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Classifying Cardiac Anomalies in Right and Left Isomerism:Concordant and Discordant Patterns

Congenital Heart Disease 2023年第1期18卷 97-111页

作者： Lilia Oreto Giuseppe Mandraffino Paolo Ciliberti Teresa P.Santangelo placido Romeo Antonio Celona placido gitto Lorenzo Galletti Fiore S.Iorio Alfredo Di Pino Aurelio Secinaro Paolo Guccione Robert H.Anderson Salvatore Agati Mediterranean Pediatric Cardiology Center Bambino GesùChildren’s HospitalVia SirinaTaorminaItaly Internal Medicine Unit Department of Clinical and Experimental MedicineUniversity of MessinaMessinaItaly Department of Pediatric Cardiology and Cardiac Surgery Bambino GesùChildren’s HospitalRomaItaly Advanced Cardiovascular Imaging Unit Department of ImagingBambino GesùChildren’s HospitalRomaItaly Radiology Department S.Vincenzo HospitalTaorminaItaly Biosciences Institute Newcastle UniversityNewcastle upon TyneUK

Aims:Evidence is emerging that,in the setting of isomerism,the atrial and bronchial arrangement are not always concordant,nor are these patterns always harmonious with the arrangement of the abdominal *** aimed to evaluate the concordance between these features in a cohort of patients with cardiac malformations in the setting of known isomerism,seeking to determine whether it was feasible to assess complexity on this basis,in this regard taking note of the potential value of bronchial as opposed to appendage *** and Results:We studied 78 patients known to have isomerism of the bronchuses,43 with right and 35 with left *** anatomy could be determined in 49 cases(63%),all but one of these being concordant with bronchial *** assessing abdominal features,in only 59 cases(76%)was splenic morphology in keeping with the thoracic *** expected,right isomerism was associated with greater complexity of cardiac malformations,with an odds ratio of 6.53,with confidence intervals from 2.2–19.3(p<0.001).The odds were slightly decreased with thoraco-abdominal disharmony,when lesions shown to carry higher risk were then found in the setting of left ***:Harmony is excellent between bronchial and appendage isomerism,but less so with the arrangement of the abdominal *** isomerism in our cohort,was indicative of a sixfold increase in intracardiac *** discordance was found between the systems,however,the cardiac anomalies were less typical of the anticipated findings for right *** isomerism of the appendages.

关键词： Isomerism asplenia polysplenia congenital heart disease bronchial isomerism atrial appendages

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Neural Regeneration Research 2013年第17期8卷 1615-1622页

作者： Letteria Spadaro Lilla Bonanno Giuseppe Di Lorenzo placido Bramanti Silvia Marino Istituto di Ricovero e Cura a Carattere Scientifico Centro Neurolesi "Bonino Pulejo" Via Provinciale Palermo

Parkinson＇s disease has a negative impact on health-related quality of life in Parkinson＇s disease patients. Depression, cognitive impairment, coping strategies, dyskinesia, gait disorders and complications of dopaminergic drugs are the variables that most affect health-related quality of life. The ecological model of human development focuses attention on both individual and social environmental factors as targets for health interventions. From this perspective, the aim of this cross-sectional survey was to evaluate the influence of gender, family size and perceived autonomy on health-related quality of life in Parkinson＇s disease patients in nOrtheastern Sicily, Italy. Ninety Parkinson＇s disease patients, attending the Movement Disorders Clinic at IRCCS Centro Neurolesi ＂Bonino-Pulejo＂（Messina）, were consecutively enrolled. The Unified Parkinson Disease Rating Scale motor subscale （UPDRS-Ⅲ） scores, the Parkinson Disease Questionnaire-39 Item scores （as a disease-specific measure of health-related quality of life）, scores on the Short Form （36） Health Survey Questionnaire （as a generic measure）, and answers to a brief checklist were recorded. A total of 85 Parkinson＇s disease patients （49% males and 51% females; mean age 70.8 ± 8.6 years mean UPDRS-Ⅲ 24.15 ± 6.55; mean disease duration 5.52 ± 4.65 years） completed the booklet of questionnaires. In the multivariate regression analysis, we included clinical and social variables as independent predictors of health-related quality of life. Our results suggest a potential compounding effect of ecological intrapersonal and interpersonal levels on health-related quality of life outcomes. Gender, self-evaluated autonomy and family size significantly impacted health-related quality of life. If quality of life is used as an indicator of treatment outcomes, an ecological perspective of the case history will be important to disclose relevant prognostic information and trigger personalized health care interventions.

