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Chinese Journal of Cancer Research 2011年第3期23卷 208-213页

作者： Xue-song Fu ping-ping li Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Integrated Traditional Chinese and Western MedicinePeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：Estradiol （E2） plays an important role in the development of breast *** postmenopausal women,the estrogen can be synthesized via aromatase （CYP19） pathway and steroid-sulfatase （STS） pathway in peripheral tissues,when the production in ovary has *** objective of our study was to explore the effects of Shu-Gan-liang-Xue Decoction （SGLXD） on the expressions of CYP19 and STS in estrogen receptor positive breast cancer MCF-7 and T47D ***：The effects of SGLXD on the cell viability of MCF-7 and T47D were analyzed by MTT *** quantitative real-time RT-PCR and Western blot,we evaluated the mRNA and protein expressions of CYP19 and STS in MCF-7 and T47D cells after SGLXD ***：By MTT assay,the cell viability rates of MCF-7 and T47D were significantly inhibited by SGLXD in a dose-dependent manner,the IC50 values were 40.07 mg/ml for MCF-7 cells and 25.62 mg/ml for T47D cells,*** evidenced by real-time PCR and Western blot,the high concentrations of SGLXD significantly down-regulated the expressions of CYP19 and STS both in the transcript level and the protein ***：The results suggest that SGLXD is a potential dual aromatase-sulfatase inhibitor by simultaneously down-regulating the expressions of CYP19 and STS in MCF-7 and T47D cells.

关键词： Shu-Gan-liang-Xue Decoction (SGLXD) Aromatase (CYP19) Steroid-sulfatase (STS) Breast cancer

Microstructural evolution of titanium matrix composite coatings reinforced by in situ synthesized TiB and TiC by laser cladding

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International Journal of Minerals,Metallurgy and Materials 2010年第4期17卷 481-488页

作者： Jun li Zhi-shui Yu Hui-ping Wang Man-ping li School of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China

Titanium-based composite coatings reinforced by in situ synthesized TiB and TiC particles were successfully fabricated on Ti6Al4V by laser cladding using Ti-B_4C-Al or Ti-B_4C-C-Al powders as the precursor *** microstructural and metallographic analyses were made by X-ray diffraction（XRD）,optical microscope（OM）,scanning electron microscopy（SEM）,and electron probe microanalysis （EPMA）.The results show that the coatings are mainly composed ofα-Ti cellular dendrites and a eutectic transformation product in which a large number of coarse and fine needle-shaped TiB and a few equiaxial TiC particles are homogeneously embedded.A thin dilution zone with a thickness of about 100μm is present at the interface,and it consists of a few TiB and TiC reinforcements and a large number of lamella grains growing parallel to the heat flux direction in which a thin needle-shaped microstructure exists due to the martensitic transformation. The microstructural evolution can be divided into four stages：precipitation and growth of primaryβ-Ti phase,formation of the binary eutecticumβ-Ti＋TiB,formation of the ternary eutecticumβ-Ti＋TiB＋TiC,and solid transformation fromβ-Ti toα-Ti.

关键词： coating laser cladding in-situ synthesis microstructure

Effects of Anastrozole Combined with Shuganjiangu Decoction on Osteoblast-like Cell Proliferation, Differentiation and OPG/RANKL mRNA Expression

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Chinese Journal of Cancer Research 2012年第2期24卷 151-156页

作者： Yan Ren Shu-yan Han ping-ping li Key Laboratory of Carcinogenesis and Traditional Research(MinlStry of Education) Department of Integrated Traditional Chinese and Western MedicinePeking University Cancer Hospital&InstituteBeijing 100142China

