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Structure and mechanical properties of nc-TiC/a-C:H nanocomposite films deposited by filtered cathodic arc technique

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Rare Metals 2016年第2期35卷 177-183页

作者： yu-Hao Zhai yu-Juan zhang Yi Peng Sheng-Mao zhang ping-yu zhang Xiao-Min zhang Key Laboratory of Ministry of Education for Special Functional Materials Henan University College of Materials and Mineral Resources Xi’an University of Architecture and Technology

nc-Ti C/a-C：H nanocomposite films were prepared by filtered cathodic arc technique. The influence of C_2H_2/Ar flow ratio on the composition, structure, and mechanical properties of films was investigated by X-ray photoelectron spectroscopy（XPS）, X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FTIR）,Raman spectroscopy, nanoindentation, and ball-on-disc tribometry. The films show a nanocomposite structure in which Ti C crystallites are embedded in the amorphous matrix of a-C：H phase. C content in films increases with the flow ratio of C_2H_2/Ar, simultaneously, the crystallite size of TiC decreases. Contrary to the nc-Ti C/a-C：H films deposited by magnetron sputtering in which the sp3 C content increases with C_2H_2 flow rate, the increase of C_2H_2 flow rate leads to the increase of sp2 C content in films deposited by filtered cathodic arc technique. The nc-Ti C/a-C：H films deposited by cathodic arc technique have a pronounced hardness maximum of 30 GPa under the C_2H_2/Ar flow ratio of 12. Tribological performance of films is controlled by the sp2 content in films. Higher sp2 content promotes the formation of graphite-like transfer layer during sliding,and results in lower wear rate and friction coefficient.

关键词： Nanocomposite films Tribological performance Hardness

Preparation and Identification of Angelica sinensis Polysaccharide-iron Complex

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Chemical Research in Chinese Universities 2005年第6期21卷 668-672页

作者： WANG Kai-ping zhang yu DAI Li-quan Faculty of Pharmacy Tongfi Medical College Huazhong University of Science and Technology Wuhan 430030 P. R. China

Angelica sinensis polysaccharide（ASP） was extracted from Angelica sinensis by boiling water. An Angelica sinensis polysaccharide-iron complex（APC） was prepared under the alkaline condition by adding a ferric chloride solution to the ASP solution. Then some identifiable properties of the complex were studied. The content of iron（ Ⅲ ） in the complex was determined with iodometry. The thermal property, the microscopic structure, the spectral characteristics, and N, C, H contents of the complex were examined by a variety of techniques including DSC, TEM, IR, NMR, and elemental analysis. The content of iron（ Ⅲ ） in the complex ranges from 10% to 40%. The DSC result shows that the melting point of the complex is about 450 ℃. The TEM result shows that the complex has an iron（ Ⅲ ） core（β-FeOOH core） linked by hydroxy and oxy bridges, with the polysaccharide chains attached to the surface of the core. The IR and NMR results also show that there is a β-FeOOH core in the complex. The elemental analysis shows that the contents of N, C, H in the complex are, respectively, lower than those of N, C, H in ASP. All our studies indicate that the APC consists of a β-FeOOH core surrounded by ASP.

关键词： Preparation Identification Angelica sinensis polysaccharide Angelica sinensis polysaccharide-iron complex

Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study

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World Journal of Emergency Medicine 2021年第2期12卷 117-123页

作者： Wen Gao yu-ping zhang Jing-fen Jin Nursing Department School of MedicineZhejiang UniversityHangzhou 310058China Nursing Department the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND: Delirium in patients in intensive care units(ICUs) is an acute disturbance and fluctuation of cognition and consciousness. Though increasing age has been found to be related to ICU delirium, there is limited evidence of the effect of age on delirium outcomes. The aim of this study is to investigate the relationship between age categories and outcomes among ICU delirium ***: Data were extracted from the electronic ICU(e ICU) Collaborative Research Database with records from 3,931 patients with delirium. Patients were classified into non-aged(<65 years), youngold(65–74 years), middle-old(75–84 years), and very-old(≥85 years) groups. A Cox regression model was built to examine the role of age in death in ICU and in hospital after controlling covariates. RESULTS: The sample included 1,667(42.4%) non-aged, 891(22.7%) young-old, 848(21.6%) middle-old, and 525(13.3%) very-old patients. The ICU mortality rate was 8.3% and the hospital mortality rate was 15.4%. Compared with the non-aged group, the elderly patients(≥65 yeras) had higher mortality at ICU discharge(χ2=13.726, P=0.001) and hospital discharge(χ2=56.347, P<0.001). The Cox regression analysis showed that age was an independent risk factor for death at ICU discharge(hazard ratio [HR]=1.502, 1.675, 1.840, 95% confidence interval [CI] 1.138–1.983, 1.250–2.244, 1.260–2.687;P=0.004, 0.001, 0.002 for the young-, middle-and very-old group, respectively) as well as death at hospital discharge(HR=1.801, 2.036, 2.642, 95% CI 1.454–2.230, 1.638–2.530, 2.047–3.409;all P<0.001).CONCLUSIONS: The risks of death in the ICU and hospital increase with age among delirious patients.

