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Acta Metallurgica Sinica(English Letters) 2012年第5期25卷 365-373页

作者： Shude JI Aili ZOU Yumei YUE Guohong L uan Yanye JIN Fu li Faculty of Aerospace Engineering Shenyang Aerospace University Shenyang 110136 China Beijing Aeronautical Manufacturing Technology Research Institute Beijing 100024 China

The rotational tool is put forward, which is composed of the one-spiral-flute shoul- der and the rotational pin with screw. Using the turbulent model of the FLUENT software, material plastic flow behavior during the process of friction stir welding of Ti6A14V alloy is researched by the numerical simulation method and then the effect of rotational tool geometry on material flow during the welding process is attained. The results show that the flow direction of the material near the rotational tool is mainly the same as the rotational direction of the tool while the material near tool flows more violently than the other regions. For the tapered rotational pin, the flow velocity of material inside the workpiece decreases with the increase of the distance away from the workpiece surface because of the change of pin diameter. For the rotational tool, the flute added to the shoulder and the screw added to the pin can greatly increase the flow velocity of material during the welding process while the peak value of the flow velocity of material appears on the flute or the screw. Moreover, the rotational tool with the one-spiral-flute shoulder is better than the tool with the concentric- circles-flute shoulder. Decreasing the width of pin screw and increasing the diameter of pin tip are both good for the increase of flow velocity.

关键词： Friction stir welding Titanium alloy Plastic flow Numericalsimulation

Effect of annealing temperature on the microstructure and mechanical properties of an as-rolled Mg-9wt.%li-3wt.%Al-1wt.%Zn alloy sheet

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Frontiers of Materials Science 2014年第3期8卷 271-280页

作者： Meng-Chang liN Shang-Qiu liN Jun-Yen uan Department of Materials Science and Engineering Chung Hsing University 250 kuo-kuang Rd. Taichung 40277 Taiwan China Green Energy and Environment Research Laboratories Industrial Technology Research Institute 195 Sec. 4 Chung-Hsing Road Hsin-Chu 31040 Taiwan China

This study investigated the effect of annealing temperature on the mechanical properties of an as-rolled Mg-9.26wt.%li-3,03wt,%Al-1,10wt.%Zn （LAZ931） alloy sheet. The dual-phase （a ＋ 13） LAZ931 alloy plate of 3 mm in thickness were roiled （67% reduction） and then annealed at temperatures at 100℃-350℃. The alloy＇s ductility showed a sharp concave downward tendency as a function of annealing temperature, The elongation of the LAZ931 alloy sheet increased with annealing temperature up to 150℃, followed by a sharp decrease of the alloy＇s ductility as the annealing temperature higher than 150℃. The specimen exhibited an extremely low elongation （only -0,5%） at annealing temperature around 300℃. Formation of brittle AIli particles on boundary resulted in li depletion zone near by grain boundary, transforming the li depletion zone into a （hcp） layer. The combined effects including brittle AIli particles on boundary and the hcp α layer on boundary resulted in the brittlement of the high-temperature-annealing sample.

关键词： Mg-li alloy annealing AIli embrittlement

Activating transcription factor 3,glucolipid metabolism,and metabolic diseases

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Journal of Molecular Cell Biology 2022年第10期14卷 1-10页

作者： Shuwei Hu Xiaojie Zhao Rui li Chencheng Hu Huĳuan Wu Jing li Yanqiao Zhang Yanyong Xu Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOH 44272USA Department of Pathology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Endocrinology Beĳing Chao-yang HospitalCapital Medical UniversityBeĳing 100020China Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Pathology of School of Basic Medical SciencesFudan UniversityShanghai 200032China Frontier Innovation Center School of Basic Medical SciencesFudan UniversityShanghai 200032China

lipids and glucose exert many essential physiological functions,such as providing raw materials or energy for cellular biosynthesis,regulating cell signal transduction,and maintaining a constant body *** of lipid and glucose metabolism can lead to glucolipid metabolic disorders linked to various metabolic diseases,such as obesity,diabetes,and cardiovascular ***,intervention in glucolipid metabolism is a key therapeutic strategy for the treatment of metabolic *** transcription factor 3(ATF3)is a transcription factor that acts as a hub of the cellular adaptive-response network and plays a pivotal role in the regulation of inflammation,apoptosis,DNA repair,and *** evidence has illustrated the vital roles of ATF3 in glucolipid ***3 inhibits intestinal lipid absorption,enhances hepatic triglyceride hydrolysis and fatty acid oxidation,promotes macrophage reverse cholesterol transport,and attenuates the progression of western diet-induced nonalcoholic fatty liver disease and *** addition to its role in lipid metabolism,ATF3 has also been identified as an important regulator of glucose ***,we summarize the recent advances in the understanding of ATF3,mainly focusing on its role in glucose and lipid metabolism and potential therapeutic implications.

