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Five-blade scratcher for treating severe rhinophyma:A retrospective study

World Journal of Clinical Cases 2024年第20期12卷 4180-4190页

作者： Yu-ping Zheng Xu-Feng He Yan-Feng Zhang Lan-Xin Geng Hui-min Zhang Hua Wan Xiang He Department of Dermatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Galactophore Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rhinophyma,a late-stage subtype of rosacea,is characterized by excessive sebaceous glands and connective tissue *** may experience respiratory disturbances and psychological distress that significantly affect their quality of life when excessive nasal hyperplasia obstructs the external nasal *** is the treatment of choice for ***,excessive bleeding,scarring,pigmentation,and high recurrence rates frequently characterize current surgical *** To evaluate the clinical effectiveness and recurrence rates after treating severe rhinophyma with the five-blade *** This study retrospectively analyzed the clinical records of 2. patients with severe rhinophyma *** Global Flushing Severity Score(GFSS),Clinician Erythema Assessment(CEA),Rhinophyma Severity Index(RHISI),Glasgow Benefit Inventory(GBI),and satisfaction scores were used to assess the recovery of patients at 6 months and 5 years,with the recurrence rate calculated at 5 years *** addition,the levels of pro-inflammatory factors(TNF-α,IL-1β,and IL-6)in the serum of patients before and after surgery were detected by *** The GFSS,CEA,and RHISI scores at 6 months and 5 years postoperatively were significantly lower than those preoperatively(P2.,2.%)reported recurrence after surgical treatment for rhinophyma in our department that was not more serious than before *** expression of pro-inflammatory factors(TNF-α,IL-1β,and IL-6)in the patient's serum was significantly reduced after surgery of five-blade *** The five-blade scratcher treatment demonstrates notable advantages,including simplicity,safety,efficacy,and cost-effectiveness,coupled with reduced bleeding,minimized scarring,lower recurrence rates,reduced the level of pro-infla

关键词： Rhinophyma Five-blade scratcher Retrospective study Efficacy Recurrence rate

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2.03至2.2.年陕西省神经管缺陷发生率下降速率及缺陷儿转归

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中国医学科学院学报 2024年第4期46卷 513-518页

作者：于敏甘露马西平智广西安交通大学医院公共卫生中心西安710049 陕西省妇幼保健院基层保健科西安710003 郑州大学公共卫生学院卫生统计教研室郑州450001

目的总结2.03至2.2.年陕西省神经管缺陷(NTDs)发生率的流行趋势和下降速率,掌握NTDs诊断时间及缺陷儿转归情况,预测2.2.至2.2.年陕西省NTDs发生率,为进一步完善出生缺陷监测系统提供新的科学依据。方法对2.03至2.2.年陕西省各级开设产... 详细信息

目的总结2.03至2.2.年陕西省神经管缺陷(NTDs)发生率的流行趋势和下降速率,掌握NTDs诊断时间及缺陷儿转归情况,预测2.2.至2.2.年陕西省NTDs发生率,为进一步完善出生缺陷监测系统提供新的科学依据。方法对2.03至2.2.年陕西省各级开设产科的医疗保健机构孕2.周至出生后7 d所有围产儿进行出生缺陷监测并收集资料,基于出生缺陷监测系统分析2.03至2.2.年NTDs发生率的分布趋势。结果陕西省2.03至2.2.年共监测围产儿1106483例,NTDs病例共848例,发生率为7.66/万,其中2.05年发生率(48.02.万)最高,2.2.年发生率(0.57/万)最低。NTDs以脊柱裂为主,占55.90%,其次为无脑儿(2..71%)和脑膨出(18.40%),三者发生率均在波动中呈显著下降趋势(P2.03至2.14年NTDs发生率下降速度较慢,年度变化百分比为-4.04,2.14至2.2.年NTDs发生率下降速度较快,年度变化百分比为-2..05。2.03至2.2.年,陕西省NTDs产前诊断的平均比例为72.88%,出生结局以死胎(61.91%)为主,其次为活产(2..77%)、死产(8.73%)、出生7 d内死亡(2.59%)。经GM(1,1)模型预测,陕西省2.2.、2.2.和2.2.年NTDs率分别为0.49/万、0.41/万和0.35/万。结论2.03至2.2.年陕西省NTDs发生率显著下降,尤其以2.14年后下降速率加快。NTDs患儿出生结局以死胎为主,其次为活产。

关键词：出生缺陷神经管缺陷产前诊断出生结局

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链式神经网络动力学及其与环状结构、星型结构对比分析

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控制理论与应用 2024年第9期41卷 1588-1597页

