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CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1029-1045页

作者： Wen-Qian Ma Ming-Chang Miao ping-an ding Bi-Bo Tan Wen-Bo Liu Shuo Guo Li-Mian Er Zhi-Dong Zhang Qun Zhao Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer Shijiazhuang 050011Hebei ProvinceChina Department of Radiotherapy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Third Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors,including gastric cancer(GC),and is associated with tumor progression and immune infiltration;however,the roles and mechanisms of CALD1 in epithe-lial-mesenchymal transition(EMT)in GC are *** To investigate the role and mechanism of CALD1 in GC progression,invasion,and *** In this study,the relationship between CALD1 and GC,as well as the possible network regulatory mechanisms of CALD1,was investigated by bioinformatics and validated by ***1-siRNA was synthesized and used to trans-fect GC *** activity was measured using the CCK-8 method,cell migration and invasive ability were measured using wound healing assay and Transwell assay,and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot.A GC cell xenograft model RESULTS Bioinformatics results showed that CALD1 was highly expressed in GC tissues,and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of *** prognosis of patients with high expression of CALD1 was worse than that of patients with low expression,and a prognostic model was constructed and *** experimental results were consistent with the results of the bioinformatics *** expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1,with the strongest expression found in AGS and MKN45 *** activity was significantly reduced after CALD1-siRNA trans-fection of AGS and MKN45 *** ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection,and the related mRNA and protein expression was *** to bioinfor-matics findings in GC samples,the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway,and was closely rel

关键词： Gastric tumor CALD1 Epithelial-mesenchymal transition Gene disruption Invasion Migration Bioinformatics

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Comparative analysis of two digestive tract reconstruction methods in total laparoscopic radical total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1109-1120页

作者： Tian-Xiang Dong Dong Wang Qun Zhao Zhi-Dong Zhang Xue-Feng Zhao Bi-Bo Tan Yu Liu Qing-Wei Liu Pei-Gang Yang ping-an ding Tao Zheng Yong Li Zi-Jing Liu Third Department of Surgery of the Fourth Hospital of Hebei Medical University Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric CancerShijiazhuang 050011Hebei ProvinceChina

BACKGROUND The incidence of gastric cancer has significantly increased in recent *** resection is the main treatment,but the method of digestive tract reconstruction after gastric cancer surgery remains *** the current study,we sought to explore a reasonable method of digestive tract reconstruction and improve the quality of life and nutritional status of patients after *** this end,we statistically analyzed the clinical results of patients with gastric cancer who underwent jejunal interposition double-tract reconstruction(DTR)and esophageal jejunum Roux-en-Y reconstruction(RY).AIM To explore the application effect of DTR in total laparoscopic radical total gastrectomy(TLTG)and evaluate its safety and *** We collected the relevant data of 77 patients who underwent TLTG at the Fourth Hospital of Hebei Medical University from October 2021 to January *** them,35 cases were treated with DTR,and the remaining 42 cases were treated with traditional *** 1:1 propensity score matching,the cases were grouped into 31 cases per group,with evenly distributed *** clinical characteristics and short-and long-term clinical outcomes of the two groups were statistically *** The two groups showed no significant differences in basic data,intraoperative blood loss,number of lymph node dissections,first defecation time after operation,postoperative hospital stay,postoperative complications,and laboratory examination results on the 1st,3rd,and 5th days after *** operation time of the DTR group was longer than that of the RY group[(307.58±65.14)min vs(272.45±62.09)min,P=0.016],but the first intake of liquid food in the DTR group was shorter than that in the RY group[(4.45±1.18)d vs(6.0±5.18)d,P=0.028].The incidence of reflux heartburn(Visick grade)and postoperative gallbladder disease in the DTR group was lower than that in the RY group(P=0.033 and P=0.038).Although there was no significant difference in bod

关键词： Gastric cancer Jejunal interposition double-tract reconstruction Roux-en-Y reconstruction Laparoscope

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江苏省2005-2020年接受抗病毒治疗的HIV/AIDS合并HBV感染及生存分析

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中华流行病学杂志 2024年第2期45卷 220-224页

作者：邱涛丁萍张之翟祥军江苏省疾病预防控制中心性病与艾滋病防制所南京210009

目的分析2005-2020年江苏省接受抗病毒治疗的HIV/AIDS合并HBV感染和生存情况,为提高抗病毒治疗效果提供参考依据。方法采用回顾性资料分析,研究对象来源于中国疾病预防控制信息系统江苏省2005-2020年HIV/AIDS首次入组抗病毒治疗基线和... 详细信息

