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An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

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Translational Neuroscience and Clinics 2016年第1期2卷 8-16页

作者： Tzuchou Lin Yihui Lin Linli Kao Yihui Kao Yuanhan Yang pingsong chou Mengni Wu Department of Neurology Kaohsiung Medical University Hospital Department of Neurology "National Taiwan University Hospital Yun-Lin Branch" Department of Neurology Kaohsiung Municipal Ta‐Tung Hospital Kaohsiung Medical University Department of Master’s Program in Neurology Faculty of Medicine Kaohsiung Medical University

Objective:The frontal lobe may be involved in circuits associated with depression,apathy,aggression,and other psychiatric *** white matter changes(WMC)are related to the severity of behavioral and psychological symptoms of dementia(BPSD)in patients with Alzheimer’s disease(AD),it is unclear which part of the WMC may play the most important role in *** study was designed to investigate the relationship between the location of WMC and the severity of BPSD in AD ***:Among patients diagnosed with Alzheimer’s disease between 2009 and2014,387 patients were retrospectively reviewed after those with pre‐existing organic brain syndrome,psychiatric diseases,or toxic‐metabolic encephalopathy were ***’demographic and laboratory data,WMC measured with brain computed tomography and scored using the age‐related white matter changes(ARWMC)scale,and neuropsychological tests,including the cognitive abilities screening instrument(CASI),the Mini‐Mental State Examination(MMSE),the clinical dementia rating scale with sum‐box(CDR‐SB),and the neuropsychiatric inventory(NPI)were ***:There was no significant difference in the NPI between patients with and without a history of stroke,hypertension,and *** significant difference in the NPI was identified between different sexes or different Apolipoprotein E(APOE)*** NPI score was significantly correlated with the duration of education(r=–0.4515,P=0.0172),CASI(r=–0.2915,P<0.0001),MMSE(r=–0.8476,P<0.0001),and CDR‐SB(r=2.2839,P<0.0001).WMC in the right frontal lobe showed a significant difference in NPI in comparison to those without WMC(P=0.0255).After adjusting for age,duration of education,and CASI,WMC in the right frontal lobe remained significantly associated with the NPI score(β=3.8934,P=0.042).Conclusions:WMC involving the right frontal lobe may play an important role in the BPSD in AD patients during their dementia *** studies are necessary to confirm

关键词： Alzheimer’s diseas white matter changes leukoaraiosis behavioral and psychological symptoms of dementia

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