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Pancreaticoduodenectomy and pancreaticoduodenectomy combined with superior mesentericportal vein resection for elderly cancer patients

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Hepatobiliary & Pancreatic Diseases International 2014年第4期13卷 428-434页

作者： Jun-Wei Sun ping-ping zhang He Ren Ji-Hui Hao Departments of Pancreatic Cancer Tianjin Medical University Cancer Institute and Hospital Thoracic Oncology Tianjin Medical University Cancer Institute and Hospital

BACKGROUND： There is an increasing frequency of pancreaticoduodenectomy（PD） and PD with superior mesenteric-portal vein（SMPV） resection in elderly cancer patients. The study aimed to investigate the safety and the survival benefits of PD and PD with SMPV resection in patients under or over 70 years of ***： We divided 296 patients who had undergone PD and PD with SMPV resection into two groups according to their ages： under or over 70 years old. The clinical data were compared between the two ***： Preoperative comorbidity rate was higher in elder patients than in younger patients（P=0.001）. The elder patients were more likely to have postoperative complications（P=0.003）.Specifically, complications above grade III were more likely to occur in the elderly patients（P=0.030）. Multivariable analysis showed that age（adjusted OR=2.557, P=0.015） and hypertension（adjusted OR=2.443, P=0.019） were independent predictors of postoperative complications. There was no significant difference in the mortality rates between the two groups（P=0.885）. In the PD with SMPV resection series, elderly patients were more likely to have postoperative complications（P=0.063）, but this difference was not statistically *** was no difference in the survival rate of patients with pancreatic ductal adenocarcinoma between the two *** type（PD vs PD with SMPV resection） did not affect the survival of ***： Age affects postoperative complication in patients undergoing either PD or PD with SMPV ***, extensive experience and advanced perioperative management lower the complication rate to an acceptablelimit. Hence it is safe and worthwhile to perform PD for elderly patients. Because of low numbers in the SMPV subset, we could not conclude whether PD with SMPV resection is feasible in elderly patients.

关键词： pancreaticoduodenectomy elderly cancer outcomes

Presbyphagia:Dysphagia in the elderly

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World Journal of Clinical Cases 2023年第11期11卷 2363-2373页

作者： Hai-Yang Feng ping-ping zhang Xiao-Wen Wang School of Rehabilitation Medicine Weifang Medical UniversityWeifang 261021Shandong ProvinceChina

Dysphagia has been classified as a“geriatric syndrome”and can lead to serious complications that result in a tremendous burden on population health and healthcare resources worldwide.A characteristic age-related change in swa-llowing is defined as“presbyphagia.”Medical imaging has shown some changes that seriously affect the safety and efficacy of ***,there is a general lack of awareness of the effects of aging on swallowing function and a belief that these changes are part of normal *** review provides an overview of presbyphagia,which has been a neglected health problem for a long *** and awareness of dysphagia in the elderly population should be strengthened,and targeted intervention measures should be actively imple-mented.

关键词： Aging Dysphagia Presbyphagia Geriatric syndromes Swallowing

Long-term follow-up of endoscopic papillectomy and the value of preventive pancreatic stent placement(with videos)

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Gastroenterology Report 2023年第1期11卷 486-491页

作者： Yuling Wang Xiaoqing zhang Zhenhua Yang Teng Wang Dongqing Zhu Jie Gao ping-ping zhang Peiqin Wang Xingang Shi Department of Gastroenterology Changhai HospitalNaval Military Medical UniversityShanghaiP.R.China Department of Emergency Changhai HospitalNaval Military Medical UniversityShanghaiP.R.China Department of Nephrology Gongli HospitalPudong New AreaShanghaiP.R.China Department of Radiology Changzheng HospitalNaval Military Medical UniversityShanghaiP.R.China Department of Gastroenterology Changzheng HospitalNaval Military Medical UniversityShanghaiP.R.China

Background:Early-stage ampullary adenomas have only been reported in a small case series on endoscopic ***,this study aimed to evaluate the long-term outcomes of early ampullary adenoma with endoscopic management and identify the risk factors for acute pancreatitis after endoscopic papillectomy(EP).Methods:In this study,115 patients who underwent EP at Changhai Hospital(Shanghai,China)between January 2012 and December 2018 were retrospectively *** was performed at 1,3,6,and 12months after *** were statistically analysed using the t-test or the Mann–Whitney U ***:A total of 107 patients were included in this study and the follow-up period was 75643 *** average age of the 107 patients was 54.6 years and the average tumor size was *** average age of the patients(53.7610.7 years vs 55.2610.5 years,P=0.482),minimum tumor size(13 vs 19mm,P=0.063),and complete resection rate(84.78%vs 85.25%,P=0.947)did not differ significantly between the stent placement and non-stent placement ***-EP acute pancreatitis rates in the non-stent placement and stent placement groups were 11.48%and 4.35%,*** risk of post-EP acute pancreatitis was significantly associated with the preoperative carcinoembryonic antigen level in univariate analysis,but not in multivariate *** risk of post-EP acute pancreatitis was not significantly associated with the placement of the pancreatic stent in either univariate or multivariate ***,delayed proximal pancreatic duct stenosis was not noted in either group during long-term ***:EP is a satisfactory option for treating adenomas of the ampulla of the duodenum.