作者：陶斌斌肖敏蒋国平南京邮电大学自动化学院人工智能学院江苏南京210023

链式结构作为一种基本结构广泛地存在于各种复杂系统当中,然而,对于链式结构的复杂网络动力学分析鲜有报道.本文以神经网络为例,研究具有链式结构的多时滞高维神经网络模型的分岔动力学,并运用流图分解法以及整体元替代法推导出特征多... 详细信息

链式结构作为一种基本结构广泛地存在于各种复杂系统当中,然而,对于链式结构的复杂网络动力学分析鲜有报道.本文以神经网络为例,研究具有链式结构的多时滞高维神经网络模型的分岔动力学,并运用流图分解法以及整体元替代法推导出特征多项式随神经元节点个数变化的递推规律式,从而分析出特征多项式方程根的分布情况.考虑神经递质传输时延对系统稳定性的影响,并得出导致系统拓扑突变的临界值.最后,通过数值仿真验证给出理论的正确性,并通过对比仿真对链式结构、星型结构与环形结构这3种结构的神经网络动力学进行分析,从而得出神经网络的结构性差异对网络分岔动力学的影响.

关键词：分岔动力学链式结构神经网络多时滞流图分解

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Asialoglycoprotein receptor 1 promotes SARS-CoV-2.infection of human normal hepatocytes

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1199-1208页

作者： Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao Jun Liu Jiangna Xun Songhua Yuan Jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin Huitong Liang min Li Fei Peng Daru Lu Jianqing Xu Hongzhou Lu Shibo Jiang {2. Zhao Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesYiwu Research InstituteFudan UniversityShanghaiChina Department of Microbiology Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Changzheng Hospital Naval Medical UniversityShanghaiChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhenGuangdongChina

Severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 *** I converting enzyme(peptidyl-dipeptidase A)2.ACE2.is the primary receptor for SARS-CoV-2.entry into host cells,and studies have shown the presence of intracellular virus particles in human hepatocytes that express ACE2.but at extremely low ***,we asked if hepatocytes might express receptors other than ACE2.capable of promoting the entry of SARS-CoV-2.into *** address this question,we performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1(ASGR1)promoted SARS-CoV-2.pseudovirus infection of HeLa *** Huh-7 cells,simultaneous knockout of ACE2.and ASGR1 prevented SARS-CoV-2.pseudovirus *** the immortalized THLE-2.hepatocyte cell line and primary hepatic parenchymal cells,both of which barely expressed ACE2.SARSCoV-2.pseudovirus could successfully establish an ***,after treatment with ASGR1 antibody or siRNA targeting ASGR1,the infection rate significantly dropped,suggesting that SARS-CoV-2.pseudovirus infects hepatic parenchymal cells mainly through an ASGR1-dependent *** confirmed that ASGR1 could interact with Spike protein,which depends on receptor binding domain(RBD)and N-terminal domain(NTD).Finally,we also used Immunohistochemistry and electron microscopy to verify that SARS-CoV-2.could infect primary hepatic parenchymal *** inhibiting ASGR1 in primary hepatic parenchymal cells by siRNA,the infection efficiency of the live virus decreased ***,these findings indicate that ASGR1 is a candidate receptor for SARS-CoV-2.that promotes infection of hepatic parenchymal cells.

关键词： ACE2 infection glycoprotein

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浅谈激光聚变

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物理 2024年第5期53卷 287-299页

作者：朱少平罗民兴北京应用物理与计算数学研究所北京100094 北京计算科学研究中心北京100093

美国国家点火装置的物理实验结果,跨越了热核聚变点火这一标志性的门槛,再次引起了学术界和大众对可控热核聚变研究的兴趣。文章介绍了热核聚变的基本概念、激光聚变的主要内涵和激光聚变点火研究的进展。

关键词：热核聚变激光聚变聚变点火

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Conversion therapy of a giant hepatocellular carcinoma with portal vein thrombus and inferior vena cava thrombus:A case report and review of literature

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World Journal of Clinical Cases 2024年第16期12卷 2847-2855页

作者： Wen-Jie Song Jian Xu Ye Nie Wei-min Li Jian-ping Li Li Yang Meng-Qi Wei Kai-Shan Tao Department of Hepatobiliary Surgery Xijing HospitalAir Force Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Radiotherapy The First Affiliated Hospital of the Fourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineXijing HospitalAir Force Medical UniversityXi'an 710000Shaanxi ProvinceChina Department of Radiology Xijing HospitalAir Force Medical UniversityXi'an 710032Shaanxi ProvinceChina

