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Calycosin improves atherosclerosis by reshaping the interaction between the gut microbiome and bile acid metabolism

Food Science and Human Wellness 2024年

作者： Jiaqi Fu Donghua Yu Yuqin Liang Xin Gao Yunhe Shi Yu Wang pingping chen Shumin Liu Fang Lu Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine

Calycosin， Astragali Radix most prominent ingredient， has drawn more attention as a result of its ability to treat atherosclerosis(AS). However， the mechanism of action has not been fully elucidated. We investigated the effects of calycosin on bile acid (BA) metabolism and gut microbiome in ApoE-/-mice fed a high-fat diet (HFD). The data showed that the aorta of ApoE-/-mice treated with HFD showed significant atheromatous plaque formation and lipid accumulation， and the levels of TC， TG and LDL-C were significantly increased， while the levels of HDL-C were significantly decreased. Calycosin can substantially regulate lipid levels， thereby alleviating liver lipid deposition induced by atherosclerosis. In addition， 16S rRNA sequencing showed that calycosin treatment has reshaped the gut microbiota disturbed by HFD， in particular， increasing the ratio of Bacteroidetes/Firmicutes， and improving the relative abundance of Bilophila， Desulfovibrio， Bacteroides， Lactobacillus， etc. Meanwhile， targeted metabolomics analysis showed that calycosin treatment significantly modulated CDCA， TCA， LCA， DCA， TDCA and bile acid pool composition， which were associated with atherosclerotic plaque areas. In addition， calycosin treatment also down-regulated FXR protein levels and up-regulated CYP7A1 protein levels in the hepatic. At the same time， calycosin inhibits the ileum FXR/TGR5 signaling pathway， inhibits BA reabsorption， promotes BA excretion， and reduces hepatic cholesterol accumulation by enterohepatic circulation. In addition， we found that calycosin significantly promoted the expression of hepatic ABCA1 and ABCG1 to mediate cholesterol efflux. Meanwhile， calycosin regulates gut microbiota， and Bacteroides， Alistipes， Desulfovibrio， Lactobacillus， Bilophila and Odoribacter are closely related to specific BAs. This enables us to further understand the relationship between BA metabolism and gut microbiota. Calycosin may reduce high-fat diet-induced hepatic cholesterol accumulation in ApoE-/-mice through gut microbiota and bile

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Energy Harvesting Space-Air-Sea Integrated Networks for MEC-Enabled Maritime Internet of Things

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China Communications 2022年第9期19卷 47-57页

作者： Zhijian Lin Xiaopei chen pingping chen School of Advanced Manufacturing Fuzhou UniversityFujian 362251China College of Physics and Information Engineering Fuzhou UniversityFujian 350108China

In recent years,various maritime applications such as unmanned surface vehicles,marine environment monitoring,target tracking,and emergency response have developed rapidly in maritime communication networks(MCNs),and these applications are often accompanied by complex computation tasks and low latency requirements.However,due to the limited resources of the vessels,it is critical to design an efficient mobile edge computing(MEC)enabled network for maritime computation.Inspired by this motivation,energy harvesting space-air-sea integrated networks(EH-SASINs)for maritime computation tasks offloading are proposed in this paper.We first make the optimal deployment of tethered aerostats(TAs)with the K-means method.In addition,we study the issue of computation task offloading for vessels,focusing on minimizing the process delay of computation task based on the proposed architecture.Finally,because of the NP-hard properties of the optimization problem,we solve it in two stages and propose an improved water-filling algorithm based on queuing theory.Simulation results show that the proposed EHSASINs and algorithms outperform the existing scenarios and can reduce about 50%of the latency compared with local computation.

