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Effect of Fatigue Loading on the Mechanical Properties and Resistance of High-strength Straight-hole Recycled Pervious Concrete to Rainstorm-based Waterlogging

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 141-148页

作者：朱平华 FAN Haifeng YAN Xiancui LIU Hui WANG Xinjie chen Chunhong Department of Civil Engineering Changzhou UniversityChangzhou 213164China

A novel high-strength straight-hole recycled pervious concrete(HSRPC)for the secondary highway pavement was prepared in this *** study aimed to investigate the effect of porosity(0.126%,0.502%,and 1.13%),vehicle loading stress level(0.5 and 0.8)and service life on the resistance to rainstormbased waterlogging of HSRPC under fatigue *** mechanical properties of HSRPC in terms of flexural strength and dynamic elastic modulus were *** waterlogging resistance of HSRPC was described by surface water depth and drainage *** microstructure of HSRPC were observed with scanning electron microscopy(SEM).Results showed that although the dynamic elastic modulus and flexural strength of HSRPC decreased with the increasing number of fatigue loading,the flexural strength of HSRPC was still greater than5 MPa after design service life of 20 *** 2.5×10^(5)times of fatigue loading,the permeability coefficient of HSRPC with a porosity of 0.502%and 1.13%increased by 18.4%and 22.9%,respectively;while the permeability coefficient of HSRPC with 0.126%porosity dropped to 0.35 mm/*** maximum surface water depth of HSRPC with a porosity of 0.126%,0.502%,and 1.13%were 8,5 and 4 mm,*** results showed that fatigue loading expanded the number and width of cracks around the tiny pores in HSRPC.

关键词： recycled pervious concrete porosity fatigue loading service life stress level rainstorm and waterlogging

Prognostic significance of combining high mobility group Box-1 and OV-6 expression in hepatocellular carcinoma

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Science China(Life Sciences) 2018年第8期61卷 912-923页

作者： Jihui Zhu Han Yu Shuzhen chen pinghua Yang Zihui Dong Yan Ling Hao Tang Shilei Bai Wen Yang Liang Tang Feng Shen Hongyang Wang Wen Wen National Center for Liver Cancer Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China International Cooperation Laboratory on Signal Transduction of Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China Department of Respiratory Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer Shanghai 200438 China

The inflammatory environment and existence of cancer stem cells are critical for progression and intrahepatic recurrence of hepatocellular carcinoma （HCC） after curative resections. Here, we investigated the prognostic significance of combining high mobility group box 1 （HMGB1） expression and hepatic progenitor marker OV6 in hepatocellular carcinoma. Expression of HMGB 1 and OV6 was evaluated using immunohistochemistry profiling in tissue microarrays containing samples from 208 HCC patients. Invasive clinical or pathological factors were found in patients with high expression of HMGB 1 or OV6. Higher HMGB1 was associated with poorer clinical outcomes, and independently related to elevated 5-year recurrence incidence （85.5% vs. 62.4%, P〈0.001）. We also found that more OV6 positive staining was correlated with poor prognosis of HCC patients （P〈0.001）. Notably, expression of HMGB 1 was positively correlated with OV6 in density （R2=0.032, P〈0.001） and reversely related to HCC outcomes. Abnormal expression of HMGBI in combination with positive staining of OV6 displayed poorer prognostic performance than single biomarker alone （area under curve （AUC） survival=0.696）. Therefore, HMGB 1 and OV6 positive staining are promising prognostic parameters for HCC, and we propose that HMGB1 and OV6 may cooperate with each other and predict poor prognosis of HCC.

关键词： hepatocellular carcinoma high mobility group box 1 hepatic progenitor marker OV6 prognosis

Histological and single-nucleus transcriptome analyses reveal the specialized functions of ligular sclerenchyma cells and key regulators of leaf angle in maize

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Molecular Plant 2024年第6期17卷 920-934页

作者： Qibin Wang Qiuyue Guo Qingbiao Shi Hengjia Yang Meiling Liu Yani Niu Shuxuan Quan Di Xu Xiaofeng chen Laiyi Li Wenchang Xu Fanying Kong Haisen Zhang pinghua Li Bosheng Li Gang Li State Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agriculture Sciences in WeifangWeifangShandong 261325China State Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai’an 271018China

