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Special prognostic phenomenon for patients with mid-range ejection fraction heart failure:a systematic review and meta-analysis

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Chinese Medical Journal 2020年第4期133卷 452-461页

作者： Pan Guo Jian-Feng Dai Chao Feng Shu-Tao Chen Jin-ping Feng Department of Cardiology Tianjin Chest HospitalTianjin 300222China Graduate School of Medicine Tianjin Medical UniversityTianjin 300070China

Background:Clinical features and outcomes of heart failure(HF)with mid-range ejection fraction(HFmrEF)remain ***,we systematically reviewed literatures of clinical research to assess and analyze characteristics and prognosis of patients with ***:PubMed,Embase,and Web of Science were searched for cohort studies up to April 23,*** features and multivariate adjusted hazard ratios(HRs)of endpoints of short-term all-cause mortality(SAM),long-term all-cause mortality(lam),long-term cardiovascular death(LCD)and long-term HF rehospitalization(LHR)among patients with HFmrEF and HF with preserved ejection fraction(HFpEF),HF with reduced ejection fraction(HFrEF)were well *** primary outcome was ***:Totally 19 studies were included in this study with 164,678 patients *** follow-up time of lam was 3.6±2.5 *** of lam,SAM,LCD,LHR indicated that the risks of patients with HFmrEF were higher than HFpEF patients but lower than HFrEF patients,as for lam,HFmrEF:HFpEF(reference)HR:1.07,95%confidence interval(CI):1.00-1.15(I2=63%,P=0.0005);HFmrEF:HFrEF(reference)HR:0.80,95%CI:0.73-0.88(I2=70%,Plam(30.94%),SAM(2.73%),LCD(17.45%),LHR(26.36%)compared with the other two ***:This systematic review and meta-analysis compared features and prognosis between patients with HFmrEF and HFpEF,HFrEF by *** appeared a special"separation phenomenon"showing rates of endpoints were inconsistent with their hazards in patients with HFmrEF compared with HFpEF patients.

关键词： Heart failure Ejection fraction Mid-range Prognosis Meta-analysis

Umbilical Cord Blood Mononuclear Cell Treatment for Neonatal Rats with Hypoxic Ischemia

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Umbilical Cord Blood Mononuclear Cell Treatment for Neonatal...

新型冠状病毒肺炎疫情中一次性使用医用口罩重复使用及消毒方法的可行性探讨

第十六届中国医师协会神经外科医师年会

作者： Hao LYU Dong Ming SUN Chi ping NG Wendy S CHENG Jun Fan CHEN Yu Zhong HE Sin Yu lam Zhi Yuan ZHENG Guo Dong HUANG Chi Chiu WANG Wise Young Wai Sang POON Division of Neurosurgery Department of SurgeryFaculty of MedicineThe Chinese University of Hong Kong Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgerythe Shenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen University W.M.Keck Center for Collaborative Neuroscience RutgersState University of New Jersey Department of Neurosurgery Hainan Hospital of People's Liberation Army General Hospital Department of Obstetrics and Gynecology The Chinese University of Hong Kong

Background:Hypoxic-Ischemic Encephalopathy(HIE) occurs when an infant’s brain has not received adequate oxygen and blood supply,resulting in ischemic and hypoxic ***,supportive care and hypothermia therapy have been the standard treatment for ***,there are still over 20% of treated infants died and 19-30% survived with significant *** animal model was first established by Vannucci et al,involving the ligation of one common carotid artery followed by *** this study,we investigated human umbilical cord blood(HUCB) and its two components mononuclear cell(MNC) and red cell fraction(RCF) in both short and long term study using a modified HIE rat ***:In this modified HIE model,both common carotid arteries were occluded,breathing 8% oxygen in a hypoxic chamber for 60-minute,followed by the release of the common carotid arteries ligature,mimicking reperfusion *** cell therapeutic study,cells were intravenously injected to HIE rat pups,and both behavioral and histological changes were assessed at selected time ***:Statistically significant behavioral improvements were demonstrated on Day 7 and 1 month between saline treated HIE rats and UCB/MNC treated ***,at 3 months,the therapeutic improvements were only showed between saline treated HIE animals and MNC treated HIE *** histological analysis one month after cell injection,the number of functional neurons were statistically increased between saline treated HIE and UCB/MNC/RCF treated HIE *** 3 months,the significant increase in functional neurons was only present in MNC treated HIE ***:We have used a bilateral temporary occlusion of 60 minutes,a moderately brain damaged model,for cell therapeutic *** umbilical cord blood(HUCB) mononuclear cell(MNC) therapy showed benefits in neonatal HIE rats in both short and long term behavioral and histological assessments.

