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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 76-82页

作者： Wen-fang YANG fei HAN Xiao-hui ZHANG ping ZHANG Jiang-hua CHEN Kidney Disease Center the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

The diagnosis of extra-pulmonary tuberculosis(TB) seems relatively difficult due to the absence of specific symptoms and signs in patients on peritoneal dialysis or *** report four cases of extra-pulmonary tuberculosis on dialysis,with two cases on peritoneal dialysis and two cases on *** presentations,therapy,and outcomes of TB infection in these patients were ***,the English literature published in the PubMed database associating extra-pulmonary tuberculosis on dialysis over the last three decades is reviewed.A total of 61 studies containing 70 cases were *** most common primary disease was diabetic nephropathy(22.86%,16/70).The peritoneum(31.42%,22/70),bone(21.42%,15/70),and lymph node(20%,14/70) were the most frequently *** organ infection was common(90%,63/70).Fever(58.57%,41/70),pain(35.71%,25/70),and enlarged lymph node(20%,14/70) were the most common ***(67.14%,47/70) and culture(40%,28/70) provided most reliable methods for clear diagnosis of *** combined treatment of isoniazid,rifampicin,pyrazinamide,and ethambutol(44.29%,31/70) was the most common *** majority of patients improved(82.86%,58/70);however,12 cases got worse(17.14%),with 10 of them dying(14.29%).Physicians should be aware of the non-specific symptoms and location of infection,and consider tuberculosis in their differential diagnoses in dialysis patients presenting with symptoms such as fever,pain,and weight loss.

关键词： Extra-pulmonary tuberculosis End stage renal disease Dialysis

Accession-specific flowering time variation in response to nitrate fluctuation in Arabidopsis thaliana

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Plant Diversity 2021年第1期43卷 78-85页

作者： fei-Hong Yan Li-ping Zhang fang Cheng Dong-Mei Yu Jin-Yong Hu CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming650201China University of Chinese Academy of Sciences Beijing100049China

Flowering time,a key transition point from vegetative to reproductive growth,is regulated by an intrinsic complex of endogenous and exogenous signals including nutrient *** hundreds of years,nitrogen has been well known to modulate flowering time,but the molecular genetic basis on how plants adapt to ever-changing nitrogen availability remains not fully *** we explore how Arabidopsis natural variation in flowering time responds to nitrate *** nitrate availability change,we detect accession-and photoperiod-specific flowering responses,which also feature a accession-specific dependency on growth *** flowering time variation correlates well with the expression of floral integrators,SOC1 and FT,in an accession-specific *** find that gene expression variation of key hub genes in the photoperiod-circadian-clock(GI),aging(SPLs)and autonomous(FLC)pathways associates with the expression change of these integrators,hence flowering time *** results thus shed light on the molecular genetic mechanisms on regulation of accession-and photoperiod-specific flowering time variation in response to nitrate availability.

关键词： Nitrate Arabidopsis thaliana Photoperiod Natural variation Flowering time Gene expression

Superballistic wavepacket spreading in double kicked rotor

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Science China(Physics,Mechanics & Astronomy) 2016年第8期59卷 9-15页

作者： ping fang Jiao Wang Department of Physics and Institute of Theoretical Physics and Astrophysics Xiamen University

We investigate possible ways in which a quantum wavepacket spreads. We show that in a general class of double kicked rotor system, a wavepacket may undergo superballistic spreading; i.e., its variance increases as the cubic of time. The conditions for the observed superballistic spreading and two related characteristic time scales are studied. Our results suggest that the symmetry of the studied model and whether it is a Kolmogorov-Arnold-Moser system are crucial to its wavepacket spreading behavior. Our study also sheds new light on the exponential wavepacket spreading phenomenon previously observed in the double kicked rotor system.