关键词： MCNs computation offloading MEC EH-SASINs

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SR-DCSK Cooperative Communication System with Code Index Modulation:A New Design for 6G New Radios

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中国通信:英文版 2023年第10期20卷 1-16页

作者： Yi Fang Wang chen pingping chen Yiwei Tao Mohsen Guizani School of Information Engineering Guangdong University of TechnologyGuangzhou 510006China School of Advanced Manufacturing Fuzhou UniversityJinjiang campus362251China Department of Machine Learning MBZUAIAbu Dhabi999041UAE

This paper proposes a high-throughput short reference differential chaos shift keying cooperative communication system with the aid of code index modulation,referred to as CIM-SR-DCSK-CC system.In the proposed CIM-SR-DCSK-CC system,the source transmits information bits to both the relay and destination in the first time slot,while the relay not only forwards the source information bits but also sends new information bits to the destination in the second time slot.To be specific,the relay employs an N-order Walsh code to carry additional log_(2)N information bits,which are superimposed onto the SRDCSK signal carrying the decoded source information bits.Subsequently,the superimposed signal carrying both the source and relay information bits is transmitted to the destination.Moreover,the theoretical bit error rate(BER)expressions of the proposed CIMSR-DCSK-CC system are derived over additive white Gaussian noise(AWGN)and multipath Rayleigh fading channels.Compared with the conventional DCSKCC system and SR-DCSK-CC system,the proposed CIM-SR-DCSK-CC system can significantly improve the throughput without deteriorating any BER performance.As a consequence,the proposed system is very promising for the applications of the 6G-enabled lowpower and high-rate communication.

关键词： differential chaos shift keying cooperative communication short reference code index modulation high throughput bit error rate

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Study on Mechanical Properties and Action Mechanism of Leather Industrial Sludge Aggregate Baking-Free Bricks

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Journal of Renewable Materials 2023年第1期11卷 453-471页

作者： Lei Guo Zekun Wang Lixia Guo pingping chen School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou450046China Henan Water Valley Research Institute Zhengzhou450046China Henan Key Laboratory of Water Environment Simulation and Treatment Zhengzhou450002China

Taking an industrial sludge and its preparation of sludge wrap shell aggregates(WSAs)instead of sand to prepare baking-free brick as the research object,the development law of mechanical properties and the influence mechanism of macro and micro characteristic parameters of the bricks under different sludge and WSAs replacement rates were studied through the macroscopic mechanical properties test,with the help of nuclear magnetic resonance(NMR),transmission electron microscopy-energy spectrum and other testing technology and pores and cracks analysis system(PCAS)software.The results showed that the compressive strength of each sample decreased with the increase of sludge content.When the sludge content was less than 30%,it was mainly affected by the water-binder ratio.When the sludge content was more than 30%,it was mainly affected by the sludge content.At the age of 7 days,with the increase in replacement rate of WSAs,the compressive strength of the S10 and S30 groups was higher than that of the control group.The compressive strength of the S50 experimental group was 30.38 MPa,and the loss of compressive strength was slight compared with the control group.The water absorption rate of the 28 days S100 experimental group increased by 10.71%compared with the control group.When the content of WSAs was less than 50%,the holes above 0.1μm in the brick can be reduced and transformed into smaller holes,with a decreasing trend of the plane porosity of the brick.The microscopic results of the baking-free brick showed that the three-phase system of WSAs-interface transition area-mortar was poorly bonded and delaminated compared with the gravel aggregate-interface transition area-mortar system,and damage was more likely to occur in the WSAs and interface transition area.The above results show that it is feasible to use sludge and WSAs instead of sand for the preparation of baking-free bricks.This technology not only solves the problem of sludge disposal,but also protects the over-exploitation of mineral resources,and the tec

关键词： Sludge wrap shell aggregates baking-free brick interface

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Influence of extraction voltage on electron and ion behavior characteristics

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Chinese Physics B 2024年第4期33卷 553-559页

作者：徐翱甘娉娉石元杰陈磊 Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621999China

The characteristics of the extracted ion current have a significant impact on the design and testing of ion source performance.In this paper,a 2D in space and 3D in velocity space particle in cell(2D3V PIC)method is utilized to simulate plasma motion and ion extraction characteristics under various initial plasma velocity distributions and extraction voltages in a Cartesian coordinate system.The plasma density is of the order of 10^(15)m^(-3)-10^(16)m^(-3)and the extraction voltage is of the order of 100 V-1000 V.The study investigates the impact of various extraction voltages on the velocity and density distributions of electrons and positive ions,and analyzes the influence of different initial plasma velocity distributions on the extraction current.The simulation results reveal that the main reason for the variation of extraction current is the spacecharge force formed by the relative aggregation of positive and negative net charges.This lays the foundation for a deeper understanding of extraction beam characteristics.

