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Epstein-Barr virus is associated with gastric carcinoma: The question is what is the significance?

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World Journal of Gastroenterology 2008年第27期14卷 4347-4351页

作者： Hugo Sousa Ana L pinto-correia Rui Medeiros Mario Dinis-Ribeiro Molecular Oncology Group and Molecular Virology Laboratory Portuguese Institute of Oncology of Porto Gastroenterology Department Portuguese Institute of Oncology of Porto

AIM: To examine the possible role of the Epstein- Barr Virus (EBV) in the development of gastric adenocarcinoma (GC). It is unclear whether EBV is involved in GC development or is a consequence of gastric inflammation secondary to immunosuppressive treatments. METHODS: A systematic review was carried out of all published observational studies on the temporal association between EBV and GC, with a view to determine a causal relationship. RESULTS: The present study showed that the worldwide crude prevalence of EBV in gastric adenocarcinoma was 8.29%. The prevalence varied from 7.08% for intestinal type and 9.82% for diffuse type of GC. It was observed that Western and Central Asian countries had a significantly higher frequency of EBV positive cases compared to South-Eastern countries. America had the highest EBV-GC prevalence whereas Europe had the lowest. CONCLUSION: The present review has demonstrated a high prevalence of EBV in gastric adenocarcinoma. However, studies designed to assess a temporal relationship and histological association using sensitive techniques should be carried out to establish the role of EBV in GC carcinogenesis.

关键词： Epstein-Barr virus infection Gastric carcinoma Systematic review

Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants

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World Journal of Gastroenterology 2006年第31期12卷 5033-5036页

作者： Ana L pinto-correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro Molecular Oncology GroupPortuguese Institute of Oncology of Porto Portugal Oncology DepartmentPortuguese Institute of Oncology of Porto Portugal Gastroenterology DepartmentPortuguese Institute of Oncology of Porto Portugal and ICBAS Abel Salazar Institute for the Biomedical SciencesPortoPortugal and CINTESIS/Faculty of Medicine University of Porto PortoPortugal

AIM： To study the role of an insertion/deletion polymorphism in the pepsinogen C （PGC） gene, an effective marker for terminal differentiation of the stomach mucosa, in the susceptibility to the development of gastric lesions. METHODS： The study was performed with 99 samples of known gastric lesions and 127 samples without evidence of neoplastic disease. PCR was employed and the 6 polymorphic alleles were amplified： Allele 1 （510 bp）, Allele 2 （480 bp）, Allele 3/4 （450/460 bp）, Allele 5 （400 bp） and Allele 6 （310 bp）. RESULTS： Our results revealed that Allele 6 carriers seemed to have protection against the development of any gastric lesion （OR = 0.34; P 〈 0.001）, non-dysplastic lesions associated with gastric adenocarcinoma such as atrophy or intestinal metaplasia （OR = 0.28; P 〈 0.001） or invasive GC （OR = 0.39; P = 0.004）. CONCLUSION： Our study reveals that the Allele 6 carrier status has a protective role in the development of gastric lesions, probably due to its association with higher expression of PGC. Moreover, the frequency of Allele 6 carriers in the control group is far higher than that obtained in Asian populations, which might represent a genetic gap between Caucasian and Asian populations.

关键词： Gastric adenocarcinoma Pepsinogen C Polymorphism

Association between EGF +61A/G polymorphism and gastric cancer in Caucasians

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World Journal of Gastroenterology 2011年第4期17卷 488-492页

作者： Ana Paula Araújo Bruno M Costa Ana L pinto-correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros Molecular Oncology Group Portuguese Institute of Oncology of Porto Life and Health Sciences Research Institute (ICVS) School of Health Sciences Oncology Department Portuguese Institute of Oncology of Porto Gastroenterology Department Portuguese Institute of Oncology of Porto Portugal Cintesis/Faculty of Medicine University of Porto Centro de Estudos em Biomedicina Health Sciences Faculty-Fernando Pessoa University Instituto de Ciencias Biomédicas de Abel Salazar Abel Salazar Institute for the Biomedical Sciences

AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.