Leaf angle(LA)is a crucial factor that affects planting density and yield in ***,the regulatory mechanisms underlying LA formation remain largely *** this study,we performed a comparative histological analysis of the ligular region across various maize inbred lines and revealed that LA is significantly influenced by a two-step regulatory process involving initial cell elongation followed by subsequent lignification in the ligular adaxial sclerenchyma cells(SCs).Subsequently,we performed both bulk and single-nucleus RNA sequencing,generated a comprehensive transcriptomic atlas of the ligular region,and identified numerous genes enriched in the hypodermal cells that may influence their specialization into ***,we functionally characterized two genes encoding atypical basic-helix-loop-helix(bHLH)transcription factors,bHLH30 and its homolog bHLH155,which are highly expressed in the elongated adaxial *** analyses revealed that bHLH30 and bHLH155 positively regulate LA expansion,and molecular experiments demonstrated their ability to activate the transcription of genes involved in cell elongation and lignification of *** findings highlight the specialized functions of ligular adaxial SCs in LA regulation by restricting further extension of ligular cells and enhancing mechanical *** transcriptomic atlas of the ligular region at single-nucleus resolution not only deepens our understanding of LA regulation but also enables identification of numerous potential targets for optimizing plant architecture in modern maize breeding.

关键词： planting specialized angle

A Wireless Foot Plantar Pressure Distribution Measurement System and Its Application in Gait Analysis

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A Wireless Foot Plantar Pressure Distribution Measurement Sy...

基于偏最小二乘回归的运动机构装配质量关键控制点判定方法

第32届中国控制与决策会议

作者： Zheng Zhao Weihai chen Zhang Yixin Ai pinghua Jiahua Wang Hangzhou Innovation Institue Beihang University School of Automation Science and Electrical Engineering Beihang University

The foot plantar pressure distribution（FPPD） is time-varying in walking process,and study on foot plantar pressure distribution can help us analyze walking gait,which plays a key role in the research field of wearable device and auxiliary medical *** for patients with leg or foot movement dysfunction,FPPD can help doctors to make scientific medical diagnosis *** the foot plantar surface is irregular and flexible,it increases the difficulty of pressure distribution *** this paper,an arrayed pressure-sensitive sensor is utilized to convert the pressure signal to resistance signal,and the resistance signal is then converted to numerical signal by embedded signal processing system based on *** last,the data of FPPD is uploaded to computer via wireless ZIGBEE *** on the proposed system,experiments are conducted on several people to analyze the FPPD in different gaits,including the standing status and walking status;and the experiment results validate this novel wireless FPPD measurement system.

关键词： FPPD array pressure-sensitive sensor signal processing gait analysis

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中国机械工程 2020年第13期31卷 1562-1569页

作者：鞠萍华陈资冉琰肖兵重庆大学机械传动国家重点实验室重庆400044

为提高复杂运动机构装配质量,提出了一种基于偏最小二乘回归(PLSR)的运动机构装配质量关键控制点判定方法。基于“功能—运动—动作”的结构化分解方法,定义了元动作和元动作链的概念;将元动作链中最后一个元动作输出运动参数作为装配... 详细信息

为提高复杂运动机构装配质量,提出了一种基于偏最小二乘回归(PLSR)的运动机构装配质量关键控制点判定方法。基于“功能—运动—动作”的结构化分解方法,定义了元动作和元动作链的概念;将元动作链中最后一个元动作输出运动参数作为装配质量的分析对象,以状态空间模型和分层迭代法为工具构建元动作链动力传递模型,建立装配质量分析对象与各级元动作内部影响因素之间的联系;利用PLSR解决各级元动作内部影响因素之间的多重共线性和样本数据过少的问题,并且以变量投影重要性指标衡量影响因素重要程度。最后,以砂轮架X轴进给运动下的元动作链为例,证明了该方法能有效地提取出与装配质量最密切的影响因素。

关键词：装配质量控制点偏最小二乘回归功能结构化分解元动作链

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临床微生物参考实验室现状与建设的思考

中华检验医学杂志 2018年第1期41卷 17-19页

作者：屈平华陈茶广州中医药大学第二附属医院广东省中医院检验医学部 510006

目前临床微生物学检验面临已知病原不断变异和“新病原”不断出现的巨大挑战。针对当前临床微生物检验所存在的问题及国内外微生物参考实验室的建设现状，本文就临床微生物参考实验室的定位和职责，以及如何建设等进行了初步的探讨。