关键词： extraction voltage plasma ion beam ion current

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A combined nanotherapeutic approach targeting farnesoid X receptor,ferroptosis,and fibrosis for nonalcoholic steatohepatitis treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2228-2246页

作者： Jiangtao Fu pingping Zhang Zhiguo Sun Guodong Lu Qi Cao Yiting chen Wenbin Wu Jiabao Zhang Chunlin Zhuang Chunquan Sheng Jiajun Xu Ying Lu Pei Wang The Center for Basic Research and Innovation of Medicine and Pharmacy(MOE) School of PharmacyNaval Medical UniversityShanghai 200433China National Demonstration Center for Experimental Pharmaceutical Education Naval Medical University/Second Military Medical UniversityShanghai 200433China Department of Diving and Hyperbaric Medicine Naval Special Medical CenterNaval Medical UniversityShanghai 200433China

Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)treatment.However,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major drawback.Ferroptosis,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of NASH.Nitric oxide(NO)is a versatile biological molecule that can degrade extracellular matrix.In this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).Biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH model.Compared with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ferroptosis.ONL@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota dysbiosis.These findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.

关键词： Nonalcoholic steatohepatitis Nanotherapy Farnesoid X receptor Ferroptosis Fibrosis Obeticholic acid S-Nitrosothiol Liproxstatin-1

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Enhancing Li-ion conduction and mechanical properties via addition of fluorine-containing metal–organic frameworks in allsolid-state cross-linked hyperbranched polymer electrolytes

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Nano Research 2022年第10期15卷 8946-8954页

作者： Wen Wen Qinghui Zeng pingping chen Xin Wen Zhenfeng Li Yu Liu Jiazhu Guan Anqi chen Wei Liu Liaoyun Zhang School of chemical sciences University of Chinese Academy of SciencesBeijing 100049China Research Institute of Petroleum Exploration&Development(RIPED) PetroChinaBeijing 100083China

Poly(ethylene oxide)(PEO)-based solid polymer electrolytes(SPEs)are commonly used in lithium metal batteries(LMBs)for their good Li-salt solvating ability and easy processability.However,the relatively low Li-ion conduction ability hinders their further development.In this work,a novel hyperbranched-polyether-type composite solid polymer electrolyte(CSPE)is prepared via a quick cross-linking reaction between aldehyde-terminated polyethylene glycol(PEG)and hyperbranched poly(ethylene imine)(HPEI)in the presence of lithium salt and fluorine-containing Zr-based metal–organic framework(MOF)UiO-66-(F)_(4).The hydrogen bonds between the fluorine atoms and amino groups in the electrolyte help to the better dispersion of UiO-66-(F)_(4) in the polymer matrix,which is beneficial to solving the problem of aggregation of nanofillers.Besides,the CSPEs with the functional MOF fillers show improvements in both electrochemical and mechanical properties.Notably,the Li-ion transference number(t)is considerably enhanced from 0.23 to 0.54.All-solid-state LMBs based on the CSPE also present good cycling performances.A high specific discharge capacity of 141.4 mAh·g^(−1) is remained after 200 cycles at 0.2 C.This study not only provides an effective synthesis method of the cross-linked hyperbranched polymer electrolyte,but also puts forward a new strategy for uniform dispersion of inorganic fillers in CSPEs.

关键词： hyperbranched cross-linked polymer electrolyte all-solid-state metal-organic frameworks composite lithium metal batteries

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Semi-interpenetrating-network all-solid-state polymer electrolyte with liquid crystal constructing efficient ion transport channels for flexible solid lithium-metal batteries

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Journal of Energy Chemistry 2022年第4期31卷 157-167页

作者： Qinghui Zeng Yu Lu pingping chen Zhenfeng Li Xin Wen Wen Wen Yu Liu Shuping Zhang Hailei Zhao Henghui Zhou Zhi-xiang Wang Liaoyun Zhang School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Pulead Technology Industry Co. LtdBeijing 102200China