关键词： neural regeneration neurodegenerative disease health-related quality of life Parkinson's disease ecological model Parkinson's Disease Questionnaire-39 Items social variables the UnifiedParkinson Disease Rating Scale motor subscales caregiver grants-supported paper

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Deficit of pursuit ocular movements in early Alzheimer's disease

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Neural Regeneration Research 2010年第20期5卷 1583-1586页

作者： Francesco Cordici Pietro Lanzafame Silvia Marino Alessandro Celona Lilla Bonanno Annalisa Baglieri Alessia Bramanti placido Bramanti IRCCS Centro Neurolesi "Bonino-Pulejo" S.S. Via Palermo C.da Casazza 98124 Messina Italy

Previous studies have demonstrated that advanced Alzheimer＇s disease（AD）patients have deficiency of eye ***,there have been no reports on eye movement in the early stages of *** aim of this study was to evaluate pursuit ocular movements（POM）provided by a vision-based non-intrusive eye tracker in patients with early *** values were significantly lower in AD patients than in normal controls（P 〈 0.01）.In AD patients,POM values were not closely correlated with the Mini-Mental State Examination scores（P = 0.3）.There was no significant difference in POM values among patients treated with or without anticholinesterase *** used a vision-based method,for non-intrusive eye tracking,which can be proposed as a possible tool for supporting the diagnosis of early AD.

关键词： Alzheimer's disease early diagnosis pursuit ocular movements smooth pursuit dysfunctions vision-based eye tracking system

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Synovial chondromatosis of the foot: Two case reports and literature review

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World Journal of Orthopedics 2019年第11期10卷 404-415页

作者： Luca Monestier Giacomo Riva placido Stissi Mahfuz Latiff Michele Francesco Surace Orthopedic and Trauma Unit ASST Settle LaghiVarese 21100Italy Residency Program in Orthopedics and Trauma University of InsubriaVarese 21100Italy Interdisciplinary Research Centre for Pathology and Surgery of the Musculoskeletal System Department of Biotechnology and Life SciencesUniversity of InsubriaVarese 21100Italy

BACKGROUND Primary synovial chondromatosis(PSC) is a rare arthropathy of the synovial joints characterized by the formation of cartilaginous nodules, which may detach and become loose bodies within the joint and may undergo secondary proliferation. PSC of the foot and ankle is exceedingly rare, with only a few cases reported in the literature. The diagnosis may be difficult and delayed until operative treatment, when it is confirmed by histological assessment. PSC may degenerate into chondrosarcoma. Operative treatment is the gold standard aiming to minimize pain, improve function, prevent or limit progression of arthritis. Surgical treatment consists in debridement by arthrotomic or arthroscopic management, but there is no consensus in the literature about timing of surgery and surgical technique. Thus, the aim of this study is to report the outcomes of the surgical treatment of two cases, together with a literature *** SUMMARY We report two cases of patients affected by PSC of the foot in stage III, according to the Milgram classification: the former PSC localized in the ankle that underwent open surgery consisted of loose bodies removal;the latter in the subtalar joint, and the choice of treatment was the arthrotomy and debridement from loose bodies, in addition to the subtalar arthrodesis. Both patients returned to complete daily and working life after *** Synovial chondromatosis is a rare benign pathology, even rarer in the ankle joint and especially in the foot. Surgery should be minimal in patients with ankle PSC,choosing the correct timing, waiting if possible until stage III. More aggressive and early surgery should be performed in patients with PSC of the foot,particularly the subtalar joint, due to the high risk of arthritic evolution.

关键词： Synovial chondromatosis Foot Ankle Review Treatment Case report

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Arthrospira maxima(Spirulina)prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第7期22卷 603-608页

作者： placido ROJAS-FRANCO Margarita FRANCO-COLÍN Vanessa BLAS-VALDIVIA María Estela MELENDEZ-CAMARGO Edgar CANO-EUROPA Laboratorio de Metabolismo I Departamento de FisiologíaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 07738Mexico Laboratorio de Neurobiología Departamento de FisiologíaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 07738Mexico Laboratorio de Toxicologia Hepática y Renal Departamento de FarmaciaEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 07738Mexico

Arthrospira maxima(Spirulina)is a cyanobacterium which is considered a nutraceutical because it has antioxidant,anti-inflammatory,and cytoprotective properties in different renal disease models(RodriguezSánchez et al... 详细信息

关键词： al. protective reticulum

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Magnetic resonance imaging markers for early diagnosis of Parkinson's disease

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Neural Regeneration Research 2012年第8期7卷 611-619页

作者： Silvia Marino Rosella Ciurleo Giuseppe Di Lorenzo Marina Barresi Simona De Salvo Sabrina Giacoppo Alessia Bramanti Pietro Lanzafame placido Bramanti Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo" Messina 98124 Italy