Objective： To investigate the effects of anastrozole combined with Shuganjiangu decoction on osteoblast-like cells. Methods： Human osteoblast-like cells MG-63 were cultured and divided into four groups control, anastrozole, Shuganjiangu decoction （SGJGD）, and anastrozole combined with SGJGD. Cell proliferation was investigated by M-IF assay. Alkaline phosphatase （ALP） and osteocalcin, the indicators of cell differentiation, were evaluated by p-nitrophenyl- phosphate method and radioimmunoassay, respectively. Gene expressions of ALP, osteocalcin, osteoprotegerin （OPG） and receptor activator of nuclear factor kappa B ligand （RANKL） were examined by real-time PCR. Results： As evidenced by MTT assay, cell proliferation of MG-63 was inhibited by anastrozole, but stimulated with treatment of SGJGD alone and combined with anastrozole （P〈O.01）. Compared with control group, ALP activity was increased by the treatment of SGJGD alone and combined with anastrozole （P〈0.01）. Also, osteocalcin secretion was enhanced with the treatment of SGJGD single and combination with anastrozole （P〈O.05）. In the real-time PCR assay, gene expressions of ALP and osteocalcin were significantly increased （P〈0.01 for ALP, P〈0.05 for osteocalcin） by the treatment of SGJGD and anastrozole combined with SGJGD, but the expression of RANKL was decreased （P〈O.05）. Moreover, anastrozole combined with SGJGD upregulated gene expression of OPG （P〈O.01）. Conclusion： SGJGD may alleviate the injury effects of anastrozole on MG-63 cells through adjusting bone formation and resorption indicators.

关键词： Shuganjiangu decoction Osteoblast-like cell Alkaline phosphatase Osteocalcin Osteoprotegerin Receptoractivator of nuclear factor kappa B ligand (RANKL)

Long-Term Chinese Herbs Decoction Administration for Management of Hot Flashes Associated with Endocrine Therapy in Breast Cancer Patients

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Chinese Journal of Cancer Research 2011年第1期23卷 74-78页

作者： Dong Xue Hong Sun ping-ping li Key Laboratory of Carcinogenesis and Translational Research（Ministry of Education） Department of Integrative MedicinePeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：To evaluate the effect of Chinese herbs decoction Shu-Gan-liang-Xue on endocrine therapy-associated hot flashes symptom in breast cancer ***：Sixty-six patients with breast cancer receiving adjuvant endocrine therapy were categorized to two groups,the control group received endocrine therapy alone,the other group is administered with Chinese herbs decoction Shu-Gan-liang-Xue besides the endocrine therapy：Shu-Gan-liang-Xue decoction was administered above 6 months per year for more than 2 *** of hot flashes per day was recorded,and the effect of Shu-Gan-liang-Xue decoction on hot flashes symptom being assessed with Kupperman Scoring ***：Sixty cases were analyzed,32 cases in endocrine therapy combining Chinese herbs decoction group,28 cases in mere endocrine therapy *** hot flashes symptom,in Chinese herbs decoction administration group,7 cases（21.9%） reported symptom disappeared,22 cases（68.7%） reported symptom alleviated,3 cases（9.4%） reported symptom not changed;in endocrine therapy alone group,5 cases（17.9%） reported symptom disappeared,13 cases（46.4%） reported symptom alleviated,10 cases（10/28,35.7%） reported symptom not *** difference between two groups was statistically significant（P=0.013）.For sleeping disorder,in Chinese herbs decoction administration group,27 cases（84.4%） reported symptom improved,5 cases（15.6%） reported no change;in endocrine therapy alone group,16 cases（57.1%） symptom improved,12 cases（42.9%） reported no change in sleeping disorder（P=0.019）,the difference was also of significance ***：Long-term Chinese herbs decoction administration remarkably improved hot flashes symptom and sleeping disorder associated with endocrine therapy,meanwhile without definite toxicity and influence on the risk of recurrence of tumor.

关键词： Breast cancer Endocrine therapy Tamoxifen Hot flashes Chinese herbs decoction

Formation Mechanism and Binding Energy for Equilateral Triangle Structure of He3+ Cluster

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Communications in Theoretical Physics 2002年第5期38卷 597-600页

作者： GOU Qing-Quan ZHANG Jian-ping li ping Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China Department of Physics Leshan Teacher's College Leshan 614000 China Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China

The formation mechanism for the equilateral triangle structure of the He3+ cluster is proposed. The curveof the total energy versus the internuclear distance R for this structure has been calculated by the method of a modifiedarrangement channel quantum mechanics. The result shows that the curve has a minimal -7.81373 a.u at 1 = 1.55 *** binding energy of He3+ with respect to He+He+ +He was calculated to be 0.1064 a.u. (about 2.89 eV). This meansthat the He3+ cluster may be formed in the equilateral triangle structure stably by the interaction of He+ with two heliumatoms.

