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中药大黄在临床应用中的功效以及对其药理作用

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基因组学与应用生物学 2017年第3期36卷 1226-1231页

作者：杨炀税丕先陈滟徐航西南医科大学研究生院泸州646000 西南医科大学药学院中药学泸州646000 四川省针灸学校成都610000 西南医科大学附属中医医院心血管内科泸州646000

分析中药大黄在临床应用中的功效和药理作用,为临床治疗提供参考。选取我院在2014年2月~2016年5月大黄临床应用资料和大黄药理实验资料,总结大量临床应用效果和药理作用。我院大黄临床应用治疗疾病包括急性胰腺炎、胃肠功能衰竭、肠梗... 详细信息

分析中药大黄在临床应用中的功效和药理作用,为临床治疗提供参考。选取我院在2014年2月~2016年5月大黄临床应用资料和大黄药理实验资料,总结大量临床应用效果和药理作用。我院大黄临床应用治疗疾病包括急性胰腺炎、胃肠功能衰竭、肠梗阻、肾病、皮肤病等,以急性胰腺炎和胃肠功能衰竭为例分析治疗效果,急性胰腺炎患者206例,连续治疗1周,两组患者血淀粉酶、DAO等均显著下降,观察组血淀粉酶、DAO显著低于对照组(p<0.05)。ICU住院危重症合并胃肠功能衰竭患者50例,分为治疗组30例和对照组20例,治疗组患儿治疗总有效率(83.3%)显著高于对照组(55.0%)(p<0.05),治疗组患儿CRP、乳酸含量显著低于对照组(p<0.05)。大黄药理包括止泻作用、大脑缺血损失保护作用、血管药物作用。大黄临床应用广泛,治疗重症胰腺炎、胃肠功能衰竭等效果明显,具有明显止泻、抗肿瘤、脑保护等效果,具有推广使用价值。

关键词：大黄临床应用药理分析重症胰腺炎

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泸州和安岳枳壳中的低极性化学成分

应用与环境生物学报 2019年第2期25卷 432-437页

作者：罗禹张添植辜晓英税丕先西南医科大学药学院泸州646000 泸州宇龙枳壳枳实研究院泸州646000

为分析比较泸州和安岳两地产枳壳中的低极性成分特别是脂肪酸和挥发油的组成,分别采用有机溶剂提取法和水蒸气蒸馏法提取泸州和安岳枳壳中的低极性成分,运用气质联用技术进行成分分析,所得成分的质谱数据经数据库检索鉴定,并应用面积归... 详细信息

为分析比较泸州和安岳两地产枳壳中的低极性成分特别是脂肪酸和挥发油的组成,分别采用有机溶剂提取法和水蒸气蒸馏法提取泸州和安岳枳壳中的低极性成分,运用气质联用技术进行成分分析,所得成分的质谱数据经数据库检索鉴定,并应用面积归一化法计算各成分的相对含量.结果显示:(1)以石油醚为溶剂提取枳壳浸膏,泸州枳壳鉴定出61种化学成分,安岳枳壳鉴定出18种化学成分,成分以脂肪酸、烷烃为主,两种枳壳中含量最高的成分均为十八碳二烯酸;(2)以水蒸气蒸馏法提取枳壳挥发油,泸州枳壳鉴定出65种化学成分,安岳枳壳鉴定出81种化学成分,以小分子烯、醇、萜类物质为主,两种枳壳中含量最高的成分均为d-柠檬烯.本研究表明不同方法提取出的化学成分种类差异明显;泸州和安岳两地产两种枳壳的脂肪酸组成具有较大的差异;挥发性成分种类相似,其含量组成有一定差异;结果可为四川地区枳壳的开发利用提供数据基础.(表3参20)

关键词：枳壳低极性成分脂肪酸挥发油气相色谱-质谱联用

Study on Extraction of Polysaccharides and Antioxidant Activity of Sagittaria sagittifolia ***

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Agricultural Science & Technology 2017年第4期18卷 724-728,732页

作者：欧丽兰税丕先朱烨张椿西南医科大学药学院四川泸州646000

[Objective] This experiment was conducted to investigate the optimal ex- traction process and antioxidant activity of polysaccharide in Sagittaria sagittifo/ia L. [Method] The effects of extraction temperature, extraction time, extraction times and material-to-liquid ratio on content of polysaccharides in S. sagittifo/ia were investi- gated. On the basis of single-factor tests, an orthogonal test was carried out to de- termine the optimal process parameters. In addition, the in-vitro antioxidant activity of S. sagittifo/ia polysaccharides was evaluated on the basis of determination of their scavenging activities against DPPH and hydroxyl free radicals and reducing power. [Result] The results showed that the optimized process parameters were as follows： material-to-liquid ratio at 1：40 （g/ml）, extraction temperature at 90 ℃, extrac- tion time of 4 h, and extraction times of 3 times. Under this condition, the content of S. sagittifo/ia polysaccharides was 29.32%. For 1 mg/ml S. sagittifo/ia polysaccha- rides, the scavenging ratios of DPPH and hydroxyl free radicals were 70.62% and 35.82%, respectively, and in the determination of reducing power, the absorbance at 700 nm was 0.453 1. [Conclusion] It could be concluded that S. sagittifolia polysac- charides have strong antioxidant capacity to have free radicals scavenged in vitro.