关键词： ATF3 glucolipid metabolism metabolic organ metabolic diseases

A novel snowdrift game model with edge weighting mechanism on the square lattice

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Frontiers of physics 2012年第3期7卷 366-372页

作者： Juan-uan Zhang Hong-yun Ning Zi-yu Yin Shi-wen Sun li Wang Jun-qing Sun Cheng-yi Xia Tianjin Key Laboratory of Intelligence Computing and Novel Softwave Technology Tianjin University of Technology Tianjin 300384China Key Laboratory of Computer Vision and System of Ministry of Education Tianjin University of TechnologyTianjin 300384China School of Physics Nankai UniversityTianjin 300071China

We propose a novel snowdrift game model with edge weighting mechanism to explore the cooperative behaviors among the players on the square lattice. Based on the assumption of three types of weight distribution including uniform, exponential and power-law schemes, the cooperation level is largely boosted in contrast with the traditional snowdrift game on the unweighted square lattice. Exten- sive numerical simulations indicate that the fraction of cooperators greatly augments, especially for the intermediate range of cost-to-benefit ratio r. Furthermore, we investigate how the cooperative behaviors are affected by the undulation amplitude of weight distribution and noise strength of strat- egy selection, respectively. The simulation results will be conducive to further understanding and analyzing the emergence of cooperation, which is a ubiquitous phenomenon in social and biological science.

关键词： snowdrift game edge weighting mechanism cooperative dynamics

Study of the Correlation of EGFR and K-RAS Gene Mutations with Its Protein Expression in Non-small Cell Lung Cancer

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Clinical oncology and cancer researeh 2010年第2期7卷 97-102页

作者： Huan-ling L uan Lei-na SUN Na DONG Yan GUO Bao-cun SUN Zhong-li ZHAN Department of Pathology of Tianjin Can-cer Hospital Tianjin Medical University Tianjin Key Laboratory of Cancer Prevention and Therapy Tianjin Diagnosis and Therapy Center of Lung Cancer Tianjin 300060 China.

OBJECTIVE To investigate gene mutations of epidermal growth factor receptor （EGFR） and K-RAS （Kirsten rat sarcoma viral oncogene） in Chinese patients with non-small cell lung cancer （NSCLC）, and study the correlation with its protein expression and its clinical significance on *** Detect the EGFR and K-RAS gene mutations status by gene sequencing and use the method of immunohistochemistry to detect EGFR and K-RAS protein *** The frequency of EGFR mutations was 33%, mainly located in exon 19 and exon 21. The frequency of K-RAS mutations was 5.5%, mainly located in codon 12. There was no case which both had EGFR and K-RAS mutations, suggesting a mutually exclusive relationship between the two. EGFR mutations are more common in adenocarcinomas （particularly those with bronchioloalveolar features）, nonsmokers and females. 16% were detected EGFR positive expression and had no correlation with EGFR mutation （P 〉 0.05）, but had significant correlation with mutation in exon 19 （P 〈 0.05）. The frequency of K-RAS positive expression was 52.5% and had no correlation with K-RAS mutation （P 〉 0.05）. Twelve （8 cases were protein-negative） out of 15 gefitinib-treated NSCLC patients with disease control carry EGFR *** EGFR protein expression has some correlation with exon 19 mutations. Combined detection of EGFR and K-RAS gene mutations can help clinicians to choose patients who may benefit from EGFR tyrosine kinase inhibitor （EGFR-TKI） and to predict the response and prognosis of gefitinib.

关键词： Epidermal growth factor receptor (EGFR) Kirstenrat sarcoma viral oncogene (K-RAS) Non-small cell lung cancer(NSCLC) EGFR tyrosine kinase inhibitor (EGFR-TKI).

The effect of scaffolding instruction on learning among nursing students in China:a meta-analysis

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Nursing Communications 2022年第1期6卷 124-131页

作者： Sha-Sha Jia Yan-Y uan Lei Chang li Xiang-Shu Cui School of Nursing Yanbian UniversityYanji 133000China.

Objective:To systematically evaluate the influence of scaffolding instruction on the learning effect of nursing students in ***:Through the databases of CNKI,Wanfang,VIP,CBM,PubMed,Cochrane library,Embase and Web of Science,the randomized controlled trials of scaffolding instruction in nursing field were collected from the establishment of the databases to the publication in March *** literature screening,data extraction and quality evaluation,meta-analysis was performed using RevMan5.3 and Stata16.0 ***:Nineteen articles were included,with a total of 2,340 nursing ***-analysis results showed that,compared with the traditional teaching method,the scaffolding instruction was significantly better in nursing students’theoretical examination scores(SMD=1.37,95%CI:1.00 to 1.75,Plity(SMD=1.51,95%CI:0.70 to 2.32,P=0.0003)and teaching satisfaction(Plity and teaching *** teaching method deserves to be applied and promoted in the field of nursing education.

