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Science China(Physics,Mechanics & Astronomy) 2024年第10期Mechanics & Astronomy) .卷 5-15页

作者： Xu-Xing Geng Kai Jin Lu Zhou Wang-Wang Tang Guoqing Yang Shangqing Liang Shao-ping Wu Guang-Ming Huang Gao-Xiang Li Department of Physics Huazhong Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal University College of Electronics and Information Hangzhou Dianzi University

Multidimensional floquet-driven alignment systems with dynamical symmetry present various exotic phenomena and applications. However, there are challenges in directly characterizing large-spin dynamical symmetry from spectra. Here, we first observe the symmetry-protected selection rules of dynamical high-dimensional parity in a large-spin(f = 4) system. We theoretically construct a floquet-driven alignment system that can be used to reveal high-dimensional spatiotemporal symmetry. In the experiment, the system is implemented in Cs atomic gas subjected to two-dimensional floquet-modulated magnetic resonance driving. By developing floquet detection protocols of alignment double-sided spectra, we directly verify symmetry-protected selection rules of dynamical high-dimensional parity for large-spin systems. This work advances the exploration of dynamical symmetry to large spins, and unravels a universal floquet scheme for the investigation of symmetry-protected selection rules.

关键词： dynamical high-dimensional symmetry symmetry-protected selection rules large-spin alignment magnetic resonance floquet two-mode detection

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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana n.nekrasova Andrei I.fischer natalia A.nesterova Anatoliy V.Dobrodumov Anzhelika V.Garshinina Olga D.Shuvaeva natalya V.Zakharova Evgenii f.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(n-vinylpyrrolidone(VP),n-methyl-n-vinylacetamide(MVAA),n-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulf.nate(naSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing n-vinylamide units(VP,MVAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAG-containing *** the case of.naSS-containing copolymers,the luminescence intensity is controlled by the values of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

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Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and f.nction

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national Science Review 2024年第2期11卷 145-154页

作者： farong Ye Cheng Li f.ng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-Tang Zheng Tianlei Ying Biao Yu ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/nHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–f.nction relationships. five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary n-glycan elicited a higher level of.neutralising antibodies against SARS-CoV-2 in mice. furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the n-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

Plasmon-enhanced ultra-high photoresponse of single-wall carbon nanotube/copper/silicon near-infrared photodetectors

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nano Research 2024年第7期17卷 5930-5936页

作者： Yi-Ming Zhao Xian-Gang Hu Chao Chen Zuo-Hua Wang An-ping Wu Hong-Wang Zhang Peng-Xiang Hou Chang Liu Hui-Ming Cheng Shenyang national Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China national Engineering Research Center for Equipment and Technology of Cold Strip Rolling College of Mechanical EngineeringYanshan UniversityQinhuangdao 066004China faculty of Materials Science and Engineering/Institute of Technology for Carbon neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Single wall carbon nanotube(SWCnT)/Si heterojunction photodetectors have the advantages of high photoresponse ability and simple structure,however,their detection wavelength range are usually lower than 1100 nm,which limits their application in the infrared *** report a SWCnT/Cu/Si photodetector with both a high photoresponse and a detection range up to the infrared band by depositing a Cu nanoparticles(nPs)layer between a SWCnT film and a n-Si *** was found that the Cu nPs produce strong surface plasmon resonance(SPR)under laser irradiation,which breaks through the limitation of Si band gap and greatly improves the photoresponse of the SWCnT/Cu/Si photodetector in the near infrared *** responsivity(R)of the photodetector in the wavelength range of 1850–1200 nm reached 2.2–14.15 mA/W,which is the highest value in the reported plasmon enhanced n-Si based photodetectors,and about 20,000 times higher than that of a SWCnT/Si *** R value for 1550 nm wavelength used in optical communications reached~8.2 mA/W,which is 64%higher than the previously reported values of commonly used *** attribute the significant increase to the strong SPR and low Schottky barrier of Cu with n-Si,which facilitates the generation and transfer of the carriers.

