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Cancer Incidence And Mortality in China,2006

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Chinese Journal of Cancer Research 2011年第1期23卷 3-9页

作者： Wan-qing Chen Si-wei Zhang Xiao-nong zou ping Zhao National Office for Cancer Prevention and Control/National Central Cancer Registry Cancer InstituteChinese Academy of Medical SciencesBeijing 100021China

Objective：To describe the cancer incidence and mortality rates in 2006 and evaluate the cancer burden in ***：Cancer registration data in 2006 from 34 cancer registries were collected,evaluated and pooled to calculate cancer incidence and mortality *** data analyses included mortality to incidence ratio（MI）,morphological verification percentage（MV%） and proportion of death certification only（DCO%）.Cumulative incidence and mortality rates were calculated using crude data,age-standardized data,and specific data for cancer site,age,sex and area（urban or rural）.Results：In 2006,34 registries with qualified registration data covered a total population of 59,567,322（46,558,108 in urban areas and 13,009,214 in rural areas）.The crude and age-standardized cancer incidence rates were 273.66 per 100,000 and 190.54 per 100,000,*** crude and age-standardized cancer mortality rates were 175.70 per 100,000 and 117.67 per 100,000,*** of lung,stomach,colon and rectum,liver,and breast in female were the five most common forms of cancer in China,which accounted for 58.99% of all new cancer *** cancer was the leading cause of cancer death,followed by stomach cancer,liver cancer,esophageal cancer and colorectal ***：Cancer is still an important public health issue in China with an increasing disease ***,the incidence rates for lung cancer,colorectal cancer and breast cancer were increasing,but those for stomach cancer and esophageal cancer were ***,age-specific incidence rate remained stable,indicating that the aging population was the major source of the increasing cancer burden.

关键词： Cancer Cancer registration Incidence Mortality

Effect of polo-like kinase 1 gene silence on cell cycle and drug resistance in K562/A02 cell

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Chinese Medical Journal 2006年第7期119卷 605-608页

作者： LIU Lin zou ping ZHANG Min TIAN Lei LIU Fang Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Polo-like kinase 1（PLK1） plays an important role in many cell-cycle-related events. At G2/Mtransition, PLK1 contributes to the activation of cyclinB/Cdc by phosphorylation of Cdc25C, centrosome functional maturation, bipolar spindle formation. In later stage of mitosis, PLK1 is involved in regulating components of the anaphase-promoting complex （APC） for mitotic exit and in the execution of cytokinesis. Moreover, recent reports have shown that PLK1 is involved in both G2 and mitotic DNA damage checkpoints. When G2/M DNA damage occurs, PLK1 activity is suppressed and cell cycle arrests to repair the damaged DNA. So far, the deregulated expression of PLK1 has been detected in many types of human tumors and PLK1 is considered as a novel prognostic marker for several tumors.

关键词： RNA interference polo-fike kinase 1 K562/A02 cell cycle drug resistance

Efficacy and safety of nerve growth factor for the treatment of neurological diseases:a meta-analysis of 64 randomized controlled trials involving 6,297 patients

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Neural Regeneration Research 2015年第5期10卷 819-828页

作者： Meng Zhao Xiao-yan Li Chun-ying Xu Li-ping zou Department of Pediatrics Chinese PLA General Hospital

OBJECTIVE： China is the only country where nerve growth factor is approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, nerve growth factor injection was listed as a national drug. The goal of this article is to evaluate comprehensively the efficacy and safety of nerve growth factor for the treatment of neurological diseases. DATA RETRIEVAL： A computer-based retrieval was performed from six databases, including the Cochrane Library, PubMed, EMBASE, Sino Med, CNKI, and the VIP database, searching from the clinical establishment of nerve growth factor for treatment until December 31, 2013. The key words for the searches were ＂nerve growth factor, randomized controlled trials＂ in Chinese and in English. DATA SELECTION： Inclusion criteria： any study published in English or Chinese referring to randomized controlled trials of nerve growth factor; patients with neurological diseases such as peripheral nerve injury, central nerve injury, cranial neuropathy, and nervous system infections; patients older than 7 years; similar research methods and outcomes assessing symptoms; and measurement of nerve conduction velocities. The meta-analysis was conducted using Review Manager 5.2.3 software. MAIN OUTCOME MEASURES： The total effective rate, the incidence of adverse effects, and the nerve conduction velocity were recorded for each study. RESULTS： Sixty-four studies involving 6,297 patients with neurological diseases were included. The total effective rate in the group treated with nerve growth factor was significantly higher than that in the control group （P 〈 0.0001, RR： 1.35, 95%CI： 1.30-1.40）. The average nerve conduction velocity in the nerve growth factor group was significantly higher than that in the control group （P 〈 0.00001, MD. 4.59 m/s, 95%CI： 4.12-5.06）. The incidence of pain or sclero- ma at the injection site in the nerve growth factor group was also higher than that in the control group （P 〈 0.00001, RR： 6.30, 95%CI： 3.53-11.27）, b

