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In vitro/in vivo studies of a novel anti-HIV self-assembly of ethyl ester of 5’-cholesteryl-phosphonyl zidovudine （ECPZ）

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In vitro/in vivo studies of a novel anti-HIV self-assembly o...

Controllability of Semilinear Integrodifferential Degenerate Sobolev Equations

第十二届全国青年药学工作者最新科研成果交流会

作者： Lina Du Junwei Jia pingju ge Yu Wang Miao Li Xin Li Yiguang Jin Department of Pharmaceutical Chemistry Beijing Institute of Radiation Medicine Pharmaceutical College of Henan University Department of Pharmacy Chinese PLA General Hospital

An amphiphilic prodrug of anti-HTV nucleoside analogue,ethyl ester of 5’-cholesteryl-phosphonyl zidovudine（ECPZ） was *** aqueous suspension containing ECPZ self-assemblies was obtained through injecting the THF solution of ECPZ into water under *** interaction may be the driving force of molecular *** self-assemblies were nanoscale with-130 nm in size,and remained stable for a long *** of ECPZ self-assemblies were investigated in various environments including buffered solutions,plasma and tissue *** was degraded very slowly in neutral solutions,but rapidly degraded quickly in acid solution with the half-lives（tin） of less than 20 *** self-assemblies showed potent anti-HTV activity on MT4 cell *** the anti-HTV 50%effective concentration（EC50） of CPZ self-assemblies was 1 nM,only equal to 1/10 of AZT EC50 in the condition of ECPZ and HTV virus added into cells simultaneously,and 1/50 of AZT EC50 in the condition of ECPZ added into cells first,then added with *** was rapidly eliminated from circulation and distributed into the mononuclear phagocyte system（MPS） including liver,spleen and lung after bolus intravenous administration of ECPZ *** MPS-targeted effect and high anti-HTV activity of ECPZ self-assemblies make them become a promising self-assembled drug delivery system（SADDS） to eradicate HTV hidden in MPS.

关键词： anti-HIV cholesterol phosphorylation prodrugs self-assembly zidovudine(AZT)

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Journal of Systems Science & Complexity 2024年第5期37卷 1923-1936页

作者： ge Zhaoqiang School of Mathematics and Statistics Xi’an Jiaotong University

In this paper, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions is investigated in the sense of integral solution in Hilbert spaces. Some sufficient and necessary conditions are obtained. Firstly, the existence and uniqueness of integral solutions of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions are considered by ge-evolution operator theory and Sadovskii's fixed point theorem, the existence and uniqueness theorem of solutions is given. Secondly, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions is studied in the sense of integral solution. The criterion for approximate controllability is provided. The obtained results have important theoretical and practical value for the study of controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions.

关键词： Approximate controllability ge-evolution operator integral solution Sadovskii’s fixed point theorem semilinear integrodifferential degenerate Sobolev equations

Polymeric piezoelectric accelerometers with high sensitivity,broad bandwidth,and low noise density for organic electronics and wearable microsystems

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Microsystems & Nanoengineering 2024年第3期10卷 63-74页

作者： Chang ge Edmond Cretu The Department of Electrical and Computer Engineering The University of British ColumbiaVancouverBCCanada

Piezoelectric accelerometers excel in vibration *** the emerging trend of fully organic electronic microsystems,polymeric piezoelectric accelerometers can be used as vital front-end components to capture dynamic signals,such as vocal vibrations in wearable speaking assistants for those with speaking ***,high-performance polymeric piezoelectric accelerometers suitable for such applications are *** organic compounds such as PVDF have inferior properties to their inorganic counterparts such as ***,most existing polymeric piezoelectric accelerometers have very unbalanced performance *** often sacrifice resonance frequency and bandwidth for a flat-band sensitivity comparable to those of PZT-based accelerometers,leading to increased noise density and limited application *** this study,a new polymeric piezoelectric accelerometer design to overcome the material limitations of PVDF is *** new design aims to simultaneously achieve high sensitivity,broad bandwidth,and low *** samples were manufactured and characterized,demonstrating an average sensitivity of 29.45 pC/g within a±10 g input range,a 5%flat band of 160 Hz,and an in-band noise density of 1.4μg/√*** results surpass those of many PZT-based piezoelectric accelerometers,showing the feasibility of achieving comprehensively high performance in polymeric piezoelectric accelerometers to increase their potential in novel applications such as organic microsystems.