目的分析2005-2020年江苏省接受抗病毒治疗的HIV/AIDS合并HBV感染和生存情况,为提高抗病毒治疗效果提供参考依据。方法采用回顾性资料分析,研究对象来源于中国疾病预防控制信息系统江苏省2005-2020年HIV/AIDS首次入组抗病毒治疗基线和随访数据库,随访观察截止时间为2022年12月31日。采用SPSS 16.0软件进行统计学分析。运用Kaplan-Meier法绘制生存曲线和log rank检验法比较生存曲线,采用Cox比例风险回归模型分析接受抗病毒治疗HIV/AIDS死亡的影响因素。结果江苏省2005-2020年首次入组抗病毒治疗HIV/AIDS共33322例,总体HBsAg检测率为57.3%(19098/33322)。在进行HBsAg检测的HIV/AIDS中,男女性别比为7.1∶1(16745∶2353),年龄(39.4±14.0)岁,已婚/同居占49.5%(9446/19098)。同性性传播占57.8%(11048/19098),异性性传播占36.6%(6990/19098)。开始接受抗病毒治疗前的CD4+T淋巴细胞(CD4)计数的M(Q1,Q3)为297(166,445)个/μl。HIV/AIDS的HBsAg阳性率为8.2%(1566/19098,95%CI:7.8%~8.6%)。在随访观察截止期内共1062例HIV/AIDS死亡。经log rank检验,是否合并HBV感染在接受抗病毒治疗后生存曲线差异有统计学意义(χ2=28.07,P<0.001)。Cox比例风险回归模型的多因素分析结果显示,入组年份、年龄、婚姻状况、HIV感染途径、抗病毒治疗前基线CD4计数和是否合并HBV感染是HIV/AIDS死亡的影响因素(均P<0.05),相比于2015年及以前入组者、年龄≥45岁和未婚者,2016-2020年入组治疗者、<45岁组和已婚/同居者的死亡风险较低;相比于基线CD4计数≥201个/μl组、其他感染途径和单纯HIV感染者,基线CD4计数≤200个/μl组、注射吸毒途径和合并HBV感染者的死亡风险较高。结论江苏省需要在HIV/AIDS抗病毒治疗工作中加强合并HBV感染的检测、管理和精准治疗,加强乙型肝炎疫苗接种对单纯HIV感染者的保护,减少HIV/AIDS死亡风险。

关键词：艾滋病病毒/艾滋病乙型肝炎病毒乙型肝炎病毒表面抗原抗病毒治疗合并感染病死率

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TIL20: A review of island biogeography and habitat fragmentation studies on subtropical reservoir islands of Thousand Island Lake, China

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 89-105页

作者： Xingfeng Si Tinghao Jin Wande Li Peng Ren Qiang Wu Di Zeng Xue Zhang Yuhao Zhao Chen Zhu ping ding Zhejiang Zhoushan Island Ecosystem Observation and Research Station Institute of Eco-ChongmingZhejiang Tiantong Forest Ecosystem National Observation and Research StationSchool of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China MOE Key Laboratory of Biosystems Homeostasis&Protection College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China

Reservoir islands formed by dam construction have the same history,clear boundaries,and large numbers that provide a natural platform for testing theories in ecology and *** this paper,we review studies of multiple zoological taxa on reservoir islands of a large lake in eastern China(Thousand Island Lake).This lake,created in 1959,has 1078 artificial land-bridge islands of varying areas and *** review summarizes the decades-long studies in island biogeography and habitat fragmentation from this island system,grouped into three topics:species richness(“how many species are there”),community structure(“who are they”),and species interaction(“how they interact with each other”).Our findings support the predictions of the Equilibrium Theory of Island Biogeography and extend this theory to predict community structure of island faunas by moving beyond assumptions of species *** addition,the extensive studies on ecological networks,including mutualistic,antagonistic,and parasitic interactions,reveal the negative impacts of habitat loss on the maintenance of such networks,even as increasing forest edge enhances the robustness of pollination *** the end of this review,we proposed several future research directions based on current studies that are simultaneously at the frontier of ecology and biogeography.

