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Automated Classification of Inherited Retinal Diseases in Optical Coherence Tomography Images Using Few-shot Learning

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Biomedical and Environmental Sciences 2023年第5期36卷 431-440页

作者： ZHAO Qi MAI Si Wei LI Qian HUANG Guan Chong GAO Ming Chen YANG Wen Li WANG ge MA Ya LI Lei PENG Xiao Yan Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Department of Computer Science RutgersThe State University of New JerseyNew Brunswick 08901USA Department of Computer Science and Engineering University at BuffaloBuffalo 14260USA Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science KeyLaboratoryBeijing 100730China

Objective To develop a few-shot learning(FSL) approach for classifying optical coherence tomography(OCT) images in patients with inherited retinal disorders(IRDs).Methods In this study, an FSL model based on a student–teacher learning framework was designed to classify images. 2,317 images from 189 participants were included. Of these, 1,126 images revealed IRDs, 533 were normal samples, and 658 were control *** The FSL model achieved a total accuracy of 0.974–0.983, total sensitivity of 0.934–0.957, total specificity of 0.984–0.990, and total F1 score of 0.935–0.957, which were superior to the total accuracy of the baseline model of 0.943–0.954, total sensitivity of 0.866–0.886, total specificity of 0.962–0.971,and total F1 score of 0.859–0.885. The performance of most subclassifications also exhibited advantages. Moreover, the FSL model had a higher area under curves(AUC) of the receiver operating characteristic(ROC) curves in most *** This study demonstrates the effective use of the FSL model for the classification of OCT images from patients with IRDs, normal, and control participants with a smaller volume of data. The general principle and similar network architectures can also be applied to other retinal diseases with a low prevalence.

关键词： Few-shot learning Student-teacher learning Knowledge distillation Transfer learning Optical coherence tomography Retinal degeneration Inherited retinal diseases

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Rationally engineered IR-783 octanoate as an enzyme-activatable fluorogenic tool for functional imaging of h Notum in living systems

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Chinese Chemical Letters 2024年第11期35卷 442-447页

作者： Lilin Song Mengru Sun Yuqing Song Feng Zhang Bei Zhao Hairong Zeng Jinhui Shi Huixin Liu Shanshan Zhao Tian Tian Heng Yin Guangbo ge Liaoning Provincial Key Laboratory of Carbohydrates Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Re-searchShanghai University of Traditional Chinese MedicineShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Health Sciences Institute China Medical UniversityShenyang 110122China Department of Gynecology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyang 110042China

As a vital negative regulator of Wnt signaling pathway,human Notum(hNotum)plays a crucial regulatory role in the progression of many human *** the relevance of h Notum to human diseases requires practical and reliable tools for visualizing h Notum activity in living ***,an enzyme-activatable fluorogenic tool(IR-783 octanoate)was rationally engineered for sensing and imaging h Notum activity in living systems by integrating computer-aided molecular design and biochemical ***-783 octanoate showed good optical properties,excellent specificity and high binding-affinity towards h Notum(K_(m)=0.98μmol/L).IR-783 octanoate could be well up-taken into the cancerous cells or tumors that over-expressed organic anion transporting polypeptides(OATPs),and then hydrolyzed by cellular h Notum to release free IR-783 ketone,which created brightly fluorescent signals around 646 *** investigations showed that IR-783 octanoate achieved a good performance for in-situ functional imaging of h Notum in both living cells,cancerous tissues and *** was also found that some SW620cells with multipolar spindles could be stained by IR-783 octanoate to emit extremely bright signals,suggesting that this agent could be used as a novel visualizing tool for tracing the cells undergoing abnormal cell ***,this study devises a highly specific fluorogenic tool for in-situ functional imaging of hNotum in living systems,which offers a practical and reliable tool to dynamically track the changes in h Notum activity under various conditions.

关键词： hNotum Optical substrate Computer-aided molecular design In-situ functional imaging Cancer diagnosis

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A new tumor-associated antigen prognostic scoring system for spontaneous ruptured hepatocellular carcinoma after partial hepatectomy

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Cancer Biology & Medicine 2018年第4期15卷 415-424页

作者： Jingjing Wu Peng Zhu Zhanguo Zhang Bixiang Zhang Chang Shu Lin Chen Renjie Feng Abdoul aziz Mba'nbo koumpa Ganxun Li Qianyun ge Department of Hepatic Surgery Center Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China Department of Neurology Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China

