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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian Tang yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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两种剂量戌酸雌二醇联合宫腔镜治疗重度宫腔粘连的效果观察

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广东医科大学学报 2017年第2期35卷 192-194页

作者：谢平柳志原刘孟丽广东省深圳市福田区妇幼保健院妇科广东省深圳市光明新区中心医院妇产科广东省深圳市光明新区中心医院影像科广东深圳518000

目的观察宫腔镜术后两种剂量戌酸雌二醇治疗重度宫腔粘连的效果。方法 86例重度宫腔粘连患者采用宫腔镜治疗,术后第3天服用8 mg/d(对照组)或16 mg/d(观察组)戌酸雌二醇,连用21 d,后5 d加用10 mg/d黄体酮,共3个疗程;比较两组疗效、复发... 详细信息

目的观察宫腔镜术后两种剂量戌酸雌二醇治疗重度宫腔粘连的效果。方法 86例重度宫腔粘连患者采用宫腔镜治疗,术后第3天服用8 mg/d(对照组)或16 mg/d(观察组)戌酸雌二醇,连用21 d,后5 d加用10 mg/d黄体酮,共3个疗程;比较两组疗效、复发率、子宫体积、月经量及不良反应。结果观察组总有效率高于对照组(86.0% vs 67.4%),复发率低于对照组(16.3% vs 34.9%),子宫体积明显大于对照组[(43.85±7.39)cm^3 vs(38.56±5.28)cm^3],治疗后第1~3个月的月经量也明显多于对照组,差异均有统计学意义(P0.05)。结论 16 mg/d戊酸雌二醇可有效预防重度宫腔粘连术后复发。

关键词：重度宫腔粘连宫腔镜手术雌二醇

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A method to study interface diffusion of arsenic into a Nb-Ti microalloyed low carbon steel

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International Journal of Minerals,Metallurgy and Materials 2012年第9期19卷 821-826页

作者： yuan-zhi Zhu Jian-ping XU The Key Laboratory of the Ministry of Education of China for Ferrous Metallurgy and Resources Utilization Wuhan University of Science and Technology Wuhan 430081 China School of Materials and Metallurgy Wuhan University of Science and Technology Wuhan 430081 China

A novel diffusion couple method was used to investigate the interface diffusion of arsenic into a Nb-Ti microalloyed low carbon steel and its effects on phase transformation at the interface. It is discovered that the content of arsenic has great effect on grain growth and phase transformation at high temperature. When the arsenic content is no more than lwt%, there is no obvious grain growth and no obvious ferrite transitional region formed at the diffusion interface. However, when the arsenic content is no less than 5wt%, the grain grows very rapidly. In addition, the arsenic-enriched ferrite transitional layer forms at the diffusion interface in the hot-rolling process, which results from a slower diffusion rate of arsenic atoms than that of carbon in ferrite.

关键词： low carbon steel alloy steel arsenic diffusion bonding phase transformation grain growth

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Thrombolysis and extracorporeal cardiopulmonary resuscitation for cardiac arrest due to pulmonary embolism:A case report

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World Journal of Critical Care Medicine 2025年第1期14卷 111-117页

作者： Guan-Xing yuan zhi-ping Zhang Jia Zhou Department of Emergency Wuhan Asia General HospitalWuhan 430056Hubei ProvinceChina Department of Neurosurgery Central Theater Command General HospitalWuhan 430000Hubei ProvinceChina