关键词： Intensive care Delirium Aging Mortality

Rapid Preparation of Monolithic Columns for Capillary Electrochromatography Separation

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Chinese Chemical Letters 2006年第6期17卷 813-816页

作者： Wen Jun GONG Yi Jun zhang yu ping zhang Seong Ho CHOI Henan Institute of Science and Technology Xinxiang 453003 Department of Chemistry Hannam University Daejon South Korea

Fritless packed silica gel columns were prepared using sol-gel technology, The part of a 75 μm i.d. capillary was filled with a mixture of methacryloxypropyltrimethoxysilane, toluene and hydrochloric acid. Four different photoinitiators such as benzoin methyl ether, Irgacure 819, Irgacure 1700 and Irgacure 1800 were added in the presence or absence of sodium dodecyl sulfate during the polymerization process. The above eight solutions were irradiated at 365 nm about 5-10 min to prepare the porous monolithic sol-gel columns by a one-step process.

关键词： Monolithic columns electrochromatography photopolymerized sol-gel.

Zhikang Capsule Ameliorates Inflammation, Drives Polarization to M2 Macrophages, and Inhibits Apoptosis in Lipopolysaccharide-induced RAW264.7 Cells

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Current Medical Science 2021年第6期41卷 1214-1224页

作者： Sheng-liang XIN Xia YANG yu-ping zhang Ke-shu XU Department of Infectious Diseases Peking University First HospitalBeijing 100034China Department of Gastroenterology Wuhan Asia General HospitalWuhan 430056China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:To explore the anti-inflammatory effect of the traditional Chinese medicine Zhikang capsule(ZKC)on lipopolysaccharide(LPS)-induced RAW264.7 ***:Safe concentrations of ZKC(0.175,0.35,and 0.7 mg/mL)were used after the half-maximal inhibitory concentration(IC_(50))of RAW264.7 cells was calculated through the CCK-8 *** addition,the optimal intervention duration of ZKC(0.7 mg/mL)on RAW264.7 cells was determined to be 6 h,since all proinflammatory mediators[tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),inteleukin-6(IL-6),cyclooxygenase-2(COX-2),inducible nitric oxide synthase(iNOS),and monocyte chemotactic protein-1(MCP-1)]had a decreasing tendency and relatively down-regulated mRNA expression levels as compared with other durations(4,8,and 12 h).RAW264.7 cells were pretreated with ZKC at various concentrations(0.175,0.35 and 0.7 mg/mL)for 6 h and then stimulated with LPS(1 μg/mL)for an additional 12 ***:In terms of inflammation,ZKC could reverse LPS-induced upregulation of TNF-α,IL-1β,IL-6,COX-2,iNOS,and MCP-1 at both the mRNA and protein levels in RAW264.7 cells in a dose-dependent *** terms of the NF-κB signaling pathway,ZKC could reduce phosphorylated p65 and promote M2 polarization of RAW264.7 cells under LPS stimulation in a dose-dependent ***,ZKC exhibited a protective effect on macrophages from ***:ZKC exhibited obvious antiinflammatory and anti-apoptotic effects on LPS-induced RAW264.7 cells at the cellular level,and a weakened NF-κB signaling pathway may be a potential significant target.

关键词： Zhikang capsule macrophage RAW 264.7 inflammation apoptosis nuclear factor kappa B

Novel Method of Preparation of Monolithic Columns for Fast Separation byγ-Ray Irradiation

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Chinese Chemical Letters 2006年第11期17卷 1485-1488页

作者： yu ping zhang Wen Jun GONG Li Qun FAN Yi Jun zhang Kwang Pill LEE Henan Institute of Science and Technology Xinxiang 453003 Department of Chemistry Graduate School Kyungpook National University South Korea

A porous monolithic sol-gel column with the solution of methacryloxypropyltrimethoxysilane in toluene with an acid catalyst was prepared in the presence and absence of sodium dodecyl sulfate. In situ polymerization was carded out by γ-ray irradiation within the capillary. The γ-radiation-initiated synthesis could generate radicals directly on the monomer avoiding use of any initiator. The chromatographic behavior of the capillary monolithic columns were studied in the modes of CEC, p-CEC and low pressure-driven separation, all the tests exhibited reversed-phase character. It provided a viable alternative to either thermally initiated or photo polymerization method for the preparation of monolithic columns.