Parkinson＇s disease （PD） is a neurodegenerative disorder characterized by selective and progressive degeneration, as well as loss of dopaminergic neurons in the substantia nigra. In PD, approximately 60-70% of nigrostriatal neurons are degenerated and 80% of content of the striatal dopamine is reduced before the diagnosis can be established according to widely accepted clinical diagnostic criteria. This condition describes a stage of disease called ＂prodromal＂, where non-motor symptoms, such as olfactory dysfunction, constipation, rapid eye movement behaviour disorder, depression, precede motor sign of PD. Detection of prodromal phase of PD is becoming an important goal for determining the prognosis and choosing a suitable treatment strategy. In this review, we present some non-invasive instrumental approaches that could be useful to identify patients in the prodromal phase of PD or in an early clinical phase, when the first motor symptoms begin to be apparent. Conventional magnetic resonance imaging （MRI） and advanced MRI techniques, such as magnetic resonance spectroscopy imaging, diffusion-weighted and diffusion tensor imaging and functional MRI, are useful to differentiate early PD with initial motor symptoms from atypical parkinsonian disorders, thus, making easier early diagnosis. Functional MRI and diffusion tensor imaging techniques can show abnormalities in the olfactory system in prodromal PD.

关键词： Parkinson’s disease early diagnosis conventional magnetic resonance imaging magnetic resonance spectroscopy diffusion-weighted imaging diffusion tensor imaging functional magnetic resonance imaging olfactory dysfunction

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Three-Dimensional Representation of Geochemical Data from a Multidimensional Compositional Space

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International Journal of Geosciences 2011年第3期2卷 231-239页

作者： Pietro Armienti placido Longo 不详

Systems described by a wide set of variables, like rock compositions, may be often modeled by a reduced set of components, like minerals, that can be represented in diagrams in two or three dimensions. This paper deals with an original algorithm that allows the representation of compositional data in tetrahedral diagrams, provided that they can be recast on the basis of four end members. The algorithm is based on the orthogonal projection of a given point belonging to Rn to the 3D-space through four Rn points representing the compositions of suitable end members. The algorithm is applied to the assessment of mass balance problems (in weight% or molar basis) as well as to the identification of the geochemical imprint revealed by isotope ratios in igneous rock suites. The fields of possible applications are by far wider, encompassing all problems of comprehensive data representation from a multidimensional space to a bi-dimensional plot.

关键词： Principal Component Analysis Phase Diagrams Rendering Geochemistry

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Diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in sporadic Creutzfeldt-Jakob disease:One-case report

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Neural Regeneration Research 2011年第29期6卷 2295-2297页

作者： Rosa Morabito Annalisa Baglieri Rosella Ciurleo Francesco Corallo Rosaria De Luca Simona De Salvo Silvia Guerrera Francesca Timpano Maria Adele Marino placido Bramanti Silvia Marino Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo"MessinaItaly

The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.

关键词： Creutzfeldt-Jacob disease fluid-attenuated inversion recovery diffusion-weighted imaging magnetic resonance imaging

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Challenges of Public Management to Consolidate the Gulf of Morrosquillo as a Competitive Tourism Destination

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Journal of Tourism and Hospitality Management 2017年第6期5卷 215-222页

作者： Hassir Lastre Sierra placido R. Cruz Chavez Universidad Autonoma de Baja California Sur Mexico

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Anxiety,depression,and quality of life in Parkinson's disease:the implications of multidisciplinary treatment

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Neural Regeneration Research 2021年第3期16卷 587-590页

作者： Viviana Lo Buono Rosanna Palmeri Simona De Salvo Matteo Berenati Agata Greco Rosella Ciurleo Chiara Sorbera Vincenzo Cimino Francesco Corallo placido Bramanti Silvia Marino Giuseppe Di Lorenzo Lilla Bonanno Department of Neurobioimaging Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Centro Neurolesi Bonino-PulejoMessinaItaly

Anxiety and depression in Parkinson's disease(PD)reduce well-being of the *** alterations influence motor skills and cognitive performance;moreover,they contribute significantly and independently to worsen rehabilitative treatment *** investigated anxiety,depression,and quality of life in PD patients subjected to multidisciplinary rehabilitative *** self-controlled study included 100 PD patients(49 males and 51 females with the mean age of 64.66 years)admitted to 60 days hospitalization rehabilitative program,between January 2017 and December ***,cognitive,linguistic abilities,and functional independence were evaluated at admission(T0 baseline visit)and 60 days after(T1)the multidisciplinary rehabilitation including motor exercises,speech therapies,and cognitive *** multidisciplinary rehabilitation improved functional status in PD patients and exerted its positive effects on mood,motor abilities,autonomy in the activities of daily life,perception of quality of life,cognitive performance and speech ***-motor symptoms may worsen severe disability and reduce quality of *** are often poorly recognized and inadequately ***,multidisciplinary rehabilitative training represents an optimal strategy to improve disease *** study was approved by Istituito di Ricovero e Cura a Carattere Scientifico(IRCCS)Centro Neurolesi"Bonino-Pulejo"Ethical Committee(approval No.6/2016)in June 2016.

关键词： anxiety depression multidisciplinary rehabilitation Parkinson's disease

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