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Alpha-synuclein preformed fibrils:a tool to understand Parkinson’s disease and develop disease modifying therapy

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Neural Regeneration Research 2021年第11期16卷 2219-2221页

作者： piotr Chmielarz Andrii Domanskyi Institute of Biotechnology HiLIFEUniversity of HelsinkiFinland Maj Institute of Pharmacology Polish Academy of SciencesDepartment of Brain BiochemistryKrakówPoland Orion Corporation Orion Pharma TurkuFinland

Parkinson’s disease(PD)is the second most common neurodegenerative disorder characterized by multiple motor and nonmotor symptoms,which include,among others,constipation,sleep disturbance,bradykinesia,gait and balance abnormalities,muscle stiffness and resting *** motor symptoms are caused by progressive age-related death of dopaminergic neurons and in the vast majority of patients suffering from age-related idiopathic PD the cause of dopaminergic neurodegeneration is *** in the familial early-onset PD where genetic mutations have been identified,the molecular mechanisms driving degeneration of dopaminergic neurons are far from ***,there is no clinically approved disease-modifying therapy capable of stopping or at least slowing down the disease progression.

关键词： degeneration Alpha driving

ON THE DISCRETE MAXIMUM PRINCIPLE FOR THE LOCAL PROJECTION SCHEME WITH SHOCK CAPTURING

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Journal of Computational Mathematics 2017年第5期35卷 547-568页

作者： piotr Skrzypacz Dongming Wei Nazarbayev University School of Science and Technology 53 Kabanbay Batyr Ave. Astana 010000 Kazakhstan

It is a well known fact that finite element solutions of convection dominated problems can exhibit spurious oscillations in the vicinity of boundary layers. One way to overcome this numerical instability is to use schemes that satisfy the discrete maximum principle. There are monotone methods for piecewise linear elements on simplices based on the up- wind techniques or artificial diffusion. In order to satisfy the discrete maximum principle for the local projection scheme, we add an edge oriented shock capturing term to the bilinear form. The analysis of the proposed stabilisation method is complemented with numerical examples in 2D.

关键词： Local projection stabilization Discrete maximum principle Shock capturing

Effect of Jet Vortex Generators on Shock Wave Induced Separation on Gas Turbine Profile

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Journal of Thermal Science 2021年第4期30卷 1435-1443页

作者： FLASZYNSKI Pawel DOERFFER piotr piotrOWICZ Michal Szewalski Institute of Fluid-Flow Machinery Polish Academy of SciencesFiszera 14PL 80-231GdanskPoland

The interaction between a shock wave and a boundary layer on a suction side of gas turbine profile,namely Transition Location Effect on Shock Wave Boundary Layer Interaction,was one of main objectives of TFAST project.A generic test section in a transonic wind tunnel was designed to carry out such *** design criteria were to reproduce flow conditions on the profile in wind tunnel as the one existing on the suction side of the turbine guide *** this paper,the effect of film cooling and jet vortex generators on the shock wave boundary layer interaction and shock induced separation is *** results for Explicit Algebraic Reynolds Stress Model with transition modeling are compared with experimental data.

关键词： shock wave gas turbine flow control jet vortex generators

Review and evaluation of cold recycling with bitumen emulsion and cement for rehabilitation of old pavements

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第4期6卷 311-323页

作者： Bohdan Dolzycki piotr Jaskula Department of Highway and Transportation Engineering Gdansk University of Technology

The article presents Polish experience with cold recycling of asphalt pavements with the usage of bituminous emulsion and cement. In the 1990 s numerous roads in Poland required immediate reinforcement due to their significant degradation. Implementation of the cold recycling technology was one of the solutions to this problem. Cold recycled mixtures contain e beside the recycled asphalt pavement and aggregate e two different types of binding agents: bituminous emulsion and Portland cement. First Polish requirements were developed in the 1990 s and were based on the Marshall test. After several years of application of these requirements, numerous transverse cracks appeared on the pavements. Field investigation showed that the frequency of transverse cracking was not uniform on all evaluated sections and that the growth rate of the number of cracks was decreasing. The main reason of extensive cracking was the overly high amount of the Portland cement and insufficient amount of the bituminous emulsion. This led to production of very stiff mixtures, with dominance of hydraulic bonds, which behaved similarly to cement-treated mixtures. The idea of flexible cold recycled base course was not utilized. This experience motivated the Polish Road Administration to develop new requirements. Second part of the article presents the new requirements for cold *** test methods as well as requirements concerning resistance to frost and water action were introduced in 2013. Implementing of the new requirements resulted in significant reduction in stiffness of the MCE mixtures. Values of stiffness modulus are even three times lower, which should significantly decrease the amount of potential reflective cracks on the pavement surface. Presently two types of technology of cold recycling are used in Poland, in-place and in-plant.

