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Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2697-2715页

作者： Ze Dai Kai-Li Deng Xiao-Mei Wang Dong-Xue Yang Chun-Lan Tang yu-ping zhou Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Institute of Digestive Disease of Ningbo University Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ningbo Key Laboratory of Translational Medicine Research on Gastroenterology and Hepatology Ningbo Key LaboratoryNingbo 315020Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)has a high incidence and *** studies have shown that indole derivatives involved in gut microbiota metabolism can impact the tumorigenesis,progression,and metastasis of *** To investigate the effect of indole-3-acetaldehyde(IAAD)on *** The effect of IAAD was evaluated in a syngeneic mouse model of CRC and CRC cell lines(HCT116 and DLD-1).Cell proliferation was assessed by Ki-67 fluorescence staining and cytotoxicity *** apoptosis was analysed by flow cytometry after staining with Annexin V-fluorescein isothiocyanate and propidium *** was investigated using the transwell *** blotting and real-time fluorescence quantitative polymerase chain reaction were performed to evaluate the expression of epithelial-mesenchymal transition related genes and aryl hydrocarbon receptor(AhR)downstream *** PharmMapper,SEA,and SWISS databases were used to screen for potential target proteins of IAAD,and the core proteins were identified through the String *** IAAD reduced tumorigenesis in a syngeneic mouse *** CRC cell lines HCT116 and DLD1,IAAD exhibited cytotoxicity starting at 24 h of treatment,while it reduced Ki67 expression in the *** results of flow cytometry showed that IAAD induced apoptosis in HCT116 cells but had no effect on DLD1 cells,which may be related to the activation of *** can also increase the invasiveness and epithelial-mesenchymal transition of HCT116 and DLD1 *** low concentrations(<12.5μmol/L),IAAD only exhibited cytotoxic effects without promoting cell *** addition,predictions based on online databases,protein-protein interaction analysis,and molecular docking showed that IAAD can bind to matrix metalloproteinase-9(MMP9),angiotensin converting enzyme(ACE),poly(ADP-ribose)polymerase-1(PARP1),matrix metalloproteinase-2(MMP2),and myeloperoxidase(MPO).CONCLUSION Indole-3-aldehyde can induce cell apoptosis and inhibit cell prol

关键词： Indole-3-acetaldehyde Colorectal cancer Tryptophan metabolism Apoptosis Epithelial-mesenchymal transition

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Expression and clinical significance of short-chain fatty acids in patients with intrahepatic cholestasis of pregnancy

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World Journal of Hepatology 2024年第4期16卷 601-611页

作者： Shuai-Jun Ren Jia-Ting Feng Ting Xiang Cai-Lian Liao yu-ping zhou Rong-Rong Xuan Department of Obstetrics and Gynecology The First Affiliated Hospital of Ningbo UniversityNingbo 315100Zhejiang ProvinceChina Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315211Zhejiang ProvinceChina Institute of Digestive Disease Ningbo UniversityNingbo 315020Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholestasis of pregnancy(ICP)is a pregnancy-specific liver condition that typically arises in the middle and late stages of ***-chain fatty acids(SCFAs),prominent metabolites of the gut microbiota,have significant connections with various pregnancy complications,and some SCFAs hold potential for treating such ***,the metabolic profile of SCFAs in patients with ICP remains *** To investigate the metabolic profiles and differences in SCFAs present in the maternal and cord blood of patients with ICP and determine the clinical significance of these *** Maternal serum and cord blood samples were collected from both patients with ICP(ICP group)and normal pregnant women(NP group).Targeted metabolomics was used to assess the SCFA levels in these *** Significant differences in maternal SCFAs were observed between the ICP and NP *** SCFAs exhibited a consistent declining trend in cord blood samples from the ICP group,mirroring the pattern seen in maternal *** analysis revealed a positive correlation between maternal serum SCFAs and cord blood SCFAs[r(Pearson)=0.88,P=7.93e-95].In both maternal serum and cord blood,acetic and caproic acids were identified as key metabolites contributing to the differences in SCFAs between the two groups(variable importance for the projection>1).Receiver operating characteristic analysis demonstrated that multiple SCFAs in maternal blood have excellent diagnostic capabilities for ICP,with caproic acid exhibiting the highest diagnostic efficacy(area under the curve=0.97).CONCLUSION Compared with the NP group,significant alterations were observed in the SCFAs of maternal serum and cord blood in the ICP group,although they displayed distinct patterns of ***,the SCFA levels in maternal serum and cord blood were significantly positively ***,certain maternal serum SCFAs,specifically caproic and acetic acids,demonst