BACKGROUND The prognosis of hepatocellular carcinoma(HCC)combined with portal and hepatic vein cancerous thrombosis is poor,for unresectable patients the combination of targeted therapy and immune therapy was the first-line recommended treatment for advanced HCC,with a median survival time of only about 2.7-6 *** this case report,we present the case of a patient with portal and hepatic vein cancerous thrombosis who achieved pathologic complete response after conversion *** SUMMARY In our center,a patient with giant HCC combined with portal vein tumor thrombus and hepatic vein tumor thrombus was treated with transcatheter arterial chemoembolization(TACE),radiotherapy,targeted therapy and immunotherapy,and was continuously given icaritin soft capsules for oral *** 7 months of conversion therapy,the patient's tumor shrank and the tumor thrombus subsided *** pathology of surgical resection was in complete remission,and there was no progression in the postoperative follow-up for 7 months,which provided a basis for the future strategy of combined conversion *** In this case,atezolizumab,bevacizumab,icaritin soft capsules combined with radiotherapy and TACE had a good *** patients with hepatocellular carcinoma combined with hepatic vein/inferior vena cava tumor thrombus,adopting a high-intensity,multimodal proactive strategy under the guidance of multidisciplinary team(MDT)is an important attempt to break through the current treatment dilemma.

关键词： Hepatocellular carcinoma Icaritin Conversion Downstaging Portal vein thrombus Case report

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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu ZHANG Zi Yu LI Xin Xin LU Yao ZHANG Lu LIU Ru Yu CHANG min WU Shu Ling GAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei ping XU Meng Jiao YI Wei XIE Yao LI ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032..Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P2.;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.02.),AST(r=0.72.,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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中国西南民族研究学会年会暨中国式现代化与西南民族地区发展学术研讨会综述

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贵州民族研究 2024年第1期45卷 177-182页

作者：谭睿敏杨江萍陈然贵州民族大学贵州贵阳550025

2.2.年11月9日至11日,由中国西南民族研究学会主办的“中国西南民族研究学会年会暨中国式现代化与西南民族地区发展学术研讨会”在凯里召开,来自全国各高校、科研机构的民族学领域专家、学者130余人参加此次研讨会。与会专家学者主要围... 详细信息

2.2.年11月9日至11日,由中国西南民族研究学会主办的“中国西南民族研究学会年会暨中国式现代化与西南民族地区发展学术研讨会”在凯里召开,来自全国各高校、科研机构的民族学领域专家、学者130余人参加此次研讨会。与会专家学者主要围绕铸牢中华民族共同体意识、西南民族研究的经验与路径、乡村振兴与乡村社会治理、中国式现代化等方面展开研讨,提出了很多有益于中国式现代化研究和民族地区发展的真知灼见。

关键词：中国式现代化铸牢中华民族共同体意识西南民族地区发展

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非高斯环境下基于最大相关熵的平滑估计器设计

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控制理论与应用 2024年第5期41卷 941-949页

作者：马海平刘婷孙圣溢费敏锐绍兴文理学院电子工程系浙江绍兴312000 上海大学机电工程与自动化学院上海200444

针对Kalman平滑估计器在非高斯噪声环境下性能衰退问题,本文提出了一种基于最大相关熵准则作为最优估计标准的平滑估计方法,将其应用于固定滞后问题的状态估计,称之为固定滞后最大相关熵平滑估计器(FLMCS).首先,使用矩阵变换,给出最大... 详细信息

针对Kalman平滑估计器在非高斯噪声环境下性能衰退问题,本文提出了一种基于最大相关熵准则作为最优估计标准的平滑估计方法,将其应用于固定滞后问题的状态估计,称之为固定滞后最大相关熵平滑估计器(FLMCS).首先,使用矩阵变换,给出最大相关熵Kalman滤波器的另一种形式;然后,以此为基础,通过引入新的状态变量来增广系统,并推导出所提平滑估计器的在线迭代方程;进一步比较平滑前后状态估计误差协方差,从理论上分析算法性能改进效果;最后,通过算例仿真验证所提平滑估计器在非高斯噪声干扰下的有效性和优越性.

关键词：平滑估计 Kalman滤波最大相关熵准则固定滞后非高斯环境

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Single-atom Rh catalysts for efficiently degrading Rhodamine B with high concentration

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Rare Metals 2024年第5期43卷 2331-2338页

作者： Shou-Yao Hu Jian-ping Guan Run-Ze Ma Yu Tao Dong-Hao Liu Jia-Xin Gong Yu Xiong Department of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Highly concentrated dye wastewater has a serious effect on the quality of natural waters;thus,developing novel catalysts to degrade dyes rapidly and efficiently is of great *** the first time,this study reports an Rh single atom loaded on a nitrogen-doped carbon(SA-Rh/CN)*** catalyst exhibits an excellent processing capacity for high concentrations of Rhodamine B(Rh B),high catalytic activity(95.7% degradation of Rh B in60 min)and excellent stability(93.5% degradation efficiency after 10 stable runs).

关键词： catalyst. catalysts loaded

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