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Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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基于生物复合材料的双曲面分段式壳体展馆

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风景园林 2019年第8期26卷 60-64页

作者：汉娜·达希[埃及] 简·彼得斯[捷克] 皮奥特·巴辛斯基[波兰] 米夏拉·梅[斯洛伐克] ZHANG Zhiqing(Translator) QIAN Leixi(Proofreader) 斯图加特大学建筑结构与结构设计研究所生物基材料与建筑材料循环系斯图加特大学生物基材料与建筑材料循环系不详

生物复合材料由于成本低、可再生和对环境友好的特性,在建筑中获得了新颖又广泛的应用。通过一对一的双曲面、参数化设计形成的分段式壳体,来展示生物材料在承重结构中的应用。这种结构由轻质的单向弯曲木和生物复合材料组成,其中,木质... 详细信息

生物复合材料由于成本低、可再生和对环境友好的特性,在建筑中获得了新颖又广泛的应用。通过一对一的双曲面、参数化设计形成的分段式壳体,来展示生物材料在承重结构中的应用。这种结构由轻质的单向弯曲木和生物复合材料组成,其中,木质纤维基核心由长木纤维以单板形式加固。进一步探讨了高3.6m,面积55m^2的展馆的建造技术以及生物复合材料应用的可能性。

关键词：生物复合材料天然纤维复合材料分段式壳体多功能性可持续性设计木质纤维素复合材料可持续性建筑

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莱赫·卡钦斯基

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新世纪周刊 2010年第16期 102-102页

作者：彼得·马切伊·卡钦斯基（piotr Maciej Kaczyn ski）欧洲政策研究中心

2010年4月10日是波兰人的“黑色星期六”。在这个充满悲情色彩的上午，波兰总统莱赫·卡钦斯基、总统夫人玛利亚及其他94名乘客，在俄罗斯斯摩棱斯克附近遭遇空难。他们此行的目的地是卡廷，70年前，前苏联的秘密警察机构“内务人民委... 详细信息

2010年4月10日是波兰人的“黑色星期六”。在这个充满悲情色彩的上午，波兰总统莱赫·卡钦斯基、总统夫人玛利亚及其他94名乘客，在俄罗斯斯摩棱斯克附近遭遇空难。他们此行的目的地是卡廷，70年前，前苏联的秘密警察机构“内务人民委员部”在那里屠杀了超过2万名波兰知识分子。

关键词：总统夫人 2010年知识分子警察机构波兰玛利亚俄罗斯目的地

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The enhanced X-ray Timing and Polarimetry mission—eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacials de Catalunya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Dello Spazio di Bologna Istituto Nazionale di Astofisica Astronomical Institute Czech Academy of Sciences Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1 CEA Paris-Saclay/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key Laboratory of Advanced Material Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degli Studi di Udine Via delle Scienze 206 Mullard Space Science Laboratory University College London Department of Nuclear and Particle Physics University of Geneva SRON Netherlands Institute for Space Research Politecnico di Milano Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessler Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave *** paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray polarimetry X-ray timing space mission:eXTP

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心血管造影和介入学会／血管内科学会（SCAI／SVM）颈动脉支架置入术培训及资格认证专家共识声明

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国际脑血管病杂志 2017年第5期25卷 385-395页

作者： Herbert D. Aronow Tyrone J. Collins William A. Gray Michael R. Jaff Bryan W. Kluck Rajah A. G. Patel Kenneth A. Rosenfield Robert D. Safian piotr S. Sobieszczyk Siddharth A. Wayangankar Christopher J. White 胡挺段振晖马敏敏 From the Cardiovascular Institute of RI Alpert Medical School of Brown University Providence Rhode Island Ochsner Medical Center New Orleans Los Angeles Columbia University Medical Center New York New York Massachusetts General Hospital Boston Massachusetts Lehigh Valley Hospital Allentown Penniosylvania Beaumont Health Royal Oak Michigan Brigham and Women's Hospital Boston Massachusetts Cleveland Clinic Cleveland Ohio 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002

颈动脉支架置入术（carotid artery stcnting，CAS）已成为心血管内科项目针对卒中预防提供的治疗方案中不可或缺的一部分。该专家共识声明的目的在于为这些项目提供医师培训和资格认证方面的指导，从而促进CAS安全有效地融入临床实践... 详细信息

颈动脉支架置入术（carotid artery stcnting，CAS）已成为心血管内科项目针对卒中预防提供的治疗方案中不可或缺的一部分。该专家共识声明的目的在于为这些项目提供医师培训和资格认证方面的指导，从而促进CAS安全有效地融入临床实践。自从2005年《颈动脉支架置入术临床能力声明》发表以来，介入器械出现了大量创新，众多临床试验和观察性研究发表，积累了丰富的真实世界临床经验，而且有健全的国家质量改进计划的广泛参与。总的来说，这些进展已导致在患者合理选择以及安全有效实施CAS所需的认知、技术和临床技能方面发生了实质性变化。因此，我们总结出版了这份指南，旨在介绍培训路径，概述能力要素，提供转归随访策略，明确设施、设备和人员要求，并提出维持CAS能力的标准。

关键词：颈动脉狭窄颈动脉支架专家共识文件卒中

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