关键词： Epidermal growth factor polymorphism Epidermal growth factor receptor Gastric cancer

Endoscopic papillary balloon dilation after sphincterotomy for difficult choledocholithiasis:A case-controlled study

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World Journal of Gastrointestinal Endoscopy 2013年第5期5卷 211-218页

作者： Bruno Rosa Pedro Moutinho Ribeiro Ana Rebelo António pinto correia José Cotter Department of Gastroenterology Alto Ave Hospital Center4835-044 Guimar esPortugal

AIM:To evaluate the efficacy and safety of endoscopic sphincterotomy(EST) + endoscopic papillary large balloon dilation(EPLBD)vs isolated ***:We conducted a retrospective single center study over two years,from February 2010 to January *** with large(≥ 10 mm),single or multiple bile duct stones(BDS),submitted to endoscopic retrograde cholangio-pancreatography(ERCP) were *** in Group A underwent papillary large balloon dilation after limited sphincterotomy(EST+EPLBD),using a through-the-scope balloon catheter gradually inflated to 12-18 mm according to the size of the largest stone and the maximal diameter of the distal bile duct on the *** in Group B(control group) underwent isolated *** were removed using a retrieval balloon catheter and/or a dormia *** necessary,mechanical lithotripsy was *** clearance of the bile duct was documented with a balloon catheter cholangiogram at the end of the *** case of residual lithiasis,a double pigtail plastic stent was placed and a second ERCP was planned within 4-6 *** patients were sent for extracorporeal lithotripsy prior to subsequent *** of EST+EPLBD(Group A) vs isolated EST(Group B) were compared regarding efficacy(complete stone clearance,number of therapeutic sessions,mechanical and/or extracorporeal lithotripsy,biliary stent placement) and safety(frequency,type and grade of complications).Statistical analysis was performed using χ 2 or Fisher’s exact tests for the analysis of categorical parameters and Student’s t test for continuous variables.A P-value of less than 0.05 was considered statistically ***:One hundred and eleven patients were included,68(61.3%) in Group A and 43(38.7%) in Group *** mean diameter of the stones was similar in the two groups(16.8 ± 4.4 and 16.0 ± 6.7 in Groups A and B,respectively).Forty-eight(70.6%) patients in Group A and 21(48.8%) in Group B had multiple BDS(P

关键词： Endoscopic papillary large balloon dilation Bile duct stones Endoscopic sphincterotomy Choledocholithiasis

Integrated CO_(2)capture and reduction catalysis:Role ofγ-Al_(2)O_(3)support,unique state of potassium and synergy with copper

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Journal of Environmental Sciences 2024年第6期140卷 113-122页

作者： Donato pinto Stefano Minorello Zhouping Zhou Atsushi Urakawa Catalysis Engineering Department of Chemical EngineeringDelft University of TechnologyDelft2629HZNetherlands

Carbon dioxide capture and reduction(CCR)process emerges as an efficient catalytic strategy for CO_(2)capture and conversion to valuable chemicals.K-promoted Cu/Al_(2)O_(3)catalysts exhibited promising CO_(2)capture efficiency and highly selective conversion to syngas(CO+H_(2)).The dynamic nature of the Cu-K system at reaction conditions complicates the identification of the catalytically active phase and surface *** present work aims at more precise understanding of the roles of the potassium and copper and the contribution of the metal oxide ***γ-Al_(2)O_(3)guarantees high dispersion and destabilisation of the potassium phase,potassium and copper act synergistically to remove CO_(2)from diluted streams and promote fast regeneration of the active phase for CO_(2)capture releasing CO while passing H_(2).A temperature of 350℃is found necessary to activate H_(2)dissociation and generate the active sites for CO_(2)*** effects of synthesis parameters on the CCR activity are also described by combination of ex-situ characterisation of the materials and catalytic testing.

关键词： Carbon dioxide Carbon capture and utilisation CO_(2)capture and reduction Solid CO_(2)sorbents Heterogeneous catalysis Potassium Copper catalysts Aluminium oxide

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A comprehensive analysis of future solar energy potential variations using a CMIP6 multi-model ensemble approach in Colombia

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Clean Energy 2024年第4期8卷 79-89页

作者： Heli AArregocés Roberto Rojano Daiver pinto Pimienta Grupo de Investigación GISA Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia Grupo Procesos Fisicoquímicos Aplicados Facultad de IngenieríaUniversidad de Antioquia SIU/UdeACalle 70 No.52–21MedellínColombia Grupo Desarrollo de Estudios y Tecnologías Ambientales del Carbono(DESTACAR) Facultad de IngenieríaUniversidad de La GuajiraRiohachaColombia

