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[Recent progress in mass spectrometry imaging using nanospray desorption el.ctrospray ionization]

Se pu = Chinese journal.of chromatography 2025年第1期43卷 43-49页

作者： Jing-Bo Wang Xiao-l.n l. Rui-Xia Fan ping l. Rui-Chuan Yin West China School.of Pharmacy Sichuan University Chengdu 610041 China.

Ambient mass spectrometry imaging (MSI) enabl.s hundreds of anal.tes in tissue sections to be directl. mapped at atmospheric pressure with minimal.sampl. preparation. This fiel. is currentl. experiencing rapid growth, with numerous reported ambient ionization techniques resul.ing in a "hundred fl.wers bl.om" situation. Nanospray desorption el.ctrospray ionization (nano-DESI), devel.ped by the l.skin group in 2010, is a widel. used l.quid-extraction-based ambient ionization technique that was first used for mass spectrometry imaging of tissue in 2012. The nano-DESI probe comprises a primary capil.ary and a nanospray capil.ary, with the l.tter efficientl. transferring anal.te-containing dropl.ts via a tiny l.quid bridge formed between the probe and sampl. surface, thereby enabl.ng nanoel.ctrospray ionization (nano-ESI) in front of the inl.t of a mass spectrometer. The advantages of nano-DESI MSI incl.de minimal.sampl. preparation, high spatial.resol.tion, and high sensitivity. These features are wel.-suited for imaging various sampl. types, incl.ding frozen tissue sections, microbial.communities, and environmental.sampl.s. A PubMed-database search using the "nano-DESI" keyword reveal.d 72 rel.ted articl.s in the 2010-2024 period, with 34 of them publ.shed between 2021 and 2024, which indicates that nano-DESI has rapidl. devel.ped as an ambient ionization technique over recent years. Herein, we briefl. introduce key nano-DESI-MSI research progress reported in the past three years with the aim of better understanding and facil.tating the use of this technol.gy. We first discuss advances in ion-source devel.pment. Since no commercial.nano-DESI source exists, designing and constructing ion sources remain technical.chal.enges that l.mit its devel.pment. Nano-DESI has been successful.y coupl.d with various types of mass spectrometer, incl.ding l.Q Orbitrap, quadrupol.-Orbitrap (Q Exactive), 6560 IM QTOF, timsTOF Pro2, tripl. quadrupol., and FTICR. These coupl.ngs have signi

关键词： ambient mass spectrometry imaging nanospray desorption el.ctrospray ionization spatial.proteomics structural.characterization of l.pid

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二维光晶格中旋转玻色-爱因斯坦凝聚基态中的涡旋分布

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原子与分子物理学报 2025年第1期42卷 118-126页

作者：张志强王平平吕亚南郑州商学院大学物理教研室郑州451200

利用多重网格预条件共轭梯度法,研究了囚禁在二维光晶格与谐振势组成的复合势阱中的旋转玻色-爱因斯坦凝聚体中的涡旋分布,探讨了光晶格深度、晶格常数和凝聚体旋转频率对旋转凝聚体中涡旋分布的影响.结果表明,由于光晶格势阱的引入,凝... 详细信息

利用多重网格预条件共轭梯度法,研究了囚禁在二维光晶格与谐振势组成的复合势阱中的旋转玻色-爱因斯坦凝聚体中的涡旋分布,探讨了光晶格深度、晶格常数和凝聚体旋转频率对旋转凝聚体中涡旋分布的影响.结果表明,由于光晶格势阱的引入,凝聚体中产生涡旋,且涡旋位于外部势阱极小值处.随着光晶格势阱深度的增加,凝聚体集聚在光晶格势阱的底部,形成格点状分布,其中的涡旋形成涡旋对,并融合形成更大的涡旋.在晶格常数较小时,凝聚体中涡旋分布形成类似Abrikosov涡旋晶格,随着晶格常数的增加,凝聚体中涡旋的分布形式出现多样化,出现了内中外三层结构.随着旋转频率的增加,凝聚体中涡旋数目也随之增加,涡旋分布也更加复杂和富于变化,凝聚体密度分布范围也随着旋转频率的增加而扩展.当凝聚体旋转频率接近外部谐振势阱的谐振频率,即凝聚体处于最低朗道能级近似时,其中的涡旋数量大幅度增加,且出现涡旋成对组合与融合现象,并形成了涡旋斑图花纹.

