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The biomechanical stability of a novel totally bioabsorbable self-retaining PLA/nano-sizedβ-TCP cervical spine interbody fusion device in single level ACDF models

The biomechanical stability of a novel totally bioabsorbable...

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第二十届全国中西医结合骨伤科学术研讨会、第二届中国医师协会中西医结合医师分会骨伤科学术年会、第十九届浙江省中西医结合骨伤科专业委员会学术年会

作者： Lu Cao ping-guo duan Xi-Lei Li Hui-Ren Wang Wu Che Jian Dong Feng-Lai Yuan Ming-Dong Zhao Dong-Sheng Zhang Department of Orthopedic Surgery Zhongshan HospitalFudan University State Key Laboratory of Molecular Engineering of Polymers Fudan University Affiliated Third Hospital ofNantong University Department of Orthopedic Surgery Jinshan HospitalFudan University Department of Mechanics Shanghai University

PURPOSE The purpose of this study was to compare the biomechanical stability provided by a novel PLA/ nano-sizedβ-TCP bioabsorbable self-retaining cervical fusion cage(BCFC) device,and compare it with tricortical itiac crest bone graft and two types of PEEK cages according to their shape and anchoring design,and furtherly to compare with tricortical iliac crest bone graft plus anterior cervical plate(ACP). METHODS Quasistatic nonconstraining torques(maximum 1.5NM) induced flexion,extension, lateral bending(±1.5NM),and axial rotation(±1.5NM) on 32 sheep cervical spines(C2-C5).The motion segment C3-C4 was firstly tested intact,the following groups were tested after complete discectomy: autologous tricortical iliac crest bone graft,Wego cage,Solis cage,and ***,the group of autologous bone graft was evaluated with *** mean range of motion(ROM) was calculated from the load-displacement curves. RESULTS No significant difference in ROM between two types of PEEK cages and BCFC could be observed in flexion and extension,BCFC device significantly decreased ROM in lateral bending and axial rotation compared with all *** significant difference in ROM between BCFC and bone graft plus ACP could be determined in lateral bending and axial rotation. CONCLUSIONS BCFC device showed comparable stability to autologous tricortical iliac crest bone graft and PEEK cages in single level ACDF models,it may be a viable alternative to current PEEK cages and anterior plate devices.

关键词： Biomechanics Cervical spine Cages Bioabsorbable Sheep

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The biomechanical stability of a novel totally bioabsorbable self-retaining PLA/nano-sizedβ-TCP cervical spine interbody fusion device in single level ACDF models

The biomechanical stability of a novel totally bioabsorbable...

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第三届全国中西医结合骨科微创学术交流会

作者： Lu Cao ping-guo duan Xi-Lei Li Hui-Ren Wang Feng-Lai Yuan Ming-Dong Zhao Wu Che Dong-Sheng Zhang Jian Dong Department of Orthopedic Surgery Zhongshan HospitalFudan University State Key Laboratory of Molecular Engineering of Polymers Fudan University Affiliated Third Hospital of Nantong University Department of Orthopedic Surgery Jinshan HospitalFudan University

Purpose:The purpose of this study was to compare the biomechanical stability provided by a novel PLA/nano-sizedβ-TCP bioabsorbable self-retaining cervical fusion cage(BCFC) device,and compare it with tricortical iliac crest bone graft and two types of PEEK cages according to their shape and anchoring design,and furtherly to compare with tricortical iliac crest bone graft plus anterior cervical plate(ACP). Methods:Quasistatic nonconstraining torques(maximum 1.5NM) induced flexion,extension,lateral bending(±1.5 NM),and axial rotation(±1.5 NM) on 32 sheep cervical spines(C2-C5).The motion segment C3-C4 was firstly tested intact,the following groups were tested after complete discectomy:autologous tricortical iliac crest bone graft, Wego cage,Solis cage,and ***,the group of autologous bone graft was evaluated with *** mean range of motion(ROM) was calculated from the loaddisplacement curves. Results:No significant difference in ROM between two types of PEEK cages and BCFC could be observed in flexion and extension,BCFC device significandy decreased ROM in lateral bending and axial rotation compared with all *** significant difference in ROM between BCFC and bone graft plus ACP could be determined in lateral bending and axial rotation. Conclusions:BCFC device showed comparable stability to autologous tricortical iliac crest bone graft and PEEK cages in single level ACDF models,it may be a viable alternative to current PEEK cages and anterior plate devices.