关键词： quantum chaos quantum transport matter waves semiclassical methods

Enhanced Hall-Petch strengthening in graphene/Cu nanocomposites

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Journal of Materials Science & Technology 2021年第28期87卷 176-183页

作者： Shuang Zhang fei Wang ping Huang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an710049China State Key Laboratory for Strength and Vibration of Mechanical Structures School of AerospaceXi’an Jiaotong UniversityXi’an710049China

Grain size dependent strength,known as Hall-Petch relation,has been approved to be valid in crystalline metals and ***,softening would eventually occur as grain size reduced into nanoscale that below a critical ***,it is essential to find a way to break the strength limitation by avoiding the deformation mechanism transition from dislocation-mediated to grain-boundary-mediated *** replacing grain boundary(GB)of nanocrystalline Cu with graphene,in the present study,molecular dynamics simulations show that graphene-boundary(GrB)embedded GrB/Cu nanocomposites exhibit enhanced enlarged Hall-Petch slope with decreasing grain *** absence of inverse-Hall-Petch relation and the extremely high strength derived at the GrB/Cu nanocomposites were interpreted by the high back stress and abundant dislocation activity that attributed from the high-degree of heterogeneous structure of the nanocomposites.

关键词： Hall-Petch relation Graphene composite Strengthening Molecular dynamics simulation Dislocations

Harnessing Interactional Sensory Genes for Rationally Reprogramming Chaotic Metabolism

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Research 2023年第3期2022卷 295-308页

作者： Chunlin Tan ping Xu fei Tao State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental Sciencesand School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

Rationally controlling cellular metabolism is of great importance but challenging owing to its highly complex and chaotic *** existing sensory proteins like histidine kinases(HKs)are understood as“sensitive nodes”of biological networks that can trigger disruptive metabolic reprogramming(MRP)upon perceiving environmental ***,the“sensitive node”genes were adopted to devise a global MRP platform consisting of a CRISPR interference-mediated dual-gene combinational knockdown toolbox and survivorship-based metabolic interaction decoding *** platform allows users to decode the interfering effects of n×n gene pairs while only requiring the synthesis of n pairs of primers.A total of 35 HK genes and 24 glycine metabolic genes were selected as the targets to determine the effectiveness of our platform in a Vibrio *** platform was applied to decode the interfering impact of HKs on antibiotic resistance in strain FA2.A pattern of combined knockdown of HK genes(sasA_8 and 04288)was demonstrated to be capable of reducing antibiotic resistance of Vibrio by *** of combined knockdown of glycine pathway genes(e.g.,gcvT and ltaE)and several HK genes(e.g.,cpxA and btsS)were also revealed to increase glycine *** platform may enable an efficient and rational approach for global MRP based on the elucidation of high-order gene interactions.A web-based 1-stop service(https://***)is also provided to simplify the implementation of this smart strategy in a broad range of cells.

关键词： metabolism Rational programming

Inverse grain-size-dependent strain rate sensitivity of face-centered cubic high-entropy alloy

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Journal of Materials Science & Technology 2021年第27期86卷 251-259页

作者： Lili Xiao ping Huang fei Wang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an710049China State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi'an Jiaotong UniversityXi’an710049China

It is well documented that the strain rate sensitivity(m)increases at refined grain size for face-centered cubic(FCC)metals and *** a series of nanoindentation testing,however,we experimentally demonstrated a striking departure from conventional FCC metals that Co Cr Fe Mn Ni high entropy alloy(HEA)with FCC lattice structure exhibits monotonously decreased m as grain size reduced fromμ30.3m to 7.2 ***,the apparent activation volume v*,which generally shows an opposite trend of m,exhibited the identical decreasing trend with reduced grain size as that of *** an unusual trend of m and its correlation with v*in the FCC HEA alloys can be understood by a distinct deformationmechanism-transitions and unique dislocation morphology evolution that differs from conventional FCC metals.

关键词： High entropy alloy Strain rate sensitivity Activation volume Deformation mechanism Wavy dislocation

Entropy-expansiveness of Geodesic Flows on Closed Manifolds without Conjugate Points

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Acta Mathematica Sinica,English Series 2016年第4期32卷 507-520页

作者： fei LIU fang WANG College of Mathematics and System Science Shandong University of Science and Technology Qingdao 266590 P. R. China School of Mathematical Sciences Capital Normal University Beijing 100048 P. R. China Beijing Center for Mathematics and Information Interdisciplinary Sciences (BCMIIS) Beijing 100048 P. R. China

In this article,we consider the entropy-expansiveness of geodesic flows on closed Riemannian manifolds without conjugate *** prove that,if the manifold has no focal points,or if the manifold is bounded asymptote,then the geodesic flow is ***,for the compact oriented surfaces without conjugate points,we prove that the geodesic flows are *** also give an estimation of distance between two positively asymptotic geodesics of an uniform visibility manifold.