Objective:Spontaneous hepatocellular carcinoma(HCC)rupture can be fatal,and hepatic resection could achieve a favorable long-term survival among all strategies of tumor ***,there is no available prognostic scoring system for patients with ruptured HCC who underwent partial ***:From January 2005 to May 2015,129 patients with spontaneous HCC rupture underwent partial *** clinical data were collected and *** risk factors affecting overall survival(OS)were used to develop the new scoring ***’s C statistics,Akaike information criterion(AIC),the relative likelihood,and the log likelihood ratio were calculated to measure the homogeneity and discriminatory ability of a prognostic ***:In the multivariable Cox regression analysis,three factors,including tumor size,preoperativeα-fetoprotein level,and alkaline phosphatase level,were chosen for the new tumor-associated antigen(TAA)prognostic scoring *** 1-year OS rates were 88.1%,43.2%,and 30.2%for TAA scores of 0–5 points(low-risk group),6–9 points(moderate-risk group),and 10–13points(high-risk group),*** TAA scoring system had superior homogeneity and discriminatory ability(Harrell’s C statistics,0.693 vs.0.627 and 0.634;AIC,794.79 vs.817.23 and 820.16;relative likelihood,both<0.001;and log likelihood ratio,45.21 vs.22.77 and 21.84)than the Barcelona Clinic Liver Cancer staging system and the Cancer of the Liver Italian Program in predicting *** results were found while predicting disease-free survival(DFS).Conclusions:The new prognostic scoring system is simple and effective in predicting both OS and DFS of patients with spontaneous ruptured HCC.

关键词： Spontaneous rupture prognostic scoring system homogeneity discriminatory ability overall survival disease-free survival hepatocellular carcinoma

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Moyamoya disease associated with ankylosing spondylitis in a 9-year-old child:a case report

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Chinese Neurosurgical Journal 2017年第3期3卷 188-191页

作者： Fan Yang Peicong ge Xun Ye Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University China National Clinical Research Center for Neurological Diseases Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease 6 Tiantanxili DongCheng District Beijing 100050 China Center of Stroke Beijing Institute for Brain Disorders Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease 6 Tiantanxili DongCheng District Beijing 100050 China

Background: Ankylosing spondylitis was reported to associate with an increased risk of cerebrovascular diseases. In this article, we aimed to report the first case of ankylosing spondylitis associated with moyamoya disease treated with encephalo-duroarterio-synangiosis. Case presentation: A 9-year-old boy with ankylosing spondylitis appeared a symptom of repeated transient ischemic attacks which performed as left hemiparesis. Magnetic resonance angiography showed a typical finding of left anterior cerebral artery, bilateral middle cerebral arteries and the supraclinoid portion of the right internal carotid artery stenosis with an abnormal vascular network at the base of the brain, diagnosed with moyamoya disease. He received a medication treatment but did not underwent revascularization surgery. After three months, ankylosing spondylitis symptoms got some relief, whereas transient ischemic attacks was more frequency. Due to the bad cerebral blood flow on acetazolamide computed tomography perfusion and poor clinical manifestation, he underwent a right encephalo-duroarterio-synangiosis. Postoperatively, the symptoms of transient ischemic attacks disappeared. Conclusions: We reported the first case of ankylosing spondylitis associated with moyamoya disease. Moyamoya disease could appear in patients with ankylosing spondylitis. Revascularization surgery probably is an effective treatment for preventing preoperative ischemic events recurrence.

关键词： Ankylosing spondylitis Moyamoya disease Transient ischemic attack

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Composition-tailor induced electrocaloric effect near room temperature in(Pb,Ba)HfO_(3)films

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Journal of Materiomics 2023年第3期9卷 502-509页

作者： Xian-Xiong Huang Peng-Zu ge Tian-Fu Zhang Qiu-Xiang Liu Yan-Ping Jiang Zhen-Hua Tang Xiao-Bin Guo Xin-Gui Tang School of Physics&Optoelectric Engineering Guangdong University of TechnologyGuangzhou510006China Jewelry Institute Guangzhou Panyu PolytechnicGuangzhou511483China School of Materials Science and Engineering Harbin Institute of TechnologyShenzhenGuangdong518055China

More and more researchers start to pay attention to the electrocaloric temperature change(DT)in polar materials,which is caused by an applied electric *** this paper,Ba-doped PbHfO_(3)(PBH)films were prepared by sol-gel *** components,microstructures,dielectric polarization and electro-caloric effects(ECEs)were *** the addition of Ba^(2+),PBH films went from antiferroelectric(AFE)to ferroelectric(FE).At the same time,their dielectric peaks shifted toward lower *** maximum DT obtained in Pb_(0.8)Ba_(0.2)HfO_(3)FE film is 41.1 K,which is an order of magnitude larger than PbHfO_(3)film(△Tge polarization change and high△T,which is needed in solid-state cooling devices.