关键词： Biomechanics Cervical spine Cages Bioabsorbable Sheep

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玻璃体腔注射康柏西普联合激光光凝治疗糖尿病性黄斑水肿的效果分析

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国际眼科杂志 2018年第6期18卷 1109-1112页

作者：李秋霞段国平曾琦胡蓉罗玲慧湖南省人民医院眼科中国湖南省长沙市410005

目的:分析玻璃体腔注射康柏西普联合视网膜激光光凝治疗糖尿病性黄斑水肿(diabetic macular edema,DME)的临床疗效。方法:选取2015-06/2016-12我院确诊的DME患者73例80眼,根据治疗方式不同分为对照组和治疗组,对照组采用视网膜激光光凝... 详细信息

目的:分析玻璃体腔注射康柏西普联合视网膜激光光凝治疗糖尿病性黄斑水肿(diabetic macular edema,DME)的临床疗效。方法:选取2015-06/2016-12我院确诊的DME患者73例80眼,根据治疗方式不同分为对照组和治疗组,对照组采用视网膜激光光凝治疗,治疗组采用玻璃体腔注射康柏西普联合激光光凝治疗。观察治疗前和治疗后3mo两组患者最佳矫正视力(BCVA)、视网膜厚度及并发症发生情况。结果:治疗后3mo,两组患者BCVA均较治疗前显著改善,且治疗组患者BCVA显著优于对照组;两组患者黄斑上方、下方、颞侧、鼻侧环状区的视网膜厚度和平均视网膜厚度均低于治疗前,且治疗组患者的平均视网膜厚度显著低于对照组,差异均有统计学意义(P<0.05)。随访期间,所有患者均未出现角膜水肿、前房炎性反应、视网膜出血、新生血管性青光眼、眼内炎等严重眼部并发症及全身不良反应。结论:与单纯视网膜激光治疗相比,玻璃体腔注射康柏西普联合视网膜激光光凝治疗DME在改善视力、恢复视网膜功能方面效果更佳,且具有良好的安全性。

关键词：康柏西普玻璃体腔注射视网膜激光光凝糖尿病性黄斑水肿

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人工晶状体眼老视验光配镜分析

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国际眼科杂志 2008年第12期8卷 2529-2530页

作者：周莉莉段国平湖南师范大学第一附属医院眼科湖南省人民医院眼科中国湖南省长沙市410005

目的:探讨人工晶状体眼老视的科学检测方法。方法:随机抽取年龄在40～75岁之间"白内障超声乳化+人工晶状体植入"术后老视患者80例(118眼)从术后1wk开始随访6mo以上,检测角膜散光度数变化,并根据患者的阅读需要和距离进行客观和主观验光... 详细信息

目的:探讨人工晶状体眼老视的科学检测方法。方法:随机抽取年龄在40～75岁之间"白内障超声乳化+人工晶状体植入"术后老视患者80例(118眼)从术后1wk开始随访6mo以上,检测角膜散光度数变化,并根据患者的阅读需要和距离进行客观和主观验光。结果:白内障术后角膜散光1wk～1mo的平均度数与术前比较差异有显著性(P<0.01),3mo的角膜散光与术前比较差异无显著性,白内障人工晶状体眼的老视近附加3个年龄组间比较差异无统计学意义。结论:白内障术后人工晶状体眼的近附加验配不随年龄的增加而增加,应待角膜散光稳定后根据被测的调节参数进行精确的验配,而不能简单地按照经验公式开出处方。

关键词：人工晶状体眼老视角膜散光近附加

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Perovskite LiBaH3 for photo-assisted dinitrogen fixation

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Science China Chemistry 2025年

作者： Kaixun Cui Yeqin Guan Yongli Cai Runze Wang Qianru Wang Wenbo Gao Jianping guo ping Chen Department of Chemical Physics University of Science and Technology of China Dalian Institute of Chemical Physics Chinese Academy of Sciences Center of Materials and Optoelectronics Engineering University of Chinese Academy of Sciences

Establishing supply chains for future ammonia energy systems requires the development of efficient materials and processes for ammonia production under mild conditions. Recent researches disclose unique functionalities of binary alkali and alkaline earth metal hydrides in mediating ammonia synthesis. Thanks to the rich compositional and structural properties of the metalhydrogen system, we herein report that LiBaH3, as a narrow band gap perovskite hydride, exhibits a strong response to visible light illumination. Specifically, hydridic hydrogen undergoes reductive elimination of producing H2and creates an electron-rich surface. Such an environment favors dinitrogen fixation to form N–H bonds. Based on this chemical property, a chemical looping ammonia synthesis process mediated by LiBaH3and driven by both photo and thermal energies was proposed and *** work demonstrates that hydride perovskites are promising candidates for mediating photo-assisted nitrogen fixation reactions.

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ICL植入术矫正超高度近视的临床效果观察

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国际眼科杂志 2013年第1期13卷 131-133页

作者：罗栋强王华段国平何书喜陈蛟湖南省人民医院眼视光中心中国湖南省长沙市410002

目的:评估有晶状体眼后房型人工晶状体(ICL)矫正超高度近视的疗效及安全性。方法:对超高度近视患者20例40眼接受普通型ICL或散光型后房型人工晶状体(TICL)治疗,术前屈光度球镜-10.0～-18.0D,柱镜-0.25～-3.00D,等效球镜-15.32D,术后随访... 详细信息