关键词： endoscopic resection pancreatic duct stent pancreatitis adenoma duodenal papilla

Photosynthetic Characteristics and Antioxidative Metabolism of Flag Leaves in Responses to Nitrogen Application During Grain Filling of Field-Grown Wheat

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Agricultural Sciences in China 2008年第2期7卷 157-167页

作者： CAI Rui-guo zhang Min YIN Yan-ping WANG ping zhang Ti-bin GU Feng DAI Zhong-min LIANG Tai-bo WU Yun-hai WANG Zhen-lin State Key Laboratory of Crop Biology/Agronomy College Shandong Agricultural University/Key Laboratory of Wheat Cultivation Physiology and Genetic Improvement Ministry of Agriculture Tai＇an 271018 PR.China

A two-factorial experiment was conducted with two wheat cultivars, SN1391 （large spike and large grain） and GC8901 （multiple spike and medium grain）, and two nitrogen （N） application rates （12 and 24 g N m^-2）, to investigate the responses of photosynthetic characteristics and antioxidative metabolism to nitrogen rates in flag leaves of field-grown wheat during grain filling. The results showed that the content of N and chlorophyll （Chl） in wheat flag leaves decreased after anthesis and the net photosynthetic rate （Pn）, effective quantum yield of PS Ⅱ （Фps n）, efficiency of excitation capture by open PS Ⅱ reaction centers （Fv′/Fm′）, and photochemical quenching coefficient （qp） began to decrease at 14 days after anthesis. However, the maximal efficiency of PS Ⅱ photochemistry （Fv/Fm） decreased slightly until the late period of senescence and the nonphotochemical quenching coefficient （NPQ） increased during flag leaves＇ senescence, As a result, a conflict came into being between absorption and utilization to light energy in flag leaves during senescence, which might accelerate the senescence of flag leaves. Compared with GC8901, the lower plant population of SN1391 during grain filling was helpful to maintain the higher content of photosynthetic pigment, activity of PS II, and Pn in flag leaves during senescence, The delayed decrease in antioxidative enzyme activity and the lower degree of membrane lipid peroxidation in the senescing leaves of SN1391 were beneficial to protect the photosynthetic apparatus, which lead to the prolonged duration of CO2 assimilation. With the increase of N application, the Chl content of SN1391 flag leaves and the efficiency of excitation captured by open PS Ⅱ centers increased. At the same time, the thermal dissipation in SN1391 flag leaves at high N （HN） treatment decreased and Фps Ⅱ improved greatly, which were favorable to the increase of Pn. The SOD, POD, CAT and APX activities in the flag leaves of SN1391 increased markedly at HN tr

关键词： wheat (Triticum aestivum L.) photosynthetic characteristics antioxidative metabolism nitrogen

Determination of Urinary Creatinine by Capillary Zone Electrophoresis

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Determination of Urinary Creatinine by Capillary Zone Electr...

Aggressive Blood Pressure Lowing Therapy in Patients with Acute Intracerebral Hemorrhage is Safe： A Systematic Review and Meta-analysis

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： ping-ping zhang Key Laboratory of Neural and Vascular Biology Department of Biochemistry and Molecular BiologyMinistry of Education Hebei Medical University

Creatinine is the catabolic end product of creatine, being produced in muscle tissues andeliminated in urine. It is a very useful clinical biomarker of renal function and an internalstandard to correct the excretion rate of other biological compounds in a urine sample. Inour previous work, a reliable, convenient and low-cost method for the determination of urinarycreatinine by capillary zone electrophoresis was established. A typical calibration plotfrom 1 mg L-1 to 200 mg L-1(R2 = 0.9978) with a detection limit of 0.15 mg L-1(S/N =3) is achieved. The relative standard deviation was less than 4.2% for peak area and 0.5%for migration time, respectively. The proposed method was successfully applied to the determinationof urinary creatinine.

关键词： creatinine capillary zone electrophoresis

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Chinese Medical Journal 2015年第18期128卷 2524-2529页

作者： Chao Pan Yang Hu Na Liu ping zhang You-ping zhang Miribanu Aimaiti Hong Deng Ying-Xing Tang Feng Xu Sui-Qiang Zhu Zhou-ping Tang Department of Neurology Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background： The influence of blood pressure （BP） lowering on intracerebral hemorrhage （ICH） patients is unclear. To assess the safety and efficacy of aggressive antihypertensive therapies in acute ICH patients, we carried out a systematic review and meta-analysis. Methods： PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and VIP database up to July 2014 were searched. H igh-quality randomized controlled trials were included. Low-quality trials were excluded. Serious adverse events were defined as the primary outcome. The secondary outcomes were hematoma enlargement （HE） at 24 h after onset, mortality, and favorable clinical outcome at 90 days. Results： Four high-quality trials involving a total of 1427 patients met the inclusion criteria and were analyzed. Odds ratios （ORs） of primary outcome was 0.96 （95% confidence interval [CI]： 0.82-1.13, P = 0.61）. ORs of HE at 24 h after onset, mortality and favorable clinical outcome at 90 days were 0.91 （95% CI： 0.72-1.17, P = 0.47）, 0.97 （95% CI： 0.79-1.20, P = 0.81）, 1.13 （95% CI： 0.98-1.30. P = 0.09） respectively. Conclusions： Aggressive BP management policies are safe and might have a potency of reducing HE and improving clinical outcome.