关键词： nerve regeneration neurological diseases nerve growth factor randomized controlledtrials meta-analysis adverse effects nerve conduction velocity neural regeneration

高压烧结制备Tb掺杂n型(Bi1–xTbx)2(Te0.9Se0.1)3合金及其微结构和热电性能

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物理学报 2020年第5期69卷 182-189页

作者：邹平吕丹徐桂英贵州民族大学材料科学与工程学院贵阳550025 北京科技大学材料科学与工程学院北京100083

采用高压烧结技术制备了稀土元素Tb掺杂的n型Bi2Te2.7Se0.3基纳米晶块体热电材料.将高压烧结成型的样品于633 K真空退火36 h.研究了Tb掺杂量对样品的晶体结构和热电性能的影响.结果表明,高压烧结制备的样品为纳米结构, Tb掺杂使样品的... 详细信息

采用高压烧结技术制备了稀土元素Tb掺杂的n型Bi2Te2.7Se0.3基纳米晶块体热电材料.将高压烧结成型的样品于633 K真空退火36 h.研究了Tb掺杂量对样品的晶体结构和热电性能的影响.结果表明,高压烧结制备的样品为纳米结构, Tb掺杂使样品的晶胞体积变大,功率因子增大,热导率降低,从而使ZT值提高.Tb掺杂量为x=0.004是最优的掺杂量,该掺杂量的高压烧结样品经退火处理后,于373 K时ZT值达到最大为0.99,并且在323-473 K范围内, ZT值均大于0.8,这对用于温差发电领域具有重要意义.

关键词：高压烧结 Tb掺杂 n型Bi2Te2.7Se0.3 热电性能

Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy

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Current Medical Science 2019年第2期39卷 211-216页

作者： Na SHEN Yong YOU Zhao-dong ZHONG Li MENG Jian-feng ZHOU ping zou Xiao-jian ZHU Hong-xiang WANG Fan-jun CHENG Institute of Hematology Union HospitalTongji Medical CollegeHtiazhong University of Science and TechnologyWuhan 430022China Department of Hematology Tongji HospitalTongji Medical CollegeHuajrong University of Science and TechnologyWuhan 430030China Department of Hematology The Central Hospital of WuhanWuhan 430014China

Discontinuation of tyrosine kinase inhibitor(TKI)therapy after achieving a persistent deep molecular response(DMR)is an urgently needed treatment goal for chronic myeloid leukemia(CML)patients and has been included in the National Comprehensive Cancer Network(NCCN)guidelines(version 2.2017)for ***,various studies have confirmed the feasibility of discontinuing TKI *** this study,we analyzed data from 45 CML patients who had discontinued TKI *** analysis was performed to predict factors that were potentially related to treatment-free remission(TFR)and identify the differences between early relapse and late *** of the 45 patients,20 exhibited molecular relapse after a median follow-up of 18 months(range,1-54 months),and the estimated TFR at 24 months was 40%.The univariate analysis revealed that a high Sokal score and interruptions or dose reductions during TKI treatment were the only baseline factors associated with poor *** results indicate that TKI discontinuation could be successfully put into practice in China.