关键词： Sagittaria sagittifolia L. Polysaccharide Antioxidant activity

Extraction and Anti-inflammatory Effects of Colchicine from Sagittaria sagittifolia

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Agricultural Science & Technology 2017年第7期18卷 1208-1212,1216页

作者：欧丽兰朱烨税丕先张椿西南医科大学药学院四川泸州646000

[Objective] This study was to study the optimal extraction technology and anti-inflammatory effects of colchicine from Sagittaria sagittifolia. [Method] The ef- fects of ethanol concentration, extraction time, extraction temperature and solid-liquid ratio on the extraction rate of colchicine from S. sagittifolia were investigated. On the basis of single-factor experiments, an L9 （34） orthogonal test was carried out to optimize the extraction process. According to the optimal extraction process, the content of colchicine in S. sagittifolia was determined by high performance liquid chromatography. The anti-inflammatory ability of colchicine was evaluated through an anti-inflammatory test in vitro. [Result] The optimal extraction process of colchicine from S. sagittifolia was as follows： ethanol concentration of 60%, extraction temper- ature of 50℃, extraction time of 30 min, and solid-liquid ratio of 1：25 （g/ml）. The content of colchicine in S. sagittifolia was determined as 40.58 μg/100 mg. Com- pared with the control, the colchicine from S. sagittifolia （9.0 and 4.5 g/kg） inhibited the increase in PGE2, TNF-α and IL-1β contents in pleural fluid （P〈0.05）. High-dose colchicine inhibited the increase in TNF-α, IL-1β and MDA contents in lung tissue （P〈0.01）, and middle-dose colchicine inhibited the increase in IL-1β content in lung tissue （P〈0.01）. [Conclusion] The colchicine in S. sagittifolia has a good anti-inflam- matory effect, which may be achieved through hindering the production of inflam- matory mediators and antioxidation.

关键词： Sagittaria sagittifolia Colchicine Anti-inflammatory effect

Optimization of Extraction Process of Chlorogenic Acid from Sambucus chinensis Lindl

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Agricultural Biotechnology 2021年第1期10卷 83-86页

作者： Lilan OU pixian shui Ting LI Chun ZHANG College of Pharmacy Southwest Medical UniversityLuzhou 646000China

[Objectives] The chlorogenic acid in Sambucus chinensis Lindl is a kind of biologically active substance with multiple pharmacological effects, but the content is relatively small. It is of great significance to find the best extraction process. Therefore, we designed single factor experiments and orthogonal experiments to screen the best conditions for extracting chlorogenic acid from S. chinensis. [Methods] With ethanol concentration, ultrasonic power, and extraction time as three single factors, single factor experiments were performed on S. chinensis, and its chlorogenic acid content was calculated from a standard curve. The contents of chlorogenic acid obtained under various conditions were compared, and then, orthogonal experiments were designed according to the orthogonal table to analyze the optimal extraction conditions of chlorogenic acid. [Results] The optimal extraction conditions of chlorogenic acid for S. chinensis were: the ethanol concentration 60%, the ultrasonic power 36 W, and the extraction time 40 min.[Conclusions] The factor that had the greatest effect on the extraction rate of chlorogenic acid in S. chinensis was ethanol concentration, followed by extraction time, and the least influencing factor was ultrasonic power. With 60% ethanol solution serving as the extractant, the ultrasonic power of 36 W, and the extraction time of 40 min, a better extraction rate was obtained. These conditions can be used as the best extraction conditions for chlorogenic acid.