关键词： scaffolding instruction Chinese nursing students learning effect meta-analysis

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基于杜芬系统的线性化准则与振动机理研究

系统工程理论与实践 2007年第8期27卷 172-176页

作者：李大望邢锋王家远深圳大学深圳市土木工程耐久性重点实验室深圳大学土木工程学院深圳518060

基于等效化误差率和熵值误差率两种评估指标并分别利用响应矩受限和方程差均方最小等效化准则,对比分析了高斯白噪声作用的杜芬系统稳态响应分布线性化解析解的预测精度;探讨了系统参数和激励强度的相关性及其对系统振动的综合影响.结... 详细信息

基于等效化误差率和熵值误差率两种评估指标并分别利用响应矩受限和方程差均方最小等效化准则,对比分析了高斯白噪声作用的杜芬系统稳态响应分布线性化解析解的预测精度;探讨了系统参数和激励强度的相关性及其对系统振动的综合影响.结果表明,线性化解的预测精度受最大熵原理支配;方程差均方最小准则规定了线性化解的基本属性,而采用已知矩信息可以改善线性化解的预测精度;上述两种评估指标的结论具有一致性;系统参数和激励强度对系统响应的影响可按相对刚度硬化系数综合表述.

关键词：杜芬系统随机振动等效准则评估指标,信息熵

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故宫图书馆《四库全书》存本考

湖南大学学报（社会科学版） 2016年第6期30卷 25-30页

作者：李士娟故宫博物院图书馆北京100009

乾隆三十八年开设"四库全书馆"开始编纂《四库全书》,历时十三年完成,先后共缮写七份分贮七阁,由于历次战乱多份被毁。本文作者在整理清宫遗存典籍时,发现故宫图书馆仍然留存有文渊阁、文津阁以及南三阁《四库全书》存本。对此,作者对... 详细信息

乾隆三十八年开设"四库全书馆"开始编纂《四库全书》,历时十三年完成,先后共缮写七份分贮七阁,由于历次战乱多份被毁。本文作者在整理清宫遗存典籍时,发现故宫图书馆仍然留存有文渊阁、文津阁以及南三阁《四库全书》存本。对此,作者对这些书籍的留存原因及其特殊的文献价值一一进行了考校,且对研究《四库全书》的编纂具有重要意义。

关键词：故宫《四库全书》存本考证

Essential role of the NO/sGC/PKG signaling pathway in morphine-induced rewarding memory

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Essential role of the NO/sGC/PKG signaling pathway in morphi...

研发创新抑制波动机制分析——基于企业生产供给波动视角

中国神经科学学会第十届全国学术会议

作者： Fang SHEN Na WANG Yi-Jing li Cai-uan CUI Neuroscience Research Institute Peking University

Objective Evidence suggests that the nitric oxide（NO）/soluble guanylyl cyclase（sGC）/cGMP dependent protein kinase（PKG） signahng pathway plays a key role in memory processing,such as the inhibitory avoidance memory,fear memory and object recognition memory,in the basal lateral amygdale（BLA） and the *** the nucleus accumbens（NAc）,including the shell and core component,is believed to be essential in the reward property induced by addictive ***,data on the role of NO/sGC/PKG signahng pathway in the NAc in rewarding memory is not *** Conditioned place preference（CPP） was used to represent the reinforcing effect of morphine in this *** on modern and traditional theoretical formulations of Pavlovian conditioning,the CPP paradigm reflects a preference for a context due to the contiguous association between the context and the drug stimulus,and considered to be close to the addictive situations of humans in reflecting the craving for a drug induced by a cue associated with the *** We found that pre-conditioning microinjecting into the NAc shell,but not the core,with the NO synthase（NOS） inhibitor L-NAME blocked the acquisition of morphine *** amnesic effect of L-NAME was mimicked by the neuronal NOS（nNOS） inhibitor 7-NI,the sGC inhibitor ODQ and the PKG inhibitor ***,microinjection of 7-NI,ODQ or Rp-8Br-PET-cGMPS into the NAc shell or the core had no effect on the retrieval of morphine ***,the reagents we used above did not produce preference or *** NO/sGC/PKG signahng pathway in the NAc shell but not core is critical for the acquisition of morphine-associated rewarding memory,whereas this signaling pathway is involved in the context-induced retrieval of rewarding memory neither in the NAc shell nor the core.

关键词： morphine reward memory conditioned place preference nucleus accumbens

来源： cnki会议评论

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经济理论与经济管理 2016年第6期36卷 72-87页

作者：李卓蒋银娟武汉大学经济与管理学院邮政编码430072

本文基于种类扩展型技术进步框架构建了理论模型,分析研发创新对企业层面生产供给波动的影响效应以及其作用机理,并利用中国制造业企业数据对理论模型进行验证。本文发现,研发创新带来的更多技术种类能够在一定程度上抵御生产波动的风险... 详细信息

本文基于种类扩展型技术进步框架构建了理论模型,分析研发创新对企业层面生产供给波动的影响效应以及其作用机理,并利用中国制造业企业数据对理论模型进行验证。本文发现,研发创新带来的更多技术种类能够在一定程度上抵御生产波动的风险,企业研发创新强度越大、全要素生产率越高,则企业产出波动性和生产率波动性越小。进一步研究发现,研发投入是通过扩展技术种类范围、提升全要素生产率间接地抑制波动,而研发产出会对企业层面波动产生直接和间接的抑制作用。因此,本文揭示了"创新性毁灭"之外研发创新影响企业层面波动的另一种机制,为改善供给状况、平抑实体经济波动提供了政策启示。

关键词：全要素生产率研发创新技术种类企业层面波动