BACKGROUND Cardiac arrest caused by acute pulmonary embolism(PE)is the most serious clinical circumstance,necessitating rapid identification,immediate cardiopulmonary resuscitation(CPR),and systemic thrombolytic *** CPR(ECPR)is typically employed as a rescue therapy for selected patients when conventional CPR is failing in settings where it can be *** SUMMARY We present a case of a 69-year-old male who experienced a prolonged cardiac arrest in an ambulance with pulseless electrical *** arrival at the emergency department with ongoing manual chest compressions,bedside pointof-care ultrasound revealed an enlarged right ventricle without *** PE was suspected as the cause of cardiac arrest,and intravenous thrombolytic therapy with 50 mg tissue plasminogen activator was administered during mechanical chest *** 31 minutes of CPR,return of spontaneous circulation was not achieved until 8 minutes after initiation of Veno-arterial extracorporeal membrane oxygenation(ECMO)*** ECMO support,the hemodynamic status and myocardial contractility significantly ***,the patient ultimately did not survive due to intracerebral hemorrhagic complications,leading to death a few days later in the *** This case illustrates the potential of combining systemic thrombolysis with ECPR for refractory cardiac arrest caused by acute PE,but it also highlights the increased risk of significant bleeding complications,including fatal intracranial hemorrhage.

关键词： Pulmonary embolism Cardiac arrest Thrombolytic therapy Cardiopulmonary resuscitation Extracorporeal membrane oxygenation Intracranial hemorrhage Case report

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Nonlinear Forced Vibration of Cantilevered Pipes Conveying Fluid

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Acta Mechanica Solida Sinica 2018年第1期31卷 32-50页

作者： zhi-yuan Liu Lin Wang Xi-ping Sun Department of Mechanics Huazhong University of Science and Technology Wuhan 430074 China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Wuhan 430074 China Tianjin Research Institute Water Transport Engineering M.O.T. Test Detection Center of Water Transport Engineering Tianjin 300356 China

The nonlinear forced vibrations of a cantilevered pipe conveying fluid under base excitations are explored by means of the full nonlinear equation of motion, and the fourth- order Runge-Kutta integration algorithm is used as a numerical tool to solve the discretized equations. The self-excited vibration is briefly discussed first, focusing on the effect of flow velocity on the stability and post-flutter dynamical behavior of the pipe system with parameters close to those in previous experiments. Then, the nonlinear forced vibrations are examined using several concrete examples by means of frequency response diagrams and phase-plane plots. It shows that, at low flow velocity, the resonant amplitude near the first-mode natural frequency is larger than its counterpart near the second-mode natural frequency. The second-mode frequency response curve clearly displays a softening-type behavior with hysteresis phenomenon, while the first-mode frequency response curve almost maintains its neutrality. At moderate flow velocity, interestingly, the first-mode resonance response diminishes and the hysteresis phenomenon of the second-mode response disappears. At high flow velocity beyond the flutter threshold, the frequency response curve would exhibit a quenching-like behavior. When the excitation frequency is increased through the quenching point, the response of the pipe may shift from quasiperiodic to periodic. The results obtained in the present work highlight the dramatic influence of internal fluid flow on the nonlinear forced vibrations of slender Pipes.

关键词： Pipe conveying fluid Base excitation Nonlinear dynamics Primary resonance,Superharmonie resonance Forced vibration

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Smooth Trajectory Planning for a Cable Driven Parallel Waist Rehabilitation Robot Based on Rehabilitation Evaluation Factors

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Chinese Journal of Mechanical Engineering 2023年第3期36卷 63-75页

作者： yuan Li Bin Zi zhi Sun ping Zhao School of Mechanical Engineering Hefei University of TechnologyHefei 230009China

Rehabilitation robots can help physiatrists to assist patients in improving their movement *** to the interaction between rehabilitation robots and patients,the robots need to complete rehabilitation training on a safe *** paper presents an approach for smooth trajectory planning for a cable-driven parallel waist rehabilitation robot(CDPWRR)based on the rehabilitation evaluation ***,motion capture technology is used to collect the motion data of several volunteers in waist *** the impact of motion variability,the feature points at the center of the human pelvis are obtained after eliminating unreasonable data through rationality ***,point-to-point waist training trajectory planning based on quintic polynomial and cycloid functions,and multipoint waist training trajectory planning based on quintic B-spline functions are carried *** corresponding planned curves and kinematics characteristics using three methods are compared and ***,the rehabilitation evaluation factors are introduced to conduct smooth trajectory planning for waist training,and the waist trajectory with better compliance is obtained based on the safety and feasibility of waist ***,the physical prototype of the CDPWRR is built,and the feasibility and effectiveness of the proposed smooth trajectory planning method are proved by numerical analysis and experiments.

