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Double-layered osmotic pump controlled release tablets of actarit: In vitro and in vivo evaluation

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 340-348页

作者： Yuenan li Hao Pan Hongliang Duan Jianting Chen Zhihong Zhu Jingxin Fan pingfei li Xinggang Yang Weisan Pan Shenyang Pharmaceutical University No.103Wenhua RoadShenyang CityLiaoning Province110016China liao Ning University No.66Chongshan Middle RoadHuanggu DistrictShenyang CityLiaoning Province110036China

The aim of the study was to develop actarit double-layered osmotic pump tablets to overcome the weak points of actarit common tablets, such as short half-life and large plasma concentration fluctuations. Single factor experiment and orthogonal test were applied to optimize the formulation;the pharmacokinetic study was performed in beagle dogs adopting actarit common tablets as reference tablets. The optimal formulation was as follows: drug layer: 150 mg actarit, 240 mg PEO-N80, 50 mg NaCl;push layer: 140 mg PEO-WSR303, 20 mg NaCl;coating solution: 30 g cellulose acetate and 6 g PEG 4000 in 1000 ml 94% acetone solution, 60 mg coating weight gain. The pharmacokinetic study showed that T max was prolonged by the contrast of commercial common tablets with constant drug release rate, but the bioavailability was equivalent. And a good in vivo –in vitro correlation of the actarit osmotic pump tablets was also established. The designed actarit osmotic pump tablets can be applied for rheumatoid arthritis, proposing a promising replacement for the marked common products.

关键词： Actarit Double-layered Osmotic pump tablet Pharmacokinetics In vivo –in vitro correlation

ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages

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Protein & Cell 2019年第8期10卷 615-628页

作者： pingfei li Xiaofei Deng Jing Luo Yufei Chen Guoyu Bi Feili Gong Zhengping Wei Na liu Huabin li Arian Laurence Xiang-Ping Yang Department of Immunology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Department of Immunology School of Basic Medicine Hubei University of Medicine The First Affiliated Hospital Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Jinan University Department of Otolaryngology-Head and Neck Surgery Center for Allergic and Inflammatory Diseases Affiliated Eye and ENT Hospital Fudan University Department of Haematology University College London Hospitals NHS trust

Dear Editor,m TORC1, as a center regulatory hub of metabolism, senses the cellular energy status, nutrition and extracellular stimuli and regulates cell growth, differentiation and functions of immune cells (Powell et al., 2012). Lysosomal localization of key signal components is critical for m TORC1 activation:m TORC1 activation requires co-localization of activated Rheb and m TORC1 to the lysosome membrane (Buerger et al., 2006).

关键词： SUBUNIT

DAPK1(death associated protein kinase 1)mediates mTORC1 activation and antiviral activities in CD8^(+)T cells

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Cellular & Molecular Immunology 2021年第1期18卷 138-149页

作者： Zhengping Wei pingfei li Ran He Huicheng liu Na liu Yu Xia Guoyu Bi Qiuyang Du Minghui Xia Lei Pei Jing Wang Guihua Wang Zhao-Hui Tang Xiang Cheng Huabin li Zhuoya li lilin Ye Arian Laurence Youming Lu Xiang-Ping Yang Department of Immunology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Immunology Hubei University of MedicineShiyan 442000China Institute of Brain Research Huazhong University of Science and TechnologyWuhan 430030China Department of Physiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Surgery Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China Laboratory of Cardiovascular Immunology Institute of CardiologyUnion HospitalTongji Medical CollegeHUSTWuhan 430030China Department of Otolaryngology Head and Neck SurgeryAffiliated Eye-Ear-Nose and Throat HospitalFudan UniversityShanghai 200433China Institute of Immunology Medical SchoolThird Military Medical UniversityChongqing 400038China Department of Haematology University College London Hospitals NHS TrustLondonUK

Mechanistic target of rapamycin complex 1(mTORCt)regulates CD8^(+)T-cell differentiation and *** the links between PI3K-AKT and mTORCI activation in CD8^(+)T cells,the molecular mechanism underlying mTORCI activation remains ***,we show that both the kinase activity and the death domain of DAPK1 are required for maximal mTOR activation and CD8^(+)T-cell *** found that TCR-induced activation of calcineurin activates DAPK1,which subsequently interacts with TSC2 via its death domain and phosphorylates TSC2 to mediate mTORCI ***,both the kinase domain and death domain of DAPK1 are required for CD8^(+)T-cell antiviral responses in an LCMV infection ***,our data reveal a novel mechanism of mTORCI activation that mediates optimal CD8^(+)T-cell function and antiviral activity.