The development of the solid-state polymer electrolytes (SPEs) for Li-ion batteries (LIBs) can effectively address the hidden safety issues of commercially used liquid electrolytes.Nevertheless,the unsatisfactory room temperature ion conductivity and inferior mechanical strength for linear PEO-based SPEs are still the immense obstacles impeding the further applications of SPEs for large-scale commercialization.Herein,we fabricate a series of semi-interpenetrating-network (semi-IPN) polymer electrolytes based on a novel liquid crystal (C6M LC) and poly(ethylene glycol) diglycidyl ether (PEGDE) via UV-irradiation at the first time.The LCs not only highly improve the mechanical properties of electrolyte membranes via the construction of network structure with PEGDE,but also create stable ion transport channels for ion conduction.As a result,a free-standing flexible SPE shows outstanding ionic conductivity(5.93×10^(-5) S cm^(-1) at 30℃),a very wide electrochemical stability window of 5.5 V,and excellent thermal stability at thermal decomposition temperatures above 360℃ as well as the capacity of suppressing lithium dendrite growth.Moreover,the LiFePO_(4)/Li battery assembled with the semi-IPN electrolyte membranes exhibits good cycle performance and admirable reversible specific capacity.This work highlights the obvious advantages of LCs applied to the electrolyte for the advanced solid lithium battery.

关键词： Solid-state polymer electrolyte Liquid crystal Semi-interpenetrating-network Ion transport channels Lithium battery

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考虑CVT输出特性的换流变剩磁测算方法

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电力自动化设备 2024年第6期44卷 90-95,109页

作者：韩平平王焱陈宇翔陈忠胡迪合肥工业大学新能源利用与节能安徽省重点实验室安徽合肥230009 国网安徽省电力有限公司电力科学研究院安徽合肥230061

特高压换流变空载合闸时,其剩磁会改变铁心磁通的大小和方向,极易造成严重的励磁涌流,导致换流变无法正常投入运行。针对换流变剩磁测算,分析电容式电压互感器(CVT)输出数据存在误差是由系统频率变化引起的,根据误差式进行校正并基于电... 详细信息

特高压换流变空载合闸时,其剩磁会改变铁心磁通的大小和方向,极易造成严重的励磁涌流,导致换流变无法正常投入运行。针对换流变剩磁测算,分析电容式电压互感器(CVT)输出数据存在误差是由系统频率变化引起的,根据误差式进行校正并基于电压积分法给出考虑CVT输出特性的换流变剩磁测算方法。在PSCAD/EMTDC中搭建相关仿真模型,对Y、D桥换流变的电压正向、负向峰值处分别进行分闸实验,并根据所提测算方法确定换流变剩磁。利用校正前、校正后以及监测的换流变剩磁完成选相合闸对比实验,实验结果表明所提方法能够有效测算换流变剩磁,为励磁涌流抑制手段提供参考依据。

关键词：换流变剩磁 CVT 电压积分法选相合闸

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Dice系数前向预测的快速正交正则回溯匹配追踪算法

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电子与信息学报 2024年第4期46卷 1488-1498页

作者：陈平平陈家辉王宣达方毅王锋福州大学先进制造学院泉州362251 广东工业大学信息工程学院广州510006 泉州师范学院信息工程学院泉州362200

为了提高压缩感知重构算法的成功率与重构精度,该文提出基于Dice前向预测的正交正则回溯匹配追踪算法(DLARBOMP)。在该算法中,首先从匹配准则与预选阶段原子选取的角度,利用Dice系数代替原子内积计算相关度,保留原始信号信息的特性,以... 详细信息

为了提高压缩感知重构算法的成功率与重构精度,该文提出基于Dice前向预测的正交正则回溯匹配追踪算法(DLARBOMP)。在该算法中,首先从匹配准则与预选阶段原子选取的角度,利用Dice系数代替原子内积计算相关度,保留原始信号信息的特性,以此选择与残差最匹配的原子,提高算法的重构精度。同时,针对信号重构过程回溯算法的时间过长问题,在每次原子迭代过程中,该文利用正则化选择多个原子而非单个原子,实现重构精度与重构时间的平衡。最后,通过稀疏1维信号与2维图像信号重构的实验结果,显示了所提DLARBOMP算法在1维信号重构时兼顾了性能与效率,在2维压缩图像信号重构时提高其峰值信噪比(PSNR),优于正交匹配追踪(OMP)及其最新改进贪婪类算法。

关键词：信号重构压缩感知 Dice系数正则回溯贪婪类算法

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