关键词： Cold recycling Mineral-cement-emulsion mixtures(MCE) Reflecting cracks Stiffness modulus Road reconstruction Fatigue life of pavement structures

Streamwise vortex generation by the rod

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Chinese Journal of Aeronautics 2019年第8期32卷 1903-1911页

作者： Ryszard SZWABA Pawel FLASZYNSKI piotr DOERFFER Department of Experimental Aerodynamics Institute of Fluid Flow Machinery Polish Academy of Sciences

The technology development related to aerodynamics is leading to ever increasing loads of wings, airfoils and turbine and compressor blades. The increase in aerodynamic forces is often leading to flow separation and depreciation of the aerodynamic performance of flying objects or propulsion systems. Flow control methods are required to avoid these negative effects. In the recent two decades the flow control by means of air-jet vortex generators has been also intensively investigated. In this method a streamwise vortex is introduced by an oblique jet. The necessity to supply air by a pipe system may be considered a disadvantage. In order to eliminate this feature, it has been proposed to put out a rod instead of a jet. It has been shown that the application of a rod can introduce the same effect as a jet, as long as the streamwise vortex generation is concerned and appropriate dimensions are used. The present paper focuses on the influence of rod vortex generators on a flow pattern downstream. The results presented here concern experimental and numerical investigations and provide guidelines for the design of a new flow control method dedicated mainly to external flows.

关键词： Air-jet vortex generator Boundary layer Flow control Rod vortex generator Streamwise vortices

Conductivity improvement of Ce_(0.8)Gd_(0.2)O_(1.9) solid electrolyte

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Journal of Rare Earths 2009年第4期27卷 655-660页

作者： Sebastian Molin Maria Gazda piotr Jasinski Faculty of Electronics Telecommunications and Informatics Gdansk University of Technology ul.Narutowicza 11/12 80-952 Gdansk Poland Faculty of Applied Physics and Mathematics Gdansk University of Technology ul.Narutowicza 11/12 80-952 Gdansk Poland

Solid oxide fuel cells based on doped cefia electrolytes offer operating temperatures of -600℃. During recent years much atten- tion was aimed at successful powder preparation with high sinter activity and high conductivity. The properties of ceria electrolyte are very sensitive to impurities introduced during powder and electrolyte fabrication. One of the most successful and commercially available processes for the production of clean powders is based on the addition of several percent metallic cations that will react with impurities and segregate into the triple points of grain boundaries. In this work the results obtained from doping of CGO20 by 2% Ca and prepared by different routes were presented. The way of introducing Ca seemed to play an important role.

关键词： rare earth solid elecllolyte electrical properties impedance spectroscopy fuel cell solid oxide fuel cells (SOFC)

Subinguinal microsurgical varicocelectomy is safe and effective in a solitary testicle

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Asian Journal of Andrology 2020年第1期22卷 120-121页

作者： piotr Dobronski Karolina Dobronska Lukasz Kupis piotr Radziszewski Department of Urology Medical University of WarsawWarsaw 02-005Poland First Department of Anesthesiology and Intensive Care Medical University of WarsawWarsaw 02-005Poland

Dear Editor,Varicocele is a common cause of male infertility,but in the course of a diagnostic infertility workup,other underlying problems are often *** to two-thirds of patients with nonidiopathic male infertility h... 详细信息

关键词： infertility patients surgical

Analytical and numerical method assessing the risk of sinkholes formation in mining areas

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International Journal of Mining Science and Technology 2015年第1期25卷 85-89页

作者： piotr Strzalkowski Krzysztof Tomiczek Faculty of Mining and Geology Silesian University of Technology

Voids, which have not been liquidated and associated with shallow mining excavations, pose a serious threat of potential formation of sinkholes. This threat is connected with the loss of stability of voids that had been formed as a result of mining operations in the deeper strata. Taking into account the impact of lower coal seams mining on shallow excavations and based on the example of a region that had been intensely exploited, this paper proposes a methodology for analysing the stability of shallow mine voids in the rock mass. Deformations in the excavation region were calculated by using FLAC2 D computer program and assigning the Coulomb–Mohr model to the rock mass. Based on the numerical analysis, this paper evaluated the stability of the void in the event of a roof support fall. The results indicate the likelihood of void formation. Based on the Budryk–Knothe theory, the deformations of rock mass and sandstone strata in the roof of the void, which had been caused by mining exploitation in consecutive years,were calculated. The results of numerical calculations and analyses were compared with the limit deformations values of sandstone in tension. It is concluded that the exploitations cause the void to break down. The proposed method can forecast the discontinuous deformations threats in the areas that have undergone shallow undermining exploitation and the areas of underground urban.

关键词：落水洞数值方法评估不连续变形风险矿区煤层开采砂岩地层

Shock Wave Smearing by Passive Control

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Journal of Thermal Science 2006年第1期15卷 43-47,42页

作者： piotr DOERFFER Oskar SZULC Rainer BOHNING IMP PAN Fiszera 14 PL-80 952 Gdansk Poland ISL Universitat Karlsruhe Karlsruhe Germany

正常冲击波，在一个机翼上终止一个本地超声的区域，限制它的表演并且成为来源高加速冲动的噪音。使用被动控制瓦解被建议冲击波。这个方法获得的流动结构的细节数字地被学习。一个新边界条件被开发了，它的应用程序的结果在嘴流动对实... 详细信息

正常冲击波，在一个机翼上终止一个本地超声的区域，限制它的表演并且成为来源高加速冲动的噪音。使用被动控制瓦解被建议冲击波。这个方法获得的流动结构的细节数字地被学习。一个新边界条件被开发了，它的应用程序的结果在嘴流动对实验被验证。崩溃被证实了并且详细说明流动细节的分析的冲击波的方法被介绍。由渐渐的压缩的一个冲击波的替换完全改变高速度的来源它的减小的冲动的噪音和熊潜力。关键词接近音速的流动 - 冲击波边界层相互作用 - 被动控制 CLC 数字 O357.

关键词：跨音速流振波边界层交互作用被动控制机翼