关键词： piezoelectric polymeric overcome

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： ge CHEN Xiaoyan CHEN Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation geostrophic adjustment

Solid Desiccant Heat Pump Fresh Air Unit using Composite Silica gel

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Journal of Thermal Science 2024年第4期33卷 1286-1300页

作者： YANG Tianyu GUO Defang ge Tianshu Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityKey Laboratory of Power Mechanical EngineeringMOE ChinaShanghai200240China Qingdao Haier A/C Electronic Co. LtdQingdao266101China

The introduction of fresh air into the indoor space leads to a significant increase in cooling or heating *** desiccant heat pump fresh air unit which can handle the latent and sensible load of fresh air efficiently have been proposed *** improve the performance of the solid desiccant heat pump fresh air unit in the fresh air handling process,in this paper,the application of composite silica gel in a heat pump fresh air unit was *** comparison between silica gel coating(SGC)and composite silica gel coating(CSGC)shows that the adsorption rate and water uptake capacity of CSGC are more than two times higher than those of *** experimental setup for the solid desiccant heat pump fresh air unit was *** performance of SGC and CSGC was tested in the setup *** show that under summer conditions,compared with the solid desiccant heat pump fresh air unit using silica gel(SGFU),the average moisture removal and COP of the one using composite silica gel(CSGFU)increased by 15%and 30%,*** winter conditions,compared with SGFU,the average humidification and COP of CSGFU increased by 42%and 17%.With optimal operation conditions of 3 min switchover time and 40 r/s compressor frequency,the COP of CSGFU under summer conditions can reach *** also show that the CSGFU and SGFU have higher COP and dehumidification rate under higher outdoor temperature and humidity ratio.

关键词： fresh air system desiccant coated heat exchanger humidification dehumidification experimental comparison

Theoretical study on the stability of nanobubbles and its verification in molecular dynamics simulation

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Particuology 2024年第4期87卷 99-105页

作者： Sheng Mi Chaofeng Hou Wei ge School of Chemical Engineering and Technology Tianjin UniversityTianjin300072China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing.100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The stability of vapor nanobubbles in bulk liquid was investigated theoretically and the critical bubble size was derived from macroscale thermodynamic equations,below which the system destabilizes with sharp drop in *** critical size was quantitatively verified in molecular dynamic simulation using the Lennard-Jones model of argon,where stronger attraction between the molecules at lower density is found to contribute most to the drop of system pressure and,as the Laplace pressure on the curved bubble interface fails to balance the pressure difference across the interface,the bubbles become *** theoretical model could be extended to other systems where reliable equations of state and interfacial tension are available.

关键词： Nanobubble Stability Phase diagram Critical size

Soft coarse-grained particle model for particle-fluid systems

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Particuology 2024年第1期84卷 178-193页

作者： Yanhao Ye Ji Xu Wei ge State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China

By modeling a group of neighboring real particles as a single coarse-grained particle(CGP),discrete particle method(DPM)is now capable of simulating industrial-scale particle-fluid ***,a systematic approach to determine the CGP properties and develop their interaction models is still lacking,which casts uncertainty on the predictivity of the *** this study,collisions between predefined particle groups are analyzed to construct kernel functions for modeling the CGPs and then the model parameters are determined by equating the statistical properties of the CGPs and the real particles in the physical process *** approach is implemented for homogeneous cooling of granular gas,then demonstrated effective in simulating experimental fluidized beds.

关键词： Coarse-grain(CG) Discrete particle method(DPM) Fluidized bed Multi-scale simulation

Flocking Effects of the Stochastic Cucker-Smale System with Noise

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Journal of Systems Science & Complexity 2024年第5期37卷 1978-1994页

作者： HAN Ning ge Bin LI Lin School of Mathematical Sciences Harbin Engineering University

In this paper, the flocking behavior of a Cucker-Smale model with a leader and noise is studied in a finite time. The authors present a Cucker-Smale system with two nonlinear controls for a complex network with stochastic synchronization in probability. Based on the finite-time stability theory of stochastic differential equations, the sufficient conditions for the flocking of stochastic systems in a finite time are obtained by using the Lyapunov function method. Finally, the numerical simulation of the particle system is carried out for the leader and noise, and the correctness of the results is verified.

关键词： Cucker-Smale model flocking behavior leader noise

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基于GPRS的无线水文自动测报系统的设计

计算机工程 2007年第2期33卷 280-282页

作者：吴秋兰梁勇张承明葛平俱山东农业大学信息学院泰安271018

提出了一种基于GPRS的无线水文自动测报方案,水文数据采集设备将采集到的水文信息利用移动网的GPRS无线网络可以及时发送到数据处理和监控中心。该系统实现了水文信息采集、传输和处理的自动化,具有及时、高效、准确、基建投资少、运行... 详细信息

提出了一种基于GPRS的无线水文自动测报方案,水文数据采集设备将采集到的水文信息利用移动网的GPRS无线网络可以及时发送到数据处理和监控中心。该系统实现了水文信息采集、传输和处理的自动化,具有及时、高效、准确、基建投资少、运行成本低等特点,解决了人工观测记录设备需要有专人管理、值守、记录、整理和上报,无法实现实时对水文信息测量、记录和传输,无法为水资源调度和防汛实时提供数据等重要问题,具有显著的社会效益和较大的经济效益。

关键词： GPRS 无线自动测报