Climate change is predicted to significantly impact solar energy generation,which is particularly concerning given that photovoltaic(PV)energy is critical to the global transition to clean energy in underdeveloped *** study analyses the PV potential variations in Colombia using a Coupled Model Intercomparison Project Phase 6(CMIP6)multi-model ensemble approach under two shared socio-economic pathway scenarios for the near(2025-50)and far(2051-2100)*** the near-future period,the Pacific,Andean and Orinoquía regions are expected to experience a decrease in PV potential ranging from 10%to 23%for all shared socio-economic *** will be particularly noticeable during the March/April/May and June/July/August *** the other hand,CMIP6 estimations indicate a 1-4%increase in PV potential across the Amazon region during the June/July/August and September/October/November *** the far future,it has been projected that the Pacific,Andean and Orinoquía regions may experience a significant decline in solar power generation due to increased cloud cover and reduced *** decrease in PV potential during the June/July/August season could range from 8%to 27%for all considered scenarios,with the Pacific region being the most *** Pacific region is projected to experience a decrease ranging from 10%to 35%for all *** is worth noting that there are noticeable differences in PV potential across various regions,which can result in changes in cloud cover and atmospheric ***,the study provides valuable insights into the PV potential in Colombia and highlights the importance of considering regional variations and climate change scenarios in future energy planning.

关键词： photovoltaic potential CMIP6 solar photovoltaic energy climate change Colombia

The Role of the Spatial Network in Urban Disaster Risk Variations:Reimagining the Notion of Spatial Vulnerability at the Urban Scale

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International Journal of Disaster Risk Science 2024年第3期15卷 303-316页

作者： Monia Del pinto Ksenia Chmutina Falli Palaiologou Lee Bosher School of Architecture Building and Civil Engineering Loughborough University School of Business University of Leicester

The notion of “spatial vulnerability” is present in most disaster studies with a strong geographical connotation and accordingly is adopted at all scales, including the urban. While enabling mapping and visualizing risk patterns at macroscales, this geocentric foundation fails to capture disaster risk dynamics associated with the urban spatial network—an element that plays a significant role in the everyday and emergency functioning of cities, enabling users' movement and interaction. Yet,urban vulnerability assessment overlooks this aspect and thus leaves urban disaster risk mechanisms partially *** study investigated the role of the network of urban public open spaces(UPOS) in the creation and progression of urban disaster risk in earthquake-prone settlements. Through a multimethod approach that integrates quantitative and qualitative methods and explores spatial configuration, planning policies, and practices of use of UPOS in everyday and emergency scenarios, our study demonstrated that UPOS configuration plays an active role in urban disaster risk. Urban public open spaces impact risk by influencing the exposure of pedestrians and their capacity for self-protection. The study further reconceptualized spatial vulnerability at the urban scale, as the fraction of vulnerability associated to the spatial network, highlighting the interplay of planning policies and spatial practices in its production and progression. Our findings make the notion of spatial vulnerability less ambiguous at the urban scale, by viewing the variable as an imbalance in capacities and exposure that generates spatially unsafe conditions. This refined conceptualization of spatial vulnerability becomes a lens for a more granular approach to urban disaster risk reduction and city planning by identifying and integrating sociospatial considerations.

关键词： Central Italy Earthquakes Pedestrian evacuation Space syntax Spatial vulnerability Urban disaster risk

Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira Maria João pinto Paulo Sargento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São João de Deus 1700-048 LisboaPortugal REQUIMTE/LAQV(Rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SOERAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco Suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in *** is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological ***:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** strategy:Six electronic databases(PubMed,EBSCO,Cochrane Library,Scielo,b-On and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using MeSH terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:Studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual *** extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was *** primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain *** outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic *** were expressed as standardized mean difference(SMD)with 95%confidence interval(CI).Results:Sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of *** was more effective in reducing pain than no treatment(SMD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(SMD=–1.10,95%CI[–1.59,–0.61])or usual care(SMD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupuncture Cancer pain Meta-analysis Systematic review

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Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural Regeneration Research 2024年第1期19卷 116-123页

作者： Susana A.Ferreira Nuno pinto Inês Serrenho Maria Vaz Pato Graça Baltazar Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal GRUBI-Systematic Reviews Group University of Beira InteriorCovilhãPortugal

Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly *** systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online *** of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete *** what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation theta-burst stimulation

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