关键词： Intrahepatic cholestasis of pregnancy Short-chain fatty acids Maternal serum Cord blood Caproic acid

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Multi-mode interaction middleware for software services

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Science in China(Series F) 2008年第8期51卷 985-999页

作者： TAO Xianping MA XiaoXing LU Jian yu ping zhou yu State Key Laboratory for Novel Software Technology Institute of Computer Software Nanjing UniversityNanjing 210093 China

Due to the independency, variability, and tailorability of software service in the open environment, the research of middleware which supports software services multi-mode interaction is thus of great importance. In this paper, an agent-based multi-mode interaction middleware model and its supporting system for software services were proposed. This model includes an interaction feature decomposition and configuration model to enable interaction programming, an agent-based middleware model, and a programmable coordination media based on reflection technology. The decomposition and configuration model for interaction features can assist programmers in interaction programming by analyzing and synthesizing interaction features. The agent-based middleware model provides a runtime framework for service multi-mode interaction. The programmable coordination media is able to effectively support software service coordination based on multimode interaction. To verify feasibility and efficiency of the above method, the design, implementation and performance analysis of Artemis-M3C, a multi-mode interaction middleware for software services, were introduced. The result shows that the above method is feasible and that the Artemis-M3C system is practical and effective in multi-mode interaction.

关键词： open environment multi-mode interaction Mobile Agent interaction mode programming programmable coordination media

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Spherical Confinement Generates Entropic Force to Accelerate Polymer Chain Detachment

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Chinese Journal of Polymer Science 2024年第3期42卷 407-416,I0010页

作者： yu-Shan Zheng Jian-ping zhou Yan Xu Kai Li Mechanical Engineering Xinjiang UniversityUrumqi 830002China

To understand the dynamic process of polymer detachment, it is necessary to determine the mean detachment time of a single breakable link, which is modeled as a spring. Normally, this time can be viewed as the escape of a Brownian particle from the potential well of the spring. However, as the free dangling length of the polymer chain increases, the conformational entropy of the chain is affected by geometric confinement. It means that the wall exerts a repulsive force on the chain, resulting in accelerated link detachment from a macroscopic perspective. In this work, we investigate the effect of entropy on the detachment rate in the case where the substrate is spherical. We demonstrate that spherical confinement accelerates chain detachment both inside and outside the sphere. An analytical expression for the mean detachment time of breakable links is given, which includes an additional pre-factor that is related to the partition function. Additionally, we analyze the expressions for entropic forces inside the sphere, outside the sphere, and on a flat wall, comparing their magnitudes to explain the difference in mean detachment time.

关键词： Polymer detachment Breakable link Entropic force Mean first passage time

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Function of macrophage-derived exosomes in chronic liver disease:From pathogenesis to treatment

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World Journal of Hepatology 2023年第11期15卷 1196-1209页

作者： Shi-Yi Xiang Kai-Li Deng Dong-Xue Yang ping Yang yu-ping zhou Health Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Institute of Digestive Disease of Ningbo University Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ningbo Key Laboratory of Translational Medicine Research on Gastroenterology and Hepatology Ningbo Key LaboratoryNingbo 315020Zhejiang ProvinceChina

Chronic liver disease(CLD)imposes a heavy burden on millions of people *** substantial research on the pathogenesis of CLD disorders,no optimal treatment is currently available for some diseases,such as liver ***,which are extracellular vesicles,are composed of various cellular *** have unique functions in maintaining cellular homeostasis and regulating cell communication,which are associated with the occurrence of ***,they have application potential in diagnosis and treatment by carrying diverse curative *** macrophages,which are key innate immune cells,show extraordinary heterogeneity and ***,macrophage-derived exosomes may play a pivotal role in the initiation and progression of various liver *** review focuses on the effects of macrophage-derived exosomes on liver disease etiology and their therapeutic potential,which will provide new insights into alleviating the global pressure of CLD.