关键词： Monolithic columns electrochromatography γ-ray irradiation polymerization.

Microdeletion on Xq27.1 in a Chinese VACTERL-Like Family with Kidney and Anal Anomalies

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Biomedical and Environmental Sciences 2024年第5期37卷 503-510页

作者： LI Min zhang yu Lan zhang Kai Li LI ping ping Lyu yu Han LIANG Ya Xin yu yue Department of Gynecology and Obstetrics Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Chinese Academy of Medical Sciences and Peking Union Medical College Beijing HospitalBeijing 100730China The Key Laboratory of Geriatrics Beijing Institute of GeriatricsBeijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

Objective VATER/VACTERL-like association is associated with adverse pregnancy *** evidence of this disorder is *** this study,we aimed to provide genetic insights to improve the diagnosis of *** We have described a Chinese family in which four members were affected by renal defects or agenesis,anal atresia,and anovaginal fistula,which is consistent with the diagnosis of a VACTERL-like *** and genetic analyses were conducted using genome and exome *** Segregation analysis revealed the presence of a recessive X-linked microdeletion in two living affected individuals,harboring a 196–380 kb microdeletion on Xq27.1,which was identified by familial exome *** sequencing was performed on the affected male,confirming a-196 kb microdeletion in Xq27.1,which included a 28%loss of the CDR-1 *** family members were included in the co-segregation analysis,and only VACTERL-like cases with microdeletions were reported in *** These results suggest that the 196–380 kb microdeletion in Xq27.1 could be a possible cause of the VATER/VACTERL-like ***,further genetic and functional analyses are required to confirm or rule out genetic background as the definitive cause of the VACTERL association.

关键词： Prenatal diagnosis VACTERL whole-genome sequencing whole-exome sequencing X-linked

Death and do-not-resuscitate order in the emergency department:A single-center three-year retrospective study in the Chinese mainland

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World Journal of Emergency Medicine 2020年第4期11卷 231-237页

作者： Chuan-qi Ding yu-ping zhang yu-wei Wang Min-fei Yang Sa Wang Nian-qi Cui Jing-fen Jin Department of Nursing the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Emergency Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhouChina

BACKGROUND:Consenting to do-not-resuscitate(DNR)orders is an important and complex medical decision-making process in the treatment of patients at the end-of-life in emergency departments(EDs).The DNR decision in EDs has not been extensively studied,especially in the Chinese ***:This retrospective chart study of all deceased patients in the ED of a university hospital was conducted from January 2017 to December *** patients with out-of-hospital cardiac arrest were ***:There were 214 patients’deaths in the ED in the three *** them,132 patients were included in this study,whereas 82 with out-of-hospital cardiac arrest were *** were 99(75.0%)patients’deaths after a DNR order medical decision,64(64.6%)patients signed the orders within 24 hours of the ED admission,68(68.7%)patients died within 24 hours after signing it,and 97(98.0%)patients had DNR signed by the family *** analysis showed that four independent factors infl uenced the family surrogates’decisions to sign the DNR orders:lack of referral(odds ratio[OR]0.157,95%confi dence interval[CI]0.047–0.529,P=0.003),ED length of stay(ED LOS)≥72 hours(OR 5.889,95%CI 1.290–26.885,P=0.022),acute myocardial infarction(AMI)(OR 0.017,95%CI 0.001–0.279,P=0.004),and tracheal intubation(OR 0.028,95%CI 0.007–0.120,P<0.001).CONCLUSIONS:In the Chinese mainland,the proportion of patients consenting for DNR order is lower than that of developed *** decision to sign DNR orders is mainly affected by referral,ED LOS,AMI,and trachea intubation.

关键词： Emergency service Do-not-resuscitate Death patients Retrospective analysis Emergency departments

Novel preparation of organic polymer-based monolithic column by microwave irradiation

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Chinese Chemical Letters 2007年第11期18卷 1399-1402页

作者： Xiong Wen Ye yu ping zhang Ling Bo Qu Li Qun Fan Bo Li Department of Chemistry Zhengzhou University Henan 450052 China Henan Institute of Science and Technology Xinxiang 453003 China

Microwave irradiation was firstly attempted for the preparation of organic-based monoliths of poly（styrene-divinylbenzene- methacrylic acid）, which single step in situ polymerization was carried out during 15 min. The colunm permeability, electrophoretic and chromatographac behaviors were comparatively evaluated using pressure-assisted CEC, GEC and low pressure-driven separation modes. The largest theoretical plates for the preparing column could be close to 18,0000 plates/m for thiourea in the mode of p-CEC. It provided a viable alternative to traditional initiation means for the perparation of monolithic capillary columns.

关键词： Monolithic columns Microwave irradiation Electrochromatography Polymerization