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Bi-level Nasal Positive Airway Pressure(BiPAP)versus Nasal Continuous Positive Airway Pressure(CPAP)for Preterm Infants with Birth Weight Less Than 1500g and Respiratory Distress Syndrome Following INSURE Treatment:A Two-center Randomized Controlled Trial

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Current Medical Science 2021年第3期41卷 542-547页

作者： Rui PAN Gao-yan CHEN Jing WANG Zhao-xian ZHOU ping-ying zhang Li-wen CHANG Zhi-hui RONG Department of Pediatrics Xicmgyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 440021China Department of Neonatology Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China

The present study aimed to examine the effectiveness of bi-level positive airway pressure(BiPAP)versus continuous positive airway pressure(CPAP)in preterm infants with birth weight less than 1500 g and respiratory distress syndrome(RDS)following intubation-surfactant-extubation(INSURE)treatment.A two-center randomized control trial was *** primary outcome was the reintubation rate of infants within 72 h of age after *** outcomes included bronchopulmonary dysplasia(BPD),necrotizing enterocolitis(NEC),retinopathy of prematurity(ROP)and incidences of adverse *** function at one year of corrected age was also compared between the two *** were 140 cases in the CPAP group and 144 in the BiPAP *** INSURE,the reintubation rates of infants within 72 h of age were 15%and 11.1%in the CPAP group and the BiPAP group,respectively(P>0.05).Neonates in the BiPAP group was on positive airway pressure(PAP)therapy three days less than in the CPAP group(12.6 d and 15.3 d,respectively,P0.05).There was no difference in lung function at one year of age between the two groups(P>0.05).In conclusion,after INSURE,the reintubation rate of infants within 72 h of age was comparable between the BiPAP group and the CPAP *** was superior to CPAP in terms of shorter durations(days)on PAP support and oxygen *** were no differences in the incidences of BPD and ROP,and lung function at one year of age between the two ventilation methods.

关键词： noninvasive ventilator neonate bronchopulmonary dysplasia continuous positive airway pressure

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Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women

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Chinese Medical Journal 2013年第11期126卷 2034-2038页

作者： ZHENG Ting-ping SUN Ai-jun XUE Wei WANG Ya-ping JIANG ying zhang ying LANG Jing-he Department of Obstetrics and Gynecology Peking Union MedicalCollege Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100730 China

Background It is now recognized that Cimicifuga foetida extract is effective in alleviating menopausal symptoms. But the durations reported were usually short. This paper compares the clinical effects of different regimens of three-month course on climacteric symptoms in Chinese women, so as to evaluate the efficacy and safety of Cimicifuga foefida extract. Methods This was a prospective, randomized trial. Ninety-six early menopausal women were recruited and randomly assigned into 3 groups to take different kinds of medicine for 3 months; participants were given Cimicifuga foefida extract daily in group A （n=32）, given estradiol valerate and progesterone capsule cycle sequentially in group B （n=32）, and given estradiol valerate and medroxyprogesterone acetate cycle sequentially in group C （n=32）. The questionnaires of Kupperman menopause index, Menopause-Specific Quality of Life, and Hospital Anxiety and Depression Scale were finished before and after the treatment. The status of vaginal bleeding and breast tenderness was recorded every day. Results Eighty-nine participants （89/96, 92.7%） completed the treatment. Kupperman menopause index decreased after taking the medicine for 3 months in each group （with all P〈0.001）, but the score after the treatment was higher in group A than in the other 2 groups. Except for the score of sexual domain in group A （P=0.103）, the scores of all domains of the Menopause-Specific Quality of Life decreased significantly after the treatment in all groups （with all P〈-0.01）. Score of anxity decreased significantly in group A （P=0.0l 5） and B （P=0.003）. Incidence of breast tenderness was 12.9% （4/31） in groupA, 36.7% （11/30） in group B, and 14.3% （4/28） in group C. Incidence of vaginal bleeding was 6.5% （2/31）in group A, 26.7% （8/30） in group B, and 82.1% （23/28）in group C. Conclusions Cimicifuga foeticla extract is effective and safe in the treatment of menopausal syndrome. It is worth extending its use in the treatment of climacteric c

关键词： Cimicifuga foetida extract menopause Kupperman menopause index menopause-specific quality of life vaginal bleeding breast tenderness

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Expression of a Hybrid Human Superoxide Dismutase with a High Affinity for Heparin

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Chemical Research in Chinese Universities 2002年第1期18卷 20-24页

作者： GOU Xiao-jun, YIN Shao-man, KONG Xiang-duo, ZHU Shi-zhen WANG Xiao-ping, zhang Hong-ying and zhang Jin Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130023, P. R. ChinaZHU HongThe Jilin Provi Jilin Univ Minist Educ Key Lab Mol Enzymol & Engn Changchun 130023 Peoples R China Jilin Province Peoples Hosp Changchun 130031 Peoples R China Jilin Univ Coll Chem Changchun 130023 Peoples R China

A designed heparin-affinity of human Cu, Zn-SOD is described. The natural leader peptide of *** Cu, Zn-SOD and a heparin-binding peptide containing a stretch of 7 Arg were fused to the N-terminal and the C-terminal of human Cu, Zn-SOD respectively. The resulted hybrid enzyme had not only a normal SOD activity but also a high affinity for heparin eluted on the heparin-Sepharose column at 0.4 mol/L NaCl. Some properties, such as the optimum pH, the thermostability and the half-life in the circulation of rats, were also analyzed.