关键词： discontinuation treatment-free remission chronic myeloid leukemia relapse

Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms

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World Journal of Pediatrics 2022年第11期18卷 761-770页

作者： Lin Wan Chu-Ting Zhang Gang Zhu Jian Chen Xiu-Yu Shi Jing Wang Li-ping zou Bo Zhang Wen-Bin Shi Chien-Hung Yeh Guang Yang Senior Department of Pediatrics Chinese PLA General HospitalBeijing100000China Department of Pediatrics the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese People’s Liberation Army BeijingChina School of Information and Electronics Beijing Institute of TechnologyBeijing100081China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Neurology and ICCTR Biostatistics and Research Design Center Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a *** sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain *** We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of *** recurrence of epileptic spasms following treatment was tracked for 12 *** were categorized as either non-relapse or relapse *** clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group *** Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a *** BASED score was significantly higher in the relapse *** in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse *** BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural *** with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.

关键词： Burden of amplitudes and epileptiform discharges score Infantile spasms Multiscale entropy Prediction Relapse

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急性髓性白血病的规范化诊治

中国实用内科杂志 2007年第14期27卷 1110-1112页

作者：邹萍华中科技大学附属协和医院血液病研究所湖北武汉430022

急性髓性白血病(AML)是最常见的血液系统恶性肿瘤。由于人口老龄化,AML发生率呈上升趋势,同时淋巴瘤、肉瘤、乳腺和睾丸肿瘤等经治疗存活的患者增多,其治疗相关骨髓增生异常综合征(MDS)、AML发生率亦逐渐上升。近年来,AML的诊断、分类... 详细信息

急性髓性白血病(AML)是最常见的血液系统恶性肿瘤。由于人口老龄化,AML发生率呈上升趋势,同时淋巴瘤、肉瘤、乳腺和睾丸肿瘤等经治疗存活的患者增多,其治疗相关骨髓增生异常综合征(MDS)、AML发生率亦逐渐上升。近年来,AML的诊断、分类标准以及治疗模式有了较多变化,并在某些领域取得了较大进展,通过联合化疗,5年无病存活率已达到30%,急性早幼粒细胞白血病的治疗更取得了可喜的突破,但老年白血病、继发性白血病的治疗仍不尽如人意。[第一段]

关键词：白血病粒细胞急性治疗造血干细胞移植

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影响合体女上装原型横向规格的重要部位

纺织学报 2007年第10期28卷 86-90页

作者：邹平辽东学院服装与纺织学院辽宁丹东118003

由于合体女上装原型模型具有很高的适合度和很强的机能性,所以建立符合人体特征的合体女上装原型至关重要。采用逐步回归,运用C++语言进行计算,建立合体女上装原型控制部位与其横向部位间的计算关系,通过对不同体型各横向部位逐步回归... 详细信息

由于合体女上装原型模型具有很高的适合度和很强的机能性,所以建立符合人体特征的合体女上装原型至关重要。采用逐步回归,运用C++语言进行计算,建立合体女上装原型控制部位与其横向部位间的计算关系,通过对不同体型各横向部位逐步回归数学模型进行比较,发现腰围对合体女上装原型横向规格的影响非常大。此结论将为服装企业提供制板经验,为服装CAD技术应用于服装样板设计方法提供理论基础。

关键词：腰围上装原型逐步回归服装制板

逐步回归中服装结构设计数学模型部位间的影响关系

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纺织学报 2007年第2期28卷 95-99页

作者：邹平辽东学院服装与纺织学院辽宁丹东118003

以往传统服装结构设计所采用的数学模型都是一元线性方程,较少采用二元线性方程,由于人体的复杂性,所以数学模型的合格率较低,已不能满足智能化发展的需要。通过C++语言对逐步回归进行计算,提出建立颈围、胸围、腰围、臀围、肩宽、身高... 详细信息

以往传统服装结构设计所采用的数学模型都是一元线性方程,较少采用二元线性方程,由于人体的复杂性,所以数学模型的合格率较低,已不能满足智能化发展的需要。通过C++语言对逐步回归进行计算,提出建立颈围、胸围、腰围、臀围、肩宽、身高6个控制部位与其它31个细部部位间的服装结构设计数学模型。将各体型各部位回归模型结果进行比较,找出部位间的影响关系及影响规律,为智能化服装CAD生产提供技术基础。

关键词：服装结构设计服装部位逐步回归数学模型