关键词： Chronic liver disease Macrophage Exosomes Function Etiology Treatment

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Effect of drying cracks on swelling and self-healing of bentonite-sand blocks used as engineered barriers for radioactive waste disposal

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1776-1787页

作者： yu Tan Guangping zhou Huyuan Zhang Xiaoya Li ping Liu School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Mechanics on Disaster and Environment in Western China (Lanzhou University) Ministry of EducationLanzhou730000China Civil and Environmental Engineering University of Wisconsin-MadisonWI53706USA

Experiments were conducted to evaluate the healing of drying cracks in air-dried bentonite-sand blocks after hydration and swelling in groundwater,providing justifications to simplify the protection of blocks prior to installation in a high-level radioactive waste *** groundwater was prepared to represent the geochemistry of Beishan groundwater,and was used to hydrate the blocks during the swelling pressure and swelling strain measurements,as Beishan is the most promising site for China's *** of the surface cracks was recorded by photography,and healing of the internal cracks was visualized by CT images and hydraulic conductivity of air-dried *** results indicate that the maximum swelling pressure and swelling strain are primarily affected by the geochemistry of Beishan groundwater,but not affected by the drying *** maximum swelling pressure and swelling strain of air-dried blocks are comparable to or even higher than the pressure and strain of fresh *** maximum swelling pressure measured in strong(*** ion strength)Beishan groundwater was 44%of the pressure measured in deionized(DI)water,and the maximum swelling strain was reduced to 23%of the strain measured in DI ***,the remained swelling of the blocks hydrated in strong Beishan groundwater was sufficient to heal the surface and internal drying cracks,as demonstrated by the pictures of surface cracks and CT *** hydraulic conductivity of the air-dried block permeated with strong groundwater was comparable(3.7×higher)to the hydraulic conductivity of the fresh block,indicating the self-healing of drying cracks after hydration and swelling in groundwater.A simplified method of protecting the block with plastic wraps before installation is recommended,since the remained swelling of the block hydrated in Beishan groundwater is sufficient to heal the drying cracks.

关键词： Beishan groundwater chemistry Bentonite buffer Drying cracks High-level radioactive waste(HLW) Self-healing Swelling

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A low-profile metamaterial absorber with ultrawideband reflectionless and wide-angular stability

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Defence Technology（防务技术） 2024年第4期34卷 258-268页

作者： Feihong Lin Zhongming Yan ping Wang yu Wang Hongcheng zhou Haoran Lu School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle Ministry of EducationChengdu 610031China China Academy of Launch Vehicle Technology Beijing 100076China

An ultrawideband reflectionless metamaterial absorber(MA)is proposed by replacing the metallic ground with the complementary split-ring resonator(CSRR)*** proposed MA exhibits-10 d B reflectivity spectrum from 1 GHz to 20 GHz,which maintains more than 90%absorption from 1.5 GHz to20 ***,it achieves angle stability for TE and TM polarization at oblique incident angles up to 40°and 65°,*** achieve broadband absorption spectrum,we have adopted a single-layer high-impedance surface(HIS)loaded with a double-layer magnetic material(MM)*** further realize the RCS reduction into a lower frequency range,we have employed the scattering cancellation technology into the traditional metallic ***,we have fabricated a sample exhibiting the 10 d B RCS reduction from 1 GHz to 20 GHz with a thickness of 10 *** and simulation results confirm that the proposed MA exhibits excellent comprehensive performance,making it suitable for many practical applications.