目的:评估有晶状体眼后房型人工晶状体(ICL)矫正超高度近视的疗效及安全性。方法:对超高度近视患者20例40眼接受普通型ICL或散光型后房型人工晶状体(TICL)治疗,术前屈光度球镜-10.0～-18.0D,柱镜-0.25～-3.00D,等效球镜-15.32D,术后随访12mo,观察指标包括UCVA,BCVA、角膜地形图、主观和客观验光、角膜内皮细胞计数、眼压测量、裂隙灯检查。结果:术后12mo,裸眼视力≥0.8者占80.0%(32眼)。30.0%(12眼)的术眼BCVA较术前提高1行,15.0%(6眼)的术眼BCVA较术前提高2行。术后12mo术眼屈光度在±0.50D者达70.0%(28眼)。术前患者平均眼压为16±2.8mmHg,术后6mo平均眼压为17±3.4mmHg,术前术后相比较差异无显著性(t=0.518,P=0.776),术前患者角膜内皮细胞计数平均为2823±243.6个/mm2,术后6mo平均为2709±273.2个/mm2,术前术后比较无显著性差异(t=0.794,P=0.422)。未发生继发性青光眼、视网膜脱离及并发性白内障。结论:ICL植入术矫正超高度近视具有良好的疗效和安全性,远期效果有待进一步观察。

关键词：超高度近视有晶状体眼后房型人工晶状体

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Insight into the particle shape on the impact of dry granular flow against a rigid barrier: A DEM study

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Journal of Earth Science 2025年

作者： Rui-Xiao Zhan Dong Su Xiang-Sheng Chen Yuan-Jun Jiang guo-ping Lei Jing-Jing Yu Key Laboratory for Resilient Infrastructures of Coastal Cities (MOE)， Shenzhen University College of Civil and Transportation Engineering， Shenzhen University School of Architecture and Urban Planning， Shenzhen University Shenzhen Key Laboratory of Green， Efficient and Intelligent Construction of Underground Metro Station， Shenzhen University Institute of Mountain Hazards and Environment， Chinese Academy of Sciences School of Transportation， Civil Engineering & Architecture， Foshan University

The effect of particle shape on the impact of dry granular flow remains an open area for further investigation. Five distinct particle shapes were examined in this study using discrete element simulations after calibrating the numerical model using a published work. The findings indicated that the particle shape had a significant influence on granular mobility. With negligible variations in normalized kinetic energy between particles of different shapes， the effect of particle shape on the increasing rate of kinetic energy became more obvious. All irregular particle scenarios had longer accumulated particle lengths down the channel than spherical particles. Variations in particle shape led to adjustments in the distribution of impact forces on the barrier. These findings substantially enhance our understanding of the distinctive effects of particle shapes on the impact mechanism of dry granular flow.

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Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： Yuxun Lu Weisi Wang Le Yu Yuqiang Zhao Ying Chen Yunhai guo Bingrong Luo Yuhua Liu Shizhu Li Liping duan Ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages

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Science China Life Sciences 2025年

作者： Liu guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han Zekun Yang Yehui duan Weijun Pang Yulong Yin Fengna Li Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences University of Chinese Academy of Sciences Laboratory of Animal Fat Deposition and Muscle Development College of Animal Science and Technology Northwest A&F University College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity, aging and metabolic disease. Since obese and lean pigs are ideal models for metabolic research. Here, we compared metabolome and transcriptome of Longissimus dorsi(LD) muscle between Taoyuan black(TB, obese) and Duroc(lean) pigs at different ages. We defined the “window phase” of intramuscular fat(IMF) deposition in TB pig, which has significantly higher IMF than Duroc pig. Our results displayed discrepant lipid composition and different expression genes(DEGs) enriched in lipid metabolism, and both metabolome and transcriptome analyses revealed stronger energy expenditure and more active amino acid and protein metabolism in Duroc pig. 10 up-and 51 down-regulated biomarker metabolites with age-and breed-specificity were identified. Potential secretory metabolites, including organic acid(fumaric acid, succinate,malic acid, and gamma-aminobutyric acid), amino acid(L-lysine, and L-glutamic acid), lipid(2-hydroxyisovaleric acid, and L-carnitine) were demonstrated a significant correlation with IMF deposition. Our research highlights the huge difference of metabolic spectrum in skeletal muscle between obese and lean model and muscle-derived secretory metabolites might act as an ambassador of intercellular communication to regulate systematic metabolism.

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Attitude and Orbit Optimal Control of Combined Spacecraft via a Fully-Actuated System Approach

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Journal of Systems Science & Complexity 2022年第2期35卷 623-640页

作者： duan Guangquan LIU guo-ping Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbin 150001China Department of Electronic and Electrical Engineering Southern University of Science and TechnologyShenzhen 518055China

This paper investigates the attitude and orbit control for the combined spacecraft formed after a target spacecraft without the autonomous control ability is captured by a service *** optimal controller of fully-actuated system is proposed to realize the attitude and orbit stabilization control of combined *** stability of the system is proved by introducing Lyapunov *** simulation of the combined spacecraft and physical experiment based on the combined spacecraft simulator(CSS)are *** simulation and experiment results demonstrate the effectiveness and practicability of the optimal controller of fully-actuated system.

关键词： Attitude control combined spacecraft fully-actuated system optimal controller orbit control

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