关键词： Entropy-expansiveness geodesic flows manifolds without conjugate points

Existence of Three Solutions for Quasilinear Elliptic Equations: an Orlicz-Sobolev Space Setting

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 287-296页

作者： fei fang Zhong TAN Department of Mathematics Beijing Technology and Business University School of Mathematical Sciences Xiamen University

In this paper, we establish the existence of three weak solutions for quasilinear elliptic equations in an Orlicz-Sobolev space via an abstract result recently obtained by Ricceri in [13].

关键词： Orlicz-Sobolev spaces quasilinear elliptic equations three critical points theorem

Changes in the food supply capacity of alpine grassland ecosystem:A dialectic synthesis of natural and anthropogenic drivers

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Advances in Climate Change Research 2020年第1期11卷 1-10页

作者： fang Yi-ping Institute of Mountain Hazards&Environment Chinese Academy of SciencesChengdu610041China College of Resource and Environment University of Chinese Academy of SciencesBeijing100049China

Grassland-based animal husbandry and livestock production is the main contributor to livelihood creation for *** using the structural dynamics method,this study quantified the changes in the food supply capacity(FSC)of alpine grassland ecosystem and sensitivity to significant *** findings indicated that:i)Natural factors were the dominated forces affecting FSC,and their contribution was 71.3%.Of these natural elements,the net primary productivity(NPP)and precipitation were the largest contributors,accounting for approximately 35%.The sensitivity index of the FSC to NPP and precipitation during grassland growing season were 4.1 and 1.9 *** the contrary,human factors like warm shed area,density of road,capacity for access to information,contributed to 28.7%of the total ***)More intense snow disaster had a larger negative impact on *** disaster can cause dramatic reduction in FSC,with a loss rate of 27.6%and with none intense disaster more negative impacts,iii)The continuing increase of FSC in the past 30 years from 1984 to 2014 was due to the significant increase of precipitation and NPP in the growing season of alpine ***,successful adaptation to climate change was critical to combat the climatic adversely impact on ***,strengthening information dissemination,road accessibility and knowledge popularization of local residents'disaster reduction should be place high priority for improving FSC。

关键词： Food supply capacity Alpine grassland ecosystem Structural dynamics method Snow disaster Permafrost

Simulating Eastern-and Central-Pacific Type ENSO Using a Simple Coupled Model

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Advances in Atmospheric Sciences 2018年第6期35卷 671-681页

作者： Xianghui fang fei ZHENG Institute of Atmospheric Sciences Fudan University International Center for Climate and Environment Science (ICCES) Institute of Atmospheric PhysicsChinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology

Severe biases exist in state-of-the-art general circulation models（GCMs） in capturing realistic central-Pacific（CP） El Nino structures. At the same time, many observational analyses have emphasized that thermocline（TH） feedback and zonal advective（ZA） feedback play dominant roles in the development of eastern-Pacific（EP） and CP El Nino-Southern Oscillation（ENSO）, respectively. In this work, a simple linear air-sea coupled model, which can accurately depict the strength distribution of the TH and ZA feedbacks in the equatorial Pacific, is used to investigate these two types of El Nino. The results indicate that the model can reproduce the main characteristics of CP ENSO if the TH feedback is switched off and the ZA feedback is retained as the only positive feedback, confirming the dominant role played by ZA feedback in the development of CP ENSO. Further experiments indicate that, through a simple nonlinear control approach, many ENSO characteristics,including the existence of both CP and EP El Nino and the asymmetries between El Nino and La Nina, can be successfully captured using the simple linear air-sea coupled model. These analyses indicate that an accurate depiction of the climatological sea surface temperature distribution and the related ZA feedback, which are the subject of severe biases in GCMs, is very important in simulating a realistic CP El Nino.

关键词： central-Pacific El Nino eastern-Pacific El Nino simple coupled model simulation asymmetry