关键词： single wall carbon nanotube photodetector silicon surface plasmon resonance copper

Early Phases of Star formation: Testing Chemical Tools

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Research in Astronomy and Astrophysics 2024年第1期24卷 96-118页

作者： n.C.Martinez S.Paron COnICET-Universidad de Buenos Aires.Instituto de Astronomía y física del Espacio Ciudad Universitaria(C1428EGA)Ciudad Autónoma de Buenos AiresArgentina

Star-forming processes strongly influence the ISM ***,many high-quality databases are available at millimeter *** them,it is possible to carry out studies that review and deepen previous *** these studies involve large samples of sources,it is preferred to use direct tools to study the molecular *** the aim of testing these tools such as the use of the HCn/HnC ratio as a thermometer,and the use of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H as "chemical clocks," we present a molecular line study toward 55 sources representing massive young stellar objects at different evolutionary stages:infrared dark clouds(IRDCs),highmass protostellar objects(HMPOs),hot molecular cores(HMCs) and ultracompact H II *** found that the use of the HCn/HnC ratio as a universal thermometer in the ISM should be taken with care because the HCn optical depth is a big issue that can affect the ***,this tool should be utilized only after a careful analysis of the HCn spectrum,checking that no line,neither the main nor the hyperf.ne ones,presents absorption *** point out that the analysis of the emission of H^(13)CO^(+),HC_(3)n,n_(2)H^(+) and C_(2)H could be useful to trace and distinguish regions among IRDCs,HMPOs and *** molecular line widths of these four species increase from the IRDC to the HMC stage,which can be a consequence of the gas dynamics related to the starforming processes taking place in the molecular *** results not only contribute with more statistics,acting as a probe of such chemical tools,useful to obtain information in large samples of sources,but also complement previous works through the analysis of other types of sources.

关键词： stars:formation ISM:molecules ISM:clouds

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Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： Kai-kai GUO Chang-ya LIU Gao-hui LI Jian-ping XIAnG Xiao-chang LEnG Yi-ke CAI Xue-bin HU Department of.neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:no significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θf),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(Pnotably,only the SR exhibited a significant correlation with multiple hemodynamic parameters(P0.5,Pnclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

fEROnIA-mediated TIR1/AfB2 oxidation stimulates auxin signaling in Arabidopsis

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Molecular Plant 2024年第5期17卷 772-787页

作者： Baiyan Lu Shengnan Wang Hanqian f.ng Jing Wang Kaixing Zhang Yilin Li ping Wu Minmin Zhang Yanshu Xia Chao Peng Chao Li School of Life Sciences East China Normal UniversityShanghai 200241China national facilty for Protein Science Shanghai Zhangjang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The phytohormone auxin plays a pivotal role in governing plant growth and *** the TRAnSPORT InHIBITOR RESPOnSE1/AUXIn SIGnALInG f-BOX(TIR1/AfB)receptors f.nction in both the nucleus and cytoplasm,the mechanism governing the distribution of TIR1/AfBs between these cellular compartments remains *** this study,we demonstrate that auxin-mediated oxidation of TIR1/AfB2 is essential for their targeting to the *** showed that small active molecules,reactive oxygen species(ROS)and nitric oxide(nO),are indispensable for the nucleo-cytoplasmic distribution of TIR1/AfB2 in trichoblasts and root *** studies revealed that this process is regulated by the fEROnIA receptor kinase–nADPH oxidase signaling ***,ROS and nO initiate oxidative modifications in TIR1C140/516 and AfB2C135/511,facilitating their subsequent nuclear *** oxidized forms of TIR1C140/516 and AfB2C135/511 play a crucial role in enhancing the f.nction of TIR1 and AfB2 in transcriptional auxin ***,our study reveals a novel mechanism by which auxin stimulates the transport of TIR1/AfB2 from the cytoplasm to the nucleus,orchestrated by the fEROnIA–ROS signaling pathway.

关键词： fEROnIA TIR1/AfBs oxidative modification nucleo-cytoplasmic distribution root hair development

Improving discharge voltage and ion storage dynamic in polyaniline via modulation of carrier charge density for magnesiummetal batteries

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nano Research 2024年第7期17卷 6168-6175页

作者： ping Luo feiyang Chao Chunli Zuo Wenwei Zhang f.ngyu Xiong Zhen Huang Dongyao Zhu Gongtao Yu Wenhui Zhong Xingbao Chen Han Tang Xiujuan Wei Qinyou An Hubei Provincial Key Laboratory of Green Materials for Light Industry School of Materials and Chemical EngineeringHubei University of TechnologyWuhan 430068China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Institute for Sustainable Transformation School of Chemical Engineering and Light IndustryGuangdong University of TechnologyGuangzhou 510006China

