检索结果-南通市图书馆

世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 3-5页

作者： Pizzichetta M.A. Talamini R. Stanganelli I. 张宪旗 Div. of med. Oncol. C Prev. Oncology Ctro. Riferimento Oncologico Aviano Via Pedemontana Occidentale 12 I 33081 Aviano Italy

Background: Amelanotic malignant melanoma is a subtype of cutaneous melanoma with little or no pigment on visual inspection. It may mimic benign and malignant variants of both melanocytic and nonmelanocytic lesions. Objectives: To evaluate whether dermoscopy is also a useful technique for the diagnosis of amelanotic/hypomelanotic melanoma (AHm) . methods: We conducted a retrospective clinical study of 151 amelanotic/hypomelanotic skin lesions from 151 patients with a m.a. age of 47 years (±17.5 SD). Digitized images of amelanotic/hypomelanotic skin lesions were converted to JPEG format and sent by e mail from the five participating centres. Lesions included 55 amelanotic/hypomelanotic nonmelanocytic lesions (AHNmL), 52 amelanotic/ hypomelanotic benign melanocytic lesions (AHBmL), and 44AHm, 10 (23%)-of which were nonpigmented, truly amelanotic melanomas (Am). The 44 AHm lesions were divided into thin melanomas (Tnm) ≤1 mm (29 cases) and thickmelanomas (Tkm) > 1mm (15 cases), according to the Breslow index. Five clinical features (elevation, ulceration, shape, borders and colour) as well as 10 dermoscopic criteria (pigment network, pigmentation, streaks, dots/globules, blue whitish veil, regression structures, hypopigmentation, leaf like areas, multiple grey bluish globules, central white patch) and eight vascular patterns (com.a. arborizing, hairpin, dotted, linear irregular, dotted and linear irregular vessels, and milky red areas) were evaluated in order to achieve clinical and dermoscopic diagnoses. Statistical analyses were performed with the χ2-test and Fishers exact test, when appropriate. Results: The most frequent and significant clinical features for Tnm.a.d Tkm were asymmetry and ulceration (the latter only for Tkm) com.a.ed with AHBmL. Irregular dots/globules (62%vs. 35%; P ≤0.03), regression structures (48%vs. 27%; P ≤0.03), irregular pigmentation (41%vs. 11%; P ≤0.03) and blue whitish veil (10%vs. 0%; P ≤0.03) were the most relevant dermoscopic criteria for Tnm in com.a.ison with AHBmL. Tkm differed

关键词：黑色素瘤色素性恶性黑素瘤点状血管多形性叶状有显著性差异临床信息白膜图像转换

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

皮肤镜检评估获得性黑色素细胞痣伴过度色素沉着离心性病灶(“Bolognia征”)的形态变化

引用

世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 25-26页

作者： Pizzichetta M.A. massone C. Grandi G. 王琼 Division of medical Oncology C-Preventive Oncology Centro di Riferimento Oncologico Via Pedemontana Occidentale 12 I- 33081 Aviano Italy Dr.

Background: melanocytic nevi with eccentric foci of hyperpigmentation (“ Bolognia sign” ) can be considered as a melanoma-simulating type of acquired melanocytic nevus. We report on the morphologic changes of this type of melanocytic nevus over a 39-month period of dermoscopic follow-up. Observations: A 5-year-old girl had a 4-mm brown papule with a peripheral blue-black area on her right upper arm. The eccentric focus of the hyperpigmentation corresponded dermoscopically to a blue-gray area of pigmentation associated with irregular brown-black globules or dots and partially with a superficial black network. After 39 months, a globular type of acquired melanocytic nevus was detectable, which clinically and dermoscopically appeared to be completely benign. A nearly identical situation was observed in 5 other melanocytic nevi, underlining the involution of the pigmented foci in these nevi. The histopathologic diagnoses of 2 lesions were consistent with a compound type of acquired melanocytic nevus with eccentric foci of hyperpigmentation. Conclusions: Dermoscopy allows identification of a morphologic pathway of modifications, probably typical for this type of melanocytic nevus in children, and therefore enables avoidance of surgical excision with attendant hypertrophic scarring in children. Conversely, in adults, when dermoscopic follow-up of melanocytic nevi reveals eccentric foci of hyperpigmentation, surgical excision of the lesion is indicated.

关键词：黑色素细胞痣过度色素沉着形态变化离心性获得性经皮肤病灶镜检组织病理学诊断随访报道

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cyclophosphamide,fluorouracil and low-dose interleukin-2 and salvage combination chemotherapy in advanced cutaneous squamous cell carcinoma

引用

Journal of Cancer metastasis and Treatment 2020年第1期6卷 168-176页

作者： Giovanni Lo Re Paolo Doretto Francesco Lo Re Fabio matrone Anna Ermacora Wally marus maria Antonietta pizzichetta Sandro Sulfaro medical Oncology and Immune-Related Tumors Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy Clinical Pathology AAS5 PordenonesePN 33170Italy Pharmacology and Clinical Toxicology University of MilanMilanMI 20129Italy Radiotherapy Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy Internal medicine AAS5 PordenonesePN 33170Italy Pathology AAS5 PordenonesePN 33170Italy medical oncology and Cancer prevention Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAvianoPN 33081Italy

A 70-year-old female with metastatic cutaneous squamous cell carcinoma(cSCC)and low-grade non-Hodgkin’s lymphoma,not amenable to cisplatin combination therapy,was treated with cyclophoshamide(Cyc)-fluorouracil(FU)-interleukin-2(IL-2)in light of high tumor immunogenicity and the potential activity of this regimen.Cyc 300 mg/m^(2)and FU 500 mg/m^(2)intravenously on day 1 and IL-24.5 mIU/day on days 3-6 and 17-20 subcutaneously every 4 weeks;Carboplatin(C)AUC 2 and paclitaxel(P)85 mg/m^(2)on days 1,8 and 15±capecitabine(Cape)every 4 weeks.After partial remission(PR)of lung metastases and local control with two cycles of first therapy followed by PR with five cycles of CP±Cape,right mastectomy was performed with evidence of viable tumor.Subsequently,the patient underwent 3 cycles of chlorambucil and is alive after 13 months of follow-up.Safety and activity of chemo-immunotherapy and salvage treatment can be achieved in cSCC.

关键词： Cutaneous squamous cell carcinoma cyclophosphamide fluorouracil interleukin-2 regulatory T cells myeloid-derived suppressor cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：