关键词： Metamaterial absorber(MA) Magnetic material(MM) High-impedance surface(HIS) Scattering cancellation technology Ultrawideband Wide-angular stable

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Beamline design for multipurpose muon beams at CSNS EMuS

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Nuclear Science and Techniques 2024年第5期35卷 1-12页

作者： Yang Hong Ying-Peng Song Lu-ping zhou Jing-yu Tang Zhi-Hao zhou Nikolaos Vassilopoulos Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China Radiotherapy Physics and Technology Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China Xi’an Jiaotong University Health Science Center Xi’an 710049China Department of Radiation Oncology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

A new muon beam facility,called the Experimental Muon Source(EMuS),was proposed for construction at the China Spallation Neutron Source(CSNS).The design of the complex muon beamlines for the EMuS baseline scheme,which is based on superconducting solenoids,superferric dipoles and room-temperature magnets,is presented *** muon beams,including surface muons,decay muons and low energy muons,have been developed for multipurpose *** optics design and simulation results of the trunk beamline and branch beamlines are *** a proton beam power of 25 kW at a standalone target station that consists of a conical graphite target and high-field superconducting solenoids,the muon beam intensity in the trunk beamline varies from 10^(7)/s for surface muons to 10^(10)/s for high-momentum decay *** at the endstations,these values vary from 10^(5)/s for surface muons to 10^(8)/s for decay muons.

关键词： Surface muons Decay muons Muon beamline Superconducting solenoids Multi-channel electrostatic separator

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Acquiring Weak Annotations for Tumor Localization in Temporal and Volumetric Data

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Machine Intelligence Research 2024年第2期21卷 318-330页

作者： yu-Cheng Chou Bowen Li Deng-ping Fan Alan yuille Zongwei zhou Department of Computer Science Johns Hopkins UniversityBaltimore 21218USA Computer Vision Lab ETH ZurichZurich 8001Switzerland

Creating large-scale and well-annotated datasets to train AI algorithms is crucial for automated tumor detection and ***,with limited resources,it is challenging to determine the best type of annotations when annotating massive amounts of unlabeled *** address this issue,we focus on polyps in colonoscopy videos and pancreatic tumors in abdominal CT scans;Both applications require significant effort and time for pixel-wise annotation due to the high dimensional nature of the data,involving either temporary or spatial *** this paper,we develop a new annotation strategy,termed Drag&Drop,which simplifies the annotation process to drag and *** annotation strategy is more efficient,particularly for temporal and volumetric imaging,than other types of weak annotations,such as per-pixel,bounding boxes,scribbles,ellipses and ***,to exploit our Drag&Drop annotations,we develop a novel weakly supervised learning method based on the watershed *** results show that our method achieves better detection and localization performance than alternative weak annotations and,more importantly,achieves similar performance to that trained on detailed per-pixel ***,we find that,with limited resources,allocating weak annotations from a diverse patient population can foster models more robust to unseen images than allocating per-pixel annotations for a small set of *** summary,this research proposes an efficient annotation strategy for tumor detection and localization that is less accurate than per-pixel annotations but useful for creating large-scale datasets for screening tumors in various medical modalities.

关键词： Weak annotation detection localization segmentation colonoscopy abdomen

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Recent advances in visible light-mediated chemical transformations of enaminones

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Chinese Chemical Letters 2024年第2期35卷 4-15页

作者： yu Han Liyun zhou Chengyu Wang Shangti Feng Rong Ma Jie-ping Wan College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China School of Chemistry and Chemical Engineering Linyi UniversityLinyi 276000China Linyi Sanfeng Chemical Co. Ltd.Linyi 276000China

Enaminones,which possesses both the nucleophilic enamine as well as electrophilic enone structures,are well known versatile building blocks in organic ***,visible light-mediated reactions have emerged as useful synthetic strategy with enhanced *** the last decade,various photochemical transformations of enaminones have been developed to construct cyclic or acyclic *** this review,we describe the recent advances in visible light-mediated chemical transformations of *** discussion on the reaction mechanism of the related reactions is given to provide guide to the ***,a summary on the existing challenges and the future outlook towards the development of practical photocatalytic reactions of enaminones is also presented.

关键词： Enaminone Visible light C-H functionalization C=C bond cleavage Cyclization Multicomponent reactions

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