关键词： Human superoxide dismutase Heparin affinity Gene expression

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RetCam与BIO在ROP筛查中的应用效果对比

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国际眼科杂志 2018年第4期18卷 748-750页

作者：孙淼张映萍中国湖南省湘潭市中心医院眼科 411100

目的:比较广角数码视网膜成像系统(RetCam)与双目间接检眼镜(BIO)在早产儿视网膜病变(ROP)筛查中的应用效果。方法:对2014-05/2017-05在我院出生的1624例3248眼早产儿进行RetCam与BIO检查,对比两种检查方法对ROP的筛查结果及不良事件发... 详细信息

目的:比较广角数码视网膜成像系统(RetCam)与双目间接检眼镜(BIO)在早产儿视网膜病变(ROP)筛查中的应用效果。方法:对2014-05/2017-05在我院出生的1624例3248眼早产儿进行RetCam与BIO检查,对比两种检查方法对ROP的筛查结果及不良事件发生情况。结果:早产儿1624例3248眼中,RetCam检出ROP患儿196例392眼,BIO检出ROP患儿189例378眼,二者的分期结果与分区病变结果比较差异无统计学意义(P>0.05);以BIO检查结果为标准,RetCam检查的敏感性、特异性、假阳性率、阳性预测值分别为100.00%、99.51%、3.57%、96.43%;RetCam与BIO的不良事件发生率分别为0.18%、0.22%,差异无统计学意义(P>0.05)。结论:RetCam与BIO筛查ROP具有较高一致性,RetCam可以替代BIO作为ROP的筛查方法。

关键词：广角数码视网膜成像系统间接检眼镜早产儿视网膜病变:筛查

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基于并行处理的分析仿真解决方案

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系统仿真学报 2008年第24期20卷 6617-6621页

作者：姚益平张颖星国防科技大学计算机学院长沙410073

分析仿真是以复杂问题分析为目的的一类仿真活动,在国防及国民经济各领域的应用日益广泛。随着仿真应用的不断深入,如何提高分析仿真的运行效率成为急需解决的问题。讨论了分析仿真的计算特点,指出了当前国内采用HLA体制、基于分布式网... 详细信息

分析仿真是以复杂问题分析为目的的一类仿真活动,在国防及国民经济各领域的应用日益广泛。随着仿真应用的不断深入,如何提高分析仿真的运行效率成为急需解决的问题。讨论了分析仿真的计算特点,指出了当前国内采用HLA体制、基于分布式网络解决方案存在的不足,分析了分析仿真的潜在并行性及面临的挑战;从国外分析仿真应用发展趋势以及国内实际情况出发,提出了基于高性能并行计算的分析仿真系统层次式体系架构,该方案可充分挖掘分析仿真的并行性,能有效支持分析仿真应用的运行和开发;同时该方案采用层次式架构,各层次内部功能相对独立,使得整个系统更易于维护和升级。

关键词：高性能仿真并行处理分析仿真仿真环境

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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review

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Structural Durability & Health Monitoring 2025年第1期19卷 25-54页

作者： Chao zhang Shang-Xi Lai Hua-ping Wang School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Special Functional Materials and Structural Design Ministry of EducationLanzhou UniversityLanzhou730000China

Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the ***,it is particularly signiﬁcant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientiﬁc basis for structural damage identiﬁcation and dynamic model modiﬁ*** view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and brieﬂy describes how to identify structural damages based on the derived modal *** paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),brieﬂy describes damage identiﬁcation methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artiﬁcial intelligence(AI)methods in the direction of modal parameter recognition and damage identiﬁcation is further *** on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identiﬁcation methods are given to provide scientiﬁc references for the optimized design and functional upgrading of SHM systems.

关键词： Structural health monitoring data information modal parameters damage identiﬁcation AI method

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新生儿泪囊炎综合疗法128例疗效分析

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国际眼科杂志 2013年第9期13卷 1919-1920页

作者：唐金萍张映萍湘潭市中心医院眼科中国湖南省411100

目的:分析探讨综合治疗方法对新生儿泪囊炎不同年龄组患儿的临床治疗效果。方法:回顾性分析128例148眼新生儿泪囊炎患儿的临床资料,根据患儿年龄分为3组,第一组为不满3月龄患儿36眼,第二组为满3～6月龄患儿67眼,第三组为满6～12月龄患... 详细信息

目的:分析探讨综合治疗方法对新生儿泪囊炎不同年龄组患儿的临床治疗效果。方法:回顾性分析128例148眼新生儿泪囊炎患儿的临床资料,根据患儿年龄分为3组,第一组为不满3月龄患儿36眼,第二组为满3～6月龄患儿67眼,第三组为满6～12月龄患儿45眼。第一组采用泪囊按摩+抗生素,第二组和第三组循序采用泪囊按摩+抗生素,泪道加压冲洗,泪道探通等方法。结果:泪囊按摩+抗生素在第一组与第二组的患儿中,差异具有显著统计学意义(χ2=26.65,P<0.05)。加压冲洗法在第二组与第三组的患儿中,差异具有统计学意义(χ2=5.23,P<0.05)。一次泪道探通法在第二组与第三组的患儿中差异具有统计学意义(χ2=3.90,P<0.05)。结论:根据患儿的年龄循序选择泪囊区按摩后联合抗生素眼液治疗,泪道加压冲洗,泪道探通的综合治疗。3mo内选择泪囊区按摩后联合抗生素眼液治疗;泪道加压冲洗或泪道探通在3～6mo进行为宜。

关键词：新生儿泪囊炎综合治疗治疗时机

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng ying Chen Jiali Pu Baorong zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： WEN Jin LIU Zhanzhi WU Zhengwei PAN Yu zhang ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-ying Ji Feng-ying zhang ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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