighbor-balanced total effect universally optimal 62k15 62k05

One-step synthesis of fluorescent smart thermo- responsive copper clusters： A potential nanothermometer in living cells

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Nano Research 2015年第6期8卷 1975-1986页

作者： chan Wang Lin ling Yagang Yao Qijun Song Key Laboratory of Food Colloids and Biotechnology Ministry of Education School of Chemical & Material Engineering Jiangnan University Wuxi 214122 China Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing Tech University Nanjing 210009 China

Temperature measurement in biology and medical diagnostics, along with sensitive temperature probing in living cells, is of great importance; however, it still faces significant challenges. Metal nanoclusters （NCs） with attractive luminescent properties may be promising candidates to overcome such challenges. Here, a novel one-step synthetic method is presented to prepare highly fluorescent copper NCs （CuNCs） in ambient conditions by using glutathione （GSH） as both the reducing agent and the protective layer preventing the aggregation of the as-formed NCs. The resultant CuNCs, with an average diameter of 2.3 nm, contain 1-3 atoms and exhibit red fluorescence （A^m = 610 nm） with high quantum yields （QYs, up to 5.0%）. Interestingly, the fluorescence signal of the CuNCs is reversibly responsive to the environmental temperature in the range of 15-80 ℃. Furthermore, as the CuNCs exhibit good biocompatibility, they can pervade the MC3T3-E1 cells and enable measurements over the physiological temperature range of 15-45 ℃ with the use of the confocal fluorescence imaging method. In view of the facile synthesis method and attractive fluorescence properties, the as-prepared CuNCs may be used as photoluminescence thermometers and biosensors.

关键词： fluorescence copper nanoclusters cellular imaging nanothermometer

Three-Dimensional Model Retrieval Using Dynamic Multi-Descriptor Fusion

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Journal of Electronic Science and Technology 2017年第2期15卷 169-177页

作者： Jau-ling Shih chang-Hsing Lee Yao-Wen Hou po-Ting Yen Department of Computer Science and information Engineering Chung Hua UniversityHsinchu 300 Pegatron Corporation.Taipei 112

In this paper, we propose a dynamic multi-descriptor fusion （DMDF） approach to improving the retrieval accuracy of 3-dimensional （3D） model retrieval systems. First, an independent retrieval list is generated by using each individual descriptor. Second, we propose an automatic relevant/irrelevant models selection （ARMS） approach to selecting the relevant and irrelevant 3D models automatically without any user interaction. A weighted distance, in which the weight associated with each individual descriptor is learnt by using the selected relevant and irrelevant models, is used to measure the similarity between two 3D models. Furthermore, a descriptor-dependent adaptive query point movement （AQPM） approach is employed to update every feature vector. This set of new feature vectors is used to index 3D models in the next search process. Four 3D model databases are used to compare the retrieval accuracy of our proposed DMDF approach with several descriptors as well as some well-known information fusion methods. Experimental results have shown that our proposed DMDF approach provides a promising retrieval result and always yields the best retrieval accuracy.

关键词： Index Terms--Three-dimensional (3D) model retrieval automatic relevant/irrelevant models selection (ARMS) feature re-weighting (FRW) query point movement (QPM).

Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying Xu chan Jin Meng Wu Jian-Ye Zhou Hui-ling Wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

Benefits of Conservation Agriculture on Soil and Water Conservation and Its Progress in China

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Agricultural Sciences in China 2011年第6期10卷 850-859页

作者： LI ling-ling HUANG Gao-bao ZHANG Ren-zhi Bill Bellotti Guangdi Li Kwong Yin chan Gansu Provincial Key Laboratory of Aridland Crop Science/Faculty of Agronomy Gansu Agricultural University Lanzhou 730070 P.R. China Faculty of Resource and Environment Gansu Agricultural University Lanzhou 730070 P.R.China School of Natural Sciences University of Western Sydney NSW 1797 Australia EH Graham Centre for Agricultural Innovation （Alliance Between Investment ＆ Industry NSW and Charles Sturt University） Wagga Wagga Agricultural Institute NSW 2650 Australia Investment ＆ Industry NSW NSW 2753 Australia