关键词： Chlorogenic acid Ultrasonic extraction Single factor Orthogonal experiment Ultraviolet spectrophotometry

Production of Sagittaria sagittifolia Beverage and Technological Condition Optimization

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Medicinal Plant 2017年第3期8卷 47-50页

作者： Lilan OU Ye ZHU Xin YU Chun ZHANG pixian shui School of Pharmacy Southwest Medical University

[Objectives] To develop a kind of antioxidant health drink which could also regulate blood sugar.[Methods]With Sagittaria sagittifolia,hawthorn and liquorice as raw materials,the orthogonal test was done to determine the optimum preparation ratio of each raw material,optimum flavor modulation ratio and optimum stabilizer type and amount.[Results]Under the conditions of 0. 4% crude polysaccharide powder amount of Sagittaria sagittifolia,10. 0 m L hawthorn extract,2. 5 m L liquorice extract,7. 0% white sugar amount,0. 5% citric acid amount,0. 2% cyclodextrine amount,0. 05 g/L sodium alginate amount,0. 5 g/L xanthan gum amount,2. 0 g/L agar amount and 20 MPa homogenization,the beverage had optimum flavor and stability.[Conclusions]The health drink obtained under these technological conditions had delicate sweet taste and rich nutrition.

关键词： Sagittaria sagittifolia Hawthorn Liquorice Health drink

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赶黄草药材质量标准提升研究

中国民族民间医药 2018年第3期27卷 33-35页

作者：牛曼思税璘李婷欧丽兰税丕先西南医科大学药学院生药教研室四川泸州646000 重庆医科大学附属第一医院肿瘤科重庆400016

目的:对赶黄草质量标准进行升级研究。方法:采用理化鉴别方法对赶黄草的水分、灰分、浸出物、薄层等进行鉴别与测定。结果:水分不得过13.0%,总灰分不得过9.0%,酸不溶性灰分不得过1.5%,醇溶性浸出物(稀乙醇、热浸)不得少于20.0%。结论:... 详细信息

目的:对赶黄草质量标准进行升级研究。方法:采用理化鉴别方法对赶黄草的水分、灰分、浸出物、薄层等进行鉴别与测定。结果:水分不得过13.0%,总灰分不得过9.0%,酸不溶性灰分不得过1.5%,醇溶性浸出物(稀乙醇、热浸)不得少于20.0%。结论:本研究提升了赶黄草的质量标准。

关键词：赶黄草质量标准升级

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金钗石斛微粉细胞破壁率及其石斛碱含量测定

泸州医学院学报 2015年第1期38卷 11-14页

作者：罗颖税丕先傅秀娟宁海燕孙琴泸州医学院药学院四川泸州646000 成都中医药大学

目的:测定金钗石斛超细微粉细胞破壁率及超细粉碎前后石斛碱含量。方法:采用细胞计数法,以薄壁细胞为评价指标,测定金钗石斛微粉的细胞破壁率,并用气相色谱法测定超细粉碎前后细粉与微粉石斛碱的含量。结果:金钗石斛细粉称样量与完整薄... 详细信息

目的:测定金钗石斛超细微粉细胞破壁率及超细粉碎前后石斛碱含量。方法:采用细胞计数法,以薄壁细胞为评价指标,测定金钗石斛微粉的细胞破壁率,并用气相色谱法测定超细粉碎前后细粉与微粉石斛碱的含量。结果:金钗石斛细粉称样量与完整薄壁细胞计数的回归分析结果表明,两者呈现显著相关,金钗石斛经超细粉碎后细胞破壁率为100%。利用气相色谱法测定金钗石斛超细粉碎前后细粉与微粉石斛碱含量分别为0.42%、0.35%。结论:此方法简单快速、准确可靠,可准确地进行金钗石斛微粉细胞破壁率及石斛碱的定量测定。

关键词：金钗石斛微粉细胞计数法石斛碱气相色谱法

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正交试验法优选复方金钗石斛保健酒渗漉工艺

中国酿造 2019年第9期38卷 182-184页

作者：李薪宇牛曼思杨阳童钰琴杨雪琴王松涛税丕先西南医科大学药学院四川泸州646000 泸州品创科技有限公司四川泸州646000

该试验以金钗石斛、人参、蒙古黄芪、五味子、茯苓为原料制作保健酒,以总黄酮含量、石斛碱含量、浸膏得率和感官评分的综合评价为考察指标,通过单因素及正交试验筛选复方金钗石斛保健酒的最佳渗漉工艺。结果表明,复方金钗石斛保健酒最... 详细信息

该试验以金钗石斛、人参、蒙古黄芪、五味子、茯苓为原料制作保健酒,以总黄酮含量、石斛碱含量、浸膏得率和感官评分的综合评价为考察指标,通过单因素及正交试验筛选复方金钗石斛保健酒的最佳渗漉工艺。结果表明,复方金钗石斛保健酒最佳渗漉工艺为加入9倍52%vol白酒浸润18h,以5mL/(min·kg)流速渗漉。在此优化条件下,渗漉液石斛碱含量、总黄酮含量、浸膏得率及感官评分别为183.37mg/L、219.74mg/L、24.81%、75分。该方法可作为复方金钗石斛保健酒的提取工艺。

关键词：金钗石斛保健酒渗漉工艺工艺优化