关键词： Biodiversity conservation Community assembly Species extinction Island Species interaction

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Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data

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World Journal of Gastroenterology 2024年第1期30卷 34-49页

作者： Yu-Wei Zhou Yue Ren Miao-Miao Lu Ling-Ling Xu Wei-Xin Cheng Meng-Meng Zhang Lin-ping ding Dong Chen Jian-Guo Gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng Peng-Lei Jiang Yi-Da Yang Peng-Xu Qian Peng-Fei Xu Xi Jin Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Endoscopy Center Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second People’s Hospital of Yuhang DistrictHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Shangcheng District People’s HospitalHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Women’s Hospital and Institute of Genetics Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Center of Stem Cell and Regenerative Medicine and Bone Marrow Transplantation CenterThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Crohn’s disease(CD)is caused by immune,environmental,and genetic *** can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains *** biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known *** achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost *** this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary *** supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid *** benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic *** importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.

关键词： Inflammatory bowel disease Crohn’s disease Lymphatic system Inside-out model Immune cells Zebrafish

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多甲氧基黄酮的神经保护作用研究进展

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武汉大学学报（理学版） 2024年第2期70卷 169-176页

作者：李虹丁平李卫岗张文生广州中医药大学中药学院广东广州510006 京师北中横琴科技研究院有限公司广东珠海519031 北京师范大学天然药物教育部工程研究中心北京100088 拱北海关技术中心广东珠海519000

多甲氧基黄酮(polymethoxyflavonoids,PMFs)是从柑橘属植物中提取的一类黄酮成分,生物活性广泛,具有神经保护作用。本文综述了PMFs在动物和细胞模型中对中枢神经系统损伤(阿尔茨海默病、帕金森病、脑缺血、脂多糖诱导的神经损伤等)的保... 详细信息

多甲氧基黄酮(polymethoxyflavonoids,PMFs)是从柑橘属植物中提取的一类黄酮成分,生物活性广泛,具有神经保护作用。本文综述了PMFs在动物和细胞模型中对中枢神经系统损伤(阿尔茨海默病、帕金森病、脑缺血、脂多糖诱导的神经损伤等)的保护和改善作用,并重点阐述其潜在作用机制,旨在深入理解PMFs的药效及分子作用机制,为神经系统相关疾病的预防和治疗提供新的思路。

关键词：多甲氧基黄酮神经系统损伤橘红素川陈皮素甜橙黄酮阿尔茨海默病(AD) 帕金森病(PD)

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一种体现构网型控制特征的柔性直流机电暂态改进建模方法

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电网技术 2024年第2期48卷 897-903页

作者：丁平安宁万凯遥李亚楼田鹏飞蔡靖中国电力科学研究院有限公司北京市海淀区100192

总结柔性直流采用构网型控制呈现的新特性并提出相应的机电暂态建模方法。通过分析,提出构网型控制替代跟网型控制给柔性直流带来的主要变化是:电压源支撑,故障穿越切换措施以及电流限幅方法。相对应的,构网控制型柔性直流机电暂态模型... 详细信息

总结柔性直流采用构网型控制呈现的新特性并提出相应的机电暂态建模方法。通过分析,提出构网型控制替代跟网型控制给柔性直流带来的主要变化是:电压源支撑,故障穿越切换措施以及电流限幅方法。相对应的,构网控制型柔性直流机电暂态模型是对跟网控制型柔性直流模型的改进,包括将换流器与交流网络的接口由传统的一个交流仿真步长内的平均功率改为平均电压;增加故障穿越措施切换逻辑以及增加基于用户自定义的电流限幅措施。通过交直流间接口方法仿真对比,以及机电、电磁暂态模型故障模拟验证所提模型的有效性。该模型能高精度模拟构网控制型柔性直流在交流电网中的动态行为,具有良好的应用价值。

关键词：电压源型换流器构网型控制电压源型接口交流故障穿越切换逻辑电流限幅机电暂态模型

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原儿茶醛对链脲佐菌素诱导小鼠糖尿病心肌病的改善作用

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现代食品科技 2024年第3期40卷 48-55页

作者：丁萍叶志明刘冰张陆勇广东药科大学新药研发中心广东广州510006 广东药科大学药学院广东广州510006

研究了原儿茶醛(Protocatechualdehyde,PCA)对糖尿病心肌病(Diabetic Cardiomyopathy,DCM)小鼠的心脏保护作用及其可能的分子机制。成功构建DCM小鼠模型后给予PCA干预治疗。记录小鼠心脏与体质量比值,测定心功能,检测心肌组织中促炎症... 详细信息