Conservation agriculture has been practised for three decades and has been spread widely. There are many nomenclatures surrounding conservation agriculture and differ to each other lightly. Conservation agriculture （CA） is a system approach to soil and water conservation, high crop productivity and profitability, in one word, it is a system approach to sustainable agriculture. Yet, because conservation agriculture is a knowledge-intensive and a complex system to learn and implement, and also because of traditions of intensive cultivation, adoption rates have been low, since to date, only about seven percent of the world＇s arable and permanent cropland area is farmed under conservation agriculture. The practice and wider extention of conservation agriculture thus requires a deeper understanding of its ecological underpinnings in order to manage its various elements for sustainable intensification, where the aim is to conserve soil and water and improve sustainability over the long term. This paper described terms related to conservation agriculture, presented the effects of conservation agriculture on soil and water conservation, crop productivity, progress and adoption of CA worldwide, emphasized obstacles and possible ways to increase CA adoption to accelerate sustainable development of China agriculture.

关键词： China conservation tillage crop residue mulch no-till soil and water conservation sustainability

Mild cognitive impairment in Parkinson’s disease:a distinct clinical entity?

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Translational Neurodegeneration 2017年第1期6卷 225-231页

作者： Ming-Ching Wen ling ling chan Louis C.S.Tan Eng King Tan Department of Research National Neuroscience InstituteSingaporeSingapore Department of Neurology National Neuroscience Institute11 Jalan Tan Tock SengSingapore 308433Singapore Department of Diagnostic Radiology Singapore General HospitalSingaporeSingapore Duke-NUS Medical School SingaporeSingapore

Background:Mild cognitive impairment in Parkinson’s disease(PD-MCI)is a common clinical *** its pathology and clinical features is important for early intervention before the onset of *** the past,variable definitions and differences in neuropsychological batteries generated divergent results of the affected cognitive *** body:The introduction of PD-MCI criteria by the Movement Disorders Society(MDS)Task Force provides a more uniform system for defining and measuring PD-MCI and may improve the validity of future ***-MCI is likely to be heterogeneous since it can coexist with Alzheimer’s disease and/or Lewy body pathologies in *** of neuropsychiatric disturbances,such as depression,anxiety and apathy,are associated with PD with or without *** addition,cognitive reserve formed by patients’unique life experiences may influence the outward cognitive performance despite the presence of the aforementioned pathogeneses and hence alter the diagnosis of ***:The overlap of cognitive impairment across different neurodegenerative diseases suggests that PD-MCI is likely to result from a mixture of complex pathophysiologies,rather than being a distinct pathologic *** MCI from other organic symptoms in PD would facilitate novel therapeutic strategies.

关键词： Mild cognitive impairment Parkinson’s disease Alzheimer disease Lewy body Neuropsychiatric comorbidities Cognitive reserve

Catheter ablation of atrial fibrillation via retrograde aortic approach in a patient with interrupted inferior vena cava:a case report

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Journal of Geriatric Cardiology 2023年第12期20卷 877-879页

作者： Hao-Tien Liu po-Cheng chang Hui-ling Lee Chung-Chuan Chou Division of Cardiology Department of Internal MedicineChang Gung Memorial HospitalTaoyuan BranchTaiwanChina Division of Cardiology Department of Internal MedicineChang Gung Memorial HospitalLinkou BranchTaiwanChina School of Medicine Chang Gung University College of MedicineTaoyuanTaiwanChina Department of Anesthesia Chang Gung Memorial HospitalTaipei BranchTaiwanChina

Radiofrequency catheter ablation(RFCA)is a cornerstone treatment of atrial fibrillation(AF).Transfemoral venous approach with transseptal puncture to assess left atrium(LA)is a mainstream method for AF *** inferior vena cava(IVC)is a rare congenital vascular anomaly which complicates electrophysiologic procedures and makes conventional approach not feasible.