关键词： mTORCI CD8^(+)T cells antiviral function

Heat-inducible SlWRKY3 confers thermotolerance by activating the SlGRXS1 gene cluster in tomato

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Horticultural Plant Journal 2024年第2期10卷 515-531页

作者： Ying Wang Wenxian Gai liangdan Yuan Lele Shang Fangman li Zhao Gong pingfei Ge Yaru Wang Jinbao Tao Xingyu Zhang Haiqiang Dong Yuyang Zhang National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

High temperature stress is one of the major environmental factors that affect the growth and development of plants. Although WRKY transcription factors play a critical role in stress responses, there are few studies on the regulation of heat stress by WRKY transcription factors,especially in tomato. Here, we identified a group I WRKY transcription factor, SlWRKY3, involved in thermotolerance in tomato. First, SlWRKY3 was induced and upregulated under heat stress. Accordingly, overexpression of SlWRKY3 led to an increase, whereas knock-out of SlWRKY3 resulted in decreased tolerance to heat stress. Overexpression of SlWRKY3 accumulated less reactive oxygen species(ROS), whereas knock-out of SlWRKY3 accumulated more ROS under heat stress. This indicated that SlWRKY3 positively regulates heat stress in tomato. In addition,SlWRKY3 activated the expression of a range of abiotic stress-responsive genes involved in ROS scavenging, such as a SlGRXS1 gene *** analysis showed that SlWRKY3 can bind to the promoters of the SlGRXS1 gene cluster and activate their expression. Collectively, these results imply that SlWRKY3 is a positive regulator of thermotolerance through direct binding to the promoters of the SlGRXS1 gene cluster and activating their expression and ROS scavenging.

关键词： Tomato WRKY transcription factor SlWRKY3 Thermotolerance SlGRXS1 Gene cluster Abiotic stress

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长沙市普通人群的精神卫生知晓情况(英文)

上海精神医学 2011年第6期23卷 353-359页

作者：彭元王晓玲李平非刘鲲长沙市疾病预防控制中心 410001

目的评定长沙市公众精神卫生和精神疾病预防知识的知晓情况。方法采用多阶段整群随机抽样方法,选取长沙市辖区随机抽取的2个城市社区和2个农村社区的1660户家庭。从15岁及以上的家庭成员中随机抽取1人进行访谈,完成卫生部推荐的精神卫... 详细信息

目的评定长沙市公众精神卫生和精神疾病预防知识的知晓情况。方法采用多阶段整群随机抽样方法,选取长沙市辖区随机抽取的2个城市社区和2个农村社区的1660户家庭。从15岁及以上的家庭成员中随机抽取1人进行访谈,完成卫生部推荐的精神卫生知晓率标准问卷(20项)调查。结果 1563人完成有效问卷调查,其中男性676人,女性887人,平均年龄(标准差)为41.9(15.9)岁。平均(标准差)应答正确率为68.5%(46.4%),城市社区平均(标准差)应答正确率[70.5%(13.6%)]高于农村社区应答正确率[66.2%13.5%)](t=6.18,p<0.001)。正确应答率与年龄负相关(r=-0.21,p<0.001),与文化程度正相关(r=0.28,p<0.001),与职业和婚姻状态的差异呈多样相关性。采用逐步回归分析发现文化程度、年龄和职业(农民或工人与其他职业比较)为精神卫生知晓率的独立相关因素。问卷20个条目总体内部一致性及4个分量表的内部一致性偏低(alpha=0.27～0.57)。结论长沙市普通居民精神卫生知识总体知晓率相对较高,但有些方面仍需提高,特别是对于精神疾病病因的认识。公众精神卫生知识的知晓能力随人口学特征不同而有较大差异,因此对不同人群进行特定的精神卫生教育可有效地提高社区居民的精神卫生知识知晓率。今后需修订调查问卷,提高信、效度和内部一致性。

关键词：普通人群精神卫生精神疾病知晓率调查

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骑车人躯干姿态对头部损伤影响研究

中国安全科学学报 2020年第1期30卷 174-179页

作者：周华唐梅刘峰张爱红李平飞谭正平西华大学汽车与交通学院四川成都610039 四川西华交通司法鉴定中心四川成都610039 汽车测控与安全四川省重点实验室四川成都610039 威马汽车科技集团有限公司四川成都610100 公安部交通管理科学研究所江苏无锡214151