研究了原儿茶醛(Protocatechualdehyde,PCA)对糖尿病心肌病(Diabetic Cardiomyopathy,DCM)小鼠的心脏保护作用及其可能的分子机制。成功构建DCM小鼠模型后给予PCA干预治疗。记录小鼠心脏与体质量比值,测定心功能,检测心肌组织中促炎症因子、肌钙蛋白I、乳酸脱氢酶(Lactate Dehydrogenase,LDH)和肌酸激酶(Creatine Kinase,CK)的表达水平,并通过苏木精-伊红(Hematoxylin Eosin,HE)和马松染色观察了心肌组织的形态学变化。检测心肌组织和大鼠心肌细胞中核苷酸结合寡聚化结构域样受体蛋白3(Nod Like Receptor Protein 3,NLRP3)等蛋白的表达,并评估了PCA对心肌细胞存活率的影响。结果显示,PCA干预DCM小鼠中心脏与体质量比值、射血分数和短轴缩短距分别增加为5.42 mg/g、54.91%和28.07%,血清中LDH、CK和肌钙蛋白I分别降低为538.51 U/L、885.93 U/L和221.87 pg/mL,同时降低了肿瘤坏死因子α,白细胞介素1β和白细胞介素6的水平(P<0.05)。同时,PCA也能有效抑制高糖引起的心肌细胞毒性和NLRP3炎症小体的激活。PCA具有保护DCM小鼠心肌的作用,抑制NLRP3炎症小体的激活可能是发挥心脏改善作用的途径。

关键词：原儿茶醛链脲佐菌素糖尿病心肌病 NLRP3

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Solutions of the Camassa-Holm Equation Near the Soliton

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Acta Mathematicae Applicatae Sinica 2023年第2期39卷 450-464页

作者： Dan-ping ding Wei LU Nonlinear Scientific Research Center School of Mathematical SciencesJiangsu UniversityZhenjiang 212013China

In this paper,solutions of the Camassa-Holm equation near the soliton Q is decomposed by pseudoconformal transformation as follows:λ^(1/2)(t)u(t,λ(t)y+x(t))=Q(y)+ε(t,y),and the estimation formula with respect toε(t,y)is obtained:|ε(t,y)|≤Ca_(3)Te^(-θ)|y|+|λ^(1/2)(t)ε0|.For the CH equation,we prove that the solution of the Cauchy problem and the soliton Q is sufficiently close as y→∞,and the approximation degree of the solution and Q is the same as that of initial data and Q,besides the energy distribution ofεis consistent with the distribution of the soliton Q in H^(2).

关键词： Camassa-Holm equation pseudo-conformal transformation the decomposition of solution soliton

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增强CT值对桥本氏甲状腺炎合并甲状腺乳头状癌中央区淋巴结转移的诊断价值

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中华内分泌外科杂志 2024年第4期18卷 520-524页

作者：丁萍章彤田敏魏培英韩志江浙江中医药大学研究生院杭州西湖大学医学院附属杭州市第一人民医院放射科杭州

目的探讨增强CT值对桥本氏甲状腺炎(Hashimoto’s thyroiditis, HT)背景下甲状腺乳头状癌(papillary thyroid carcinoma, PTC)中央区淋巴结转移(central lymph node metastasis, CLNM)的诊断价值。方法回顾性分析经手术及病理证实的209例PTC患者的209枚中央区淋巴结, 将其分为HT组与non-HT组, 其中HT组淋巴结77枚(52枚阴性和25枚阳性)和non-HT组淋巴结132枚(74枚阴性和58枚阳性)。在增强CT图像上测量淋巴结CT值, 通过受试者工作特异度曲线分析增强CT值在两组中的最佳阈值及相应敏感度、特异度。结果两组阳性淋巴结增强CT值分别为(103.2±21.1)Hu和(101.9±25.4)Hu(t=0.23,P>0.05), 两组阴性淋巴结增强CT值分别为(72.0±15.8)Hu和(68.5±10.9)Hu(t=-1.38,P>0.05)。HT组与non-HT组增强CT值的曲线下面积分别为0.882和0.918, 最佳阈值分别为78.8 Hu和74.7 Hu, 相应诊断两组CLNM的敏感度分别为92.0%和91.4%, 特异度分别为67.3 %和77.0%。结论增强CT值对HT组和non-HT组CLNM均具有较高的诊断效能, 且两者诊断效能相近, 为早期临床制定个性化治疗方案提供理论依据。

关键词：甲状腺乳头状癌桥本氏甲状腺炎中央区淋巴结转移体层摄影术

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