关键词： He3+ cluster, binding energy, equilateral triangle structure

Saline conducted electric coagulation (SCEC):original experience in experimental hepatectomy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 186-191页

作者： Guo-ping DING li-ping CAO Da-ren liU Ri-sheng QUE Department of General Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective: To evaluate the feasibility and superiority of a new coagulating and hemostatic method named "saline conducted electric coagulation (SCEC)". Methods: The Peng's multifunction operative dissector (PMOD) was modified to enable saline to effuse persistently out of its nib at a constant speed. In a group of six New Zealand rabbits, two hepatic lobes of each rabbits were resected respectively by SCEC and conventional electric coagulation (EC). The features of SCEC were recorded by photo and compared with conventional EC. After 7 d, the coagulating depth was measured in each residual hepatic lobe. Hepatic tissue was dyed by hematoxylin and eosin (HE) and studied under a microscope. Results: The coagulating depth increased with the continuation of SCEC time. Hepatectomies were performed successfully, no rabbit died in the perioperative period. The incisal surface of SCEC was gray-white with no red bleeding point. There was a thick solidified layer at the margin and a thin red-white intermittent layer between the solidified layer and normal hepatic tissue at the vertical section of SCEC. The mean coagulating depth of SCEC was 1.8 cm vs. 0.3 cm of conventional EC. Pathological examination showed a mild inflammatory reaction by SCEC. Conclusions: SCEC is a feasible and safe method for surgical hemostasis. As a new technique for liver resection, SCEC shows better coagulating effect and milder inflammatory reaction than conventional EC. Our study shows bloodless liver resection can also be performed by SCEC, especially for liver malignant tumor.

关键词： Saline Electric coagulation Hepatectomy Hemostasis Bloodless liver resection

Formation Mechanism and Binding Energy for Regular Octahedral Structure of li_6 Cluster

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Communications in Theoretical Physics 2008年第12期50卷 1407-1410页

作者： ZHAO Yan-ping li ping GOU Qing-Quan liU Wei-Na Institute of Atomic and Molecular Physics Sichuan University Chengdu 610065 China

The formation mechanism for the regular octahedral structure of liscluster is proposed. The curve of the total energy versus the separation R between any two neighboring nuclei has been calculated by using the method of Gou＇s modified arrangement channel quantum mechanics （MACQM）. The result shows that the curve has a minimal energy of -44.736 89 a.u. at R = 5.07a0. When R approaches infinity, the total energy of six lithium atoms has the value of -44.568 17 a.u. So the binding energy of li6 with respect to six lithium atoms is 0.1687 a.u. Therefore, the binding energy per atom for li6 is 0.028 12 a.u., or 0.7637 eV, which is greater than the binding energy per atom of 0.453 eV for li2 and the binding energy per atom of 0.494 eV for li3 calculated in our previous work. This means that the li6 cluster may be formed in a regular octahedral structure with a greater binding energy.

关键词： li6 cluster formation mechanism binding energy

Enhanced expression of epidermal growth factor receptor gene in gastric mucosal cells by the serum derived from rats treated with electroacupuncture at stomach meridian acupoints

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World Journal of Gastroenterology 2006年第34期12卷 5557-5561页

作者： Zong-Bao Yang Jie Yan Xiao-ping Zou Shou-Xiang Yi Xiao-Rong Chang Ya-ping lin Xi-ping li College of Acupuncture and Moxibustion Hunan University of Traditional Chinese Medicine Changsha 410007 Hunan Province China

AIM: To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHODS: The stress-induced gastric mucosal injury in rat model was established by water-immersion and restrained stress methods. 52 rats were randomly divided into: normal group (n = 8), model group (n = 8), model serum group (n = 12), stomach serum group (n = 12), and gallbladder serum group (n = 12). The gastric mucosal cells were separated by pronase-EDTA digestion method and incubated with serum. The EGFR gene expression in gastric mucosal cells was detected by reverse transcription-polymerase chain reaction (RT-PCR) method. RESULTS: Compared with normal group (0.6860 ± 0.0594), the serum derived from rats of the stomach group (1.2272 ± 0.0813, P = 0.00 0.05) and in model serum group (0.8516 ± 0.0409) with an extremely obvious difference (P = 0.001 < 0.01). Furthermore, the EGFR gene expression in stomach serum group was significantly higher than that in gallbladder serum group (P = 0.00 < 0.01). CONCLUSION: The present study shows that serumderived from rats treated with electroacupuncture at stomach meridian acupoints can distinctly increase the EGFR gene expression of gastric mucosal cells. Therefore, there is certain meridian specificity in the serum, which could provide a proof for the TCM theory “particular relation between meridian and internal organ”.