关键词： Waist rehabilitation robot Trajectory planning B-spline Rehabilitation evaluation factor

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Interfacial microstructure evolution of 12Cr1MoV/TP347H dissimilar steel welded joints during aging

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International Journal of Minerals,Metallurgy and Materials 2021年第9期28卷 1497-1505页

作者： yuan Li Yan-ping Zeng zhi-chun Wang School of Materials Science&Engineering University of Science and Technology BeijingBeijing 100083China North China Electric Power Research Institute Co. Ltd.Beijing 100045China

The interfacial microstructure evolution of 12Cr1MoV/TP347H dissimilar steel welded joints with a nickel-based filler metal during aging was studied in detail to elucidate the mechanism of premature failures of this kind of *** results showed that not only a band of granular Cr_(23)C_(6)carbides were formed along the fusion boundary in the ferritic steel during aging,but also a large number of granular or plate-like Cr_(23)C_(6)carbides,which have a cube-cube orientation relationship with the matrix,were also precipitated on the weld metal side of the fu-sion boundary,making this zone be etched more easily than the other zone and become a dark etched *** faults were found in some Cr_(23)C_(6)*** the as-welded state,deformation twins were observed in the weld metal with a fully austenitic *** peak micro-hardness was shifted from the ferritic steel side to the weld metal side of the fusion boundary after aging and the peak value increased *** on the experimental results,a mechanism of premature failures of the joints was proposed.

关键词： ferritic/austenitic dissimilar steel welded joint interfacial microstructure aging nickel-based filler metal mechanism of premature failures

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Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa Shen Chang Cheng Yu-Han Wang Wen-Chao Cheng De-zhi yuan Wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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浙江蝮蛇毒中三种磷脂酶A2的比较

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Acta Biochimica et Biophysica Sinica 1984年第6期 664-671页

作者：武祥福蒋芝萍陈远聪中国科学院上海生物化学研究所上海华东化工学院中国科学院上海生物化学研究所 1982年毕业实习生

从浙江蝮蛇毒中纯化了三种磷脂酶A2。前文已报道了其中二种——中性磷脂酶A2,即蝮蛇毒素（Agkistrodotoxin）和碱性磷脂酶A2——的纯化及性质的研究。本文报道的是第三种,即酸性磷脂酶A2的纯化方法,比较了这三种磷脂酶A2的特性,包括分... 详细信息

从浙江蝮蛇毒中纯化了三种磷脂酶A2。前文已报道了其中二种——中性磷脂酶A2,即蝮蛇毒素（Agkistrodotoxin）和碱性磷脂酶A2——的纯化及性质的研究。本文报道的是第三种,即酸性磷脂酶A2的纯化方法,比较了这三种磷脂酶A2的特性,包括分子量、氨基酸组成、N末端、等电点、热稳定性、酶活性、毒性和溶血活性等。结果表明,它们有相似的分子量和热稳定性,但在其他方面却有显著的差别。在酶活性方面,酸性酶活性最高,碱性酶活性最低;对小白鼠的致死毒性,中性酶最高,碱性酶较低,而酸性酶几乎不表现毒性;对大白鼠红细胞的溶血现象,碱性酶最强,中性酶次之,酸性酶几乎不溶血。因此推测磷脂酶A2的溶血效应与磷脂酶A2分子的电荷有关。

关键词：蝮蛇毒磷脂酶脂肪酶 A2 神经毒性小白鼠蝮蛇毒素酸性酶缓冲液 PLA 柱层析分离中性酶虎蛇毒素大白鼠家鼠属浙江

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