Rechargeable magnesium-metal batteries(RMBs)have gained much attention due to their abundant resources as well as high ***,the high charge density of Mg^(2+)is one of the main reasons for the slow kinetics performance of RMBs,and modulation of the charge density is an important strategy to improve the kinetics and electrochemical performance of ***,we report on the conductive polymer polyaniline(PAnI)for RMBs,which is found to have excellent kinetics and high discharge voltage when storing MgCl^(+).In the storage of MgCl^(+),PAnI exhibits a high average discharge voltage platform is 2.3 V ***^(2+)/Mg,which is higher than that in storage of Mg^(2+).We demonstrated the reversible intercalation/de-intercalation of MgCl^(+)in PAnI accompanying with the reversible transformation between the quinone ring(C–C,–n=)and the benzene ring(C=C,–nH–)during charging and *** f.nctional theory calculation reveals that PAnI exhibit higher voltages(2.25 V vs.1.82 V)along with lower diffusion energy barriers(1.27 eV vs.1.55 eV)for MgCl^(+)storage compared to Mg^(2+)*** work ref.nes the storage mechanism of PAnI in RMBs and provides new guidelines for the application of PAnI in RMBs.

关键词： rechargeable magnesium-metal batteries cathode materials polyaniline MgCl+storage

Development of T cell antigen-based human coronavirus vaccinesagainst nAb-escaping SARS-CoV-2 variants

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Science Bulletin 2024年第15期69卷 2456-2470页

作者： Hao Zhou ping Leng Yang Wang Kaiwen Yang Chen Li David M.Ojcius Pengfei Wang Shibo Jiang College of Medical Technology Chengdu University of Traditional Chinese MedicineChengdu 611137China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chongqing Traditional Chinese Medicine HospitalChongqing 400016China Shanghai Pudong Hospital Fudan University Pudong Medical CenterShanghai Institute of Infectious Disease and BiosecuritySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biomedical Sciences University of the PaciﬁcArthur Dugoni School of DentistrySan FranciscoCA 94115USA Key Laboratory of Medical Molecular Virology of Ministry of Education/Ministry of Health/Chinese Academy of Medical Sciences Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghai 200032China

Currently approved vaccines have been successful in preventing the severity of COVID-19 and hospitalization. These vaccines primarily induce humoral immune responses;however, highly transmissible and mutated variants, such as the Omicron variant, weaken the neutralization potential of the vaccines, thus,raising serious concerns about their efficacy. Additionally, while neutralizing antibodies(nAbs) tend to wane more rapidly than cell-mediated immunity, long-lasting T cells typically prevent severe viral illness by directly killing infected cells or aiding other immune cells. Importantly, T cells are more cross-reactive than antibodies, thus, highly mutated variants are less likely to escape lasting broadly cross-reactive T cell immunity. Therefore, T cell antigen-based human coronavirus(HCoV) vaccines with the potential to serve as a supplementary weapon to combat emerging SARS-CoV-2 variants with resistance to n Abs are urgently needed. Alternatively, T cell antigens could also be included in B cell antigen-based vaccines to strengthen vaccine efficacy. This review summarizes recent advancements in research and development of vaccines containing T cell antigens or both T and B cell antigens derived from proteins of SARS-CoV-2 variants and/or other HCo Vs based on different vaccine platforms.

关键词： COVID-19 Immune escape Omicron variant SARS-CoV-2 T cell antigen-based vaccine

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Inflow and outflow permeability tests in a very soft clay under low stresses

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3270-3283页

作者： J.W.S.Vargas f.A.B.Danziger f.R.Lopes T.Lunne federal University of Rio de Janeiro Rio de JaneiroBrazil norwegian Geotechnical Institute OsloNorway

In situ inflow and outflow permeability tests with the BAT probe at SarapuíII soft clay test site are presented.A description of the BAT permeability test is provided,discussing its advantages and shortcomings,especially in the case of very soft clays under low *** pressures were monitored during probe installation and were found to be slightly lower than piezocone u2 pore pressures,consistent with the position of the *** role of filter tip saturation was investigated after the usual saturation procedure provided an unsatisfactory pore pressure response during probe *** show that the vacuum saturation procedure provides adequate response during installation and increases the reliability of the coefficient of permeability determination in early *** inflow and outflow tests yielded similar results,indicating that careful execution of the test can lead to good test repeatability regardless of the loading *** sequences of alternated inflow and outflow tests have yielded similar results,indicating that soil reconsolidation and filter clogging were negligible in the tests *** are presented concerning the relationship between index parameters and the in situ coefficient of permeability for SarapuíII clay,which plot outside the range of existing databases.

关键词： Permeability test Soft clay BAT probe Inflow and outflow tests