关键词： Ferroelectric Electrocaloric effects Landau-Devonshire theory Solid-state cooling

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Transcriptome and Metabolome Analyses of Sea Cucumbers Apostichopus japonicus in Southern China During the Summer Aestivation Period

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Journal of Ocean University of China 2021年第1期20卷 198-212页

作者： YANG Qiuhua ZHANG Xusheng LU Zhen HUANG Ruifang TRAN Ngoc Tuan WU Jianshao YANG Fuyuan ge Hui ZHONG Chenhui SUN Qian ZHOU Chen LIN Qi Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province Fisheries Research Institute of FujianXiamen 361013China Guangdong Provincial Key Laboratory of Marine Biology Marine Biology InstituteShantou UniversityShantou 515063China

Aestivation is a common strategy of sea cucumbers(Apostichopus japonicus)in response to high-temperature *** studies have individually investigated the immune and physiological alterations at the aestivation ***,these studies have not evaluated the relationship between immunity and *** this study,we explored the transcriptome and metabolome of *** during the aestivation stage to study the *** transcriptome analysis of dormant(aestivation)and revived *** generated 2368 differentially expressed genes,including 927 downregulated genes and 1441 upregulated *** on gene Ontology and Kyoto Encyclopedia of genes and genomes enrichment analyses,the downregulated genes in the dormant group were found to be involved in DNA replication,RNA metabolic process,and protein metabolism,which results in the inhibition of motility,skeletal development,neural activity,cell proliferation,and development of *** contrast,the upregulated genes were found to be associated with fatty acid metabolism,carbohydrate hydrolysis,and *** the metabolome analysis,the downregulated metabolites were found to be associated with fatty acid metabolism,starch and sucrose metabolism,and TCA *** indicates that dormant sea cucumbers consume reserved carbohydrates and fatty acids to maintain low levels of energy *** protein-protein interaction network analysis further revealed that carbohydrate hydrolysis promoted phagocytosis activity in the dormant *** study provides new insights into potential molecular mechanisms of sea cucumber survival in high-temperature conditions,which is critical in aquaculture of sea cucumbers.

关键词： aestivation Apostichopus japonicus hypometabolism fatty acid metabolism carbohydrate hydrolysis phagocytosis

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Enhanced figure of merit for famatinite Cu_(3)SbSe_(4)via band structure tuning and hierarchical architecture

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Journal of Materiomics 2023年第6期9卷 1263-1272页

作者： Lijun Zhao Haolin Ye Xinmeng Wu Jian Yang Lihua Yu Zhongqi Shi Shahid Hussain Guanjun Qiao Junhua Xu Bangzhi ge Li Wang Chongjian Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100JiangsuChina State Key Laboratory of Solidification Processing Key Laboratory of Radiation Detection Materials and DevicesMinistry of Industry and Information TechnologyNorthwestern Polytechnical UniversityXi'an710072ShaanxiChina School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013JiangsuChina State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'an710049ShaanxiChina

The p-type Te-free Cu_(3)SbSe_(4)with famatinite structure is a potential candidate for thermoelectric materials due to the low cost and eco-friendly constituent ***,its strong bipolar effect and high lattice thermal conductivity(klat)are the main challenges for its performance ***,we report a new strategy to enhance its figure of merit zT~0.86 at 673 K for Cu_(3)Sb_(0.95)Fe_(0.05)Se_(2.8)S_(1.2)via band structure tuning and hierarchical ***,S substituted Se atoms in lattice can widen the band gap to alleviate the bipolar ***,Fe doping in Sb site significantly increases the density of states,thus increasing the carrier effective mass,and obtaining a remarkably high Seebeck coefficient of~560 mV/K at 300 ***,the induced hierarchical architecture defects resulting in a minimum klat of~0.48 W·m^(-1)·K^(-1)at 673 ***,the improved Seebeck coefficient combined with low thermal conductivity leads to an enhanced zT.

关键词： Cu3SbSe4-Based materials Defects Band gap Thermoelectric properties Solid solution

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Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ

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Frontiers of Medicine 2024年第3期18卷 465-483页

作者： Fei Xu Han Chen Changyi Zhou Tongtong Zang Rui Wang Shutong Shen Chaofu Li Yue Yu Zhiqiang Pei Li Shen Juying Qian Junbo ge Department of Cardiology and Laboratory of Heart Valve Disease West China HospitalSichuan UniversityChengdu610041China Department of Cardiology Zhongshan HospitalFudan UniversityResearch Unit of Cardiovascular Techniques and DevicesChinese Academy of Medical SciencesShanghai200032China Shanghai Institute of Cardiovascular Diseases Shanghai200032China National Clinical Research Center for Interventional Medicine&Shanghai Clinical Research Center for Interventional Medicine(19MC1910300) Shanghai200032China