关键词： Electroacupuncture Serum Stomach meridian acupoints Gastric mucosal cells Epidermal growth Factor receptor Gene expression

Time Trends of Cancer Incidence in Urban Beijing,1998-2007

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Chinese Journal of Cancer Research 2011年第1期23卷 15-20页

作者： Ning Wang Wei-xing Zhu Xiu-mei Xing Lei Yang ping-ping li Wei-cheng You Key laboratory of Carcinogenesis and Translational Research （Ministry of Education） Beijing Cancer Registry Beijing 100142 China Key laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Cancer Epidemiology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective：To report the time trends of cancer incidence in urban Beijing from 1998 to ***：All data were obtained from Beijing Cancer Registry from 1998-2007 in urban *** trends of incidence rate of cancer were assessed by annual percentage change（APC） of age-standardized incidence rate（ASR） of world standard population during this 10-year ***：For all 156851 cancer cases combined,the incidence rate rose in both males and females,with an APC of 2.23% and 3.74%,*** incidence rate of upper gastrointestinal cancers declined significantly,with an APC of-2.83% in esophageal cancer and-1.37% in male gastric cancer,while lower gastrointestinal cancer,such as colorectal cancer,increased with an APC of 4.08%.The rates of kidney and bladder cancer increased with an APC of 7.93% and 5.57%,*** women,the APC continued to rise in breast cancer（4.98%）,ovary cancer（6.16%）,cervix uteri cancer（11.74%）,corpus uteri cancer（6.96%） and thyroid gland cancer（13.39%）.The rate of prostate cancer among men increased with an APC of 8.58%;the rate of lymphoma and leukemia increased with APC of 5.48% and 5.44%,***：Because of population aging and urban modernization,the cancer burden in Beijing has become more and more severe and similar to the western developed countries.

关键词： Oncology Epidemiology Incidence Trend

Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion

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World Journal of Stem Cells 2020年第5期12卷 368-380页

作者： Qi-Yuan Chang Si-Wen Zhang ping-ping li Zheng-Wei Yuan Ji-Chun Tan Department of Obstetrics and Gynecology Shengjing Hospital of China Medical UniversityShenyang 110022Liaoning ProvinceChina Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of liaoning Province Shenyang 110004Liaoning ProvinceChina Key Laboratory of Health Ministry for Congenital Malformation Shengjing Hospital of China Medical UniversityBenxi 117004Liaoning ProvinceChina

BACKGROUND Intrauterine adhesion(IUA)can cause serious damage to women’s reproductive health,yet current treatment methods are difficult to achieve satisfactory *** our previous studies,we demonstrated that menstrual-derived stromal stem cells(MenSCs),with high proliferative capacity and self-renewal ability,have a powerful therapeutic effect in patients with severe ***,safety assessment of MenSCs transplantation is essential for its further *** To evaluate the short-,medium-,and long-term biosafety of MenSCs via intrauterine transplantation in a rat model of IUA,with a focus on toxicity and *** MenSCs were injected into the sub-serosal layer of the uterus in an IUA rat model,for 3 d,3 mo,and 6 mo separately,to monitor the corresponding acute,sub-chronic,and chronic *** rats of the same age served as negative *** effects were evaluated by body weight,organ weight,histopathology,hematology,and biochemistry *** of MenSCs was investigated in Balb/c-nu mice in vivo and by colony formation assays in *** Compared with the same week-old control group,all of the IUA rats receiving MenSC transplantation demonstrated no obvious changes in body weight,mainorgan weight,or blood cell composition during the acute,sub-chronic,and chronic observation *** the same time,serum biochemical tests showed no adverse effects on metabolism or liver and kidney *** 4 wk of subcutaneous injection of Men SCs in Balb/c-nu nude mice,no tumor formation or cell metastasis was ***,there was no tumor colony formation of Men SCs during soft agar culture in *** There is no acute,sub-chronic,or chronic poisoning,infection,tumorigenesis,or endometriosis in rats with IUA after Men SC *** above results suggest that intrauterine transplantation of Men SCs is safe for endometrial treatment.

关键词： Menstrual blood-derived stromal cells Endometrial treatment Intrauterine adhesion Stem cell transplantation Biosafety Toxicity