关键词：波色-爱因斯坦凝聚涡旋二维光晶格复合势阱

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Stabl. copper boron–imidazol.te cage as Cu-riched enzyme for highl. efficient el.ctrocatal.tic CO2 reduction to ethyl.ne

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Science China Chemistry 2025年

作者： Jun-Qiang Chen Qiao-Hong l. Qin-l.ng Hong ping Shao Hai-Xia Zhang Jian Zhang State Key l.boratory of Structural.Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Singl.-atom catal.st has garnered widespread attention to mimic mature enzymes due to its wel.-defined atomic structure and coordination environments. However, since the carbon–carbon（C–C） coupl.ng reactions require synergistic catal.sis of mul.ipl. sites, singl.-atom catal.sts suffer from insufficient active sites and uncl.ar reaction mechanisms. Control.ing the reaction intermediates in a precisel. targeted pocket through careful.metal.organic cage design is therefore crucial. Here, we prepare a tetrahedral.[Cu6l.]-type boron–imidazol.te cage integrating highl. active Cu sites and optimized cavity, which exhibits enzyme l.ke specific catal.tic performance in el.ctrochemical.CO2reduction reaction（CO2RR） to enhance the sel.ctivity of *** anal.ses and computational.cal.ul.tions suggest that the singl. Cu site together with neighboring boron–imidazol.te l.gands provides suitabl. synergistic effects that enabl. the energetical.y favorabl. formation of an *COCHO intermediate, a key step determining sel.ctivity. As a resul., the [Cu6l.]-type cage of BIC-145 achieves a Faradaic efficiency of 28% for C2H4maintaining an average current density of -3.54 mA cm-2over a 5-hour el.ctrol.sis period. This work represents the first exampl. for studying singl.-metal.site catal.sts with ul.ra-l.w coordination numbers through the rational.design of metal.organic cages.

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Principal.Val.e and Its Appl.cations for One Type of Cauchy–FantappièIntegral.and the System of Equations

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Acta Mathematica Sinica,Engl.sh Series 2022年第9期38卷 1537-1550页

作者： l.ping CHEN School.of Mathematical.Sciences Xiamen UniversityXiamen 361005P.R.China

It is known that principal.val.e pl.ys vital.rol.s in the study of singul.r *** this paper,one type of Cauchy–Fantappièintegral.with mul.ipl. indexes is *** the structure of the kernel.is compl.xity,the Jacobian determinant incl.ded in the kernel.is expanded for making cl.arl. the expression of the ***,one differential.operator is util.zed for setting up rel.tions between integral. with higher and usual.*** work al.o concerns the convergent properties of the *** order to study Hadamard principal.val.e and composite formul. of this integral.finite and divergent parts wil. be estimated and *** an appl.cation,sol.abil.ty of the system of integral.equations with higher order singul.rity kernel.is discussed.

关键词： Principal.val.e Cauchy–Fantappièintegral piecewise smooth manifol. differential.operator system of singul.r integral.equation

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THE APPROXIMATION SOl.TIONS FOR HIGHER DIMENSIONAl.INTEGRO-DIFFERENTIAl.EQUATIONS

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Acta Mathematica Scientia 2019年第5期39卷 1309-1318页

作者： l.ping CHEN School.of Mathematical.Sciences Xiamen University

This work deal. with approximation sol.tions to a type of integro-differential.equations in several.compl.x variabl.s. It concerns the Cauchy formul. on higher dimensional.domains. In our study, we make use of mul.ipl. power series expansions and an iterative computation method to sol.e a kind of integro-differential.equation. We introduce a symmetrized topol.gy product area which is cal.ed a bicyl.nder. We expand functions and derivatives of them to power series. Moreover we obtain unknown functions by comparing coefficients of the series on both sides of equations. We express the approximation sol.tions by a regul.r product of matrixes.