为研究电动二轮车与SUV正面碰撞事故形态中,骑车人头部损伤指标(HIC)与躯干横摆角、前倾角及参与方碰撞速度的关系,基于MADYMO软件验证后的运动型多用途车(SUV)与电动二轮车多刚体模型设计仿真试验。结果表明:骑车人HIC值随躯干横摆角... 详细信息

为研究电动二轮车与SUV正面碰撞事故形态中,骑车人头部损伤指标(HIC)与躯干横摆角、前倾角及参与方碰撞速度的关系,基于MADYMO软件验证后的运动型多用途车(SUV)与电动二轮车多刚体模型设计仿真试验。结果表明:骑车人HIC值随躯干横摆角的增大逐渐减小;电动二轮车车速不超过15 km/h或SUV车速超过50 km/h时,骑车人HIC值随躯干前倾角的增大逐渐减小;电动二轮车车速超过15 km/h或SUV车速不超过50 km/h时,骑车人HIC值随躯干前倾角的增大先增大后减小;提前同时增大骑车人躯干横摆角和前倾角可降低骑车人头部损伤程度。

关键词：电动二轮车运动型多用途车(SUV) 骑车人躯干横摆角前倾角头部损伤指标(HIC)

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水平定向钻进50年回顾

非开挖技术 2023年第2期 17-24页

作者：范苏瑞李平飞(译) 不详

在最近庆祝水平定向钻进(HDD)进入地下建筑市场50周年之际,Trenchless Works对水平定向钻进技术在21世纪为地下建筑行业所做贡献进行了总结分析。

关键词：水平定向钻地下建筑非开挖

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车身结构设计课程计算机仿真实验教学探讨

科教导刊 2022年第36期 75-77页

作者：李平飞吴涛西华大学汽车与交通学院四川成都610039

车身结构设计是西华大学车辆工程专业重要的专业课,研究型仿真实验对培养学生综合分析问题的能力及创新意识具有重要作用。论文分析了该课程实验教学中存在的问题及新教学计划的对策,介绍了课程教学中所涉及的计算机仿真技术,并在实验... 详细信息

车身结构设计是西华大学车辆工程专业重要的专业课,研究型仿真实验对培养学生综合分析问题的能力及创新意识具有重要作用。论文分析了该课程实验教学中存在的问题及新教学计划的对策,介绍了课程教学中所涉及的计算机仿真技术,并在实验教学中通过采用计算机仿真技术突破实验条件限制,使学生不仅进一步掌握了专业软件的应用,而且培养了学生独立思考和综合分析的能力。

关键词：车身结构设计研究型实验教学计算机仿真能力

ATP6V0d2 mediates leucine-induced mTORCI activation and polarization of macrophages

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Protein & Cell 2019年第8期10卷 615-619页

作者： pingfei li Xiaofei Deng Jing Luo Yufei Chen Guoyu Bi Feili Gong Zhengping Wei Na liu Huabin li Arian Laurence Xiang-Ping Yang Department of Immunology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Immuno logy School of Basic Medicine Hubei University of Medicine Shiyan 442000 China The First Affiliated Hospital Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Jinan University Guangzhou 510632 China Department of Otolaryngology-Head and Neck Surgery Center for Allergic and Inflammatory Diseases Affiliated Eye and ENT Hospital Fudan University Shanghai 200031 China Department of Haematology University College London Hospitals NHS trust London UK

Dear Editor, mTORCI, as a center regulatory hub of metabolism, senses the cellular energy status, nutrition and extracellular stimuli and regulates cell growth, differentiation and functions of immune cells (Powell et al., 2012). Lysosomal localization of key signal comp orients is critical for mTORCI activati on: mTORCI activation requires co-localization of activated Rheb and mTORCI to the lysosome membrane (Buerger et al., 2006). Signals in eluding growth factors, cellular stresses and energy levels act on the disruption the formation of tuberous sclerosis complex (TSC) complex, comprised of TSC1, TSC2 and TBC1D7, which leads to the translocation and activation of Rheb on the lysosome membrane (Dibble et al., 2012). In response to nutrient levels, specifically the availability of amino acids and glucose (Efeyan et al., 2013), mTORCI is recruited to the lysosomal surface by Rag GTPases that are heterodimers of RagA or RagC bound to RagB or RagD. Multiple protein complexes have been implicated in regulation of mTORCI upon nutrient sensing including Ragulator, GATOR1, GATOR2, KICSTOR and vacuolar ATPases (Wolfson et al., 2017). Vacuolar ATPases are large multiple-protein complexes that acidify the lysosome and may mediate additional functions independent of their proton pump activity (Nishi and Forgac, 2002).

关键词： ATP6V0d2 mediates leucine-induced mTORCI activation macrophages