关键词： Hypoxic Ischemic Encephalopathy animal model cell therapeutic

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护理管理杂志 2020年第4期20卷 280-284页

作者：林清黄韵芝孙桂萍香港理工大学护理学院香港中山职业技术学院社会工作教研室中山市528400

经呼吸道飞沫传播可能是新型冠状病毒主要的传播途径,佩戴一次性使用医用口罩能有效减少呼吸道传染病人传人的机会,在一次性使用医用口罩缺乏的情况下是否能重复使用是当前公众关注的问题。文章归纳了国内的口罩种类及重复使用的观点及... 详细信息

经呼吸道飞沫传播可能是新型冠状病毒主要的传播途径,佩戴一次性使用医用口罩能有效减少呼吸道传染病人传人的机会,在一次性使用医用口罩缺乏的情况下是否能重复使用是当前公众关注的问题。文章归纳了国内的口罩种类及重复使用的观点及消毒方法,分析了现有消毒方法,包括紫外线、阳光、高温及化学消毒法可能存在的利弊。在新型冠状病毒肺炎疫情影响下,公众可以根据所处的地区、自身的健康情况,以及家庭中一次性使用医用口罩的存储量等情况综合考虑是否重复利用一次性使用医用口罩。

关键词：新型冠状病毒肺炎一次性使用医用口罩重复使用消毒

The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey

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Infectious Diseases of Poverty 2015年第1期4卷 371-381页

作者： Juan Yang Mark Jit Kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.Lau Joseph T.Wu Hong-jie Yu Key Laboratory of Surveillance and Early-warning on Infectious Disease Division of Infectious DiseaseChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206China Modelling and Economics Unit of Public Health in England LondonUK Department of Infectious Disease Epidemiology London School of Hygiene and Tropical MedicineLondonUK WHO Collaborating Centre for Infectious Disease Epidemiology and Control School of Public HealthLi Ka Shing Faculty of MedicineThe University of Hong Kong2/F North WingPatrick Manson Building7 Sassoon RoadPok Fu LamHong Kong Special Administrative RegionChina

Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy ***:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal *** participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in ***-reported costs from the survey were validated by a review of hospital accounts for a small sample of the ***:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying *** average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),*** medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,*** influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 ***$146;inpatients:US$1,800 ***$1,189).In the baseline ana

关键词： Influenza Cost analysis China

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数字人文视角下lam资源整合路径研究

情报科学 2021年第4期39卷 157-164页

作者：贾琼王萍吉林大学管理学院吉林长春130022

【目的/意义】以跨领域协作为特征的数字人文理念,将为lam资源的数据化转变、组织与知识服务带来积极影响,也为lam资源整合提供了新的视角与思路。【方法/过程】基于文献知识图谱,可视化透视了二者在资源、技术与服务层面的契合度,并据... 详细信息

【目的/意义】以跨领域协作为特征的数字人文理念,将为lam资源的数据化转变、组织与知识服务带来积极影响,也为lam资源整合提供了新的视角与思路。【方法/过程】基于文献知识图谱,可视化透视了二者在资源、技术与服务层面的契合度,并据此构建了数字人文视角下lam资源整合的逻辑框架,最后从机构协同合作、数据驱动、技术驱动与需求导向四个层面,总结了数字人文视角下lam资源整合的可行路径。【结果/结论】数字人文与lam资源整合理念存在一定的契合度;数字人文从机构、资源、技术与服务四个层面,丰富lam资源整合的路径。【创新/局限】从理论层面较为完整的阐述了数字人文视角下lam资源整合的逻辑与路径,在实践层面仍存在资源样本选择与验证等局限与拓展空间。

关键词：数字人文 lam资源资源整合机构协同整合路径

基于lamé曲线的Delta并联机器人拾放操作轨迹的优化与试验验证

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机械工程学报 2015年第1期51卷 52-59页

作者：解则晓商大伟任凭中国海洋大学工程学院青岛266100

提出了高速Delta并联机器人拾放操作轨迹的一种实现及优化的方法。在笛卡儿空间中利用lamé曲线平滑竖直运动与水平运动之间的直角过渡部分,确定运动轨迹形状。用高阶多项式运动特性对一维曲线弧位移进行三维规划,获得运动轨迹插补点的... 详细信息

提出了高速Delta并联机器人拾放操作轨迹的一种实现及优化的方法。在笛卡儿空间中利用lamé曲线平滑竖直运动与水平运动之间的直角过渡部分,确定运动轨迹形状。用高阶多项式运动特性对一维曲线弧位移进行三维规划,获得运动轨迹插补点的位置、速度和加速度信息。通过Delta机器人运动学模型和动力学模型将笛卡儿空间内的轨迹信息映射到机器人关节空间,以关节电动机的近似输出能量函数为目标优化lamé曲线的参数。在试验样机平台上进行测试,测量不同lamé曲线参数的运动轨迹在运动停止后机构残余振动的情况,通过比较验证了参数优化后的轨迹具有良好的实际性能,能够获得满足实践要求的轨迹曲线。