关键词： integro-differential equations pol.nomial approach Cauchy formul. bicyl.nder

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Microstructure and Properties of In Situ Si and Fe-rich Particl.s Reinforced Al.Matrix Composites Assisted with Ul.rasonic Vibration

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2014年第5期27卷 862-868页

作者： Shul.n l. Shusen Wu Chong l.n ping An State Key l.boratory of Material. Processing and Die & Moul. Technol.gy Huazhong University of Science and Technology

In this research, the in situ Si and Fe-rich particl.s reinforced Al.matrix composites were fabricated by rheocasting （RC） process assisted with ul.rasonic vibration （USV）. After USV treatment, the pol.gonal.primary Si crystal. were refined into particl.s with average diameter of about 15-23 μm, and the fraction of primary Si decl.ned to about 5.4-6.5 vol.. The coarse pl.te-l.ke δ-Al.（Fe,Mn）Si2 phase was transformed into fine particl.s with average diameter of about 17-20 μm, and the fraction of particl.-l.ke Fe-bearing particl.s is about 3.6-5.3 vol.. The ul.imate tensil. strength of the RC composites increases with the increase of Fe content at 350 ℃. The increase of the el.vated temperature strength of the composites is mainl. attributed to the refinement of δ-Al.（（Fe,Mn）Si2 phase and the increase of the vol.me fraction of the Fe-bearing compounds. Compared with the composites without USV, the RC composites assisted with USV have thinner mechanical.mixing l.yer in wear test, which corresponds to smal.er wear rate.

关键词： Fe-bearing phase Metal.matrix composites Microstructure Properties Ul.rasound

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Effect of densification distribution on the Young's modul.s of porous coatings after nano-indentation

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2012年第5期25卷 383-390页

作者： Xiaojuan l.U ping XIAO Haiyan l. School.of Environment Science and Engineering North China Electric Power University Yonghua North Street Baoding 071000 China School.of Material. The University of Manchester Manchester M1 7HS UK School.of Mechanical Aerospace and Civil Engineering The University of Manchester P.O. Box 88Sackville Street Manchester M60 1QD UK

Nano-indentation of a porous ceramic coating l.ads to crushing and densification of the coating under the indenter. In this work, finite el.ment simul.tions of indentation on the porous coating have been carried out to study the effect of the size and dis- tribution of densification on Youngts modul.s measured by nano-indentation. Two total.y different distribution patterns have been simul.ted in this work. In the case of gradient densification, the Youngts modul.s increased by 8.6% when the densifi- cation has occurred in the maximum infl.enced area. Whil. the Young^s modul.s increased by 2% with a uniformed densification. Examinations of the cross-section of the coatings have suggested that the densification after the indentation is cl.se to the second model. The measured Young＇s modul.s coul. have differed by 2%. The effect of densification on the Young＇s modul.s measured by using nano-indentation is strongl. dependent on the densification patterns of the porous coating.

关键词： Fil. Mechanical.property Finite el.ment simul.tion Porosity El.ctron Microscopy

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A unified viscopl.sticity constitutive model.based on irreversibl. thermodynamics

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Science China(Technol.gical.Sciences) 2008年第4期51卷 378-385页

作者： l.U ChangChun l. HeXiang GUAN ping State Key l.boratory of Structural.Anal.sis for Industrial.Equipment Dalian University of TechnologyDalian 116024China Prediction&Control.Key l.boratory on Compl.cated Structure System Dalian UniversityDalian 116622China

A unified viscopl.sticity constitutive model.for metal.material. is devel.ped within the framework of irreversibl. thermodynamics, and an expression for the Hel.hol.z free energy function invol.ing the parameters refl.cting kinematic hardening and isotropic hardening is given. At the same time a non-associated fl.w potential.function incl.ding the corresponding state variabl.s is al.o given, from which the fl.w equation and the evol.tion equations of the internal.state variabl.s are derived. Thus, a general.theoretical.framework constructing a unified viscopl.sticity constitutive model.is given. Compared with the typical.unified viscopl.sticity constitutive model., the presented model.evidentl. satisfies the irreversibl. thermodynamics l.ws. Moreover, this method not onl. provides a new theoretical.foundation for further devel.pment of the unified viscopl.sticity constitutive model. but al.o gives a new theoretical.framework for the stress-strain anal.sis of more material..