关键词： Antihypertensive Therapy: Blood Pressure: Hematoma Enlargement Hypertension Intracerebral Hemorrhage

Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma

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Cell Research 2001年第3期11卷 209-216页

作者： QIN WEN XIN, DA FANG WAN, FEN YONG SUN, ping ping zhang, LI WEI HAN, YI HUANG, HUI QIU JIANG, XIN TAI ZHAO, MEI HE. YUN YE, WEN MING CONG, MENG CHAO WU, LI SHENG zhang, NAN WU YANG, JIAN REN GU National LaBoratory for Oncogenes and Related Gencs, Shanghai National Laboratory for Oncogenes and Related Genes Shanghai Cancer Institute 25/Ln 2200 Xie Tu Road Shanghai 200032 China. Shanghai GeneCore Biotechnologies 200 Tian Lin Road Shanghai 200233 China. Eastern Hepatobiliary Surgery Hospital Second Military Medical University 225 Changhai Road Shanghai 200433 China. Cancer Hospital Guangxi Medical University Nanning 500021 China.

Using a combination of hybridization of PAC to a cDNA library and RACE technique, we isolated a novel cDNA, designated as C17orf25 (Chromosome 17 open rea(ling frame 25, previously named it HC71A), from the deletion region on chromosome 17p13.3. The cDNA encodes a protein of 313 amino acids with a calculated molecular mass of 34.8 kDa. C17orf25 is divided into 10 exons and 9 introns, spanning 23 kb of genomic DNA. Northern blot analysis showed that the mRNA expression of C17orf25 was decreased in hepatocellular carcinoma samples as compared to adjacent noncancerous liver tissues from the same patients. The transfection of C17or25 into the hepatocellular carcinoma cell SMMC7721 and overexpression could inhibit the cell growth. The above results indicate that C17orf25 is a novel human gene, and the cloning and preliminary characterization of C17orf25 is a prerequisite for further functional analysis of this novel gene in human hepatocellular carcinoma.

关键词： Chromosome 17p13.3 1lss of heterozygosity hepatocellular carcinoma transfection novel human gene (C17orf25)

Challenge, opportunity and development： Influencing factors and tendencies of curriculum innovation on undergraduate nursing education in the mainland of China

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Chinese Nursing Research 2017年第3期4卷 113-116页

作者： Yan Gao ping-ping zhang Su-Fang Wen Yang-Guang Chen School of Nursing Guilin Medical University Guangxi Zhuang Autonomous Region 541001 China Affiliated Hospital of Guilin Medical University Guangni Zhuang Autonomous Region 541001 China

Background： As the deep influence of traditional medical education, many undergraduate nursing colleges and universities in China still keep the traditional disease-focused curriculum system. However, it became outdated as the Chinese high nursing education developed. Meanwhile, the increasing demand of nursing human resources stimulates the enrollment expansion of colleges. All of these bring more difficulties and opportunities for nurse educators who are endeavoring to reform the undergraduate curriculum. Methods： The authors retrospectively reviewed the related literature, illustrated the existing challenges and opportunities during the curriculum renewal process in China. This paper also analyzed the ten- dencies of Chinese baccalaureate curriculum innovation. Results： Chinese current undergraduate nursing curriculum has larger proportion of basic medical courses, which brings great challenge for nursing educators. In the meantime, the expansion of enroll- ment brings conflicts with existing nursing education resources in China. Integration, humanization, internationalization and diversification are main tendencies leading the future nursing curriculum innovation in China. Conclusions： The more effective teaching innovations in the nursing education system are in great demand.

关键词： China Nursing education Undergraduate education Curriculum Innovation Influencing factor

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逐段单调函数的高度与拓扑共轭

数学学报（中文版） 2018年第2期61卷 243-260页

作者：张萍萍李伟年滨州学院理学院

迭代运算下,函数值可以交叉于不同的子区间,使得逐段单调函数的高度异常复杂.本文考虑一个非单调点的连续函数类.首先给出高度的充分必要条件,以此获得此类函数的一种划分.其次针对函数类的一个非空子集,给出判定拓扑共轭的充分必要条... 详细信息

迭代运算下,函数值可以交叉于不同的子区间,使得逐段单调函数的高度异常复杂.本文考虑一个非单调点的连续函数类.首先给出高度的充分必要条件,以此获得此类函数的一种划分.其次针对函数类的一个非空子集,给出判定拓扑共轭的充分必要条件和构造拓扑共轭的新方法.进一步地,我们阐明这样的事实：两个逐段单调函数拓扑共轭是其高度相等的充分不必要条件,最后举例说明.

关键词：迭代逐段单调函数高度拓扑共轭