关键词：临床微生物参考实验室

广州弗朗西斯菌的鉴定与命名以及获得国际认可的经验介绍

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中华检验医学杂志 2014年第10期37卷 796-798页

作者：屈平华陈茶广东省中医院检验医学部广州510006

本文以广州弗朗西斯菌（ Francisella guangzhouensis）为实例，阐述如何利用生物信息资源进行细菌新种的鉴定、如何进行新种的命名和命名的拉丁化、如何进行新种的合格化、以及《国际细菌命名法》中与新种命名和鉴定相关的一些内容，... 详细信息

本文以广州弗朗西斯菌（ Francisella guangzhouensis）为实例，阐述如何利用生物信息资源进行细菌新种的鉴定、如何进行新种的命名和命名的拉丁化、如何进行新种的合格化、以及《国际细菌命名法》中与新种命名和鉴定相关的一些内容，从而为临床微生物学工作者发现和命名新的病原菌提供指导。

关键词：弗朗西斯菌属分类法

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地热梯级供暖方案优化研究

暖通空调 2011年第7期41卷 112-118页

作者：邹平华陈少玲哈尔滨工业大学

以某低温地热水供暖工程为例,分析了利用板式换热器与热泵机组联合供热的设计和运行情况,指出现有系统存在浪费地热能资源的缺点,提出了两种优化方案,分析比较了两种方案的能耗及性能指标,得出现有地热资源条件下较为合理的运行方式和... 详细信息

以某低温地热水供暖工程为例,分析了利用板式换热器与热泵机组联合供热的设计和运行情况,指出现有系统存在浪费地热能资源的缺点,提出了两种优化方案,分析比较了两种方案的能耗及性能指标,得出现有地热资源条件下较为合理的运行方式和地热尾水温度。

关键词：地热水供暖热泵性能指标地热尾水温度

Novel benzothiazole derivatives target the Gac/Rsm two-component system as antibacterial synergists against Pseudomonas aeruginosa infections

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ACTA PHARMACEUTICA SINICA B 2024年第11期14卷 4934-4961页

作者： Liu, Jun Wu, Wenfu Hu, Jiayi Zhao, Siyu Chang, Yiqun chen, Qiuxian Li, Yujie Tang, Jie Zhang, Zhenmeng Wu, Xiao Jiao, Shumeng Xiao, Haichuan Zhang, Qiang Du, Jiarui Zhao, Jianfu Ye, Kaihe Huang, Meiyan Xu, Jun Zhou, Haibo Zheng, Junxia Sun, pinghua Jinan Univ Coll Pharm State Key Lab Bioact Mol & Druggabil Assessment Guangzhou 510632 Peoples R China Shihezi Univ Sch Pharm Key Lab Xinjiang Phytomedicine Resource & Utilizat Minist Educ Shihezi 832003 Peoples R China Guangdong Univ Technol Sch Biomed & Pharmaceut Sci Guangzhou 510006 Peoples R China Jinan Univ Guangzhou Affiliated Hosp 1 Dept Oncol Guangzhou 510632 Peoples R China Univ Sydney Fac Med & Hlth Sydney NSW 2006 Australia

The management of antibiotic-resistant, bacterial biofilm infections in skin wounds poses an increasingly challenging clinical scenario. Pseudomonas aeruginosa infection is difficult to eradicate because of biofilm formation and antibiotic resistance. In this study, we identified a new benzothiazole derivative compound, SN12 (IC50 Z 43.3 nmol/L), demonstrating remarkable biofilm inhibition at nanomolar concentrations in vitro. In further activity assays and mechanistic studies, we formulated an unconventional strategy for combating P. aeruginosa-derived infections by targeting the two-component (Gac/ Rsm) system. Furthermore, SN12 slowed the development of ciprofloxacin and tobramycin resistance. By using murine skin wound infection models, we observed that SN12 significantly augmented the antibacterial effects of three widely used antibiotics-tobramycin (100-fold), vancomycin (200-fold), and ciprofloxacin (1000-fold)-compared with single-dose antibiotic treatments for P. aeruginosa infection in vivo. The findings of this study suggest the potential of SN12 as a promising antibacterial synergist, highlighting the effectiveness of targeting the two-component system in treating challenging bacterial biofilm infections in humans. 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Pseudomonas aeruginosa Biofilm Antibiotic resistant Two-component system Antibacterial synergist