Atherosclerosis is a chronic artery disease that causes various types of cardiovascular *** smooth muscle cells(VSMCs),the main components of atherosclerotic plaque,switch from contractile to synthetic phenotypes during *** is crucial in regulating VSMC phenotypes in atherosclerosis,and it can be reversely regulated by ***,the specific effects of deubiquitinases on atherosclerosis have not been thoroughly *** this study,RNAi screening in human aortic smooth muscle cells was performed to explore the effects of OTU family deubiquitinases,which revealed that silencing OTUB1 inhibited PDGF-BB-stimulated VSMC phenotype *** in vivo studies using Apoe−/−mice revealed that knockdown of OTUB1 in VSMCs alleviated atherosclerosis plaque burden in the advanced stage and led to a stable plaque ***,VSMC proliferation and migration upon PDGF-BB stimulation could be inhibited by silencing OTUB1 in *** RNA-sequencing data indicated that knocking down OTUB1 influenced VSMC differentiation,adhesion,and *** spectrometry of ubiquitinated protein confirmed that proteins related to cell growth and migration were differentially ***,we found that OTUB1 recognized the K707 residue ubiquitylation of PDGFRβwith its catalytic triad,thereby reducing the K48-linked ubiquitylation of PDGFRβ.Inhibiting OTUB1 in VSMCs could promote PDGFRβdegradation via the ubiquitin–proteasome pathway,so it was beneficial in preventing VSMCs’phenotype *** findings revealed that knocking down OTUB1 ameliorated VSMCs’phenotype switch and atherosclerosis progression,indicating that OTUB1 could be a valuable translational therapeutic target in the future.

关键词： atherosclerosis vascular smooth muscle cell ubiquitylation deubiquitinase OTUB1 PDGFRβ

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Hydrogen sulfide, a signaling molecule in plant stress responses

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Journal of Integrative Plant Biology 2021年第1期63卷 146-160页

作者： Jing Zhang Mingjian Zhou Heng Zhou Didi Zhao Cecilia Gotor Luis CRomero Jie Shen Zhenglin ge Zhirong Zhang Wenbiao Shen Xingxing Yuan Yanjie Xie Laboratory Center of Life Sciences College of Life SciencesNanjing Agricultural UniversityNanjing 210095China Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientfficas y Universidad de SevillaSevilla 41092Spain Institute of Industrial Crops Jiangsu Academy of Agricultural SciencesNanjing 210014China

Gaseous molecules, such as hydrogen sulfide(H_2S)and nitric oxide(NO), are crucial players in cellular and(patho)physiological processes in biological systems. The biological functions of these gaseous molecules, which were first discovered and identified as gasotransmitters in animals, have received unprecedented attention from plant scientists in recent decades. Researchers have arrived at the consensus that H_2S is synthesized endogenously and serves as a signaling molecule throughout the plant life ***, the mechanisms of H_2S action in redox biology is still largely unexplored. This review highlights what we currently know about the characteristics and biosynthesis of H_2S in plants. Additionally,we summarize the role of H_2S in plant resistance to abiotic stress. Moreover, we propose and discuss possible redox-dependent mechanisms by which H_2S regulates plant physiology.

关键词： gasotransmitter hydrogen sulfide persulfidation plant physiology redox signaling stress response

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Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS)

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Cellular & Molecular Immunology 2011年第1期8卷 88-91页

作者： Xin Liu Lijie Dong Xuejun Zhang Baoya Wang Xinting Wang Hu Li Jinyan He Lin ge Xiang Jing Zhi Yao Jie Yang Department of Immunology Basic Medical CollegeTianjin Medical UniversityTianjinChina Tianjin Key Laboratory of Cellular and Molecular Immunology TianjinChina Key Laboratory of Educational Ministry of China TianjinChina Laboratory of Molecular Immunology Research Center of Basic Medical SciencesTianjin Medical UniversityTianjinChina Department of Ultrasonography Tianjin Third Central HospitalTianjinChina

The multifunctional protein p100 is a vital transcriptional regulator that increases gene transcription by forming a physical bridge between promoter-specific transcription factors and the basal transcription *** identify potential signal transduction pathways in which human p100 acts as a coregulator and to find target promoter regions that may interact with p100,we performed a promoter microarray assay called chromatin immunoprecipitation-guided ligation and selection(ChIP-GLAS).From this assay,we determined that a set of promoter fragments,including several factors in the transforming growth factor beta(TGF-β)signaling pathway,exhibited interaction with *** ChIP-GLAS data were validated by RT-PCR assessing the mRNA expression of various factors in the TGF-b signaling pathway in cell lines.

关键词： chromatin immunoprecipitation microarray p100 protein

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