关键词： Delta并联机器人拾放操作轨迹规划 lamé曲线参数优化

苯并(a)芘致毒的鱼的分子生态毒理学指标研究

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中国环境科学 1999年第5期19卷 417-420页

作者：陈加平徐立红吴振斌张甬元林群声中国科学院水生生物研究所湖北武汉430072 香港城市大学生物及化学系

通过测定典型的多环芳烃类物质苯并（a）芘（BaP）致毒后鱼体内几种重要分子生态毒理学指标的变化，来反映苯并（a）芘致毒对鱼体的影响．结果表明，肝脏ATPase活性降低，GST活性升高，DNA加合物相对标记水平（RAL）也增大，而EROD活性... 详细信息

通过测定典型的多环芳烃类物质苯并（a）芘（BaP）致毒后鱼体内几种重要分子生态毒理学指标的变化，来反映苯并（a）芘致毒对鱼体的影响．结果表明，肝脏ATPase活性降低，GST活性升高，DNA加合物相对标记水平（RAL）也增大，而EROD活性没有明显改变．这说明苯并（a）芘致毒对鱼体正常生命活动产生了重大影响，并具有潜在的致癌性．

关键词：苯并(a)芘分子生态毒理学 DNA加合物鱼体

再谈乙型肝炎病毒反转录酶区/表面抗原区基因变异的临床发生特点及意义

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解放军医学杂志 2018年第5期43卷 361-366页

作者：刘妍徐东平解放军302医院临床研究管理中心/全军传染病研究所北京100039

在我国,拉米夫定(lam)、阿德福韦酯(ADV)和恩替卡韦(ETV)长期广泛用于临床抗乙型肝炎病毒(HBV)治疗,导致恩替卡韦耐药患者累积增加,耐药变异形式复杂多样,其挽救治疗也成了临床关注的重点问题。HBV聚合酶/反转录酶(RT)区/表面抗原(HBsA... 详细信息

在我国,拉米夫定(lam)、阿德福韦酯(ADV)和恩替卡韦(ETV)长期广泛用于临床抗乙型肝炎病毒(HBV)治疗,导致恩替卡韦耐药患者累积增加,耐药变异形式复杂多样,其挽救治疗也成了临床关注的重点问题。HBV聚合酶/反转录酶(RT)区/表面抗原(HBsAg)S区基因重叠,核苷(酸)类似物引起的耐药变异可同时造成S区基因变异,其中rt A181T变异可同时引起sW172终止突变,形成截短型HBsAg,影响疾病进展;rt A181T有时还可引起sW172非终止变异,其临床发生特点和意义尚不明确;HBsAg阴转是慢性乙型肝炎功能性治愈的重要标志,但临床上有少数患者可同时检出血清HBsAg和HBs Ab阳性,其意义与机制尚未完全明确。我们的研究发现,发生在HBsAg主要亲水区(MHR)的免疫逃逸相关变异多见于隐匿性HBV感染患者和HBsAg/HBs Ab双阳性的HBV感染患者,其中如发生新增N-糖基化变异,则进展为肝细胞癌的风险显著增加;从患者分离的免疫逃逸变异株可显著降低HBsAg的抗原性和反应性。上述研究有助于深入认识HBV RT/S基因变异发生的临床特点、机制和意义,帮助临床合理制定抗病毒治疗方案,预测疾病进展风险。

关键词：肝炎病毒,乙型反转录酶区耐药变异 HBsAg主要亲水区免疫逃逸相关变异

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星际转移发射机会搜索方法

北京理工大学学报 2008年第3期28卷 226-229页

作者：徐瑞乔栋蒋惠萍北京理工大学宇航科学技术学院北京100081

针对星际探测任务发射机会搜索中,等高线图法计算量大和基于遗传算法的搜索方法难以得到精确最优解的问题,提出了一种混合搜索方法.该方法根据探测任务要求,定义待搜索目标函数,并确定搜索域;结合lam-bert定理与Gauss算法对该问题进行降... 详细信息

针对星际探测任务发射机会搜索中,等高线图法计算量大和基于遗传算法的搜索方法难以得到精确最优解的问题,提出了一种混合搜索方法.该方法根据探测任务要求,定义待搜索目标函数,并确定搜索域;结合lam-bert定理与Gauss算法对该问题进行降维;采用全局-局部混合搜索方法求解,解决了传统方法计算量大、计算效率低、求解最优解困难的问题.以1627 Ivar小行星的交会任务为例验证了该方法,其结果表明,采用混合搜索方法可以快速获得最优的星际转移发射机会.

关键词：发射机会搜索遗传算法混合搜索小行星交会