关键词： fibrillation atrial vena

Photocatalytic degradation of organic pollutants using green oil palm frond-derived carbon quantum dots/titanium dioxide as multifunctional photocatalysts under visible light radiation

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Chinese Journal of Chemical Engineering 2022年第11期51卷 21-34页

作者： Zeng Wei Heng Woon chan Chong Yean ling Pang Lan Ching Sim Chai Hoon Koo Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul RahmanSungai Long CampusJalan Sungai LongCheras43000 KajangSelangorMalaysia Centre for Photonics and Advanced Materials Research Universiti Tunku Abdul RahmanSungai Long CampusJalan Sungai LongCheras43000 KajangSelangorMalaysia

The present work suggested the use of waste oil palm frond as an alternative precursor for nitrogendoped carbon quantum dots(NCQDs)and proposed a straightforward in-situ hydrothermal method for the preparation of NCQDs/TiO_(2)*** elemental composition,morphological,structural and optical characteristics of NCQDs/TiO_(2)nanocomposites have been comprehensively *** successful grafting of NCQDs on TiO_(2)matrix was confirmed by the formation of Ti AOAC bond and the electronic coupling between theπ-states of NCQDs and the conduction band of TiO_(2).For the first time,the oil palm frond-derived NCQDs/TiO_(2)was adopted in the photodegradation of methylene blue(MB)under visible-light *** a result,the photocatalytic efficiency of NCQDs/TiO_(2)nanocomposites(86.16%)was 2.85 times higher than its counterpart TiO_(2)(30.18%).The enhanced performance of nanocomposites was attributed to the pivotal roles of NCQDs serving as electron mediator and visiblelight ***,the optimal NCQDs loading was determined at 4 ml while the removal efficiency of NCQDs/TiO_(2)-4 was the highest at a catalyst dosage of 1 g.L^(-1)under alkaline *** research work is important as it proposed a new insight to the preparation of biomass-based NCQDs/TiO_(2)using a facile synthetic method,which offers a green and sustainable water remediation technology.

关键词： Oil palm frond biomass N-doped carbon quantum dots Titanium-dioxide In-situ hydrothermal Visible light photocatalysis Methylene blue

A three-year longitudinal study of the relation between left atrial diameter remodeling and atrial fibrillation ablation outcome

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Journal of Geriatric Cardiology 2018年第7期15卷 496-501页

作者： Hui-ling Lee Yi-Ting Hwang po-Cheng chang Ming-Shien Wen Chung-Chuan Chou Department of Anesthesia Chang Gung Memorial Hospital Taipei Taiwan China Department of Statistics National Taipei University Taipei Taiwan China Division of Cardiology Department of Internal Medicine Chang Gung Memorial Hospital Taipei Taiwan China chang Gung University College of Medicine Taoyuan Taiwan China

Background The long-term prognostic influence of left atrial diameter （LAD） remodeling on the status of post-radiofrequency catheter ablation （RI CA） atrial fibrillation （AF） is unclear. This study employed a two-stage model from 3-year echocardiographic data to ascertain whether the two-stage model predicts RFCA outcome more favorably than models using the baseline LAD. Methods Data were retrospectively collected from 263 consecutive patients with drug-refractory AF undergoing RFCA. Regular echocardiographic measurements of LAD were performed at baseline, 1, 3, 6, and 12 months and then every 6 months after RFCA. Sex, age, type of AF, number of RFCA, and AF status were recorded. We obtain the actual （predicted） 3-year LAD using a longitudinal linear mixed model （1st stage）. Logistic regression models based on the baseline LAD （Model 1）, actual （predicted） 3-year LAD （Model 2）（2nd stage）, and observed 3-year LAD （Model 3） were constructed to predict RFCA outcome. The area under the receiver operating characteristic curve （AUC） were used to assess the performance of models. Results The lowess smoothed curve indicated that the LAD declined over the first three months and remained stable up to 36 months after RFCA. The degree of LAD reduction was significantly influenced by the baseline LAD. Non-paroxysmal AF, large LAD and female gender were significant predictors of AF recurrence. Model 2 had the largest AUC among the three models. Conclusions This longitudinal study-based two-stage model outperforms the original logistic model using the baseline LAD. Non-paroxysmal AF, larger LAD and female gender are significant predictors of RFCA failure.

关键词： Atrial fibrillation Left atrial diameter Longitudinal data Radiofrequency catheter ablation Two-stage model