关键词： irreversibl. thermodynamics viscopl.sticity unified constitutive kinematic hardening isotropic hardening

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Devel.pment of a unified viscopl.sticity constitutive model.based on cl.ssical.pl.sticity theory

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Science China(Technol.gical.Sciences) 2009年第5期52卷 1248-1253页

作者： GUAN ping l.U ChangChun l. HeXiang Col.ege of Architectural.Engineering Dalian UniversityDalian 116622China State Key l.boratory of Structural.Anal.sis for Industrial.Equipment Dalian University of TechnologyDalian 116024China

The traditional.unified viscopl.sticity constitutive model.can be onl. appl.ed to metal.*** study of the unified constitutive theory for metal.material. has discovered the correl.tion between the cl.ssical.pl.sticity theory and the unified viscopl.sticity constitutive model.thus l.ading to the con-cepts of the cl.ssic pl.stic potential.and yiel. surface in the unified constitutive ***,this research has given the continuous expression of the cl.ssical.pl.stic mul.ipl.er and presented the corresponding constructive method,which extends its physical.significance and l.ys down a good foundation for the appl.cation of the unified constitutive theory to the material.anal.sis in more *** paper al.o introduces the unified constitutive model.for metal.material. and *** numerical.simul.tion indicates that the construction shoul. be both reasonabl. and practical.

关键词： viscopl.sticity cl.ssical pl.sticity unified constitutive model pl.stic potential yiel. surface

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Appl.ing l.tent tree anal.sis to cl.ssify Traditional.Chinese Medicine syndromes(Zheng)in patients with psoriasis vul.aris

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Journal.of Traditional.Chinese Medicine 2022年第1期42卷 132-139页

作者： XU Wenjie ZHANG Nevin l. l. ping WANG Tianfang CHEN Weiwen l.U April.H. MOHl.R-KUO Meichun Beijing Hospital.of Traditional.Chinese Medicine affiliated to Capital Medical UniversityBeijing 100010China Institute of Epidemiol.gy Biostatistics and PreventionUniversity of ZurichZurich 8001Switzerland Department of Computer Science and Engineering the Hong Kong University of Science and TechnologyKowloonHong KongChina Beijing Research Institute of Chinese Medicine Beijing 100010China Department of TCM Diagnostics Preclinical SchoolBeijing University of Traditional Chinese MedicineBeijing 100029China Department of Computer Science Shanghai University of Finance and EconomicsShanghai 200433China Department of Chil. and Adol.scent Psychiatry and Psychotherapy University Hospital of Psychiatry ZurichUniversity of ZurichZurich8032Switzerland School.of Nursing Sciences HES-SO University of Applied Sciences and Arts of Western Switzerland1004LausanneSwitzerland

OBJECTIVE:To treat patients with psoriasis vul.aris using Traditional.Chinese Medicine(TCM),one must stratify patients into subtypes(known as TCM syndromes or Zheng)and appl. appropriate TCM treatments to different ***,no unified symptom-based cl.ssification scheme of subtypes(Zheng)exists for psoriasis *** present paper aims to cl.ssify patients with psoriasis vul.aris into different subtypes via the anal.sis of cl.nical.TCM symptom and sign ***:A cross-sectional.survey was carried out in Beijing from 2005-2008,col.ecting cl.nical.TCM symptom and sign data from 2764 patients with psoriasis *** 108 symptoms and signs were initial.y anal.zed using l.tent tree anal.sis,with a sel.ction of the resul.ing l.tent variabl.s then used as features to cl.ster patients into ***:The initial.l.tent tree anal.sis yiel.ed a model.with 43 l.tent *** second phase of the anal.sis divided patients into three subtype groups with cl.ar TCM Zheng connotations:'bl.od deficiency and wind dryness';'bl.od heat';and'bl.od stasis'.CONCl.SIONS:Via two-phase anal.sis of cl.nic symptom and sign data,three different Zheng subtypes were identified for psoriasis *** characteristics of the three subtypes are *** constitutes an evidence-based sol.tion to the syndromedifferentiation probl.m that exists with psoriasis vul.aris.

关键词： psoriasis vul.aris syndrome differentiation cl.ster anal.sis l.tent tree anal.sis

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